Explanipedia

WHEAT ALLERGY, A NEW AND EMERGING THREAT OF FOOD ALLERGY FOR CHILDREN Open

Pakit Vichyanond, Ken‐ichi Nagakura, Punchama Pacharn, Gary Wong, Hugh A. Sampson · 2025

Molecular Diagnosis to IgE-mediated Wheat Allergy and Wheat-Dependent Exercise-Induced Anaphylaxis Open

Witchaya Srisuwatchari, Kantima Kanchanapoomi, Punchama Pacharn · 2025

Novel <i>CTSA</i> Variant Identified in a Thai Family With Late‐Infantile Galactosialidosis Open

Lukana Ngiwsara, Dhachdanai Dhachpramuk, Phannee Sawangareetrakul, Sherry Vongphit, Punchama Pacharn , et al. · 2025

Galactosialidosis (GS) is a rare lysosomal storage disease (LSD) with variable onset caused by a defect in protective protein/cathepsin A (PPCA) encoded by the CTSA gene. The late‐infantile onset is characterized by developmental delay, vi…

Sensitization profile of Thai children with fish allergy Open

Supaluk Tangvalelerd, Surapon Piboonpocanun, Unchalee Raungsirarak, Manaporn Sirichuwong, Pakit Vichyanond , et al. · 2025

Introduction: Fish allergies are common food allergies, and in Thailand, the prevalence of fish allergies in children ranges from 0.29% to 1.1%. Common fish allergens include parvalbumin, enolase, and aldolase. Method: This cross-sectional…

Sensitization profile of Thai children with fish allergy Open

Supaluk Tangvalelerd, Surapon Piboonpocanun, Unchalee Raungsirarak, Manaporn Sirichuwong, Pakit Vichyanond , et al. · 2025

Introduction: Fish allergies are common food allergies, and in Thailand, the prevalence of fish allergies in children ranges from 0.29% to 1.1%. Common fish allergens include parvalbumin, enolase, and aldolase.Method: This cross-sectional …

Exploring geographical variances in component‐resolved diagnosis within the Asia‐Pacific region Open

Carmen Riggioni, Agnes Sze Yin Leung, Christine Wai, Janet M. Davies, Mongkhon Sompornrattanaphan , et al. · 2025

Component‐resolved diagnostics (CRD) have revolutionized allergy diagnosis, offering enhanced accuracy and insights into allergen sensitization patterns. This review explores geographical variances in CRD for food and aeroallergens across …

Disparities in pediatric anaphylaxis triggers and management across Asia Open

Agnes Sze Yin Leung, Elizabeth Huiwen Tham, Punchama Pacharn, Yuhan Xing, Hoang Kim Tu Trinh , et al. · 2024

Background The epidemiology and management of anaphylaxis are not well‐reported in Asia. Methods A regional pediatric anaphylaxis registry was established by the Asia‐Pacific Research Network for Anaphylaxis (APRA), using standardized prot…

Epitope-specific IgE, IgG4, and IgG1 antibodies for clinical phenotyping of IgE-mediated wheat allergy Open

Mayte Suárez‐Fariñas, Witchaya Srisuwatchari, Andrew Delgado, Galina Grishina, Pakit Vichyanond , et al. · 2024

Factor associated with food allergy among preschool children with atopic dermatitis, and resolution of atopic dermatitis Open

Supaluk Tangvalelerd, Kantima Kanchanapoomi, Prapasri Kulalert, Punchama Pacharn, Orathai Jirapongsananuruk , et al. · 2024

Preschool AD children with FA were found to have significantly greater AD severity at AD onset and a longer duration to AD resolution compared to AD children without FA.

Treatment difficulties in wheat oral immunotherapy and the predictive value of wheat-specific IgE Open

Punchama Pacharn, Siriluck Witeetanavanich, Witchaya Srisuwatchari, Nuntanut Rutrakool, Chulamanee Wongteerayanee , et al. · 2024

The initial wheat and omega-5-gliadin-sIgEs were significant risk factors for complicated OIT patients and could be used to monitor these patients carefully during the OIT period.

