P.S. Fenwick
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View article: T2 A novel drug target: IL-36 signalling drives inflammation and poor bacterial clearance in COPD
T2 A novel drug target: IL-36 signalling drives inflammation and poor bacterial clearance in COPD Open
The inflammatory cytokine IL-36γ is increased in COPD lungs, whereas its endogenous inhibitor IL-36 receptor antagonist (IL-36RA) is reduced. IL-36 receptor signalling drives neutrophilic inflammation. Macrophages are critical in modulati…
View article: S28 Non-invasive nasal sampling using nasosorption may identify COPD inflammatory profiles and have a role as a diagnostic tool in exacerbations
S28 Non-invasive nasal sampling using nasosorption may identify COPD inflammatory profiles and have a role as a diagnostic tool in exacerbations Open
COPD is a heterogenous disease and there is ongoing need to identify biomarkers for treatable endotypes. Nasosorption is a non-invasive and safe way of sampling the respiratory tract to obtain undiluted endothelial lining fluid. This stud…
View article: P208 Extracellular vesicles from COPD small airway fibroblasts spread senescence to healthy fibroblasts
P208 Extracellular vesicles from COPD small airway fibroblasts spread senescence to healthy fibroblasts Open
Background COPD is associated with cellular senescence and fibrosis. Extracellular vesicles (EVs) are membrane-derived vesicles involved in intercellular communication. EVs contain miRNAs, mRNA and proteins and have been implicated in COPD…
View article: P53 Phosphoinositide-3 kinase and mek inhibition prevents uptake of bacteria by airway epithelial cells
P53 Phosphoinositide-3 kinase and mek inhibition prevents uptake of bacteria by airway epithelial cells Open
Introduction Bacteria are associated with COPD exacerbations with Haemophilus influenzae, and Streptococcus pneumoniae being predominant. Airway epithelium can protect pathogens from host defences and antibiotic treatment by internalisatio…