Aung Pyae Phyo
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View article: Causes of death in rural southeast Asia by electronic verbal autopsy: a population-based observational study
Causes of death in rural southeast Asia by electronic verbal autopsy: a population-based observational study Open
For the Myanmar, Karen, Bangla, Thai, Lao and Khmer translations of the abstract see Supplementary Materials section.
View article: <i>Plasmodium vivax</i> malaria relapse risk depends on transmission intensity: evidence from a longitudinal study in northwest Thailand
<i>Plasmodium vivax</i> malaria relapse risk depends on transmission intensity: evidence from a longitudinal study in northwest Thailand Open
Background In northwest Thailand the provision of radical cure to prevent relapses of Plasmodium vivax malaria has decreased P. vivax caseloads and decreased transmission. While malaria control measures were increased, we performed a prosp…
View article: Investigating the Abbott-Bioline™ malaria antigen Pf/Pv rapid diagnostic test
Investigating the Abbott-Bioline™ malaria antigen Pf/Pv rapid diagnostic test Open
The Abbott-Bioline™ Malaria Ag Pf/Pv RDT that were obtained in 2024 failed to detect microscopically confirmed cases of malaria and is not fit for purpose. This test should no longer be used and should be replaced by one with adequate perf…
View article: How can the ethical conduct of verbal autopsies be enhanced? Lessons from Southeast Asia
How can the ethical conduct of verbal autopsies be enhanced? Lessons from Southeast Asia Open
Verbal autopsy research is vital for understanding community mortality, informing health interventions and policies in low- and middle-income countries. However, overlooking the community perspectives on deaths can undermine the ethical co…
View article: Understanding the primary healthcare context in rural South and Southeast Asia: a village profiling study
Understanding the primary healthcare context in rural South and Southeast Asia: a village profiling study Open
Background Understanding contextual factors is critical to the success of health service planning and implementation. However, few contextual data are available at the village level in rural South and Southeast Asia. This study addressed t…
View article: A mixed methods study investigating factors affecting adherence to Plasmodium vivax malaria primaquine radical cure regimens among migrants along the Myanmar-Thailand border
A mixed methods study investigating factors affecting adherence to Plasmodium vivax malaria primaquine radical cure regimens among migrants along the Myanmar-Thailand border Open
Background The countries within the Greater Mekong Region of Southeast Asia have pledged to eliminate malaria by 2030. Elimination of Plasmodium vivax malaria is challenging as it requires radical cure to prevent relapse. Understanding and…
View article: Understanding the primary healthcare context in rural South and Southeast Asia: a village profiling study
Understanding the primary healthcare context in rural South and Southeast Asia: a village profiling study Open
The use of comprehensive village profiles is one way of characterising contextual factors important for the implementation of primary healthcare interventions and service planning in rural areas. However, there are few such data available …
View article: Molecular markers of artemisinin resistance during falciparum malaria elimination in Eastern Myanmar
Molecular markers of artemisinin resistance during falciparum malaria elimination in Eastern Myanmar Open
Background Artemisinin resistance in Plasmodium falciparum threatens global malaria elimination efforts. To contain and then eliminate artemisinin resistance in Eastern Myanmar a network of community-based malaria posts was instituted and …
View article: Does acute malnutrition in young children increase the risk of treatment failure following artemisinin-based combination therapy? A WWARN individual patient data meta-analysis
Does acute malnutrition in young children increase the risk of treatment failure following artemisinin-based combination therapy? A WWARN individual patient data meta-analysis Open
View article: Molecular markers of artemisinin resistance during falciparum malaria elimination in Eastern Myanmar
Molecular markers of artemisinin resistance during falciparum malaria elimination in Eastern Myanmar Open
