Philip Prathipati
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View article: 526 miR-15a and miR-15b modulate natural killer and CD8<sup>+</sup>T-cell activation and anti-tumor immune response by targeting PD-L1 in neuroblastoma
526 miR-15a and miR-15b modulate natural killer and CD8<sup>+</sup>T-cell activation and anti-tumor immune response by targeting PD-L1 in neuroblastoma Open
Background Neuroblastoma (NB) is an enigmatic and deadliest pediatric cancer to treat. The major obstacles to effective immuno- therapy treatments in NB are defective immune cells and the immune evasion tactics deployed by the tumor cells …
View article: miR-15a and miR-15b modulate natural killer and CD8+T-cell activation and anti-tumor immune response by targeting PD-L1 in neuroblastoma
miR-15a and miR-15b modulate natural killer and CD8+T-cell activation and anti-tumor immune response by targeting PD-L1 in neuroblastoma Open
View article: SAP30, an oncogenic driver of progression, poor survival, and drug resistance in neuroblastoma
SAP30, an oncogenic driver of progression, poor survival, and drug resistance in neuroblastoma Open
View article: New insights into exosome mediated tumor-immune escape: Clinical perspectives and therapeutic strategies
New insights into exosome mediated tumor-immune escape: Clinical perspectives and therapeutic strategies Open
Recent advances in extracellular vesicle biology have uncovered a substantial role in maintaining cell homeostasis in health and disease conditions by mediating intercellular communication, thus catching the scientific community's attentio…
View article: COVID-19 AND CANCER COMORBIDITY: THERAPEUTIC OPPORTUNITIES AND CHALLENGES (RUSSIAN TRANSLATION)
COVID-19 AND CANCER COMORBIDITY: THERAPEUTIC OPPORTUNITIES AND CHALLENGES (RUSSIAN TRANSLATION) Open
The coronavirus disease 2019 (COVID-19) is a viral disease caused by a novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that affects the respiratory system of infected individuals. COVID-19 spreads between humans through …
View article: COVID-19 and Cancer Comorbidity: Therapeutic Opportunities and Challenges
COVID-19 and Cancer Comorbidity: Therapeutic Opportunities and Challenges Open
The coronavirus disease 2019 (COVID-19) is a viral disease caused by a novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that affects the respiratory system of infected individuals. COVID-19 spreads between humans through …
View article: Amino Acids Regulate Cisplatin Insensitivity in Neuroblastoma
Amino Acids Regulate Cisplatin Insensitivity in Neuroblastoma Open
Neuroblastoma are pediatric, extracranial malignancies showing alarming survival prognosis outcomes due to their resilience to current aggressive treatment regimens, including chemotherapies with cisplatin (CDDP) provided in the first line…
View article: BioHackathon 2015: Semantics of data for life sciences and reproducible research
BioHackathon 2015: Semantics of data for life sciences and reproducible research Open
We report on the activities of the 2015 edition of the BioHackathon, an annual event that brings together researchers and developers from around the world to develop tools and technologies that promote the reusability of biological data. W…
View article: A prospective compound screening contest identified broader inhibitors for Sirtuin 1
A prospective compound screening contest identified broader inhibitors for Sirtuin 1 Open
View article: Integrating sequence and gene expression information predicts genome-wide DNA-binding proteins and suggests a cooperative mechanism
Integrating sequence and gene expression information predicts genome-wide DNA-binding proteins and suggests a cooperative mechanism Open
DNA-binding proteins (DBPs) perform diverse biological functions ranging from transcription to pathogen sensing. Machine learning methods can not only identify DBPs de novo but also provide insights into their DNA-recognition dynamics. How…
View article: Evaluating the significance of hypoglycemia in promoting insulin induced hypertension by using a glucose clamp model
Evaluating the significance of hypoglycemia in promoting insulin induced hypertension by using a glucose clamp model Open
Background: Hypoglycemia unawareness is a detrimental risk factor in diabetic patients leading to serious complications if left untreated. Previous studies from our group determined that recurrent insulin induced hypoglycemia (RIIH) promot…
View article: Rational design, synthesis, and structure–activity relationships of 5-amino-1H-pyrazole-4-carboxylic acid derivatives as protein tyrosine phosphatase 1B inhibitors
Rational design, synthesis, and structure–activity relationships of 5-amino-1H-pyrazole-4-carboxylic acid derivatives as protein tyrosine phosphatase 1B inhibitors Open
View article: Identification of potential inhibitors based on compound proposal contest: Tyrosine-protein kinase Yes as a target
Identification of potential inhibitors based on compound proposal contest: Tyrosine-protein kinase Yes as a target Open
A search of broader range of chemical space is important for drug discovery. Different methods of computer-aided drug discovery (CADD) are known to propose compounds in different chemical spaces as hit molecules for the same target protein…