Perspectives and gaps in the management of food allergy and anaphylaxis in the Asia-Pacific Region Open

Agnes Sze Yin Leung, Ruby Pawankar, Punchama Pacharn, Lydia Su Yin Wong, Duy Le Pham , et al. · 2023

Our study offers a cross-sectional evaluation of the management practices for FA in each Asia Pacific Association of Allergy Asthma and Clinical Immunology member country or territory. Urgent actions are required to enhance allergy service…

Omega-5 and Gamma Gliadin are the Major Allergens in Adult-Onset IgE-Mediated Wheat Allergy: Results from Thai Cohort with Oral Food Challenge [Corrigendum] Open

Surapon Piboonpocanun, Torpong Thongngarm, Chamard Wongsa, Punchama Pacharn, Onrapak Reamtong , et al. · 2023

[This corrects the article DOI: 10.2147/JAA.S315202.].

Children with wheat anaphylaxis and with low wheat specific IgE have a different IgE immunoblot pattern than those with high wheat specific IgE Open

Nuntanut Rutrakool, Surapon Piboonpocanun, Unchalee Wangthan, Witchaya Srisuwatchari, Torpong Thongngarm , et al. · 2023

Wheat anaphylaxis can occur in patients with low wheat-sIgE. Predominant wheat allergens recognized by patients with WAlo were different than those with WAhi. Such difference could be responsible for anaphylaxis at even low levels of wheat…

Identifying the stability of a new wheat gliadin extract by protein analysis, skin tests and cell degranulation assay Open

Chortip Chansangsawat, Surapon Piboonpocanun, Pisit Ubonsri, Punchama Pacharn, Witchaya Srisuwatchari , et al. · 2023

To determine the stability of in-house gliadin extracts, SPT or cell degranulation assay provided additional information to SDS-PAGE. The extracts were stable for up to 12 months.

Three novel homozygous <i>ITGB2 </i>mutations among two patients with leukocyte adhesion defect type-1: Two case reports Open

Yiwa Suksawat, Punchama Pacharn, Nunthana Siripipattanamongkol, Boonchai Boonyawat · 2022

Molecular analysis is essential for definitive diagnosis, early treatment implementation, and prevention of LAD-1 in future pregnancy.

Comprehending the allergen repertoire of shrimp for precision molecular diagnosis of shrimp allergy Open

Christine Wai, Nicki Y.H. Leung, Agnes Sze Yin Leung, Sai Ming Ngai, Punchama Pacharn , et al. · 2022

Background Clinical management of shrimp allergy is hampered by the lack of accurate tests. Molecular diagnosis has been shown to more accurately reflect the clinical reactivity but the full spectrum of shrimp allergens and their clinical …

Defining Biomarkers to Predict Natural Resolution in Shrimp Allergy Open

Surapon Piboonpocanun, Suttipong Ittiporn, Pisit Ubonsri, Anchalee Wangtan, Punchama Pacharn , et al. · 2022

Specific bioassays can be used to identify patients with RSA. Oral shrimp challenges in these patients may provide a higher rate of passing the challenges and finally reintroducing shrimp in their diet.

Psychosocial factors and lack of asthma knowledge undermine child and adolescent adherence to inhaled corticosteroid Open

Preyanit Takkinsatian, Sasitorn Chantaratin, MSc S. Sirisakpanit, Witchaya Srisuwatchari, Punchama Pacharn , et al. · 2021

Objective: This study aimed to evaluate inhaled corticosteroid (ICS) adherence and identify factors associated with nonadherence in pediatric asthma patients. Methods: A total of 134 patients aged 8–18 years old were included…

Harmonizing allergy care–integrated care pathways and multidisciplinary approaches Open

L B Daniels, Sally Barker, Yoon‐Seok Chang, Tinatin Chikovani, Audrey DunnGalvin , et al. · 2021

Omega-5 and Gamma Gliadin are the Major Allergens in Adult-Onset IgE-Mediated Wheat Allergy: Results from Thai Cohort with Oral Food Challenge Open

Surapon Piboonpocanun, Torpong Thongngarm, Chamard Wongsa, Punchama Pacharn, Onrapak Reamtong , et al. · 2021

Surapon Piboonpocanun,1 Torpong Thongngarm,2 Chamard Wongsa,2 Punchama Pacharn,3 Onrapak Reamtong,4 Mongkhon Sompornrattanaphan2 1Institute of Molecular Biosciences, Mahidol University, Salaya, Nakhonpathom, Thailand; 2Division of Allergy …

Author response for "The role of the environment in shaping the trends of childhood asthma – an Asian perspective" Open

