Prossy Naluyima
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View article: The vast majority of SARS-CoV-2 infections were asymptomatic in a clinic-based cohort of people with and without HIV in four African countries
The vast majority of SARS-CoV-2 infections were asymptomatic in a clinic-based cohort of people with and without HIV in four African countries Open
The vast majority of people with positive SARS-CoV-2 RT-PCR were asymptomatic. Universal screening may be needed to fully understand the epidemiology of SARS-CoV-2 and future outbreaks of similar respiratory viruses, capture early infectio…
View article: Sustaining Functionality of Not-for-Profit Health Organisations During Pandemics: Lessons and COVID 19 Experience from Makerere University Walter Reed Project
Sustaining Functionality of Not-for-Profit Health Organisations During Pandemics: Lessons and COVID 19 Experience from Makerere University Walter Reed Project Open
Not for profit health organisations (NPHOs) complement government health response efforts, hence the need for their continued functionality during pandemic situations. In this article we highlight lessons from Makerere University Walter Re…
View article: Evidence of <i>Orientia</i> spp. Endemicity among Severe Infectious Disease Cohorts, Uganda
Evidence of <i>Orientia</i> spp. Endemicity among Severe Infectious Disease Cohorts, Uganda Open
At 3 severe infection cohort sites in Uganda, Orientia seropositivity was common. We identified 4 seroconversion cases and 1 PCR-positive case. These results provide serologic and molecular support for Orientia spp. circulating in sub-Saha…
View article: High frequency of HIV precursor-target-specific B cells in sub-Saharan populations
High frequency of HIV precursor-target-specific B cells in sub-Saharan populations Open
View article: Long-term Mortality Among Hospitalized Adults with Sepsis in Uganda: a Prospective Cohort Study
Long-term Mortality Among Hospitalized Adults with Sepsis in Uganda: a Prospective Cohort Study Open
Background Twelve-month mortality in sepsis survivors has not been previously characterized in sub-Saharan Africa. Methods Hospitalized adults with ≥ 2 modified systemic inflammatory response syndrome (SIRS) criteria (temperature < 36°C or…
View article: Safety, tolerability, and immunogenicity of the Ebola Sudan chimpanzee adenovirus vector vaccine (cAd3-EBO S) in healthy Ugandan adults: a phase 1, open-label, dose-escalation clinical trial
Safety, tolerability, and immunogenicity of the Ebola Sudan chimpanzee adenovirus vector vaccine (cAd3-EBO S) in healthy Ugandan adults: a phase 1, open-label, dose-escalation clinical trial Open
View article: Causes and Risk of Long-Term Sepsis Mortality in Uganda: A Prospective Cohort Study
Causes and Risk of Long-Term Sepsis Mortality in Uganda: A Prospective Cohort Study Open
View article: 1169. Derivation And Validation of an International Clinical Prognostication Model for 28-day Sepsis Mortality.
1169. Derivation And Validation of an International Clinical Prognostication Model for 28-day Sepsis Mortality. Open
Background Survival prediction models have largely been derived and validated only in high-resource Western countries or in single center studies. We sought to create a prediction model for 28-day mortality using laboratory and physiologic…
View article: Training Needs for Emerging Infectious Diseases Research, Surveillance and Control in High-Risk and Resource-Constrained Settings: Findings and Recommendations for Uganda
Training Needs for Emerging Infectious Diseases Research, Surveillance and Control in High-Risk and Resource-Constrained Settings: Findings and Recommendations for Uganda Open
Background Uganda is prone to Emerging Infectious Diseases (EIDs) which can cause serious epidemics and pandemics. Uganda’s capacity for EID research, surveillance and control is improving but still low partly due to inadequate highly know…
View article: Developing capacity for implementation and evaluation of vaccine trials in Uganda: Perspective of the Makerere University Walter Reed Project
Developing capacity for implementation and evaluation of vaccine trials in Uganda: Perspective of the Makerere University Walter Reed Project Open
Introduction: Infectious diseases and neglected tropical diseases continue to be a major challenge in resource limited settings, causing significant morbidity and mortality. Although vaccines are a key biomedical prevention tool, resource …
View article: Assessment of tuberculosis disease activity in people infected with Mycobacterium tuberculosis and living with HIV: A longitudinal cohort study
Assessment of tuberculosis disease activity in people infected with Mycobacterium tuberculosis and living with HIV: A longitudinal cohort study Open
View article: Routine HIV clinic visit adherence in the African Cohort Study
Routine HIV clinic visit adherence in the African Cohort Study Open
Background Retention in clinical care is important for people living with HIV (PLWH). Evidence suggests that missed clinic visits are associated with interruptions in antiretroviral therapy (ART), lower CD4 counts, virologic failure, and o…
