Punit Prakash
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View article: SAT-308 Unravelling Thermotolerance in Adrenocortical Carcinoma: Implications for Hyperthermia-Based Therapies
SAT-308 Unravelling Thermotolerance in Adrenocortical Carcinoma: Implications for Hyperthermia-Based Therapies Open
Disclosure: S. Fiachetti: None. N. Mullen: None. S. Feely: None. R. Challapalli: None. P.T. Donlon: None. M. Hassany: None. M. O'Halloran: None. C. Hantel: None. P. Prakash: None. M.C. Dennedy: None. Introduction: Adrenocortical carcinoma …
View article: SAT-289 Rationally designed cholesterol coated peptide NS as a novel therapeutic strategy in the management of Adrenocortical Carcinoma
SAT-289 Rationally designed cholesterol coated peptide NS as a novel therapeutic strategy in the management of Adrenocortical Carcinoma Open
Disclosure: M. Hassany: None. R. Challapalli: None. O. Covarrubias-Zambrano: None. S. Feely: None. S. Fiachetti: None. M. Luconi: None. M. O'Halloran: None. C. Hantel: None. P. Prakash: None. S. Bossmann: None. M.C. Dennedy: None. Manageme…
View article: Quantitative assessment of thermal ablation in small animal tumor models: implications for pre-clinical studies of combination treatments
Quantitative assessment of thermal ablation in small animal tumor models: implications for pre-clinical studies of combination treatments Open
Background . Radiofrequency (RF) and other thermal ablation modalities in combination with systemic therapies are the subject of investigations for the treatment of tumors at risk of recurrence after first line therapies. The potential of …
View article: Iron Oxide Nanoparticle Uptake, Toxicity, and Steroidogenesis in Adrenocortical Carcinoma Cells Using a Multicellular in vitro Model
Iron Oxide Nanoparticle Uptake, Toxicity, and Steroidogenesis in Adrenocortical Carcinoma Cells Using a Multicellular in vitro Model Open
ACC cells actively internalise IONPs without significant impairment of viability or steroidogenesis at pharmacologically relevant concentrations. However, non-specific uptake by monocytes and endothelial cells reduces delivery efficiency. …
View article: Effect of local radiofrequency hyperthermia on the intratumoral pressure and extracellular matrix stiffness in hepatocellular carcinoma
Effect of local radiofrequency hyperthermia on the intratumoral pressure and extracellular matrix stiffness in hepatocellular carcinoma Open
Local RFHT induces time- and heating profile-dependent alterations in intratumoral pressure and stiffness in a rat model of HCC, suggesting that RFHT interventions may modulate tumor biophysics and influence drug delivery.
View article: A Novel Pipeline for Adrenal Gland Segmentation: Integration of a Hybrid Post-Processing Technique with Deep Learning
A Novel Pipeline for Adrenal Gland Segmentation: Integration of a Hybrid Post-Processing Technique with Deep Learning Open
Accurate segmentation of adrenal glands from CT images is essential for enhancing computer-aided diagnosis and surgical planning. However, the small size, irregular shape, and proximity to surrounding tissues make this task highly challeng…
View article: Adrenocortical Cancer Cell uptake of Iron Oxide Nanoparticles
Adrenocortical Cancer Cell uptake of Iron Oxide Nanoparticles Open
Adrenocortical carcinoma (ACC) is a rare cancer with poor prognosis, treated primarily through surgery and chemotherapy. Other treatments like radiation or thermal ablation for metastases have limited success, and recurrence is common. Mor…
View article: Impact of Power and Time in Hepatic Microwave Ablation: Effect of Different Energy Delivery Schemes
Impact of Power and Time in Hepatic Microwave Ablation: Effect of Different Energy Delivery Schemes Open
Microwave ablation often involves the use of continuous energy-delivery protocols with a fixed power and time. To achieve larger ablation zones, a range of protocols and power levels have been studied in experimental studies. The objective…
View article: Development and Characterization of 3-Dimensional Cell Culture Models of Adrenocortical Carcinoma
Development and Characterization of 3-Dimensional Cell Culture Models of Adrenocortical Carcinoma Open
Adrenocortical carcinoma (ACC) is a rare malignancy of the adrenal cortex that is associated with a poor prognosis. Developing effective treatment options for ACC is challenging owing to the current lack of representative preclinical model…
View article: 8543 Non-Specific Uptake Of Magnetic Iron Oxide Nanoparticles Into Adrenocortical Carcinoma Cells, Endothelium And Primary Monocytes
8543 Non-Specific Uptake Of Magnetic Iron Oxide Nanoparticles Into Adrenocortical Carcinoma Cells, Endothelium And Primary Monocytes Open
Disclosure: R. Challapalli: None. A. Sorushanova: None. C. Hong: None. N.J. Mullen: None. S. Feely: None. O. Covarrubias-Zambrano: None. J. Covarrubias: None. S. Varghese: None. C. Hantel: None. P. Owens: None. M. O’Halloran: None. P. Prak…
View article: Assessment of thermochromic phantoms for characterizing microwave ablation devices
Assessment of thermochromic phantoms for characterizing microwave ablation devices Open
Background and purpose Thermochromic gel phantoms provide a controlled medium for visual assessment of thermal ablation device performance. However, there are limited studies reporting on the comparative assessment of ablation profiles ass…
View article: Dielectric characterisation of human adrenal glands and adrenal tumours for the development of microwave ablation technologies for hypertension treatment
Dielectric characterisation of human adrenal glands and adrenal tumours for the development of microwave ablation technologies for hypertension treatment Open
Adrenal gland-induced hypertension results from underlying adrenal gland disorders including Conn's syndrome, Cushing's syndrome, and Pheochromocytoma. These adrenal disorders are a risk for cardiovascular and renal morbidity and mortality…
View article: Bronchoscopy-Guided High-Power Microwave Ablation in an in vivo Porcine Lung Model
Bronchoscopy-Guided High-Power Microwave Ablation in an in vivo Porcine Lung Model Open
Introduction: Percutaneous microwave ablation (MWA) is clinically accepted for the treatment of lung tumors and oligometastatic disease. Bronchoscopic MWA is under development and evaluation in the clinical setting. We previously reported …
View article: Characterization of a Biochemical Mouse Model of Primary Aldosteronism for Thermal Therapies
Characterization of a Biochemical Mouse Model of Primary Aldosteronism for Thermal Therapies Open
Introduction Aldosterone-producing adenoma (APA) is the most common cause of endocrine-related hypertension but surgery is not always feasible. Current medical interventions are associated with significant side effects and poor patient com…
View article: Assessment of thermochromic phantoms for characterizing microwave ablation devices
Assessment of thermochromic phantoms for characterizing microwave ablation devices Open
Background and Purpose Thermochromic gel phantoms provide a controlled medium for visual assessment of thermal ablation device performance. However, there are limited studies reporting on the comparative assessment of ablation profiles ass…
View article: Directional microwave ablation in spine: experimental assessment of computational modeling
Directional microwave ablation in spine: experimental assessment of computational modeling Open
Computational models and experimental studies illustrate the feasibility of controlled dMWA in bone tissue.
