Fan Wu
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View article: Influence of diabetes on short-term mortality of patients with acute type A aortic dissection: a meta-analysis
Influence of diabetes on short-term mortality of patients with acute type A aortic dissection: a meta-analysis Open
This meta-analysis of retrospective studies suggests that DM may be associated with higher short-term mortality in ATAAD. Given the observational nature of the evidence, further prospective studies are needed to clarify this relationship.
View article: HDAC3 represses Nrf2-GDF11 signaling to drive chondrocyte adipogenesis in temporomandibular joint osteoarthritis
HDAC3 represses Nrf2-GDF11 signaling to drive chondrocyte adipogenesis in temporomandibular joint osteoarthritis Open
Our findings indicate that aberrant biomechanical force induces HDAC3 upregulation, which suppresses Nrf2-mediated transactivation of GDF11, thereby promoting chondrocyte adipogenesis and exacerbating TMJ OA progression.
View article: Expert Consensus on the Diagnosis and Treatment of Malignant Mesothelioma of the Tunica Vaginalis Testis
Expert Consensus on the Diagnosis and Treatment of Malignant Mesothelioma of the Tunica Vaginalis Testis Open
Malignant mesothelioma of the tunica vaginalis testis (MMTVT) is a rare malignancy originating from mesothelial cells of the testicular tunica vaginalis. Due to its insidious onset and local aggressiveness, most patients are diagnosed at a…
View article: UniCount: Mining Large-Scale Video Data for Universal Repetitive Action Counting
UniCount: Mining Large-Scale Video Data for Universal Repetitive Action Counting Open
We introduce the Open Sequential Repetitive Action Counting (OSRAC) task, which aims to count all repetitions and locate transition boundaries of sequential actions from large-scale video data, without relying on predefined action categori…
View article: Electroacupuncture promotes post-stroke motor recovery through miR-124-3p-mediated regulation of NRG1/ErbB4 signaling pathway
Electroacupuncture promotes post-stroke motor recovery through miR-124-3p-mediated regulation of NRG1/ErbB4 signaling pathway Open
Objective Electroacupuncture has demonstrated beneficial effects in post-stroke motor dysfunction, yet the molecular mechanisms underlying its therapeutic efficacy remain incompletely understood. This study aims to investigate whether elec…
View article: Advances in hydrogel research: a 25-year bibliometric overview
Advances in hydrogel research: a 25-year bibliometric overview Open
View article: Effectiveness and safety of Tuina massage therapy for paediatric fever: a systematic review and meta-analysis of randomised controlled trials
Effectiveness and safety of Tuina massage therapy for paediatric fever: a systematic review and meta-analysis of randomised controlled trials Open
This meta-analysis suggests that traditional Chinese Tuina may be a promising adjunctive therapy for pediatric fever. Careful consideration of each child's specific conditions is necessary to ensure safety and comfort. Future research shou…
View article: Expert Consensus on the Diagnosis and Treatment of Malignant Pericardial Mesothelioma
Expert Consensus on the Diagnosis and Treatment of Malignant Pericardial Mesothelioma Open
Primary malignant pericardial mesothelioma (PMPM), a rare pericardium‐derived malignancy, urgently requires standardized diagnostic and therapeutic protocols. This consensus, established by the Chinese Alliance of Research for Mesothelioma…
View article: MergeNet: Knowledge Migration Across Heterogeneous Models, Tasks, and Modalities
MergeNet: Knowledge Migration Across Heterogeneous Models, Tasks, and Modalities Open
In this study, we focus on heterogeneous knowledge transfer across entirely different model architectures, tasks, and modalities. Existing knowledge transfer methods (e.g., backbone sharing, knowledge distillation) often hinge on shared el…
View article: B2Pin2-Enabled Reductive Thioesterification of Aryl Triflates with Thiocarbonates
B2Pin2-Enabled Reductive Thioesterification of Aryl Triflates with Thiocarbonates Open
In this work, we demonstrate aryl thioester synthesis via an unprecedented B2Pin2-mediated reductive coupling of aryl triflates with thiocarbonates. This method demonstrates good to high efficiency for 2,6-disubstituted aryl substrates, wh…
View article: Diastereo- and Enantioselective Allylation of α-Hydroxy Ketones Enabled by Palladium/Borinic acid Dual Catalysis
Diastereo- and Enantioselective Allylation of α-Hydroxy Ketones Enabled by Palladium/Borinic acid Dual Catalysis Open
