Daqi Wang
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View article: International expert consensus on gene therapy for hereditary hearing loss: Based on clinical trials
International expert consensus on gene therapy for hereditary hearing loss: Based on clinical trials Open
This work was supported by the National Natural Science Foundation of China, the German Research Foundation (DFG) via the Cluster of Excellence, and others.
View article: Gene Therapy vs Cochlear Implantation in Restoring Hearing Function and Speech Perception for Individuals With Congenital Deafness
Gene Therapy vs Cochlear Implantation in Restoring Hearing Function and Speech Perception for Individuals With Congenital Deafness Open
Importance OTOF gene therapy (GT) has been shown to improve hearing and speech. The efficacy of GT remains to be compared against cochlear implantation (CI), the current gold standard for congenital deafness. Objective To evaluate treatmen…
View article: Size-dependent performance of white light <i>μ</i>LEDs for intelligent vehicle lighting and communication
Size-dependent performance of white light <i>μ</i>LEDs for intelligent vehicle lighting and communication Open
In this paper, size-dependent illumination performances of white light micro light-emitting diodes ( μ LEDs) and a visible light communication (VLC) system were demonstrated. The white light μ LEDs from 10 μ m to 200 μ m were prepared by e…
View article: Audiological characteristics following gene therapy in patients with autosomal recessive deafness 9
Audiological characteristics following gene therapy in patients with autosomal recessive deafness 9 Open
This work was funded by the National Natural Science Foundation of China.
View article: Frequency-Resolved Forward Capacitance in GaN-based LEDs
Frequency-Resolved Forward Capacitance in GaN-based LEDs Open
This study establishes a unified framework for interpreting dynamic capacitive responses in InGaN-based light-emitting diodes (LEDs) through forward-bias capacitance-voltage-frequency spectroscopy. A hybrid impedance model integrating seri…
View article: Bilateral gene therapy in children with autosomal recessive deafness 9: single-arm trial results
Bilateral gene therapy in children with autosomal recessive deafness 9: single-arm trial results Open
Gene therapy is a promising approach for hereditary deafness. We recently showed that unilateral AAV1-hOTOF gene therapy with dual adeno-associated virus (AAV) serotype 1 carrying human OTOF transgene is safe and associated with functional…
View article: Crystal Structures and Hirshfeld Surface Analysis of Two Inner Salts of 3-carboxy-2-(quinolinium-1-ylmethyl)propanoate, and 3-(3-carbamoylpyridinium-1-yl)-2-(carboxymethyl)propanoate
Crystal Structures and Hirshfeld Surface Analysis of Two Inner Salts of 3-carboxy-2-(quinolinium-1-ylmethyl)propanoate, and 3-(3-carbamoylpyridinium-1-yl)-2-(carboxymethyl)propanoate Open
Two crystalline inner salts 3-carboxy-2-(quinolinium-1-ylmethyl)propanoate dihydrate (1), and 3-(3-carbamoylpyridinium-1-yl)-2-(carboxymethyl)propanoate (2) were featured by the X-ray diffraction analysis, IR, mp, and elemental analysis. S…
View article: Mechanisms and otoprotective strategies of programmed cell death on aminoglycoside-induced ototoxicity
Mechanisms and otoprotective strategies of programmed cell death on aminoglycoside-induced ototoxicity Open
Aminoglycosides are commonly used for the treatment of life-threatening bacterial infections, however, aminoglycosides may cause irreversible hearing loss with a long-term clinical therapy. The mechanism and prevention of the ototoxicity o…
View article: Engineering of the AAV-Compatible Hair Cell-Specific Small-Size Myo15 Promoter for Gene Therapy in the Inner Ear
Engineering of the AAV-Compatible Hair Cell-Specific Small-Size Myo15 Promoter for Gene Therapy in the Inner Ear Open
Adeno-associated virus (AAV)-mediated gene therapy is widely applied to treat numerous hereditary diseases in animal models and humans. The specific expression of AAV-delivered transgenes driven by cell type-specific promoters should furth…
View article: CCDC 1445265: Experimental Crystal Structure Determination
