Explanipedia

Plasmodium ARK1 regulates spindle formation during atypical mitosis and forms a divergent chromosomal passenger complex Open

Rita Tewari, A. L. Nagar, Ryuji Yanase, Mohammad Zeeshan, David Ferguson , et al. · 2025

Mitosis in Plasmodium spp., the causative agent of malaria, is fundamentally different from model eukaryotes, proceeding via a bipartite microtubule organising centre (MTOC) and lacking canonical regulators such as Polo and Bub1 kinases. D…

Plasmodium ARK1 regulates spindle formation during atypical mitosis and forms a divergent chromosomal passenger complex Open

A. L. Nagar, Ryuji Yanase, Mohammad Zeeshan, David Ferguson, Steven Abel , et al. · 2025

Mitosis in Plasmodium spp., the causative agent of malaria, is fundamentally different from model eukaryotes, proceeding via a bipartite microtubule organising centre (MTOC) and lacking canonical regulators such as Polo and Bub1 kinases. D…

PfPPM2 signalling regulates asexual division and sexual conversion of human malaria parasite Plasmodium falciparum Open

Akanksha Rawat, Neelam Antil, MEENAKSHI MEENAKSHI, Bhagyashree Deshmukh, Akhila Balakrishna , et al. · 2025

Malaria parasite undergoes interesting developmental transition in human and mosquito host. While it divides asynchronously in the erythrocytes, it switches to sexual forms, which is critical for disease transmission. We report a novel sig…

Efficient Medicinal Image Transmission and Resolution Enhancement via GAN Open

Rishabh Kumar Sharma, M. M. Sharma, Pushkar Sharma, Jeetashree Aparjeeta · 2024

While X-ray imaging is indispensable in medical diagnostics, it inherently carries with it those noises and limitations on resolution that mask the details necessary for diagnosis. B/W X-ray images require a careful balance between noise s…

miR-449a mediated repression of the cell cycle machinery prevents neuronal apoptosis Open

Monika Chauhan, Komal Singh, Chen Chongtham, A G Aneeshkumar, Pushkar Sharma · 2024

Aberrant activation of the cell cycle of terminally differentiated neurons results in their apoptosis and is known to contribute to neuronal loss in various neurodegenerative disorders like Alzheimer's Disease. However, the mechanisms that…

Classical autophagy proteins LC3B and ATG4B facilitate melanosome movement on cytoskeletal tracks Open

Amrita Ramkumar, Divya Murthy, Desingu Ayyappa Raja, Archana Singh, Anusha Krishnan , et al. · 2024

Macroautophagy/autophagy is a dynamic and inducible catabolic process that responds to a variety of hormonal and environmental cues. Recent studies highlight the interplay of this central pathway in a variety of pathophysiological diseases…

Hematological effects of Azadirachta indica (Neem) extract on New Zealand white male rabbits: A comprehensive study Open

Pushkar Sharma, Bhoopendra Singh, Priyanka Swami, Sushant Srivastava · 2024

Neem (Azadirachta indica) is a versatile tree native to India, with bioactive compounds in its seed, leaf, flower, bark, and roots, offering a wide range of applications. While concerns about neem causing sterility in some bird species hav…

Integrative analysis of common SNPS and imputation accuracy across diverse genomic densities in Asian, exotic, and Indian sheep breeds Open

Priyanka Swami, Jaswant Singh, Pushkar Sharma, Sunil Kumar Meena · 2024

The present study aimed to explore pure SNP densities within Indian, Asian, and exotic sheep breeds using Ovine 50K SNP BeadChip data. This study explored Common Single Nucleotide Polymorphisms (SNPs) in datasets A, B, C, and D, revealing …

Protein kinase PfPK2 mediated signalling is critical for host erythrocyte invasion by malaria parasite Open

Rahul Rawat, Ankit Gupta, Neelam Antil, Sonika Bhatnagar, Monika Singh , et al. · 2023

