Pu Wang
YOU?
Author Swipe
View article: Nuclear PD-L1 drives IFN-γ-promoted lung metastasis of triple-negative breast cancer via POLR2A-mediated transcriptional activation of LY6E
Nuclear PD-L1 drives IFN-γ-promoted lung metastasis of triple-negative breast cancer via POLR2A-mediated transcriptional activation of LY6E Open
Our findings unveil a novel IFN-γ-nuclear PD-L1/POLR2A-LY6E signaling axis critical for TNBC lung metastasis. This immune-independent mechanism, driven by nuclear PD-L1 transcriptional activity, provides a mechanistic basis for the limited…
View article: Real‐World Data Analysis on Early Mortality in Chinese Multiple Myeloma Patients: Analysis of 1093 Patients During a 15‐Year Period
Real‐World Data Analysis on Early Mortality in Chinese Multiple Myeloma Patients: Analysis of 1093 Patients During a 15‐Year Period Open
Despite the survival benefit observed in recent decades, early mortality (EM) remains critical in newly diagnosed multiple myeloma (NDMM) patients, with heterogeneous definitions and risk factors across studies. Besides, prognostic models …
View article: Inflammatory macrophage-derived itaconate inhibits DNA demethylase TET2 to prevent excessive osteoclast activation in rheumatoid arthritis
Inflammatory macrophage-derived itaconate inhibits DNA demethylase TET2 to prevent excessive osteoclast activation in rheumatoid arthritis Open
Itaconate, a macrophage-specific anti-inflammatory metabolite, has recently emerged as a critical regulator in rheumatoid arthritis pathogenesis. We found that itaconate is a TNF-α responsive metabolite significantly elevated in the serum …
View article: Research on Production Decision-Making of Assembly Enterprises Based on Dynamic Bayesian Sampling and Multi-Stage Optimization
Research on Production Decision-Making of Assembly Enterprises Based on Dynamic Bayesian Sampling and Multi-Stage Optimization Open
This paper focuses on the production decision-making problems of electronic product assembly enterprises, and comprehensively uses probability theory, statistics and optimization theory to construct a series of innovative models and algori…
View article: An optimized study of v-band clamp sealing performance in marine diesel engine exhaust pipes
An optimized study of v-band clamp sealing performance in marine diesel engine exhaust pipes Open
The reliability of sealing systems in marine diesel engine exhaust pipes is critical for ensuring operational safety and efficiency under harsh working conditions. This study analyzes the sealing performance of V-band clamps in the exhaust…
View article: CAF-VTON: Cross-Attention Layered Fusion Based Latent Diffusion Virtual Try-On
CAF-VTON: Cross-Attention Layered Fusion Based Latent Diffusion Virtual Try-On Open
Virtual try-on technology has gained significant attention in e-commerce, digital retail, and virtual reality due to its ability to enhance user experience and reduce return rates. However, generating accurate and natural virtual try-on re…
View article: Integrating ICH Good Clinical Practice (GCP) Principles and Essential Documentation into Dermatology Residency Education in China
Integrating ICH Good Clinical Practice (GCP) Principles and Essential Documentation into Dermatology Residency Education in China Open
Integrating International Council for Harmonisation Good Clinical Practice (ICH GCP) principles, including essential documentation and ethical standards, into medical education is crucial for building clinical trial capabilities and advanc…
View article: Integrated analyses of metabolome, leaf anatomy, epigenome, and transcriptome under different light intensities reveal dynamic regulation of histone modifications on the high light adaptation in <i>Camellia sinensis</i>
Integrated analyses of metabolome, leaf anatomy, epigenome, and transcriptome under different light intensities reveal dynamic regulation of histone modifications on the high light adaptation in <i>Camellia sinensis</i> Open
SUMMARY Camellia sinensis is an industrial crop characterized by specific secondary metabolites, which provide numerous benefits to human health. Previous researches reveal that the secondary metabolism of tea plants is significantly affec…
View article: Umbilical Cord Mesenchymal Stem Cells Attenuate Podocyte Injury in Diabetic Nephropathy Rats by Inhibiting Angpltl4/Integrin <i>β</i>3 in the Glomerulus
Umbilical Cord Mesenchymal Stem Cells Attenuate Podocyte Injury in Diabetic Nephropathy Rats by Inhibiting Angpltl4/Integrin <i>β</i>3 in the Glomerulus Open
In this study, we investigated the therapeutic effects and mechanisms of umbilical cord mesenchymal stem cells (UCMSCs) in diabetic nephropathy (DN) ZDF (FA/FA) rats. The therapeutic effects were assessed by renal function tests, the urina…
View article: Light-chain amyloidosis with concomitant symptomatic myeloma (CRAB-SLiM features): clinical characteristics, cytogenetic abnormalities, and outcomes
Light-chain amyloidosis with concomitant symptomatic myeloma (CRAB-SLiM features): clinical characteristics, cytogenetic abnormalities, and outcomes Open
There was an apparent discrepancy in the distribution and prognostic implication of CA among different plasma cell diseases. Patients with MM-AL had the worst clinical outcomes, requiring extended duration of induction therapy and maintena…
View article: Double-Hit/Triple-Hit Myeloma: An Adverse Prognostic Factor That Can be Overcome By Minimal Residual Disease Negativity
Double-Hit/Triple-Hit Myeloma: An Adverse Prognostic Factor That Can be Overcome By Minimal Residual Disease Negativity Open
Objective： The outcome of double-hit/triple-hit multiple myeloma (DH/TH MM) remains poor. We aimed to demonstrate the clinical characteristics, response, minimal residual disease (MRD) status and survival of DH/TH MM in novel drug era. Met…
View article: Maintenance therapy promotes profound organ and haematologic response in light-chain amyloidosis patients not undergoing autologous stem cell transplantation
Maintenance therapy promotes profound organ and haematologic response in light-chain amyloidosis patients not undergoing autologous stem cell transplantation Open
This study identified the clinical benefits of maintenance therapy in patients with AL who did not undergo ASCT in real-world practice.
