Pushpa Gupta
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View article: Adopting ayurveda in health management complements “One health” approaches
Adopting ayurveda in health management complements “One health” approaches Open
View article: Correction to: Preparation and Preclinical Evaluation of Inhalable Particles Containing Rapamycin and Anti-Tuberculosis Agents for Induction of Autophagy
Correction to: Preparation and Preclinical Evaluation of Inhalable Particles Containing Rapamycin and Anti-Tuberculosis Agents for Induction of Autophagy Open
View article: Immunotherapy With 5, 15-DPP Mediates Macrophage M1 Polarization and Modulates Subsequent Mycobacterium tuberculosis Infectivity in rBCG30 Immunized Mice
Immunotherapy With 5, 15-DPP Mediates Macrophage M1 Polarization and Modulates Subsequent Mycobacterium tuberculosis Infectivity in rBCG30 Immunized Mice Open
Tuberculosis (TB) is a significant and continuing problem worldwide, with a death toll of around 1.5 million human lives annually. BCG, the only vaccine against TB, offers a varied degree of protection among human subjects in different reg…
View article: A Potent Inhibitor of IL-10/STAT3 Axis Signaling Modulates Anti-Inflammatory Responses and Boosts Anti-Tuberculosis Immunity in rBCG30 Immunized Mice
A Potent Inhibitor of IL-10/STAT3 Axis Signaling Modulates Anti-Inflammatory Responses and Boosts Anti-Tuberculosis Immunity in rBCG30 Immunized Mice Open
Aims and Objectives: In the present study we tried to improve anti-TB immunity offered by 2 nd generation rBCG30 vaccine. We attempted to bolster rBCG30 invoked anti-TB immunity in mice through modulation of the IL-10/STAT3 interaction med…
View article: Animal Models of Tuberculosis
Animal Models of Tuberculosis Open
Aims and objectives: Tuberculosis (TB) remain a leading cause of death globally among among infectious diseases that has killed more number of people than any other infectious diseases. It was Robert Koch who recognized the spectrum of pat…
View article: Use of ICT to Enhance the Learning Process in Higher Education
Use of ICT to Enhance the Learning Process in Higher Education Open
ICTs in Education refers to the development of information and communications technology specifically for teaching/learning purposes, while the ICTs in education involves the adoption of general components of information and communication …
View article: Improved Mycobacterium tuberculosis clearance after the restoration of IFN‐γ <sup>+</sup> TNF‐α <sup>+</sup> CD4 <sup>+</sup> T cells: Impact of PD‐1 inhibition in active tuberculosis patients
Improved Mycobacterium tuberculosis clearance after the restoration of IFN‐γ <sup>+</sup> TNF‐α <sup>+</sup> CD4 <sup>+</sup> T cells: Impact of PD‐1 inhibition in active tuberculosis patients Open
Prolonged therapy, drug toxicity, noncompliance, immune suppression, and alarming emergence of drug resistance necessitate the search for therapeutic vaccine strategies for tuberculosis (TB). Such strategies ought to elicit not only IFN‐γ,…
View article: Sphingosine-1-Phosphate (S-1P) Promotes Differentiation of Naive Macrophages and Enhances Protective Immunity Against Mycobacterium tuberculosis
Sphingosine-1-Phosphate (S-1P) Promotes Differentiation of Naive Macrophages and Enhances Protective Immunity Against Mycobacterium tuberculosis Open
Sphingosine-1-phosphate (S-1P) is a key sphingolipid involved in the pathobiology of various respiratory diseases. We have previously demonstrated the significance of S-1P in controlling non-pathogenic mycobacterial infection in macrophage…
View article: The sensor kinase MtrB of Mycobacterium tuberculosis regulates hypoxic survival and establishment of infection
The sensor kinase MtrB of Mycobacterium tuberculosis regulates hypoxic survival and establishment of infection Open
Paired two-component systems (TCSs), having a sensor kinase (SK) and a cognate response regulator (RR), enable the human pathogen Mycobacterium tuberculosis to respond to the external environment and to persist within its host. Here…
View article: Multiple strain infection of Mycobacterium leprae in a family having 4 patients: A study employing short tandem repeats
Multiple strain infection of Mycobacterium leprae in a family having 4 patients: A study employing short tandem repeats Open
The study suggested that three family members viz, elder daughter, father and younger daughter could be infected by M. leprae from 3 different sources and the history of the disease and genetic analysis showed that the middle daughter acqu…
View article: Amplification and sequencing of Short Tandem Repeats v1
Amplification and sequencing of Short Tandem Repeats v1 Open
To depict the variability among strains 2 STRs viz., GT6 and TA11CA3 region were amplified. All PCR reactions were carried out in 50μl total volume with 100 pmol of each primer and approximately 20 ng of template DNA. PCR reactions were pe…
View article: Inhibiting PD-1 Restores Poly-Functional T Cell Response in Tuberculosis and Synergizes with Chemotherapy
