Putao Yuan
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View article: Targeting Msx2 as a brake in the fusion fate of osteoclasts and an anabolic therapy in pre-clinical models of osteoporosis
Targeting Msx2 as a brake in the fusion fate of osteoclasts and an anabolic therapy in pre-clinical models of osteoporosis Open
Highly conserved homeobox genes are closely related to bone formation during embryogenesis, while their role in adult bone resorption remains unclear. In this study, we found that the homeobox gene MSX2 actively participates bone metabolis…
View article: FTO SUMOylation regulates the differentiation of bone marrow mesenchymal stromal cells in inflammatory bowel disease-induced bone loss
FTO SUMOylation regulates the differentiation of bone marrow mesenchymal stromal cells in inflammatory bowel disease-induced bone loss Open
The gut-bone axis is critical for body homeostasis, but bone loss often complicates inflammatory bowel disease (IBD) with unclear mechanisms. Here, we found that IBD mice showed reduced bone formation, with bone marrow mesenchymal stromal …
View article: Visomitin Attenuates Pathological Bone Loss by Reprogramming Osteoclast Metabolism via the STAT3/LDHB Axis
Visomitin Attenuates Pathological Bone Loss by Reprogramming Osteoclast Metabolism via the STAT3/LDHB Axis Open
A persistently substantial energy demand and metabolic reprogramming endure throughout the entire course of osteoclastogenesis, accompanied by an intensified oxidative stress. Hence, balancing cellular energy metabolism and maintaining red…
View article: Publisher Correction: Restrained Mitf-associated autophagy by Mulberroside A ameliorates osteoclastogenesis and counteracts OVX-Induced osteoporosis in mice
Publisher Correction: Restrained Mitf-associated autophagy by Mulberroside A ameliorates osteoclastogenesis and counteracts OVX-Induced osteoporosis in mice Open
View article: l-arginine promotes angio-osteogenesis to enhance oxidative stress-inhibited bone formation by ameliorating mitophagy
l-arginine promotes angio-osteogenesis to enhance oxidative stress-inhibited bone formation by ameliorating mitophagy Open
View article: Restrained Mitf-associated autophagy by Mulberroside A ameliorates osteoclastogenesis and counteracts OVX-Induced osteoporosis in mice
Restrained Mitf-associated autophagy by Mulberroside A ameliorates osteoclastogenesis and counteracts OVX-Induced osteoporosis in mice Open
View article: Urolithin B reduces cartilage degeneration and alleviates osteoarthritis by inhibiting inflammation
Urolithin B reduces cartilage degeneration and alleviates osteoarthritis by inhibiting inflammation Open
Urolithin B, generated through the metabolism of microbiota, exhibits anti-inflammatory and cartilage-protective effects.
View article: Arginine promotes angio-osteogenesis by attenuating oxidative stress-induced bone loss and ameliorating mitophagy
Arginine promotes angio-osteogenesis by attenuating oxidative stress-induced bone loss and ameliorating mitophagy Open
Osteoporosis is one of the most common bone diseases in middle-aged and elderly populations worldwide. Development of new drugs to treat the disease is a key focus of research. Current treatments for osteoporosis mainly directed at promoti…
View article: Restrained Mitf-associated autophagy by Mulberroside A ameliorates osteoclastogenesis and counteracts OVX-Induced osteoporosis in mice
Restrained Mitf-associated autophagy by Mulberroside A ameliorates osteoclastogenesis and counteracts OVX-Induced osteoporosis in mice Open
Background and Purpose: Overactivated osteoclasts disrupt the mineral homeostasis of bone, inducing osteoporosis. Despite the rapid development of pharmacological therapy in osteoporosis, a safer and more effective treatment remains to be …
View article: USP7 Inhibits Osteoclastogenesis <i>via</i> Dual Effects of Attenuating TRAF6/TAK1 Axis and Stimulating STING Signaling