Background Artemisinin resistance in Plasmodium falciparum threatens global malaria elimination efforts. To contain and then eliminate artemisinin resistance in Eastern Myanmar a network of community-based malaria posts was instituted and …
View article: Ethical and cultural implications for conducting verbal autopsies in South and Southeast Asia: a qualitative study
Ethical and cultural implications for conducting verbal autopsies in South and Southeast Asia: a qualitative study Open
Introduction Causes of deaths often go unrecorded in lower income countries, yet this information is critical. Verbal autopsy is a questionnaire interview with a family member or caregiver to elicit the symptoms and circumstances preceding…
View article: Outbreaks of COVID-19 in a tuberculosis treatment sanatorium on the Thailand-Myanmar border: a retrospective cohort analysis
Outbreaks of COVID-19 in a tuberculosis treatment sanatorium on the Thailand-Myanmar border: a retrospective cohort analysis Open
Background Tuberculosis (TB) is a chronic condition, with overlapping symptoms to those of coronavirus disease 2019 (COVID-19). There has been inconsistent evidence on whether TB is a predisposing factor for developing severe COVID-19. The…
View article: A systematic review of neglected tropical diseases (NTDs) in Myanmar
A systematic review of neglected tropical diseases (NTDs) in Myanmar Open
Background Neglected tropical diseases (NTDs) affect most impoverished communities in developing countries, like Myanmar in Southeast Asia. NTDs have been understudied and underreported in Myanmar. Methods A systematic review of published …
View article: Severe falciparum malaria in pregnancy in Southeast Asia: a multi-centre retrospective cohort study
Severe falciparum malaria in pregnancy in Southeast Asia: a multi-centre retrospective cohort study Open
View article: Outbreaks of COVID-19 in a tuberculosis treatment sanatorium on the Thailand-Myanmar border: a retrospective cohort analysis
Outbreaks of COVID-19 in a tuberculosis treatment sanatorium on the Thailand-Myanmar border: a retrospective cohort analysis Open
Background: Tuberculosis (TB) is a chronic condition, with overlapping symptoms to those of coronavirus disease 2019 (COVID-19). There has been inconsistent evidence on whether TB is a predisposing factor for developing severe COVID-19. T…
View article: Susceptibility of Southeast Asian Plasmodium falciparum isolates to P218
Susceptibility of Southeast Asian Plasmodium falciparum isolates to P218 Open
A major threat to the goal of eliminating malaria, particularly in Southeast Asia, is the spread of Plasmodium falciparum resistant to artemisinin-based combination therapies. P218 is a drug candidate designed to combat antifolate-sensitiv…
View article: Severe Falciparum and Vivax Malaria on the Thailand-Myanmar Border: A Review of 1503 Cases
Severe Falciparum and Vivax Malaria on the Thailand-Myanmar Border: A Review of 1503 Cases Open
Background The northwestern border of Thailand is an area of low seasonal malaria transmission. Until recent successful malaria elimination activities, malaria was a major cause of disease and death. Historically the incidences of symptoma…
View article: Born too soon in a resource-limited setting: A 10-year mixed methods review of a special care baby unit for refugees and migrants on the Myanmar-Thailand border
Born too soon in a resource-limited setting: A 10-year mixed methods review of a special care baby unit for refugees and migrants on the Myanmar-Thailand border Open
Background Preterm birth is a major public health concern with the largest burden of morbidity and mortality falling within low- and middle-income countries (LMIC). Materials and methods This sequential explanatory mixed methods study was …
View article: Ethical and Cultural Implications for Conducting Verbal Autopsies in South and Southeast Asia: A Qualitative Study
Ethical and Cultural Implications for Conducting Verbal Autopsies in South and Southeast Asia: A Qualitative Study Open
View article: Prevalence of knowledge and attitude about secondhand smoke among pregnant women attending antenatal care at Central Women’s hospital in Myanmar
Prevalence of knowledge and attitude about secondhand smoke among pregnant women attending antenatal care at Central Women’s hospital in Myanmar Open
Public health experts are aware of secondhand smoke (SHS) dangers, particularly for vulnerable groups like pregnant women. This study aims to describe the prevalence of SHS among pregnant women, including their knowledge, and attitude towa…
