Q. C. Truong-Bolduc
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View article: Impact of Blue Light on Nafcillin Resistance in Staphylococcus aureus: The Role of AbcA Efflux Pump
Impact of Blue Light on Nafcillin Resistance in Staphylococcus aureus: The Role of AbcA Efflux Pump Open
View article: NorA and Tet38 efflux pumps enable <i>Staphylococcus aureus</i> survival in the cystic fibrosis airway environment, resistance to antibiotics, and coinfection with <i>Pseudomonas aeruginosa</i>
NorA and Tet38 efflux pumps enable <i>Staphylococcus aureus</i> survival in the cystic fibrosis airway environment, resistance to antibiotics, and coinfection with <i>Pseudomonas aeruginosa</i> Open
Efflux pumps play multiple roles in bacterial physiology, environmental adaptation, and antibiotic resistance. Early cystic fibrosis (CF) airway infections start with Staphylococcus aureus ( SA ), often later followed by Pseudomonas aerugi…
View article: Enhanced Quinolone Resistance and Differential Expression of Efflux Pump nor Genes in Staphylococcus aureus Grown in Platelet Concentrates
Enhanced Quinolone Resistance and Differential Expression of Efflux Pump nor Genes in Staphylococcus aureus Grown in Platelet Concentrates Open
Background/Objective: Platelet concentrates (PCs) are used in transfusion medicine to treat bleeding disorders. Staphylococcus aureus, a predominant PC contaminant, has been implicated in several adverse transfusion reactions. The aim of t…
View article: Blue Light Compromises Bacterial β‐Lactamases Activity to Overcome β‐Lactam Resistance
Blue Light Compromises Bacterial β‐Lactamases Activity to Overcome β‐Lactam Resistance Open
Objective In this study, we evaluated the effectiveness of antimicrobial blue light (aBL; 410 nm wavelength) against β‐lactamase‐carrying bacteria and the effect of aBL on the activity of β‐lactamases. Methods Pseudomonas aeruginosa , Esch…
View article: Phenazine-1 carboxylic acid of <i>Pseudomonas aeruginosa</i> induces the expression of <i>Staphylococcus aureus</i> Tet38 MDR efflux pump and mediates resistance to phenazines and antibiotics
Phenazine-1 carboxylic acid of <i>Pseudomonas aeruginosa</i> induces the expression of <i>Staphylococcus aureus</i> Tet38 MDR efflux pump and mediates resistance to phenazines and antibiotics Open
In this study, we showed that phenazine-1 carboxylic acid (PCA) of Pseudomonas aeruginosa induced the expression of Tet38 efflux pump triggering Staphylococcus aureus resistance to tetracycline and phenazines. Exposure of S. aureus RN6390 …
View article: Editorial: Microbial interactions and survival mechanisms in chronic respiratory infections
Editorial: Microbial interactions and survival mechanisms in chronic respiratory infections Open
Citation: Truong-Bolduc QC, Liao C-H, Nakaminami H, Strahilevitz J and Leanse LG (2024) Editorial: Microbial interactions and survival mechanisms in chronic respiratory infections. Front. Microbiol. 15:1387518. doi: 10.3389/fmicb.2024.1387…
View article: <i>Staphylococcus aureus</i> AbcA transporter enhances persister formation under β-lactam exposure
<i>Staphylococcus aureus</i> AbcA transporter enhances persister formation under β-lactam exposure Open
We evaluated the role of Staphylococcus aureus AbcA transporter in bacterial persistence and survival following exposure to the bactericidal agents nafcillin and oxacillin at both the population and single-cell levels. We show that AbcA ov…
View article: NorA efflux pump mediates <i>Staphylococcus aureus</i> response to <i>Pseudomonas aeruginosa</i> pyocyanin toxicity
NorA efflux pump mediates <i>Staphylococcus aureus</i> response to <i>Pseudomonas aeruginosa</i> pyocyanin toxicity Open
Endogenous transporters protect Staphylococcus aureus against antibiotics and also contribute to bacterial defense from environmental toxins. We evaluated the effect of overexpression of four efflux pumps, NorA, NorB, NorC, and Tet38, on S…
View article: Role of <i>Staphylococcus aureus</i> Tet38 in Transport of Tetracycline and Its Regulation in a Salt Stress Environment