Signalling pathways in malaria parasite remain poorly defined and major reason for this is the lack of understanding of the function of majority of parasite protein kinases and phosphatases in parasite signalling and its biology. In the pr…

Protein kinase PfPK2 mediated signalling is critical for host erythrocyte invasion by malaria parasite Open

Rahul Rawat, Ankit Gupta, Neelam Antil, Sonika Bhatnagar, Thottethodi Subrahmanya Keshava Prasad , et al. · 2023

Signalling pathways in malaria parasite remain poorly defined and major reason for this is the lack of understanding of the function of majority of parasite protein kinases and phosphatases in parasite signalling and its biology. In the pr…

Exploration, collection and conservation of genetic resources of Swertia Chirayita in Darjeeling and Sikkim Himalayas Open

Bandan Thapa, Binoy Chhetri, Suresh Kumar Mahato, Pushkar Sharma, Sarad Gurung , et al. · 2023

Aerides multiflora Roxb.: An Important Ornamental and Medicinal Orchid Open

Bandan Thapa, Pushkar Sharma, Sumita Pradhan, Prajjwal Pradhan · 2022

Aerides multiflora Roxb. belonging to the family Orchidaceae is known for its multi-utility. It is being used in the preparation and for cuts and wounds traditionally and traded for its fragrance and as a cut flower. Among the isolates stu…

Dystocia due to Post-Cervical Uterine Torsion along with Foetal Ascites in a Cross-Bred Holstein-Friesian Cow Open

Pushkar Sharma, Sobran Singh Mahour, Atul Singh Parihar, Sachin Sankhla, Neeraj Khushwah · 2022

A twisting or rolling of the uterus along its longitudinal axis is known as uterine torsion (Roberts, 2004). Compared to other domestic animal species, bovines have a significantly higher prevalence of dystocia (Dutt et al., 2021). Uterine…

A VPS15-like kinase regulates apicoplast biogenesis and autophagy by promoting PI3P generation in Toxoplasma gondii Open

Rahul Rawat, Priyanka Bansal, Pushkar Sharma · 2022

Phosphoinositides are important second messengers that regulate key cellular processes in eukaryotes. While it is known that a single phosphoinositol-3 kinase (PI3K) catalyses the formation of 3’-phosphorylated phosphoinositides (PIPs) in …

A VPSl5-like kinase regulates apicoplast biogenesis and autophagy by promoting PI3P generation in Toxoplasma gondii Open

Rahul Rawat, Priyanka Bansal, Pushkar Sharma · 2022

Phosphoinositides are important second messengers that regulate key cellular processes in eukaryotes. While it is know that a single phosphoinositol-3 kinase (PI3K) catalyses the formation of 3’-phosphorylated phosphoinositides (PIPs) in a…

PI4‐kinase and PfCDPK7 signaling regulate phospholipid biosynthesis in Plasmodium falciparum Open

Ranjana Maurya, Anuj Tripathi, Manish Kumar, Neelam Antil, Yoshiki Yamaryo‐Botté , et al. · 2021

Composite Pheochromocytoma—A Rare Clinical Entity: A Case Series Open

Pushkar Sharma, Paul Jacob, Santosh Raj, Elanthenral Sigamani, Marie Therese Manipadam · 2021

Background: Composite pheochromocytoma is a rare entity with tumor comprising both pheochromocytoma and neuroblastic elements.The clinical outcome of such a composite tumor is not fully understood.In this case series, we report three cases…

Protein kinase TgCDPK7 regulates vesicular trafficking and phospholipid synthesis in Toxoplasma gondii Open

Priyanka Bansal, Neelam Antil, Manish Kumar, Yoshiki Yamaryo‐Botté, Rahul Rawat , et al. · 2021

Apicomplexan parasites are causative agents of major human diseases. Calcium Dependent Protein Kinases (CDPKs) are crucial components for the intracellular development of apicomplexan parasites and are thus considered attractive drug targe…