USP7 Inhibits Osteoclastogenesis <i>via</i> Dual Effects of Attenuating TRAF6/TAK1 Axis and Stimulating STING Signaling Open
Ubiquitination is a reversible post-translational modification implicated in cell differentiation, homeostasis, and organ development. Several deubiquitinases (DUBs) decrease protein ubiquitination through the hydrolysis of ubiquitin linka…
View article: Urolithin A Promotes Angiogenesis and Tissue Regeneration in a Full-Thickness Cutaneous Wound Model
Urolithin A Promotes Angiogenesis and Tissue Regeneration in a Full-Thickness Cutaneous Wound Model Open
The treatment of chronic wound is an important topic of current clinical issue. Neovascularization plays a crucial role in skin wound healing by delivering fresh nutrients and oxygen to the wound area. The aim of this study was to investig…
View article: Mechanical force promotes dimethylarginine dimethylaminohydrolase 1-mediated hydrolysis of the metabolite asymmetric dimethylarginine to enhance bone formation
Mechanical force promotes dimethylarginine dimethylaminohydrolase 1-mediated hydrolysis of the metabolite asymmetric dimethylarginine to enhance bone formation Open
View article: USP1 inhibition suppresses the progression of osteosarcoma via destabilizing TAZ
USP1 inhibition suppresses the progression of osteosarcoma via destabilizing TAZ Open
Mutations and altered expression of deubiquitinating enzymes (DUBs) profoundly influence tumor progression. Ubiquitin-specific protease 1 (USP1) is a well-characterized human DUB reportedly overexpressed in and associated with maintaining …
View article: EIF4A3-induced circular RNA PRKAR1B promotes osteosarcoma progression by miR-361-3p-mediated induction of FZD4 expression
EIF4A3-induced circular RNA PRKAR1B promotes osteosarcoma progression by miR-361-3p-mediated induction of FZD4 expression Open
View article: DUSP6 expression is associated with osteoporosis through the regulation of osteoclast differentiation via ERK2/Smad2 signaling
DUSP6 expression is associated with osteoporosis through the regulation of osteoclast differentiation via ERK2/Smad2 signaling Open
View article: Author response for "The SFRP1 inhibitor WAY ‐316606 attenuates osteoclastogenesis through dual modulation of canonical Wnt signaling"
Author response for "The SFRP1 inhibitor WAY ‐316606 attenuates osteoclastogenesis through dual modulation of canonical Wnt signaling" Open
View article: Author response for "The SFRP1 inhibitor WAY ‐316606 attenuates osteoclastogenesis through dual modulation of canonical Wnt signaling"
Author response for "The SFRP1 inhibitor WAY ‐316606 attenuates osteoclastogenesis through dual modulation of canonical Wnt signaling" Open
View article: miR-21-5p targets SKP2 to reduce osteoclastogenesis in a mouse model of osteoporosis
miR-21-5p targets SKP2 to reduce osteoclastogenesis in a mouse model of osteoporosis Open
View article: An Antioxidant Sesquiterpene Inhibits Osteoclastogenesis Via Blocking IPMK/TRAF6 and Counteracts OVX-Induced Osteoporosis in Mice
An Antioxidant Sesquiterpene Inhibits Osteoclastogenesis Via Blocking IPMK/TRAF6 and Counteracts OVX-Induced Osteoporosis in Mice Open
Excessive bone resorption induced by increased osteoclast activity in postmenopausal women often causes osteoporosis. Although the pharmacological treatment of osteoporosis has been extensively developed, a safer and more effective treatme…
View article: ML264 inhibits osteosarcoma growth and metastasis via inhibition of JAK2/STAT3 and WNT/β‐catenin signalling pathways
ML264 inhibits osteosarcoma growth and metastasis via inhibition of JAK2/STAT3 and WNT/β‐catenin signalling pathways Open
Osteosarcoma, the most common bone malignancy, has a high morbidity rate and poor prognosis. Krüppel‐like factor 5 (KLF5) is a key transcriptional regulator of cellular proliferation whose overexpression is observed in osteosarcoma cell li…