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View article: A tissue-scale strategy for sensing threats in barrier organs
A tissue-scale strategy for sensing threats in barrier organs Open
Summary Barrier organs rely on a limited set of pattern recognition receptors (PRRs) to detect diverse immunogenic challenges. How organs assess threats and adjust immune responses to balance host protection with collateral tissue damage r…
Reconstructing signaling histories of single cells via perturbation screens and transfer learning Open
Manipulating the signaling environment is an effective approach to alter cellular states for broad-ranging applications, from engineering tissues to treating diseases. Such manipulation requires knowing the signaling states and histories o…
View article: Diffusion barriers imposed by tissue topology shape Hedgehog morphogen gradients
Diffusion barriers imposed by tissue topology shape Hedgehog morphogen gradients Open
Animals use a small number of morphogens to pattern tissues, but it is unclear how evolution modulates morphogen signaling range to match tissues of varying sizes. Here, we used single-molecule imaging in reconstituted morphogen gradients …
View article: Diffusion barriers imposed by tissue topology shape morphogen gradients
Diffusion barriers imposed by tissue topology shape morphogen gradients Open
Animals use a small number of morphogens to pattern tissues, but it is unclear how evolution modulates morphogen signaling range to match tissues of varying sizes. Here, we used single molecule imaging in reconstituted morphogen gradients …
Lhx2 is a progenitor-intrinsic modulator of Sonic Hedgehog signaling during early retinal neurogenesis Open
An important question in organogenesis is how tissue-specific transcription factors interact with signaling pathways. In some cases, transcription factors define the context for how signaling pathways elicit tissue- or cell-specific respon…
Author response: Lhx2 is a progenitor-intrinsic modulator of Sonic Hedgehog signaling during early retinal neurogenesis Open
Article Figures and data Abstract Editor's evaluation Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Abstract An important question in organ…
Lhx2 is a progenitor-intrinsic modulator of Sonic Hedgehog signaling during early retinal neurogenesis Open
An important question in organogenesis is how tissue-specific transcription factors interact with signaling pathways. In some cases, transcription factors define the context for how signaling pathways elicit tissue- or cell-specific respon…
Synthetic Developmental Biology: Understanding Through Reconstitution Open
Reconstitution is an experimental strategy that seeks to recapitulate biological events outside their natural contexts using a reduced set of components. Classically, biochemical reconstitution has been extensively applied to identify the …
Communication codes in developmental signaling pathways Open
A handful of core intercellular signaling pathways play pivotal roles in a broad variety of developmental processes. It has remained puzzling how so few pathways can provide the precision and specificity of cell-cell communication required…
A Scube2-Shh feedback loop links morphogen release and spread to morphogen signaling to enable scale invariant patterning of the ventral neural tube Open
To enable robust patterning, morphogen systems should be resistant to variations in gene expression and tissue size. Here we explore how the Sonic Hedgehog (Shh) morphogen gradient in the ventral neural tube enables scaled patterning in em…
View article: Specific oxylipins enhance vertebrate hematopoiesis via the receptor GPR132
Specific oxylipins enhance vertebrate hematopoiesis via the receptor GPR132 Open
Significance Small-molecule enhancers of hematopoietic stem cell transplant could improve the safety of this treatment and expand the pool of eligible patients. We previously showed that the lipid 11,12-epoxyeicosatrienoic acid (EET) enhan…
Specific Oxylipins Enhance Vertebrate Hematopoiesis via the Receptor GPR132 Open
Epoxyeicosatrienoic acids (EETs) are endogenous lipid signaling molecules with cardioprotective and vasodilatory actions. We recently showed that exogenous addition of 11,12-EET enhances hematopoietic induction and engraftment in mice and …