Purva Gopal
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View article: A recurrent ACAA2 variant causes a dominant syndrome of lipodystrophy, lipomatosis, infantile steatohepatitis and hypoglycemia
A recurrent ACAA2 variant causes a dominant syndrome of lipodystrophy, lipomatosis, infantile steatohepatitis and hypoglycemia Open
View article: Performance of GALAD, GAAD, and ASAP for Early HCC Detection in Chronic Liver Disease: A Systematic Review and Meta-Analysis
Performance of GALAD, GAAD, and ASAP for Early HCC Detection in Chronic Liver Disease: A Systematic Review and Meta-Analysis Open
Background: Multi-biomarker panels have shown promise to improve hepatocellular carcinoma (HCC) surveillance in patients with chronic liver disease; however, we lack comparative data on their relative performance for early-stage HCC detect…
View article: Chemoprevention of hepatocellular carcinoma using N-acetylgalactosamine-conjugated siRNAs
Chemoprevention of hepatocellular carcinoma using N-acetylgalactosamine-conjugated siRNAs Open
The ability to prevent hepatocellular carcinoma (HCC) in patients with chronic liver disease remains an unmet clinical need. We performed a head-to-head comparison of N-acetylgalactosamine (GalNAc)-conjugated small interfering RNA (siRNA)-…
View article: Somatic mutations in TBX3 promote hepatic clonal expansion by accelerating VLDL secretion
Somatic mutations in TBX3 promote hepatic clonal expansion by accelerating VLDL secretion Open
Somatic mutations that increase clone fitness or resist disease are positively selected, but the impact of these mutations on organismal health remains unclear. We previously showed that Tbx3 deletion increases hepatocyte fitness within fa…
View article: Somatic loss-of-function mutations in CIDEB reduce hepatic steatosis by increasing lipolysis and fatty acid oxidation
Somatic loss-of-function mutations in CIDEB reduce hepatic steatosis by increasing lipolysis and fatty acid oxidation Open
View article: Clinicopathologic Features of Untreated Colorectal Cancer with Acellular Mucin–Only Lymph Nodes
Clinicopathologic Features of Untreated Colorectal Cancer with Acellular Mucin–Only Lymph Nodes Open
Lymph nodes (LNs) containing only acellular mucin are considered negative for metastasis in treated colorectal cancers (CRCs). However, no data exist on how to stage these LNs in untreated CRCs. We collected 63 untreated CRC cases with LNs…
View article: Bacteria-induced colitis in naked mole rats is alleviated by probiotic treatment: a new mammalian model for acute inflammatory disease
Bacteria-induced colitis in naked mole rats is alleviated by probiotic treatment: a new mammalian model for acute inflammatory disease Open
Enteropathogenic bacteria are a major cause of morbidity and mortality globally. Mouse models have been indispensable in advancing our understanding of infectious diseases caused by intestinal pathogens and in identifying physical, chemica…
View article: Improvement in Adenoma Detection Rate with Distal Attachment Device Endo-Wing™-Assisted Colonoscopy: A Randomized Control Trial
Improvement in Adenoma Detection Rate with Distal Attachment Device Endo-Wing™-Assisted Colonoscopy: A Randomized Control Trial Open
Aim: Endo-Wing™ is a soft silicone device with six wing-like projections attached at the end of the colonoscope that provides superior visualization by flattening the colonic fold and helps to maintain a central view of the colonoscope dur…
View article: Mechanistic basis for protection against fatty liver disease by <i>CIDEB</i> loss-of-function mutations
Mechanistic basis for protection against fatty liver disease by <i>CIDEB</i> loss-of-function mutations Open
Background & Aims Somatic and germline CIDEB mutations are associated with protection from chronic liver diseases. The mechanistic basis and whether CIDEB suppression would be an effective therapy against fatty liver disease remain unclear…
View article: Impact of age on clinical outcomes among patients with hepatocellular carcinoma: A systematic review and meta-analysis
Impact of age on clinical outcomes among patients with hepatocellular carcinoma: A systematic review and meta-analysis Open
View article: The evolving role of liver biopsy: Current applications and future prospects
The evolving role of liver biopsy: Current applications and future prospects Open
