Explanipedia

Efficacy, Hemodynamic Stability and Safety of Hyperbaric Bupivacaine versus Hyperbaric Ropivacaine in Spinal Anaesthesia for Elective Caesarean Sections: A Randomised Controlled Trial Open

Shah Mehndi Masih, Saajid Hameed, Priya Choudhry · 2024

Functional multiomics reveals genetic and pharmacologic regulation of surface CD38 in multiple myeloma Open

Priya Choudhry, Corynn Kasap, Bonell Patiño-Escobar, Olivia Gugliemini, Huimin Geng , et al. · 2024

Functional glycoproteomics by integrated network assembly and partitioning Open

Matthew E. Griffin, John W. Thompson, Yao Xiao, Michael J. Sweredoski, Rita B. Aksenfeld , et al. · 2023

SUMMARY The post-translational modification (PTM) of proteins by O-linked β- N -acetyl-D-glucosamine (O-GlcNAcylation) is widespread across the proteome during the lifespan of all multicellular organisms. However, nearly all functional stu…

The surfaceome of multiple myeloma cells suggests potential immunotherapeutic strategies and protein markers of drug resistance Open

Ian Ferguson, Bonell Patiño-Escobar, Sami T. Tuomivaara, Yu-Hsiu T. Lin, Matthew A. Nix , et al. · 2022

Functional multi-omics reveals genetic and pharmacologic regulation of surface CD38 in multiple myeloma Open

Priya Choudhry, Corynn Kasap, Bonell Patiño-Escobar, Olivia Gugliemini, Huimin Geng , et al. · 2021

CD38 is a surface ectoenzyme expressed at high levels on myeloma plasma cells and is the target for the monoclonal antibodies (mAbs) daratumumab and isatuximab. Pre-treatment CD38 density on tumor cells is an important determinant of mAb e…

Defining the cell surface proteomic landscape of multiple myeloma reveals immunotherapeutic strategies and biomarkers of drug resistance Open

Ian Ferguson, Bonell Patiño-Escobar, Sami T. Tuomivaara, Yu-Hsiu T. Lin, Matthew A. Nix , et al. · 2021

The myeloma cell surface proteome (“surfaceome”) not only determines tumor interaction with the microenvironment but serves as an emerging arena for therapeutic development. Here, we use glycoprotein capture proteomics to first define surf…

CRISPR-based screens uncover determinants of immunotherapy response in multiple myeloma Open

Poornima Ramkumar, Anthony Abarientos, Ruilin Tian, Meghan Seyler, Jaime T. Leong , et al. · 2020

Cancer cells commonly develop resistance to immunotherapy by loss of antigen expression. Combinatorial treatments that increase levels of the target antigen on the surface of cancer cells have the potential to restore efficacy to immunothe…

Proteasome inhibitor-induced modulation reveals the spliceosome as a specific therapeutic vulnerability in multiple myeloma Open

Hector H. Huang, Ian Ferguson, Alexis M. Thornton, Prabhakar Bastola, Christine Lam , et al. · 2020

Enhancing the efficacy of proteasome inhibitors (PI) is a central goal in myeloma therapy. We proposed that signaling-level responses after PI may reveal new mechanisms of action that can be therapeutically exploited. Unbiased phosphoprote…

DNA methyltransferase inhibitors upregulate CD38 protein expression and enhance daratumumab efficacy in multiple myeloma Open

Priya Choudhry, Margarette C. Mariano, Huimin Geng, Thomas G. Martin, Jeffrey L. Wolf , et al. · 2019

Author(s): Choudhry, Priya; Mariano, Margarette C; Geng, Huimin; Martin, Thomas G; Wolf, Jeffrey L; Wong, Sandy W; Shah, Nina; Wiita, Arun P

Efficient tumor killing and minimal cytokine release with novel T-cell agonist bispecific antibodies Open

Nathan D. Trinklein, Duy Pham, Ute Schellenberger, Ben Buelow, Andrew Boudreau , et al. · 2019

T-cell-recruiting bispecific antibodies (T-BsAbs) have shown potent tumor killing activity in humans, but cytokine release-related toxicities have affected their clinical utility. The use of novel anti-CD3 binding domains with more favorab…

Proteasome inhibitor-induced modulation reveals the spliceosome as a specific therapeutic vulnerability in multiple myeloma Open

Hector H. Huang, Ian Ferguson, Alexis M. Thornton, Christine Lam, Yu-Hsiu T. Lin , et al. · 2018

Enhancing the efficacy of proteasome inhibitors is a central goal in myeloma therapy. We proposed that signaling-level responses after PI would reveal new mechanisms of action that could be therapeutically exploited. Unbiased phosphoproteo…

Seeking Convergence and Cure with New Myeloma Therapies Open

Priya Choudhry, Derek Galligan, Arun P. Wiita · 2018

High-Throughput Method for Automated Colony and Cell Counting by Digital Image Analysis Based on Edge Detection Open

Priya Choudhry · 2016

Counting cells and colonies is an integral part of high-throughput screens and quantitative cellular assays. Due to its subjective and time-intensive nature, manual counting has hindered the adoption of cellular assays such as tumor sphero…

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