Qaiser Jabeen
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View article: Lemongrass Alleviates Primary Dysmenorrhea Symptoms by Reducing Oxidative Stress and Inflammation and Relaxing the Uterine Muscles
Lemongrass Alleviates Primary Dysmenorrhea Symptoms by Reducing Oxidative Stress and Inflammation and Relaxing the Uterine Muscles Open
Primary dysmenorrhea (PD) is characterized by lower abdominal spasms and painful cramps during menstruation in females with a normal pelvic anatomy. Cymbopogon citratus (DC.) Stapf, commonly known as lemongrass, is consumed in the form of …
View article: Protective effects of <i>Indigofera argentea</i> against acetic acid-induced inflammatory bowel disease are mediated by modulating antioxidant and inflammatory mediators.
Protective effects of <i>Indigofera argentea</i> against acetic acid-induced inflammatory bowel disease are mediated by modulating antioxidant and inflammatory mediators. Open
Results of this study indicated that Ia.Cr protected mice against acetic acid-induced inflammatory bowel disease by decreasing endogenous inflammatory biomarkers and oxidative damages.
View article: Evaluation of Antiurolithiatic Effects of <i>Moringa oleifera</i> Lam. Leaves Extract: <i>In-vitro</i>, <i>in-silico</i> and <i>in-vivo</i> Approaches
Evaluation of Antiurolithiatic Effects of <i>Moringa oleifera</i> Lam. Leaves Extract: <i>In-vitro</i>, <i>in-silico</i> and <i>in-vivo</i> Approaches Open
Objective: Moringa oleifera Lam. (Moringaceae), has traditionally been used for various renal diseases including urolithiasis. Considering the therapeutic and nutritional values, the present study was designed to investigate the antiurolit…
View article: Characterization of <i>Sesuvium sesuvioides</i> Using High-Performance Liquid Chromatography and Validation of Its In Vivo Anti-hyperthyroidism Effect via Suppressing Oxidative Stress and Inflammatory Markers
Characterization of <i>Sesuvium sesuvioides</i> Using High-Performance Liquid Chromatography and Validation of Its In Vivo Anti-hyperthyroidism Effect via Suppressing Oxidative Stress and Inflammatory Markers Open
Sesuvium sesuvioides was used to treat inflammation, arthritis, gout, and thyroid dysfunction. The current study evaluated the antihyperthyroidism effect of S. sesuvioides to consolidate its traditional use. High-performance …
View article: Vigna mungo possesses pharmacological potential for the management of hyperthyroidism and improves estrus cycle disturbances
Vigna mungo possesses pharmacological potential for the management of hyperthyroidism and improves estrus cycle disturbances Open
The study was designed to investigate the pharmacological potential of 70%methanolic extract of Vigna mungo for the management of hyperthyroidism and estrus cycle disturbances in female rats. The preliminary phytochemical analysis of the e…
View article: Pharmacological Investigation of Aqueous Methanolic Extract of Ficus carica against Thyroxine-induced Hyperthyroidism
Pharmacological Investigation of Aqueous Methanolic Extract of Ficus carica against Thyroxine-induced Hyperthyroidism Open
Plants have been considered the best alternatives to chemical entities. Therefore, Ficus carica L. (Fig) was selected to investigate its protective role against experimentally-induced hyperthyroidism. A 70% aqueous methanolic extract of F.…
View article: COVID-19 and severity of liver diseases: Possible crosstalk and clinical implications
COVID-19 and severity of liver diseases: Possible crosstalk and clinical implications Open
COVID-19-infected individuals and those who recovered from the infection have been demonstrated to have elevated liver enzymes or abnormal liver biochemistries, particularly with preexisting liver diseases, liver metabolic disorders, viral…
View article: Anxiolytic and Antidepressant Potential of Methanolic Extract of <i>Neurada procumbens</i> Linn. in Mice
Anxiolytic and Antidepressant Potential of Methanolic Extract of <i>Neurada procumbens</i> Linn. in Mice Open
Neurada procumbens Linn. possesses a wide range of phytochemical and bioactive entities such as flavonoids and polyphenols that decrease the oxidative stress and enhance synaptic plasticity, resulting in accelerated healing processes. Almo…
View article: Chemical profiling and evaluation of toxicological, antioxidant, anti-inflammatory, anti-nociceptive and tyrosinase inhibitory potential of Portulacaria afra using in-vitro, in-vivo and in-silico studies
Chemical profiling and evaluation of toxicological, antioxidant, anti-inflammatory, anti-nociceptive and tyrosinase inhibitory potential of Portulacaria afra using in-vitro, in-vivo and in-silico studies Open
Portulacaria afra Jacq (Portulacaceae) is a medicinal plant used traditionally in the treatment of pain and inflammation. This study aimed to evaluate the phytochemical composition, toxicity, antinociceptive, and enzyme inhibition potentia…
