Punit R. Rachh
YOU?
Author Swipe
View article: Formulation and development of bilayer tablet containing irbesartan and metformin hydrochloride for diabetic hypertensive patients
Formulation and development of bilayer tablet containing irbesartan and metformin hydrochloride for diabetic hypertensive patients Open
Background: Hypertension is a common complication of type II diabetes. The present research work aimed to develop bilayer tablets that would manage type II diabetes patients with hypertension. The prepared bilayer tablet has an immediate-r…
View article: Optimization and evaluation of nebivolol hydrochloride loaded transferosomes using Box-Behnken experimental design
Optimization and evaluation of nebivolol hydrochloride loaded transferosomes using Box-Behnken experimental design Open
Background: This study optimizes and evaluates transferosomes containing Nebivolol Hydrochloride to enhance the drug's bioavailability and therapeutic efficacy. Ultra-deformable vesicles called transferosomes help to increase drug administ…
View article: Optimizing irbesartan spherical agglomerates through principal component analysis and experimental design
Optimizing irbesartan spherical agglomerates through principal component analysis and experimental design Open
Background: This study explores the amalgamation of crystallization and agglomeration through spherical crystallization, aiming to develop the spherical crystals of Irbesartan with improved micromeritic properties. The main objective is to…
View article: Optimization and evaluation of transdermal delivery system for nebivolol hydrochloride
Optimization and evaluation of transdermal delivery system for nebivolol hydrochloride Open
Background: Nebivolol hydrochloride, a β1-receptor antagonist known for its antihypertensive properties, boasts a plasma half-life of 10 hours and an oral bioavailability of 12%. In this study, we aimed to enhance the therapeutic effective…
View article: Effect of hydrophilic polymer and binder on drug release of metformin HCl sustained release tablet
Effect of hydrophilic polymer and binder on drug release of metformin HCl sustained release tablet Open
To develop an oral sustained release Metformin HCl tablet by wet granulation technique, using different grades of hydroxyl propyl methylcellulose (HPMC) in different concentration and by varying binder concentrations. Metformin HCl was rec…
View article: In vitro, in vivo and stability assessment of optimised nanoparticulate matrix tablet of nebivolol hydrochloride
In vitro, in vivo and stability assessment of optimised nanoparticulate matrix tablet of nebivolol hydrochloride Open
The objective of the present study was to define the effects on the antihypertension activity and pharmacokinetics of an optimised nanoparticulate matrix tablet containing nebivolol hydrochloride. The nanoparticulate matrix tablet was form…
View article: Evaluation of anti-inflammatory and analgesic activity of optimized lipid based non-aqueous nanoemulsion of naproxen in experimental animals
Evaluation of anti-inflammatory and analgesic activity of optimized lipid based non-aqueous nanoemulsion of naproxen in experimental animals Open
Naproxen is a nonsteroidal anti-inflammatory drug, it has analgesic, anti-inflammatory and antipyretic effect by inhibiting prostaglandin synthesis via inhibition of cyclooxygenase enzymes. This study was designed to evaluate analgesic and…
View article: Compatability study of selexipag and ezetimibe with selected excipients in formulation of bilayer tablet
Compatability study of selexipag and ezetimibe with selected excipients in formulation of bilayer tablet Open
Present study was carried out to study compatibility of Selexipag and Ezetimibe with selected generally regarded as safe excipients and to prepare bilayer tablet. Isothermal stress testing was performed in binary a mixture which was subjec…
View article: Formulation and evaluation of selexipag and ezetimibe bi-layer tablet by novel approach
Formulation and evaluation of selexipag and ezetimibe bi-layer tablet by novel approach Open
Hypertension and hypercholesterolemia are two common diseases that often coexist. The combined presence of hypertension and hypercholesterolemia increases considerably the risk for cardiovascular complications. Selexipag is used to treat s…
View article: Invitro and in-vivo evaluation of optimized sustain release nanoparticulate tablet of vildagliptin
Invitro and in-vivo evaluation of optimized sustain release nanoparticulate tablet of vildagliptin Open
The objective of the present investigation was to evaluate pharmacodynamics and pharmacokinetic parameters of optimized nanoparticulate sustain release tablet of Vildagliptin prepared by using Anti-solvent method containing polymer HPMC K1…