View article: Predictors of All-Cause Mortality Among People With Human Immunodeficiency Virus (HIV) in a Prospective Cohort Study in East Africa and Nigeria
Predictors of All-Cause Mortality Among People With Human Immunodeficiency Virus (HIV) in a Prospective Cohort Study in East Africa and Nigeria Open
Background Introduction of antiretroviral therapy (ART) has been associated with a decline in human immunodeficiency virus (HIV)-related mortality, although HIV remains a leading cause of death in sub-Saharan Africa. We describe all-cause …
View article: Prevalence and risk factors associated with HIV and syphilis co-infection in the African Cohort Study: a cross-sectional study
Prevalence and risk factors associated with HIV and syphilis co-infection in the African Cohort Study: a cross-sectional study Open
View article: Assessing the impact of HIV support groups on antiretroviral therapy adherence and viral suppression in the African cohort study
Assessing the impact of HIV support groups on antiretroviral therapy adherence and viral suppression in the African cohort study Open
Background Support groups for people living with HIV (PLWH) may improve HIV care adherence and outcomes. We assessed the impact of support group attendance on antiretroviral therapy (ART) adherence and viral suppression in four African cou…
View article: Transient Reductions in Human Immunodeficiency Virus (HIV) Clinic Attendance and Food Security During the Coronavirus Disease 2019 (COVID-19) Pandemic for People Living With HIV in 4 African Countries
Transient Reductions in Human Immunodeficiency Virus (HIV) Clinic Attendance and Food Security During the Coronavirus Disease 2019 (COVID-19) Pandemic for People Living With HIV in 4 African Countries Open
The coronavirus disease 2019 (COVID-19) pandemic and associated public health responses have disrupted daily living activities with economic and health consequences globally. We observed transient decreases in human immunodeficiency virus …
View article: In-vitro Immunomodulatory activity of Azadirachta indica A.Juss. Ethanol: water mixture against HIV associated chronic CD4+ T-cell activation/ exhaustion
In-vitro Immunomodulatory activity of Azadirachta indica A.Juss. Ethanol: water mixture against HIV associated chronic CD4+ T-cell activation/ exhaustion Open
View article: In-vitro Immunomodulatory activity of Azadirachta indica A.Juss. Ethanol: water mixture against HIV
In-vitro Immunomodulatory activity of Azadirachta indica A.Juss. Ethanol: water mixture against HIV Open
View article: The Joint Mobile Emerging Disease Clinical Capability (JMEDICC) laboratory approach: Capabilities for high-consequence pathogen clinical research
The Joint Mobile Emerging Disease Clinical Capability (JMEDICC) laboratory approach: Capabilities for high-consequence pathogen clinical research Open
Following the 2013-2016 Ebola virus outbreak in West Africa, numerous groups advocated for the importance of executing clinical trials in outbreak settings. The difficulties associated with obtaining reliable data to support regulatory app…
View article: Terminal Effector CD8 T Cells Defined by an IKZF2+IL-7R− Transcriptional Signature Express FcγRIIIA, Expand in HIV Infection, and Mediate Potent HIV-Specific Antibody-Dependent Cellular Cytotoxicity
Terminal Effector CD8 T Cells Defined by an IKZF2+IL-7R− Transcriptional Signature Express FcγRIIIA, Expand in HIV Infection, and Mediate Potent HIV-Specific Antibody-Dependent Cellular Cytotoxicity Open
HIV-1 infection expands large populations of late-stage differentiated CD8 T cells that may persist long after viral escape from TCR recognition. In this study, we investigated whether such CD8 T cell populations can perform unconventional…
View article: Ontogeny of CD4 <sup>+</sup> T Lymphocytes with Phenotypic Susceptibility to HIV-1 during Exclusive and Non-Exclusive Breastfeeding in HIV-1-exposed Ugandan Infants
Ontogeny of CD4 <sup>+</sup> T Lymphocytes with Phenotypic Susceptibility to HIV-1 during Exclusive and Non-Exclusive Breastfeeding in HIV-1-exposed Ugandan Infants Open
The T-cell phenotype associated with susceptibility to HIV-1 infection (CCR5+, gut-homing, CM CD4+ T cells) was preferentially expressed in nonexclusively breastfed infants, a group of infants at increased risk for HIV-1 acquisition.
View article: Sex and Urbanicity Contribute to Variation in Lymphocyte Distribution across Ugandan Populations
Sex and Urbanicity Contribute to Variation in Lymphocyte Distribution across Ugandan Populations Open
Management of patient care and interpretation of research data require evaluation of laboratory results in the context of reference data from populations with known health status to adequately diagnose disease or make a physiological asses…
View article: Brief Report
Brief Report Open
The significance of HIV-associated immune activation and microbial translocation in Sub-Saharan African population remains poorly defined. We assessed biomarkers of inflammation, microbial translocation, and cellular activation and found m…