Explanipedia

Molecular pathobiology of breast fibroepithelial tumours Open

Raymond J. Lim, Sara Haghani, Hui Yi Tay, B.Y. Lim, Bavani Kannan , et al. · 2025

100P Comprehensive genomic landscape of Asian and African breast cancer (BC) patients (pts) Open

V.Y.M. Heong, Jonathan Chan, Ruiqiang Weng, Puay Hoon Tan, G.E. Lee , et al. · 2025

Polymorphous adenocarcinoma-like tumor of the breast: The first case report from Japan Open

Yuki Hara, Puay Hoon Tan, Foschini Maria Pia, Hiroshi Yano, Stephen G. Sawada , et al. · 2025

Polymorphous adenocarcinoma-like (PmA-like) tumor of the breast is a rare salivary gland-like neoplasm, with few cases reported globally. We present the first case of a PmA-like tumor with a fibrous pseudocapsule from Japan, including radi…

Reducing inappropriate investigations for minor lower limb cellulitis Open

Libin Liang, Daryl Yin Keong Lo, Elaine Jing-Mei Pang, Eugene Tan, Adrian Chung Thien Lim , et al. · 2025

Lower limb cellulitis is a frequently encountered condition in the acute hospital setting, yet many patients with only mild lower limb cellulitis undergo unnecessary collection of blood cultures and X-ray imaging. This leads to increased h…

Classification of Fibroepithelial Lesions of the Breast in Core Needle Biopsy With Implications for Further Management Open

Emad A. Rakha, Cecily Quinn, Wendy A. Raymond, Kimberly H. Allison, Sunil Badve , et al. · 2025

Effects of RARα ligand binding domain mutations on breast fibroepithelial tumor function and signaling Open

Xi Huang, Ley Moy Ng, Po-Hsien Lee, Peiyong Guan, Mun Juinn Chow , et al. · 2025

Evaluating the Nighttime Human Activity in Green Spaces among Three Major Urban Agglomerations in China Using Green Lighting Index Open

Puay Hoon Tan, Mingyang Lv, Huadong Guo, Changyong Dou, Jin Xue , et al. · 2025

Identification of plasma protein biomarkers for endometriosis and the development of statistical models for disease diagnosis Open

Elizna M. Schoeman, Scott Bringans, Kirsten E. Peters, Tammy M. Casey, Christina E. Andronis , et al. · 2024

STUDY QUESTION Can a panel of plasma protein biomarkers be identified to accurately and specifically diagnose endometriosis? SUMMARY ANSWER A novel panel of 10 plasma protein biomarkers was identified and validated, demonstrating strong pr…

Comprehensive molecular characterization of collecting duct carcinoma for therapeutic vulnerability Open

Peiyong Guan, Jianfeng Chen, Chengqiang Mo, Tomoya Fukawa, Chao Zhang , et al. · 2024

Collecting duct carcinoma (CDC) is an aggressive rare subtype of kidney cancer with unmet clinical needs. Little is known about its underlying molecular alterations and etiology, primarily due to its rarity, and lack of preclinical models.…

Mapping the cited evidence of ductal carcinoma in situ from the 5th edition of the World Health Organisation classification of tumours of the breast Open

Clarissa Jing Wen Wong, Nur Diyana Md Nasir, Valerie Cui Yun Koh, Fiona Campbell, Stephen B. Fox , et al. · 2024

Aims Ductal carcinoma in situ (DCIS) is recognised by the World Health Organisation (WHO) Classification of Tumours (WCT) as a non‐invasive neoplastic epithelial proliferation confined to the mammary ducts and lobules. This report categori…

Moving Forward on Tumor Pathology Research Reporting: A Guide for Pathologists From the World Health Organization Classification of Tumors Living Evidence Gap Map by Tumour Type Group Open

Richard Colling, Iciar Indave, Javier Del Aguilla, Ramon Cierco Jiménez, Fiona Campbell , et al. · 2024

Evidence-based medicine (EBM) can be an unfamiliar territory for those working in tumor pathology research, and there is a great deal of uncertainty about how to undertake an EBM approach to planning and reporting histopathology-based stud…

Outcomes in Nonmetastatic Hormone Receptor–Positive HER2-Negative Pure Mucinous Breast Cancer: A Multicenter Cohort Study Open

Ryan Tan, Whee Sze Ong, Kyung-Hun Lee, Seri Park, Jabed Iqbal , et al. · 2024

Background: Although considered a favorable subtype, pure mucinous breast cancer (PMBC) can recur, and evidence for adjuvant therapy is limited. We aimed to compare outcomes of nonmetastatic PMBC with invasive ductal carcinoma (IDC) and in…

Dataset for reporting of the invasive carcinoma of the breast: recommendations from the International Collaboration on Cancer Reporting (ICCR) Open

Ian O. Ellis, Fleur Webster, Kimberly H. Allison, Chau T. Dang, Helenice Gobbi , et al. · 2024