Inhibiting PD-1 Restores Poly-Functional T Cell Response in Tuberculosis and Synergizes with Chemotherapy Open
View article: Evaluation of Aggregated Ag85B Antigen for Its Biophysical Properties, Immunogenicity, and Vaccination Potential in a Murine Model of Tuberculosis Infection
Evaluation of Aggregated Ag85B Antigen for Its Biophysical Properties, Immunogenicity, and Vaccination Potential in a Murine Model of Tuberculosis Infection Open
Protein aggregates have been reported to act as a reservoir that can release biologically active, native form of precursor protein. Keeping this fact into consideration, it is tempting to exploit protein aggregate-based antigen delivery sy…
View article: Protective effect of antigen excess immune complex in guinea pigs infected with Mycobacterium tuberculosis
Protective effect of antigen excess immune complex in guinea pigs infected with Mycobacterium tuberculosis Open
Background & objectives: Immune complexes (ICs) play a crucial role which can either be beneficial or pathological to the host. Involvement of circulating immune complexes (CICs) has been shown in tuberculosis (TB) cases (adults and neonat…
View article: Modelling of cerebral tuberculosis in BALB/c mice using clinical strain from patients with CNS tuberculosis infection
Modelling of cerebral tuberculosis in BALB/c mice using clinical strain from patients with CNS tuberculosis infection Open
Background & objectives: Central nervous system (CNS) infection caused by Mycobacterium tuberculosis (MTB) is the most severe form of extrapulmonary tuberculosis (EPTB) due to a high level of mortality and morbidity. Limited studies are av…
View article: MicroRNA 26a (miR-26a)/KLF4 and CREB-C/EBPβ regulate innate immune signaling, the polarization of macrophages and the trafficking of Mycobacterium tuberculosis to lysosomes during infection
MicroRNA 26a (miR-26a)/KLF4 and CREB-C/EBPβ regulate innate immune signaling, the polarization of macrophages and the trafficking of Mycobacterium tuberculosis to lysosomes during infection Open
For efficient clearance of Mycobacterium tuberculosis (Mtb), macrophages tilt towards M1 polarization leading to the activation of transcription factors associated with the production of antibacterial effector molecules such as nitric oxid…
View article: Murine model of TB meningitis
Murine model of TB meningitis Open
Our findings demonstrated the design of a novel murine model of CNS-TB using a C3 strain and that replicated events of EPTB dissemination. This model will promote efforts to understand the pathogenesis CNS-TB infection for development of i…
View article: TLR Agonist Augments Prophylactic Potential of Acid Inducible Antigen Rv3203 against Mycobacterium tuberculosis H37Rv in Experimental Animals
TLR Agonist Augments Prophylactic Potential of Acid Inducible Antigen Rv3203 against Mycobacterium tuberculosis H37Rv in Experimental Animals Open
In general, the members of Lip gene family of Mycobacterium tuberculosis evoke strong immune response in the host. Keeping this fact into consideration, we investigated role of Rv3203, a cell wall associated protein with lipolytic activity…
View article: MicroRNA 17-5p regulates autophagy in<i>Mycobacterium tuberculosis</i>-infected macrophages by targeting Mcl-1 and STAT3
MicroRNA 17-5p regulates autophagy in<i>Mycobacterium tuberculosis</i>-infected macrophages by targeting Mcl-1 and STAT3 Open
Autophagy plays a crucial role in the control of bacterial burden during Mycobacterium tuberculosis infection. MicroRNAs (miRNAs) are small non-coding RNAs that regulate immune signalling and inflammation in response to challenge by pathog…
View article: MicroRNA let-7 Modulates the Immune Response to Mycobacterium tuberculosis Infection via Control of A20, an Inhibitor of the NF-κB Pathway
MicroRNA let-7 Modulates the Immune Response to Mycobacterium tuberculosis Infection via Control of A20, an Inhibitor of the NF-κB Pathway Open
View article: Efficacy of moxifloxacin & econazole against multidrug resistant (MDR) Mycobacterium tuberculosis in murine model
Efficacy of moxifloxacin & econazole against multidrug resistant (MDR) Mycobacterium tuberculosis in murine model Open
Background & objectives: Studies have shown the bactericidal potential of econazole and clotrimazole against Mycobacterium tuberculosis under in vitro and ex vivo conditions along with their synergism with conventional antituberculosis dru…
View article: Constitutive expression of SMAR1 confers susceptibility to Mycobacterium tuberculosis infection in a transgenic mouse model
Constitutive expression of SMAR1 confers susceptibility to Mycobacterium tuberculosis infection in a transgenic mouse model Open
SMAR1 transgenic mice exhibited susceptibility to M. tuberculosis infection in vivo irrespective of genetic background. This susceptibility was attributed to downregulation of Th1 response and its hallmark cytokine IFN-γ. Hence, SMAR1 play…