View article: Case Report: A case report of multiple co-infections (melioidosis, paragonimiasis, Covid-19 and tuberculosis) in a patient with diabetes mellitus and thalassemia-trait in Myanmar
Case Report: A case report of multiple co-infections (melioidosis, paragonimiasis, Covid-19 and tuberculosis) in a patient with diabetes mellitus and thalassemia-trait in Myanmar Open
Burkholderia pseudomallei is a soil-dwelling aerobic bacterium prevalent in tropical and subtropical regions, particularly in Southeast Asia and Northern Australia. It is the causal organism of melioidosis, a severe infection that can mani…
View article: Comparison of Antibody Responses and Parasite Clearance in Artemisinin Therapeutic Efficacy Studies in the Democratic Republic of Congo and Asia
Comparison of Antibody Responses and Parasite Clearance in Artemisinin Therapeutic Efficacy Studies in the Democratic Republic of Congo and Asia Open
Background Understanding the effect of immunity on Plasmodium falciparum clearance is essential for interpreting therapeutic efficacy studies designed to monitor emergence of artemisinin drug resistance. In low-transmission areas of Southe…
View article: Case Report: A case report of multiple co-infections (melioidosis, paragonimiasis, Covid-19 and tuberculosis) in a patient with diabetes mellitus and thalassemia-trait in Myanmar
Case Report: A case report of multiple co-infections (melioidosis, paragonimiasis, Covid-19 and tuberculosis) in a patient with diabetes mellitus and thalassemia-trait in Myanmar Open
Burkholderia pseudomallei is a soil-dwelling aerobic bacterium prevalent in tropical and subtropical regions, particularly in Southeast Asia and Northern Australia. It is the causal organism of melioidosis, a severe infection that can man…
View article: An open dataset of Plasmodium vivax genome variation in 1,895 worldwide samples
An open dataset of Plasmodium vivax genome variation in 1,895 worldwide samples Open
This report describes the MalariaGEN Pv4 dataset, a new release of curated genome variation data on 1,895 samples of Plasmodium vivax collected at 88 worldwide locations between 2001 and 2017. It includes 1,370 new samples contributed by M…
View article: Anti-Gametocyte Antigen Humoral Immunity and Gametocytemia During Treatment of Uncomplicated Falciparum Malaria: A Multi-National Study
Anti-Gametocyte Antigen Humoral Immunity and Gametocytemia During Treatment of Uncomplicated Falciparum Malaria: A Multi-National Study Open
Introduction Understanding the human immune response to Plasmodium falciparum gametocytes and its association with gametocytemia is essential for understanding the transmission of malaria as well as progressing transmission blocking vaccin…
View article: Artemisinin resistance in the malaria parasite, Plasmodium falciparum, originates from its initial transcriptional response
Artemisinin resistance in the malaria parasite, Plasmodium falciparum, originates from its initial transcriptional response Open
View article: Defining the burden of febrile illness in rural South and Southeast Asia: an open letter to announce the launch of the Rural Febrile Illness project
Defining the burden of febrile illness in rural South and Southeast Asia: an open letter to announce the launch of the Rural Febrile Illness project Open
In rural areas of South and Southeast Asia malaria is declining but febrile illnesses still account for substantial morbidity and mortality. Village health workers (VHWs) are often the first point of contact with the formal health system, …
View article: Clinical impact of vivax malaria: A collection review
Clinical impact of vivax malaria: A collection review Open
Background Plasmodium vivax infects an estimated 7 million people every year. Previously, vivax malaria was perceived as a benign condition, particularly when compared to falciparum malaria. Reports of the severe clinical impacts of vivax …
View article: Plasmodium falciparum rosetting protects schizonts against artemisinin
Plasmodium falciparum rosetting protects schizonts against artemisinin Open
A*STAR, NMRC-OF-YIRG, HRC e-ASIA, Wellcome.
View article: Determinants of Primaquine and Carboxyprimaquine Exposures in Children and Adults with Plasmodium vivax Malaria
Determinants of Primaquine and Carboxyprimaquine Exposures in Children and Adults with Plasmodium vivax Malaria Open
Primaquine is the only widely available drug for radical cure of Plasmodium vivax malaria. There is uncertainty whether the pharmacokinetic properties of primaquine are altered significantly in childhood or not.