Role of <i>Staphylococcus aureus</i> Tet38 in Transport of Tetracycline and Its Regulation in a Salt Stress Environment Open
This study shows that S. aureus Tet38 is a tetracycline efflux pump regulated by KdpD/E regulator. These findings are the first direct demonstration of Tet38-mediated tetracycline efflux, which had previously been inferred from its ability…
View article: Staphylococcus aureus Tet38 Efflux Pump Structural Modeling and Roles of Essential Residues in Drug Efflux and Host Cell Internalization
Staphylococcus aureus Tet38 Efflux Pump Structural Modeling and Roles of Essential Residues in Drug Efflux and Host Cell Internalization Open
The Staphylococcus aureus Tet38 membrane protein has distinct functions, including drug efflux and host cell attachment and internalization mediated by interaction with host cell CD36. Using structural modeling and site-directed mutagenesi…
View article: Tet38 of Staphylococcus aureus Binds to Host Cell Receptor Complex CD36–Toll-Like Receptor 2 and Protects from Teichoic Acid Synthesis Inhibitors Tunicamycin and Congo Red
Tet38 of Staphylococcus aureus Binds to Host Cell Receptor Complex CD36–Toll-Like Receptor 2 and Protects from Teichoic Acid Synthesis Inhibitors Tunicamycin and Congo Red Open
Using an affinity column retention assay, we showed that the purified Tet38 membrane transporter of Staphylococcus aureus bound specifically to host cell CD36 and to the complex CD36–Toll-like receptor 2 (TLR-2), but not to TLR-2 alone or …
View article: Tet38 Efflux Pump Contributes to Fosfomycin Resistance in Staphylococcus aureus
Tet38 Efflux Pump Contributes to Fosfomycin Resistance in Staphylococcus aureus Open
Fosfomycin inhibits MurA following uptake by the GlpT transporter of glycerol-3-phosphate in Escherichia coli . In Staphylococcus aureus , plasmid overexpression of the Tet38 efflux pump and a glpT mutant resulted in increased MICs and dec…
View article: Transcriptional Regulator TetR21 Controls the Expression of the Staphylococcus aureus LmrS Efflux Pump
Transcriptional Regulator TetR21 Controls the Expression of the Staphylococcus aureus LmrS Efflux Pump Open
TetR21 controls the expression of Tet38 and LmrS efflux pumps. A tetR21 mutant, QT21, exhibited a 4-fold increase in the transcription level of lmrS . Staphylococcus aureus lmrS overexpressor showed increases of 4-fold and 2-fold, respecti…
View article: Efflux Transporter of Siderophore Staphyloferrin A in Staphylococcus aureus Contributes to Bacterial Fitness in Abscesses and Epithelial Cells
Efflux Transporter of Siderophore Staphyloferrin A in Staphylococcus aureus Contributes to Bacterial Fitness in Abscesses and Epithelial Cells Open
The siderophores staphyloferrin A (SA) and staphyloferrin B (SB) of Staphylococcus aureus are essential for iron acquisition in the iron-restricted environment of the host, such as in subcutaneous abscesses. SA and SB are secreted by SfaA …
View article: Tet38 Efflux Pump Affects Staphylococcus aureus Internalization by Epithelial Cells through Interaction with CD36 and Contributes to Bacterial Escape from Acidic and Nonacidic Phagolysosomes
Tet38 Efflux Pump Affects Staphylococcus aureus Internalization by Epithelial Cells through Interaction with CD36 and Contributes to Bacterial Escape from Acidic and Nonacidic Phagolysosomes Open
We previously reported that the Tet38 efflux pump is involved in internalization of Staphylococcus aureus by A549 lung epithelial cells. A lack of tet38 reduced bacterial uptake by A549 cells to 36% of that of the parental strain RN6390. U…
View article: Role of the Tet38 Efflux Pump in Staphylococcus aureus Internalization and Survival in Epithelial Cells
Role of the Tet38 Efflux Pump in Staphylococcus aureus Internalization and Survival in Epithelial Cells Open
We previously identified the protein Tet38 as a chromosomally encoded efflux pump of Staphylococcus aureus that confers resistance to tetracycline and certain unsaturated fatty acids. Tet38 also contributes to mouse skin colonization. In t…