View article: Evaluation of <i>Caralluma edulis</i> for its Potential Against Obesity, Atherosclerosis and Hypertension
Evaluation of <i>Caralluma edulis</i> for its Potential Against Obesity, Atherosclerosis and Hypertension Open
Obesity, a chronic metabolic condition, is an increase in fat mass and blood lipid levels mainly causing atherosclerosis and hypertension, which further lead to cardiovascular complications. The objective of the study was to investigate th…
View article: LC-ESI-MS analysis, antioxidant, anti-diabetic and molecular docking studies on <i>Corchorus depressus</i> (L.) C.Chr
LC-ESI-MS analysis, antioxidant, anti-diabetic and molecular docking studies on <i>Corchorus depressus</i> (L.) C.Chr Open
The present study encompasses the ethnomedicinal consumption of Corchorus depressus (L.) C.Chr. (C. depressus) for diabetes. Samples were subjected to LC-ESI-MS analyses. The n-hexane, methanolic and water extracts wer…
View article: Hepatoprotective effect of Cordia rothii extract against CCl4-induced oxidative stress via Nrf2–NFκB pathways
Hepatoprotective effect of Cordia rothii extract against CCl4-induced oxidative stress via Nrf2–NFκB pathways Open
View article: Antibacterial and in vivo toxicological studies of Bi2O3/CuO/GO nanocomposite synthesized via cost effective methods
Antibacterial and in vivo toxicological studies of Bi2O3/CuO/GO nanocomposite synthesized via cost effective methods Open
View article: Pharmacological Role of <i>Capparis decidua</i> (Forssk.) Edgew in Preventing Cyclophosphamide-induced Myelosuppression and Modulating Innate and Adaptive Immune Response
Pharmacological Role of <i>Capparis decidua</i> (Forssk.) Edgew in Preventing Cyclophosphamide-induced Myelosuppression and Modulating Innate and Adaptive Immune Response Open
Background Capparis decidua (Forssk.) Edgew is reported to be practiced in the traditional system of medicine for the management of various immunological pathologies. Purpose The current study was designed to evaluate the modulatory effect…
View article: <i>Geranium wallichianum</i> D. Don Ex Sweet Ameliorates Rheumatoid Arthritis by Curtailing the Expression of COX-II and Inflammatory Cytokines as Well as by Alleviating the Oxidative Stress
<i>Geranium wallichianum</i> D. Don Ex Sweet Ameliorates Rheumatoid Arthritis by Curtailing the Expression of COX-II and Inflammatory Cytokines as Well as by Alleviating the Oxidative Stress Open
Geranium wallichianum D. Don ex sweet traditionally been used as home remedy for backaches, joint pain, colic, and rheumatism. The objective of this study was to investigate the therapeutic benefits of plant in an adjuvant-induced arthriti…
View article: Pharmacological Investigation of <i>Asphodelus tenuifolius</i> Cav<i>.</i> for its Potential Against Thrombosis in Experimental Models
Pharmacological Investigation of <i>Asphodelus tenuifolius</i> Cav<i>.</i> for its Potential Against Thrombosis in Experimental Models Open
Background Thrombosis is a major disorder which is an outcome of an imbalance in the hemostatic system that develop undesirable blood clot and hinder blood circulation. Purpose The current study was designed to verify the potential of aque…
View article: Pharmacological evaluation of Typha domingensis for its potentials against diet-induced hyperlipidemia and associated complications
Pharmacological evaluation of Typha domingensis for its potentials against diet-induced hyperlipidemia and associated complications Open
Purpose: To evaluate the hyperlipidemic potential of the methanolic-aqueous extract of Typha domingensis Pers.Method: Hyperlipidemia was induced in Wistar rats with high fat diet (HFD). The animals were divided into five groups; normal con…
View article: Phytochemical profiling, anti-inflammatory, analgesic and antipyretic potentials of Portulacaria afra Jacq: Molecular docking of unexplored bioactive compounds
Phytochemical profiling, anti-inflammatory, analgesic and antipyretic potentials of Portulacaria afra Jacq: Molecular docking of unexplored bioactive compounds Open
Natural products play an important role in novel drug discovery by providing structural leads for the pharmacotherapeutic agents against a variety of diseases. This study aimed to evaluate the possible, anti-inflammatory, antipyretic activi…
View article: Thyroid Dysfunction: In Connection with PCOS
Thyroid Dysfunction: In Connection with PCOS Open
As the prevalence of endocrine dysfunction is increasing and is associated with many complications including polycystic ovary syndrome (PCOS) which, itself is a risk factor of thyroid dysfunction. Although the causality of this association…
View article: Pharmacological Evaluation of <i>Mentha piperita</i> Against Urolithiasis: An <i>In Vitro</i> and <i>In Vivo</i> Study
