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View article: Single-nucleus and spatial transcriptomics reveal the cell populations of intercalary meristems in bamboo
Single-nucleus and spatial transcriptomics reveal the cell populations of intercalary meristems in bamboo Open
Intercalary meristems (IcMs), specialized developmental zones that drive rapid stem elongation in monocots, exhibit distinct spatiotemporal dynamics; however, their genetic basis remains poorly understood due to their transient activity an…
View article: Study on the phosphorylation of NAD <sup>+</sup> -specific isocitrate dehydrogenase in the pathogenic bacteria <i>Stenotrophomonas maltophilia</i> and <i>Xanthomonas sacchari</i>
Study on the phosphorylation of NAD <sup>+</sup> -specific isocitrate dehydrogenase in the pathogenic bacteria <i>Stenotrophomonas maltophilia</i> and <i>Xanthomonas sacchari</i> Open
Isocitrate dehydrogenases (IDHs) regulate the distribution of carbon flux between the TCA cycle and glyoxylate shunt through reversible phosphorylation that influences pathogen virulence. Current studies only indicate that NADP+-specific I…
Advancing metal organic framework and covalent organic framework design <i>via</i> the digital-intelligent paradigm Open
AI and machine learning combined with multiscale simulations accelerate framework materials design. This review summarizes AI-assisted strategies for synthesis prediction, condition optimization, and inverse functional design.
View article: Cancer cells surviving cisplatin chemotherapy increase stress-induced OMA1 activity and mitochondrial fragmentation
Cancer cells surviving cisplatin chemotherapy increase stress-induced OMA1 activity and mitochondrial fragmentation Open
Cancer is one of the leading causes of deaths worldwide. Once cancer cells acquire therapy resistance, they become the main driver of cancer lethality in patients. Thus, mechanisms of therapy resistance must be investigated to improve pati…
An Approximate Constant-Q Viscoacoustic Full Waveform Inversion Method Based on Gradient Preconditioning Open
In viscoelastic media, velocity and quality factor (Q) exhibit crosstalk in full waveform inversion (FWI), where the gradient vector of Q is dominated by velocity, thereby impairing the accuracy of final inversion results. While sequential…
Fault Diagnosis of Rolling Bearing Based on Spectrum-Adaptive Convolution and Interactive Attention Mechanism Open
With the development of artificial intelligence technology, intelligent fault diagnosis methods based on deep learning have received extensive attention. Among them, convolutional neural network (CNN) has been widely applied in the fault d…
View article: Experimental Study and Application of Underground Gasification Characteristics of Long Flame Coal in Xinjiang Oilfield
Experimental Study and Application of Underground Gasification Characteristics of Long Flame Coal in Xinjiang Oilfield Open
Underground coal gasification technology is an advanced technology for coal gasification directly in the coal seam. By injecting oxidants, the combustion reaction inside the coal seam is triggered to generate syngas. This technology can no…
View article: Effects of protein source and seaweed supplementation on mineral intake, milk mineral concentrations, and iodine transfer efficiency from feed to milk in lactating dairy cows
Effects of protein source and seaweed supplementation on mineral intake, milk mineral concentrations, and iodine transfer efficiency from feed to milk in lactating dairy cows Open
The objective of this experiment was to study the effects of protein source and seaweed supplementation on intake, milk concentration, and transfer efficiency of minerals from feed to cow milk. Twelve multiparous Nordic Red cows were used …
GDM enhanced acetylcholine induced vasoconstriction in human umbilical vein via CHRM3 and CACNA1C upregulation linked to promoter hypomethylation Open
Intrauterine exposure to hyperglycemia increases the risk of hypertension disorders in the offspring. Vascular dysfunction has a critical role in hypertension development. This study aimed to investigate the effects of GDM on human umbilic…
Targeted metabolomic and transcriptomic analyses provide insights into flavonoid biosynthesis in the grain of Foxtail millet Open
BACKGROUND: Foxtail millet (Setaria italica L.), a traditional Chinese crop, is valued for its rich abundance of health-beneficial compounds (e.g., flavonoids). Despite the nutritional significance of flavonoids, their biosynthetic pathway…
Genome-wide analysis of the TCP transcription factor family in mung bean and its dynamic regulatory network under salt stress Open