Asymmetric allylation reaction between unsymmetrical allyl carbonates and α-hydroxy ketones synergistically catalyzed by a palladium/borinic acid catalytic platform has been developed. The reaction proceeds through nucleophilic activation …
View article: Fine-Grained Guidance for Retrievers: Leveraging LLMs' Feedback in Retrieval-Augmented Generation
Fine-Grained Guidance for Retrievers: Leveraging LLMs' Feedback in Retrieval-Augmented Generation Open
Retrieval-Augmented Generation (RAG) has proven to be an effective method for mitigating hallucination issues inherent in large language models (LLMs). Previous approaches typically train retrievers based on semantic similarity, lacking op…
View article: Brønsted acid catalyzed green and efficient construction of α-amino peroxides from 3-hydroxyisoindolinones and hydroperoxides
Brønsted acid catalyzed green and efficient construction of α-amino peroxides from 3-hydroxyisoindolinones and hydroperoxides Open
View article: Hypervalent iodine-catalyzed amide and alkene coupling enabled by lithium salt activation
Hypervalent iodine-catalyzed amide and alkene coupling enabled by lithium salt activation Open
Hypervalent iodine catalysis has been widely utilized in olefin functionalization reactions. Intermolecularly, the regioselective addition of two distinct nucleophiles across the olefin is a challenging process in hypervalent iodine cataly…
View article: A Facile Synthesis of 2-Oxazolines via Dehydrative Cyclization Promoted by Triflic Acid
A Facile Synthesis of 2-Oxazolines via Dehydrative Cyclization Promoted by Triflic Acid Open
2-oxazolines are common moieties in numerous natural products, pharmaceuticals, and functional copolymers. Current methods for synthesizing 2-oxazolines mainly rely on stoichiometric dehydration agents or catalytic dehydration promoted by …
View article: Lewis Acid-Catalyzed Halonium Generation for Morpholine Synthesis and Claisen Rearrangement
Lewis Acid-Catalyzed Halonium Generation for Morpholine Synthesis and Claisen Rearrangement Open
We disclose here practical strategies toward the synthesis of morpholines and Claisen rearrangement products based on the divergent reactivity of a common halonium intermediate. These reactions employ widely available alkenes in a Lewis ac…
View article: A mild and concise synthesis of aryloxy phosphoramidate prodrug of alcohols <i>via</i> transesterification reaction
A mild and concise synthesis of aryloxy phosphoramidate prodrug of alcohols <i>via</i> transesterification reaction Open
A synthesis of aryloxy phosphoramidate prodrug of alcohols enabled by a transesterification strategy is described here.
View article: Chiral Hypervalent Iodine Catalysis Enables an Unusual Regiodivergent Intermolecular Olefin Aminooxygenation
Chiral Hypervalent Iodine Catalysis Enables an Unusual Regiodivergent Intermolecular Olefin Aminooxygenation Open
A novel iodide-catalyzed intermolecular aminooxygenation strategy is described here. Amide is used as the O- and N- source to probe for regiocontrol strategies. Notably, simple additives can be selectively introduced to achieve regiodiverg…
View article: Halonium Catalysis: An Underutilized and Underexplored Catalytic Concept in Olefin Functionalizations
Halonium Catalysis: An Underutilized and Underexplored Catalytic Concept in Olefin Functionalizations Open
Iodonium catalysis is described here to accomplish an intermolecular olefin oxyamination reaction. Urea is used as the O- and N-source to add across both activated and unactivated alkenes in a regioselective manner. Mechanistic studies con…
View article: The efficacy of jade moxibustion in knee osteoarthritis
The efficacy of jade moxibustion in knee osteoarthritis Open
Introduction: This study aims to compare clinical effect between Jade moxibustion and traditional moxibustion, and to determine the clinical effect of Jade moxibustion on knee osteoarthritis (KOA). Methods/Design: This is a 2-parallel-grou…
View article: Progress in the conceptual design of the CFETR toroidal field coil with rectangular conductors
Progress in the conceptual design of the CFETR toroidal field coil with rectangular conductors Open
A comprehensive research facility project was approved in December 2018 with funding of 345 million EUR, to support the research and development of the China Fusion Engineering Test Reactor (CFETR). As part of this project, a full-size CFE…
View article: Optogenetic inhibition of cortex neurons attenuates pain-related affective responses and social behavioral disorder in inflammatory pain rat model
Optogenetic inhibition of cortex neurons attenuates pain-related affective responses and social behavioral disorder in inflammatory pain rat model Open