CCDC 1445265: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1899901: Experimental Crystal Structure Determination
CCDC 1899901: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1889803: Experimental Crystal Structure Determination
CCDC 1889803: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1890372: Experimental Crystal Structure Determination
CCDC 1890372: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1899727: Experimental Crystal Structure Determination
CCDC 1899727: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1899743: Experimental Crystal Structure Determination
CCDC 1899743: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1899902: Experimental Crystal Structure Determination
CCDC 1899902: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1890370: Experimental Crystal Structure Determination
CCDC 1890370: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Preclinical evaluation of the efficacy and safety of AAV1-hOTOF in mice and non-human primates
Preclinical evaluation of the efficacy and safety of AAV1-hOTOF in mice and non-human primates Open
Pathogenic mutations in the OTOF gene cause autosomal recessive hearing loss 9 (DFNB9), one of the most common forms of auditory neuropathy. There is no biological treatment for DFNB9. Here, we designed an OTOF gene therapy agent by dual A…
View article: Effect of Grain Coalescence on Dislocation and Stress Evolution of GaN Films Grown on Nanoscale Patterned Sapphire Substrates
Effect of Grain Coalescence on Dislocation and Stress Evolution of GaN Films Grown on Nanoscale Patterned Sapphire Substrates Open
Two types of nucleation layers (NLs), including in-situ low-temperature grown GaN (LT-GaN) and ex-situ sputtered physical vapor deposition AlN (PVD-AlN), are applied on cone-shaped nanoscale patterned sapphire substrate (NPSS). The initial…
View article: CCDC 2265343: Experimental Crystal Structure Determination
CCDC 2265343: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: The crystal structure of 4-aminiumbiphenyl benzenesulfonate, C<sub>18</sub>H<sub>17</sub>NO<sub>3</sub>S
The crystal structure of 4-aminiumbiphenyl benzenesulfonate, C<sub>18</sub>H<sub>17</sub>NO<sub>3</sub>S Open
C 18 H 17 NO 3 S, monoclinic, Cc (no. 9), a = 32.036(3) Å, b = 7.2154(7) Å, c = 7.4283(8) Å, β = 99.943(2) ∘ , V = 1691.3(3) Å 3 , Z = 4, R gt ( F ) = 0.0343, wR ref ( F 2 ) = 0.0821, T = 298 K.
View article: Four Non-covalent Bonded Anhydrous Supramolecular Salts of Triphenylmethylamine and Organic Acids
Four Non-covalent Bonded Anhydrous Supramolecular Salts of Triphenylmethylamine and Organic Acids Open
This text reports the triphenylmethylamine based supramolecular salts formation in crystalline solids 1 – 4 , where the acids have been integrated. Addition of the triphenylmethylamine to the solution of organic acid makes the correspondin…
View article: The crystal structure of 5,7-dinitropyrazolo[5,1-<i>b</i>]quinazolin-9(4<i>H</i>)-one, C<sub>10</sub>H<sub>5</sub>N<sub>5</sub>O<sub>5</sub>
The crystal structure of 5,7-dinitropyrazolo[5,1-<i>b</i>]quinazolin-9(4<i>H</i>)-one, C<sub>10</sub>H<sub>5</sub>N<sub>5</sub>O<sub>5</sub> Open
C 10 H 5 N 5 O 5 , monoclinic, P 2 1 / c (no. 14), a = 10.9546(11) Å, b = 7.3433(8) Å, c = 13.2567(15) Å, β = 102.972 ( 5 ) ∘ $102.972{(5)}^{\circ }$ , V = 1039.19(19) Å 3 , Z = 4, R g t ${R}_{gt}$ ( F ) = 0.0630, w R r…
View article: Advances in gene therapy hold promise for treating hereditary hearing loss
Advances in gene therapy hold promise for treating hereditary hearing loss Open
Gene therapy focuses on genetic modification to produce therapeutic effects or treat diseases by repairing or reconstructing genetic material, thus being expected to be the most promising therapeutic strategy for genetic disorders. Due to …
View article: The pathogenesis of common Gjb2 mutations associated with human hereditary deafness in mice
The pathogenesis of common Gjb2 mutations associated with human hereditary deafness in mice Open
Mutations in GJB2 (Gap junction protein beta 2) are the most common genetic cause of non-syndromic hereditary deafness in humans, especially the 35delG and 235delC mutations. Owing to the homozygous lethality of Gjb2 mutations in mice, the…