The TCP gene family encodes plant-specific transcription factors that regulate plant growth, development, and stress responses. Although this gene family has been widely studied in various species, its function in mung bean ( Vigna radiata…
Enhanced Reduction of Nitrate to Ammonia at the Co-N Heteroatomic Interface in MOF-Derived Porous Carbon Open
The electrocatalytic reduction of nitrate is an efficient and green method for NH3 production. In this study, a Co-containing MOF with a stable three-dimensional carbon framework that offers abundant metal active sites is prepared as a pre…
View article: Acute chromatin decompaction stiffens the nucleus as revealed by nanopillar-induced nuclear deformation in cells
Acute chromatin decompaction stiffens the nucleus as revealed by nanopillar-induced nuclear deformation in cells Open
Chromatin architecture is critical in determining nuclear mechanics. Most studies focus on the mechanical rigidity conferred by chromatin condensation from densely packed heterochromatin, but less is known on how transient chromatin decomp…
A novel microfluidic viscometer for measuring viscosity of ultrasmall volumes of Newtonian and non-Newtonian liquids Open
Viscosity is a critical fluid property that significantly influences fluid behavior and performance across various systems. Most commercial viscometers require relatively large sample volumes (on the order of milliliters), which restricts …
View article: Targeted metabolomic and transcriptomic analyses provide insights into flavonoid biosynthesis in the grain of foxtail millet
Targeted metabolomic and transcriptomic analyses provide insights into flavonoid biosynthesis in the grain of foxtail millet Open
Background Foxtail millet (Setaria italica L.), a traditional Chinese crop, is valued for its considerable abundance of compounds with health benefits (e.g., flavonoids). Despite the nutritional significance of flavonoids, their biosynthet…
Integrating bulk and single-cell RNA sequencing reveals SH3D21 promotes hepatocellular carcinoma progression by activating the PI3K/AKT/mTOR pathway Open
As a novel genetic biomarker, the potential role of SH3D21 in hepatocellular carcinoma remains unclear. Here, we decipher the expression and function of SH3D21 in human hepatocellular carcinoma. The expression level and clinical significan…
Full-azimuth angle domain reverse time migration Open
With the advent of wide-azimuth and high-density acquisition technologies, seismic data has become richer and more informative, necessitating advanced seismic imaging techniques. This paper presents a full-azimuth reverse time migration im…
View article: Assessment of urban traffic vehicle emissions reduction after integration of ‘traffic light countdown’ module in navigation
Assessment of urban traffic vehicle emissions reduction after integration of ‘traffic light countdown’ module in navigation Open
As China experiences a dramatic surge in carbon emissions from the transportation sector, reducing these emissions has become crucial in mitigating climate change. Since 2020, Navigation Service Providers has collaborated with traffic poli…
Associations between prenatal phthalate exposure and newborn telomere length: Effect modification by infant sex Open
Our study suggests that maternal exposure to phthalates is linked to shorter telomere length in neonates, especially in female infants.
Transcranial electrical stimulation as a therapeutic strategy for Alzheimer's disease: Current uses and challenges Open
Alzheimer's disease (AD) is an age-related neurodegenerative disorder for which there are currently rarely effective drug treatments available to halt or slow down its progression. With the aging of the world population, AD as the primary …
View article: Rational design of nitrogen and fluorine co-doped metal-free porous carbons electrocatalysts for highly efficient oxygen reduction and zinc-air batteries
Rational design of nitrogen and fluorine co-doped metal-free porous carbons electrocatalysts for highly efficient oxygen reduction and zinc-air batteries Open
The oxygen reduction reaction (ORR) is an important reaction in fuel cells and metal air batteries. The reaction is affected by slow kinetics and the use of high-priced and resource-scarce platinum-based catalysts. Therefore, there is an u…
Progress in antileishmanial drugs: Mechanisms, challenges, and prospects Open
Leishmaniasis, a neglected tropical disease caused by Leishmania parasites, continues to pose global health challenges. Current treatments face issues like resistance, safety, efficacy, and cost. This review covers the discovery, mechanism…