Histopathologic evaluation of liver biopsy has played a longstanding role in the diagnosis and management of liver disease. However, the utility of liver biopsy has been questioned by some, given the improved imaging modalities, increased …
View article: Spatial omics-based machine learning algorithms for the early detection of hepatocellular carcinoma
Spatial omics-based machine learning algorithms for the early detection of hepatocellular carcinoma Open
View article: Utility of IMP3, p53, and S100P immunohistochemical stains in distinguishing reactive atypia from dysplasia in cholecystectomy specimens
Utility of IMP3, p53, and S100P immunohistochemical stains in distinguishing reactive atypia from dysplasia in cholecystectomy specimens Open
Background Distinguishing reactive atypia from dysplasia in cholecystectomy specimens can be histologically challenging. The aim of this study was to evaluate the utility of IMP3, p53, and S100P immunostains in differentiating reactive aty…
View article: Utility of IMP3, p53, and S100P Immunohistochemical Stains in Distinguishing Reactive Atypia from Dysplasia in Cholecystectomy Specimens
Utility of IMP3, p53, and S100P Immunohistochemical Stains in Distinguishing Reactive Atypia from Dysplasia in Cholecystectomy Specimens Open
Background: Distinguishing reactive atypia from dysplasia in cholecystectomy specimens can be histologically challenging. The aim of this study was to evaluate the utility of IMP3, p53, and S100P immunostains in differentiating reactive at…
View article: PKD1 mutant clones within cirrhotic livers inhibit steatohepatitis without promoting cancer
PKD1 mutant clones within cirrhotic livers inhibit steatohepatitis without promoting cancer Open
View article: Liver cancer initiation is dependent on metabolic zonation but decoupled from premalignant clonal expansion
Liver cancer initiation is dependent on metabolic zonation but decoupled from premalignant clonal expansion Open
The origin of cancer is poorly understood because cells that obtain truncal mutations are rarely fate mapped in their native environments. A defining feature of the liver is zonation, or the compartmentalization of metabolic functions in h…
View article: Proportion of Time Covered by Hepatocellular Carcinoma Surveillance in Patients With Cirrhosis
Proportion of Time Covered by Hepatocellular Carcinoma Surveillance in Patients With Cirrhosis Open
INTRODUCTION: Hepatocellular carcinoma (HCC) surveillance is associated with improved early tumor detection, but effectiveness is limited by underuse. We characterized adherence to HCC surveillance using proportion of time covered (PTC) an…
View article: Artificial intelligence-based pathology as a biomarker of sensitivity to atezolizumab–bevacizumab in patients with hepatocellular carcinoma: a multicentre retrospective study
Artificial intelligence-based pathology as a biomarker of sensitivity to atezolizumab–bevacizumab in patients with hepatocellular carcinoma: a multicentre retrospective study Open
View article: Hepatocellular Carcinoma Surveillance Patterns and Outcomes in Patients With Cirrhosis
Hepatocellular Carcinoma Surveillance Patterns and Outcomes in Patients With Cirrhosis Open
View article: Herpes Proctitis in Men Mimicking Rectal Adenocarcinoma: Two Cases of an Easily Overlooked Diagnosis in the Proximal Rectum
Herpes Proctitis in Men Mimicking Rectal Adenocarcinoma: Two Cases of an Easily Overlooked Diagnosis in the Proximal Rectum Open
We describe two cases of rectal herpes simplex virus (HSV) infection in men that clinically mimicked rectal adenocarcinoma. Herpes infection in this location more commonly presents as an anal mass with viral inclusions in squamous epitheli…
View article: Cholangiocarcinoma: Pathologic and Molecular Classification in the Era of Precision Medicine
Cholangiocarcinoma: Pathologic and Molecular Classification in the Era of Precision Medicine Open
Context.— Cholangiocarcinoma (CCA) is a heterogeneous cancer of the bile duct, and its diagnosis is often challenging. Objective.— To provide insights into state-of-the-art approaches for the diagnosis of CCA. Data Sources.— Literature rev…
View article: Multidisciplinary care for patients with HCC: a systematic review and meta-analysis
Multidisciplinary care for patients with HCC: a systematic review and meta-analysis Open