Phosphorylation of Rhoptry Protein RhopH3 Is Critical for Host Cell Invasion by the Malaria Parasite Open

Roseleen Ekka, Ankit Gupta, Sonika Bhatnagar, Pawan Malhotra, Pushkar Sharma · 2020

Host cell invasion by the malaria parasite is critical for establishing infection in human host and is dependent on discharge of key ligands from organelles like rhoptry and microneme, and these ligands interact with host RBC receptors. In…

Aberrant activation of neuronal cell cycle caused by dysregulation of ubiquitin ligase Itch results in neurodegeneration Open

Monika Chauhan, Prashant Kumar Modi, Pushkar Sharma · 2020

Clinical Efficacy of Ceftiofur Sodium, Gentamicin Sulfate and Zingiber Officinal on Serum Biochemical Constituents of Endometritic Buffaloes Open

Pushkar Sharma, Sushant Srivastava · 2019

Effect of ascorbic acid on preservability of spermatozoa of buffalo bull after storage of epididymis at temperature 4 0C and -196 0C Open

Saurabh Saurabh, Sushant Srivastava, Pushkar Sharma, Vijay Gautam · 2018

Incidence of major reproductive disorders of buffaloes in Agroclimatic zone of Eastern Uttar Pradesh Open

Sunil Kumar Verma, Sushant Srivastava, Saurabh Saurabh, Shailendra Verma, Pushkar Sharma · 2018

The present study, incidence of reproductive disorders in 7471 buffaloes were recorded from the data available in the form of case registered at Teaching Veterinary Clinical Complex, College of Veterinary science and Animal Husbandry, N.D.…

Autophagy-Related Protein ATG18 Regulates Apicoplast Biogenesis in Apicomplexan Parasites Open

Priyanka Bansal, Anuj Tripathi, Vandana Thakur, Asif Mohmmed, Pushkar Sharma · 2017

Mechanisms by which 3′-phosphorylated phosphoinositides (3′-PIPs) regulate the development of apicomplexan parasites Plasmodium falciparum and Toxoplasma gondii are poorly understood. The catabolic process of autophagy, which is dependent …

Classical autophagy proteins LC3B and ATG4B facilitate melanosome movement on cytoskeletal tracks Open

Amrita Ramkumar, Divya Murthy, Desingu Ayyappa Raja, Archana Singh, Anusha Krishnan , et al. · 2017

Macroautophagy/autophagy is a dynamic and inducible catabolic process that responds to a variety of hormonal and environmental cues. Recent studies highlight the interplay of this central pathway in a variety of pathophysiological diseases…

PfCDPK1 mediated signaling in erythrocytic stages of Plasmodium falciparum Open

Sudhir Kumar, Manish Kumar, Roseleen Ekka, Jeffrey D. Dvorin, Aditya S. Paul , et al. · 2017

Calcium Dependent Protein Kinases are key effectors of calcium signaling in malaria parasite. PfCDPK1 is critical for asexual development of Plasmodium falciparum , but its precise function and substrates remain largely unknown. Using a co…

Role and regulation of p27 in neuronal apoptosis Open

Surbhi Jaiswal, Pushkar Sharma · 2016

It is necessary for the cell‐cycle machinery of neurons to be suppressed to promote differentiation and maintenance of their terminally differentiated state. Reactivation of the cell cycle in response to neurotoxic insults leads to neurona…

Regulation of Neuronal Cell Cycle and Apoptosis by MicroRNA 34a Open

Prashant Kumar Modi, Surbhi Jaiswal, Pushkar Sharma · 2015

The cell cycle of neurons remains suppressed to maintain the state of differentiation and aberrant cell cycle reentry results in loss of neurons, which is a feature in neurodegenerative disorders like Alzheimer's disease (AD). Present stud…

Pushkar Sharma YOU? Author Swipe