Background and Objectives Current national or regional guidelines for the pathology reporting on invasive breast cancer differ in certain aspects, resulting in divergent reporting practice and a lack of comparability of data. Here we repor…

Case report: Metastatic ovarian mucinous carcinoma to the breast: diagnostic challenges and pitfalls Open

Natthawadee Laokulrath, Siew Kuan Lim, Hwee Yong Lim, Mihir Gudi, Puay Hoon Tan · 2024

Metastases to the breast from extramammary sources are extremely rare, with the ovary, primarily high-grade serous carcinoma, being the most common origin. We report a case of breast metastases from advanced stage ovarian mucinous carcinom…

HER2-low breast cancers: challenges in the interpretation of immunohistochemistry Open

Noel Chia, Mihir Gudi, Emad A. Rakha, Puay Hoon Tan · 2024

Overexpression of human epidermal growth factor receptor 2 (HER2) protein in breast cancers carries significant prognostic and therapeutic implications. Anti-HER2 blockade has shown to be a useful adjunct to surgery in treating HER2-positi…

Peroxiredoxin 3 regulates breast cancer progression via ERK-mediated MMP-1 expression Open

Pei‐Jou Chua, Suet-Hui Ow, Cheng-Teng Ng, Wan-Hong Huang, Jie-Ting Low , et al. · 2024

Peroxiredoxin 3 (PRDX3), a mitochondrial hydrogen peroxide scavenger, is known to be upregulated during tumorigenesis and cancer progression. In this study, we provide evidence for the first time that PRDX3 could regulate cellular signalin…

Tumours of the nipple – evidence gaps mapped from the fifth edition of the WHO classification of tumours of the breast: preliminary results Open

Zi Long Chow, Nur Diyana Md Nasir, Menaka Dilani Samarawickrema Lokuhetty, Puay Hoon Tan · 2024

Challenges and Clinical Relevance of Modern Breast Pathology Reporting: Your Questions Answered Open

Rahul Deb, Natthawadee Laokulrath, Leena Chagla, Puay Hoon Tan · 2024

Background: Breast pathology reporting, especially for breast cancer, has evolved through the years, from terse succinct diagnostic conclusions with scant histological details to the current comprehensive reporting guidelines…

Predictive and prognostic biomarkers in breast tumours Open

Melissa Krystel‐Whittemore, Puay Hoon Tan, Hannah Y. Wen · 2023

A Preliminary Investigation into Search and Matching for Tumor Discrimination in World Health Organization Breast Taxonomy Using Deep Networks Open

Abubakr Shafique, Ricardo González, Liron Pantanowitz, Puay Hoon Tan, Alberto Machado , et al. · 2023

Breast cancer is one of the most common cancers affecting women worldwide. It includes a group of malignant neoplasms with a variety of biological, clinical, and histopathologic characteristics. There are more than 35 different histologic …

A New Hierarchy of Research Evidence for Tumor Pathology: A Delphi Study to Define Levels of Evidence in Tumor Pathology Open

Richard Colling, Iciar Indave, Javier del Aguila, Ramon Cierco Jiménez, Fiona Campbell , et al. · 2023

The hierarchy of evidence is a fundamental concept in evidence-based medicine, but existing models can be challenging to apply in laboratory-based health care disciplines, such as pathology, where the types of evidence and contexts are sig…

Adipose-enriched peri-tumoral stroma, in contrast to myofibroblast-enriched stroma, prognosticates poorer survival in breast cancers Open

Hannah Si Hui Lau, Veronique Kiak Mien Tan, Benita Kiat Tee Tan, Yirong Sim, Jelmar Quist , et al. · 2023

The prognostic value of CD39+CD8+ T cells as a potential surrogate marker of tumor-specific T cells in Asian triple-negative breast cancer Open

Jia Meng, Tan Jing Ying Tira, Craig Ryan Joseph, Jiangfeng Ye, Jeffrey Chun Tatt Lim , et al. · 2023

Triple-negative breast cancer (TNBC) is a highly aggressive breast cancer subtype that is generally associated with poor prognosis in affected patients. Unfortunately, recently approved immune checkpoint inhibitors are efficacious in only …

Ductal adenocarcinoma of the prostate with oncocytic morphology Open

Lavisha S. Punjabi, Chee Kwan Ng, Liang Cheng, Puay Hoon Tan · 2023

A Preliminary Investigation into Search and Matching for Tumour Discrimination in WHO Breast Taxonomy Using Deep Networks Open

Abubakr Shafique, Ricardo González, Liron Pantanowitz, Puay Hoon Tan, Alberto Machado , et al. · 2023

Breast cancer is one of the most common cancers affecting women worldwide. They include a group of malignant neoplasms with a variety of biological, clinical, and histopathological characteristics. There are more than 35 different histolog…

Figure S1-9; Supplementary methods from VHL Deficiency Drives Enhancer Activation of Oncogenes in Clear Cell Renal Cell Carcinoma Open