View article: Effect of Nutraceutical Formulation Ovajal on DHT and Fructose-induced Polycystic Ovary Syndrome in a Rodent Model
Effect of Nutraceutical Formulation Ovajal on DHT and Fructose-induced Polycystic Ovary Syndrome in a Rodent Model Open
Polycystic ovary syndrome is a most common female reproductive disorder, involving endocrine and metabolic disorders with unclear etiology. It may clinically be manifested in young women of reproductive age as oligo-ovulation, abnormal lev…
View article: FORMULATION DEVELOPMENT AND EVALUATION OF SUSTAIN RELEASE NANOPARTICULATE TABLET OF VILDAGLIPTIN
FORMULATION DEVELOPMENT AND EVALUATION OF SUSTAIN RELEASE NANOPARTICULATE TABLET OF VILDAGLIPTIN Open
Vildagliptin belongs to a class of orally active anti-diabetic drug which inhibits dipeptidyl peptidase-4 (DPP-4) and to raise the emission of insulin in the β-cells, thereby decreasing blood glucose level. Current study aims to raise the …
View article: FORMULATION AND DEVELOPMENT OF NOVEL GASTRORETENTIVE MICROBALLOONS OF REPAGLINIDE
FORMULATION AND DEVELOPMENT OF NOVEL GASTRORETENTIVE MICROBALLOONS OF REPAGLINIDE Open
The present study involves preparation and evaluation of Microballoons of Repaglinide which is having poor solubility in water and low oral bioavailability. Repaglinide, an oral hypoglycemic agent, is rapidly absorbed and eliminated from t…
View article: FORMULATION AND DEVELOPMENT OF LIPID BASED NON-AQUEOUS NANO EMULSION FOR SELECTED NSAID
FORMULATION AND DEVELOPMENT OF LIPID BASED NON-AQUEOUS NANO EMULSION FOR SELECTED NSAID Open
Oral administration of non-steroidal anti-inflammatory drugs is avoided in patients with disease like peptic ulcer, gastro esophageal reflux (GERD), irritable bowel syndrome. Administration of drug through topical route through the skin co…
View article: Formulation, Development, Evaluation and Solubility Enhancement of Lercanidipine Hydrochloride by Solid Dispersion Techniques
Formulation, Development, Evaluation and Solubility Enhancement of Lercanidipine Hydrochloride by Solid Dispersion Techniques Open
Background: Solid dispersions (SDs) are the dispersion of hydrophobic drugs in an inert hydrophilic carrier. SDs are prepared to improve the dissolution properties and bioavailability of slightly water-soluble drug molecules by dispersing …
View article: Nanosuspension of Poorly Soluble Anti-Diabetic Drug for Enhancement of Solubility and Dissolution
Nanosuspension of Poorly Soluble Anti-Diabetic Drug for Enhancement of Solubility and Dissolution Open
Canagliflozin is an anti-diabetic drug used in the adjuvant therapy for type-II diabetes as the inhibitor of sodium‐glucose co‐transporter-2 in the renal tubules. The poor solubility and permeability of the drug show limitations in the for…
View article: Review on Teneligliptin: A novel antihyperglycemic agent
Review on Teneligliptin: A novel antihyperglycemic agent Open
Diabetes mellitus relates a metabolic disorder of collective aetiology which is characterized by chronic hyperglycaemia caused due to disturbances of carbohydrate, lipid and protein metabolism due to impaired β cell function of pancreas or…
View article: Equine Rabies Immunoglobulin: A Review
Equine Rabies Immunoglobulin: A Review Open
Rabies is a major cause of human death in many developing countries. There is a worldwide shortage of human and equine rabies immune globulin. The WHO recommends combined administration of rabies vaccine and rabies immune globulin to patie…
View article: Microparticulate hot melt pallets technology: a review
Microparticulate hot melt pallets technology: a review Open
Recent advances in novel drug delivery (NDDS) aims to enhance safety and efficacy of drug molecule by formulating a convenient dosage form for ease of administration and to achieve better patient compliance. Depending upon functionality, i…
View article: REVIEW ON POTENT ANTI-DIABETIC PLANTS OR HERBS FROM TRADITIONAL MEDICINE
REVIEW ON POTENT ANTI-DIABETIC PLANTS OR HERBS FROM TRADITIONAL MEDICINE Open
This review focuses on Indian Herbal drugs and plants used in the treatment of diabetes, especially in India. Diabetes is an important human ailment afflicting many from various walks of life in different countries. diabetes is one of the …
View article: A REVIEW ON FAST DISSOLVING TABLET
A REVIEW ON FAST DISSOLVING TABLET Open
The convenience of administration and improved patient compliance are important in the design of oral drug delivery system which remains the preferred route of drug delivery inspite of various disadvantages. Fast disintegrating tablets (FD…