Agnes Sze Yin Leung, Elizabeth Huiwen Tham, Jing Li, Punchama Pacharn, Takumi Takizawa , et al. · 2021

Exercise-food challenge test in patients with wheat-dependent exercise-induced anaphylaxis Open

Witchaya Srisuwatchari, Mongkhon Sompornrattanaphan, Orathai Jirapongsananuruk, Nualanong Visitsunthorn, Punchama Pacharn · 2021

For WDEIA, time to diagnosis was delayed, and one-third of patients had recurrent acute urticaria proceeding anaphylaxis onset. Our exercise-food challenge test could be utilized safely in both children and adult and able to elicit symptom…

Is mold sensitization associated with severe asthma exacerbation in children? Open

Isree Leelayuwattanakul, Kittipos Visitsunthorn, Witchaya Srisuwatchari, Punchama Pacharn, Orathai Jirapongsananuruk , et al. · 2020

Alternaria sensitization, an age younger than 6 years, and a paternal history of atopy were associated with SAE in asthmatic children.

Feasibility of a 3-step protocol of wheat oral immunotherapy in children with severe wheat allergy Open

Chulamanee Wongteerayanee, Pattara Tanticharoenwiwat, Nuntanut Rutrakool, Anchalee Senavonge, Nivat Jeekungwal , et al. · 2020

The new 3-step wheat OIT protocol was feasible in these highly wheat-sensitized patients. Despite a high retention rate, a high rate of adverse effects was observed both during DBPCFC and build-up phases.

Clinical Characteristics and Proposed Wheat-Cofactor Challenge Protocol with a High Diagnostic Yield in Adult-Onset IgE-Mediated Wheat Allergy Open

Torpong Thongngarm, Chamard Wongsa, Punchama Pacharn, Surapon Piboonpocanun, Mongkhon Sompornrattanaphan · 2020

Torpong Thongngarm,1 Chamard Wongsa,1 Punchama Pacharn,2 Surapon Piboonpocanun,3 Mongkhon Sompornrattanaphan1 1Division of Allergy and Clinical Immunology, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, B…

Clinical Characteristics and Proposed Wheat-Cofactor Challenge Protocol with a High Diagnostic Yield in Adult-Onset IgE-Mediated Wheat Allergy Open

Torpong Thongngarm, Chamard Wongsa, Punchama Pacharn, Surapon Piboonpocanun, Mongkhon Sompornrattanaphan · 2020

WDEIA was the most common phenotype. Our modified 3-day protocol could differentiate WA and WDEIA and yielded a high positivity rate (94.4%). It should be used cautiously as severe reactions can occur.

Validation and Reliability of the Thai version of the Food Allergy Quality of Life Questionnaire-Parent Form (FAQLQ-PF) Open

Wannaporn Limpitikul, Witchaya Srisuwatchari, Orathai Jirapongsananuruk, Nualanong Visitsunthorn, Punchama Pacharn · 2020

The FAQLQ-PF Thai version is a reliable and valid tool for assessing HRQL in Thai children with food allergy.

A potential role of gliadin extract skin prick test in IgE-mediated wheat allergy Open

Thunyatorn Phisitbuntoon, Orathai Jirapongsananuruk, Punchama Pacharn, Unchalee Wangthan, Witchaya Srisuwatchari , et al. · 2020

Compared to other in-house and commercial wheat extracts and sIgE to wheat and ω-5 gliadin, SPT with an in-house gliadin extract yielded the highest performance for the diagnosis IgE-mediated wheat allergy.

Clinical and in vitro cross-reactivity of cereal grains in children with IgE-mediated wheat allergy Open

Witchaya Srisuwatchari, Surapon Piboonpocanun, Unchalee Wangthan, Orathai Jirapongsananuruk, Nualanong Visitsunthorn , et al. · 2020

The cross-reactivity rate was quite low for oat and Job's tears compared to that of barley; therefore, avoidance of all cereal grains may be unnecessary in patients with severe wheat allergy.

Characterization of children with IgE-mediated wheat allergy and risk factors that predict wheat anaphylaxis Open

Witchaya Srisuwatchari, Pakit Vichyanond, Orathai Jirapongsananuruk, Nualanong Visitsunthorn, Punchama Pacharn · 2020

Children with wheat allergy presented very early in life. AD was found in approximately half of the patients, and more commonly in SO. Median MWD of SPT and sIgE level to wheat were significantly higher in WA. These data will aid in furthe…

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