View article: Metabolite regulation of epigenetics in cancer
Metabolite regulation of epigenetics in cancer Open
The catalytic activity of most epigenetic enzymes requires a metabolite produced by central carbon metabolism as a cofactor or (co-)substrate. The concentrations of these metabolites undergo dynamic changes in response to nutrient levels a…
View article: Temsirolimus inhibits FSP1 enzyme activity to induce ferroptosis and restrain liver cancer progression
Temsirolimus inhibits FSP1 enzyme activity to induce ferroptosis and restrain liver cancer progression Open
Ferroptosis is a non-apoptotic mode of cell death characterized by iron-dependent accumulation of lipid peroxidation. While lipid radical elimination reaction catalyzed by glutathione peroxidase 4 (GPX4) is a major anti-ferroptosis mechani…
View article: Genomic sequencing reveals convergent adaptation during experimental evolution in two budding yeast species
Genomic sequencing reveals convergent adaptation during experimental evolution in two budding yeast species Open
Convergent evolution is central in the origins of multicellularity. Identifying the basis for convergent multicellular evolution is challenging because of the diverse evolutionary origins and environments involved. Haploid Kluyveromyces la…
View article: Itaconate and dimethyl itaconate upregulate IL-6 production in the LPS-induced inflammation in mice
Itaconate and dimethyl itaconate upregulate IL-6 production in the LPS-induced inflammation in mice Open
Itaconate is one of the most studied immunometabolites produced by myeloid cells during inflammatory response. It mediates a wide range of anti-inflammatory and immunoregulatory effects and plays a role in a number of pathological states, …
View article: Characterization of the complete chloroplast genome and development of molecular markers of Salix
Characterization of the complete chloroplast genome and development of molecular markers of Salix Open
Salix is an economically and ecologically multi-functional tree species widely distributed in China. The five species sequenced in this study are of great ornamental value and suitable for plant phytoremediation owing to their ability to a…
View article: Unraveling the Independent Role of METTL3 in m6A Modification and Tumor Progression in Esophageal Squamous Cell Carcinoma
Unraveling the Independent Role of METTL3 in m6A Modification and Tumor Progression in Esophageal Squamous Cell Carcinoma Open
METTL3 and METTL14 are considered to faithfully form the m6A writing complex in a 1:1 ratio, regulating the fate of mRNA by adding m6A modifications. However, recent studies have shown inconsistent expression and prognostic value of METTL3…
View article: Light-chain Amyloidosis with Concomitant Symptomatic Myeloma (CRAB-SLiM Features): Clinical Characteristics, Cytogenetic Abnormalities, and Outcomes
Light-chain Amyloidosis with Concomitant Symptomatic Myeloma (CRAB-SLiM Features): Clinical Characteristics, Cytogenetic Abnormalities, and Outcomes Open
Patients with light chain (AL) amyloidosis and concomitant symptomatic multiple myeloma (MM) are known to have a worse prognosis, while the prognostic implication of cytogenetic abnormalities (CA) and optimal treatment schemes are not well…
View article: Changes in macrophage infiltration and podocyte injury in lupus nephritis patients with repeated renal biopsy: Report of three cases
Changes in macrophage infiltration and podocyte injury in lupus nephritis patients with repeated renal biopsy: Report of three cases Open
BACKGROUND In this study, we retrospectively analysed macrophage infiltration and podocyte injury in three patients with diffuse proliferative lupus nephritis (LN) who underwent repeated renal biopsy. CASE SUMMARY Clinical data of three di…
View article: Coupling of Perinuclear Actin Cap and Nuclear Mechanics in Regulating Flow‐Induced Yap Spatiotemporal Nucleocytoplasmic Transport
Coupling of Perinuclear Actin Cap and Nuclear Mechanics in Regulating Flow‐Induced Yap Spatiotemporal Nucleocytoplasmic Transport Open
Mechanical forces, including flow shear stress, govern fundamental cellular processes by modulating nucleocytoplasmic transport of transcription factors like Yes‐associated Protein (YAP). However, the underlying mechanical mechanism remain…
View article: Update on the outcome of M‐protein screening program of multiple myeloma in China: A 7‐year cohort study
Update on the outcome of M‐protein screening program of multiple myeloma in China: A 7‐year cohort study Open
Background To improve the early detection rate of multiple myeloma (MM), the M‐protein screening system has been performed in the hospital population at Zhongshan Hospital Fudan University since 2014, with electrophoretic‐based monoclonal …
View article: Early minimal residual disease eradication in light chain amyloidosis generates deeper and faster cardiac response
Early minimal residual disease eradication in light chain amyloidosis generates deeper and faster cardiac response Open
Minimal residual disease (MRD) is of growing interest in light chain (AL) amyloidosis and is associated with higher rates of cardiac response. A new graded cardiac response criteria has been proposed for better assessment of cardiac improv…
View article: Clinical profiles in multiple myeloma patients with extreme survivals: a study from a National Medical Center in China
Clinical profiles in multiple myeloma patients with extreme survivals: a study from a National Medical Center in China Open
The disparities in the survivals of MM patients indicated that some unexpected factors have influenced the outcomes in the real-world setting.