Background: Given the complexity of managing HCC, professional society guidelines advocate multidisciplinary care (MDC) for patients with HCC. However, implementation of MDC programs requires a significant investment of time and resources.…
View article: Positive selection of somatically mutated clones identifies adaptive pathways in metabolic liver disease
Positive selection of somatically mutated clones identifies adaptive pathways in metabolic liver disease Open
View article: Supplementary Fig. S1-S8 from Blocking Monocytic Myeloid-Derived Suppressor Cell Function via Anti-DC-HIL/GPNMB Antibody Restores the <i>In Vitro</i> Integrity of T Cells from Cancer Patients
Supplementary Fig. S1-S8 from Blocking Monocytic Myeloid-Derived Suppressor Cell Function via Anti-DC-HIL/GPNMB Antibody Restores the <i>In Vitro</i> Integrity of T Cells from Cancer Patients Open
Supplementary Fig. S1. Early stages CRC patients expressed very low DC-HIL expression on MDSCs. Supplementary Fig. S2. No effect of anti-CD14 mAb on T cell suppressor function of MDSCs. Supplementary Fig. S3. DC-HILneg MC38 and CT26 mouse …
View article: Supplementary Table S1 -S5 from Blocking Monocytic Myeloid-Derived Suppressor Cell Function via Anti-DC-HIL/GPNMB Antibody Restores the <i>In Vitro</i> Integrity of T Cells from Cancer Patients
Supplementary Table S1 -S5 from Blocking Monocytic Myeloid-Derived Suppressor Cell Function via Anti-DC-HIL/GPNMB Antibody Restores the <i>In Vitro</i> Integrity of T Cells from Cancer Patients Open
Supplementary Table S1. Summary of MDSC analysis of metastatic cancer patents. aAll cancer patients are diagnosed as stage III or IV. Supplementary Table S2. Correlation of variables and expansion of DC-HIL+ MDSCs among colorectal cancer p…
View article: Supplementary Figure 1 from Improved Performance of Serum Alpha-Fetoprotein for Hepatocellular Carcinoma Diagnosis in HCV Cirrhosis with Normal Alanine Transaminase
Supplementary Figure 1 from Improved Performance of Serum Alpha-Fetoprotein for Hepatocellular Carcinoma Diagnosis in HCV Cirrhosis with Normal Alanine Transaminase Open
Supplementary Figure 1. Box Plot of serum AFP by Etiology, Race, and ALT in Patients with cirrhosis and HCC
View article: Supplementary Tables 1-3 from Improved Performance of Serum Alpha-Fetoprotein for Hepatocellular Carcinoma Diagnosis in HCV Cirrhosis with Normal Alanine Transaminase
Supplementary Tables 1-3 from Improved Performance of Serum Alpha-Fetoprotein for Hepatocellular Carcinoma Diagnosis in HCV Cirrhosis with Normal Alanine Transaminase Open
Supplementary Table 1. Sensitivity and Specificity with Fixed Specificity of 90% or Fixed Sensitivity of 70% Supplementary Table 2. Cross-validation of the AUCs of AFP for HCC detection Supplementary Table 3. Clinical Characteristics of Va…
View article: Supplementary Fig. S1-S8 from Blocking Monocytic Myeloid-Derived Suppressor Cell Function via Anti-DC-HIL/GPNMB Antibody Restores the <i>In Vitro</i> Integrity of T Cells from Cancer Patients
Supplementary Fig. S1-S8 from Blocking Monocytic Myeloid-Derived Suppressor Cell Function via Anti-DC-HIL/GPNMB Antibody Restores the <i>In Vitro</i> Integrity of T Cells from Cancer Patients Open
Supplementary Fig. S1. Early stages CRC patients expressed very low DC-HIL expression on MDSCs. Supplementary Fig. S2. No effect of anti-CD14 mAb on T cell suppressor function of MDSCs. Supplementary Fig. S3. DC-HILneg MC38 and CT26 mouse …
View article: Data from Blocking Monocytic Myeloid-Derived Suppressor Cell Function via Anti-DC-HIL/GPNMB Antibody Restores the <i>In Vitro</i> Integrity of T Cells from Cancer Patients
Data from Blocking Monocytic Myeloid-Derived Suppressor Cell Function via Anti-DC-HIL/GPNMB Antibody Restores the <i>In Vitro</i> Integrity of T Cells from Cancer Patients Open
Purpose:Blocking the function of myeloid-derived suppressor cells (MDSC) is an attractive approach for cancer immunotherapy. Having shown DC-HIL/GPNMB to be the T-cell-inhibitory receptor mediating the suppressor function of MDSCs, we eval…
View article: Supplementary Figure 1 from Improved Performance of Serum Alpha-Fetoprotein for Hepatocellular Carcinoma Diagnosis in HCV Cirrhosis with Normal Alanine Transaminase
Supplementary Figure 1 from Improved Performance of Serum Alpha-Fetoprotein for Hepatocellular Carcinoma Diagnosis in HCV Cirrhosis with Normal Alanine Transaminase Open
Supplementary Figure 1. Box Plot of serum AFP by Etiology, Race, and ALT in Patients with cirrhosis and HCC