Pharmacological Evaluation of <i>Mentha piperita</i> Against Urolithiasis: An <i>In Vitro</i> and <i>In Vivo</i> Study Open
Background: Mentha piperita L. (peppermint) is one of the most widely consumed medicinal herbs that has gained attention from food and pharmaceutical industries due to its distinct aroma and taste. Purpose: Present study was aimed to ratio…
View article: Salsola imbricata Forssk. ameliorates acetic acid-induced inflammatory bowel disease by modulating dysregulated antioxidant enzyme system and cytokine signaling pathways in mice
Salsola imbricata Forssk. ameliorates acetic acid-induced inflammatory bowel disease by modulating dysregulated antioxidant enzyme system and cytokine signaling pathways in mice Open
Objective: To explore the protective effect of the crude extract of Salsola imbricata against acetic acid-induced inflammatory bowel disease in mice and its mechanism of action. Methods: Ethanolic crude extract of Salsola imbricata was cha…
View article: Effect of Abutilon indicum in thyroxine-induced hyperthyroidism in rat
Effect of Abutilon indicum in thyroxine-induced hyperthyroidism in rat Open
The study was designed to investigate the antithyroid activity of the crude methanolic (70%) extract of aerial parts of Abutilon indicum in male albino rats. The extract was prepared and analyzed for the presence of phytochemical constitue…
View article: "Evaluation of Antiurolithiatic Potential of Moringa Oleifera Seed Extract"
"Evaluation of Antiurolithiatic Potential of Moringa Oleifera Seed Extract" Open
Hina Ali, Ayesha Nadeem, Mariya Anwaar and Qaiser Jabeen* Author Affiliations Department of Pharmacology, Faculty of Pharmacy, Pakistan Received: June 18, 2021 | Published: June 29, 2021 Corresponding author: Qaiser Jabeen, Department of P…
View article: Insight into Therapeutic Role of Plant-derived Medicines in Thyroid Dysfunction
Insight into Therapeutic Role of Plant-derived Medicines in Thyroid Dysfunction Open
Endocrine disorders are very common in Asia of which the thyroid dysfunction (TD) represents a major subset. The prevalence of TD is rising to an alarming rate. The thyroid gland (TG) is morphologically a butterfly-shaped organ, located an…
View article: EVALUATION OF ANTI-INFLAMMATORY, ANALGESIC AND ANTIPYRETIC ACTIVITIES OF SALSOLA IMBRICATA FORSSK IN RATS
EVALUATION OF ANTI-INFLAMMATORY, ANALGESIC AND ANTIPYRETIC ACTIVITIES OF SALSOLA IMBRICATA FORSSK IN RATS Open
Salsola imbricata has folkloric repute in the treatment of painful and inflammatory conditions. Therefore, present study was undertaken to assess the anti-inflammatory, analgesic and antipyretic activities of aqueous-ethanol crude extract …
View article: COVID-19 and inhibitors of the renin–angiotensin–aldosterone system
COVID-19 and inhibitors of the renin–angiotensin–aldosterone system Open
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), main cause of coronavirus disease 2019 (COVID-19), uses the aminopeptidase angiotensin-converting enzyme 2 (ACE2) for entry into the ho...
View article: Phytochemical Screening, Antioxidant, Antibacterial, Antifungal Potential and in vivo Acute Toxicity of the Crude Extract of Cordia Rothii and Viola Serpens
Phytochemical Screening, Antioxidant, Antibacterial, Antifungal Potential and in vivo Acute Toxicity of the Crude Extract of Cordia Rothii and Viola Serpens Open
Background: Plants contain numerous bioactive compounds with valuable pharmacological activities and can be used as a novel therapeutic agent. Methods: The objective of the current study was to evaluate phytochemical screening, antioxidant…
View article: <i>Citrus aurantium</i> Ameliorates Cisplatin-Induced Nephrotoxicity
<i>Citrus aurantium</i> Ameliorates Cisplatin-Induced Nephrotoxicity Open
We aimed to study the effects of Citrus aurantium ( C. aurantium ) on renal functions in cisplatin-induced nephrotoxicity in rats. The study involved male Wistar rats weighing 250–300 g that were fed and kept under standard conditions. Rat…
View article: Chemically-Induced Peptic Ulcer: Gastroprotective Effects of Peach Fruit
Chemically-Induced Peptic Ulcer: Gastroprotective Effects of Peach Fruit Open
Background: Peptic ulcer, an inflammatory breach in the gastric and duodenal mucosa, is caused by hyper secretion of gastric acid and defective mucosal protective elements, affecting approximately 4 million people each year.The currently a…
View article: Pharmacological Evaluation of Coriander Seeds against High Fat Diet-Induced Cholelithiasis
Pharmacological Evaluation of Coriander Seeds against High Fat Diet-Induced Cholelithiasis Open
Coriander (Coriandrum sativum L.) seeds have been documented for their traditional use in lowering cholesterol.The seeds were evaluated for their anticholelithic effects as no satisfactory pharmacological treatment is yet available for cho…