View article: Current Status and Emerging Techniques for Measuring the Dielectric Properties of Biological Tissues
Current Status and Emerging Techniques for Measuring the Dielectric Properties of Biological Tissues Open
The dielectric properties of biological tissues are key parameters that support the design and usability of a wide range of electromagnetic-based medical applications, including for diagnostics and therapeutics, and allow the determination…
View article: Guest Editorial Introduction to the Special Section on Image-Guided Therapies
Guest Editorial Introduction to the Special Section on Image-Guided Therapies Open
Numerous medical imaging modalities are clinically available and widely used in disease diagnosis and monitoring therapy response. Imaging data are also increasingly being used for constructing patient-specific computational models to info…
View article: Adrenal ablation as a treatment for hypertension: analyzing the dielectric properties of adrenal glands for microwave ablation technologies
Adrenal ablation as a treatment for hypertension: analyzing the dielectric properties of adrenal glands for microwave ablation technologies Open
Adrenal gland-induced hypertension, also known as secondary hypertension, is a medical condition caused by an underlying adrenal pathology, most typically adrenocortical adenomas. Current clinical practices involve pharmacotherapy or surgi…
View article: Propagation of Radiofrequency and Microwaves in Tissue
Propagation of Radiofrequency and Microwaves in Tissue Open
A wide variety of devices and systems employing nonionizing electromagnetic energy has been developed and are in clinical use for controlled tissue heating. In the field of oncology, electromagnetic energy-based systems have been used for …
View article: Computational modeling of microwave ablation with thermal accelerants
Computational modeling of microwave ablation with thermal accelerants Open
Computational models of MWA with thermal accelerants provide insight into the impact of accelerant on MWA, and with further development, could predict ablations with a variety of gel injection sites.
View article: Treating Primary Aldosteronism-Induced Hypertension: Novel Approaches and Future Outlooks
Treating Primary Aldosteronism-Induced Hypertension: Novel Approaches and Future Outlooks Open
Primary aldosteronism (PA) is the most common cause of secondary hypertension and is associated with increased morbidity and mortality when compared with blood pressure–matched cases of primary hypertension. Current limitations in patient …
View article: AB052. SOH23ABS_030. Treatment planning approaches for the management of functioning adrenal nodules
AB052. SOH23ABS_030. Treatment planning approaches for the management of functioning adrenal nodules Open
Background: Primary aldosteronism is the most common cause of secondary hypertension worldwide. Thermal ablation, via a minimally invasive interventional radiological approach or laparoscopic surgical approach, offers an option for the tar…
View article: Sublethal Hyperthermia Transiently Disrupts Cortisol Steroidogenesis in Adrenocortical Cells
Sublethal Hyperthermia Transiently Disrupts Cortisol Steroidogenesis in Adrenocortical Cells Open
Primary aldosteronism is the most common cause of secondary hypertension. The first-line treatment adrenalectomy resects adrenal nodules and adjacent normal tissue, limiting suitability to those who present with unilateral disease. Use of …
View article: Effects of Ballistocardiogram Peak Detection Jitters on the Quality of Heart Rate Variability Features: A Simulation-Based Case Study in the Context of Sleep Staging
Effects of Ballistocardiogram Peak Detection Jitters on the Quality of Heart Rate Variability Features: A Simulation-Based Case Study in the Context of Sleep Staging Open
Heart rate variability (HRV) features support several clinical applications, including sleep staging, and ballistocardiograms (BCGs) can be used to unobtrusively estimate these features. Electrocardiography is the traditional clinical stan…
View article: In Vitro Measurement and Mathematical Modeling of Thermally-Induced Injury in Pancreatic Cancer Cells
In Vitro Measurement and Mathematical Modeling of Thermally-Induced Injury in Pancreatic Cancer Cells Open
Thermal therapies are under investigation as part of multi-modality strategies for the treatment of pancreatic cancer. In the present study, we determined the kinetics of thermal injury to pancreatic cancer cells in vitro and evaluated pre…
View article: Experimental Validation of Diffraction Lithography for Fabrication of Solid Microneedles
Experimental Validation of Diffraction Lithography for Fabrication of Solid Microneedles Open
Microneedles are highly sought after for medicinal and cosmetic applications. However, the current manufacturing process for microneedles remains complicated, hindering its applicability to a broader variety of applications. As diffraction…