Mengqi Li
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View article: Constructing Localized Van Der Waals Gaps in Cubic‐Phase GeMnTe <sub>2</sub> Thermoelectric Material
Constructing Localized Van Der Waals Gaps in Cubic‐Phase GeMnTe <sub>2</sub> Thermoelectric Material Open
Cubic‐phase GeMnTe 2 shows high potential to replace state‐of‐the‐art rhombohedral GeTe for medium temperature thermoelectric application owing to its lower cost. The high structural symmetry can also suppress phase transition during servi…
View article: Dextran sulfate inhibits the invasion, migration, and programmed death-ligand 1 expression in human gastric cancer cells by affecting the M2 tumor-associated macrophage polarization
Dextran sulfate inhibits the invasion, migration, and programmed death-ligand 1 expression in human gastric cancer cells by affecting the M2 tumor-associated macrophage polarization Open
Objective The aim of this study was to investigate the role of dextran sulfate (DS) in M0-to-M2 macrophage polarization and its effect on programmed death-ligand 1 (PD-L1) expression, invasion, migration, proliferation, and apoptosis of hu…
View article: Engineering CO2-Fixing Carboxysome into Saccharomyces cerevisiae to Improve Ethanol Production
Engineering CO2-Fixing Carboxysome into Saccharomyces cerevisiae to Improve Ethanol Production Open
Bacterial microcompartments (BMCs) are intracellular structures for compartmentalizing specific metabolic pathways in bacteria. As a unique type of BMCs, carboxysomes utilize protein shells to sequester ribulose-1,5-bisphosphate carboxylas…
View article: Targeting polyamine metabolism induces oxidative/carbonyl stress to reinvigorate antitumor immunity in prostate cancer
Targeting polyamine metabolism induces oxidative/carbonyl stress to reinvigorate antitumor immunity in prostate cancer Open
Immunotherapy of prostate cancer (PCa) remains challenging due to the immunosuppressive nature of the tumor microenvironment (TME). Oxidative damage enhances immunogenic cell death (ICD) to counteract immunotherapy resistance in PCa, but i…
View article: Recapitulating dengue virus infection with human pluripotent stem cell-derived liver organoids for antiviral screening
Recapitulating dengue virus infection with human pluripotent stem cell-derived liver organoids for antiviral screening Open
Dengue virus (DENV) poses a major global health threat, affecting an estimated 100 to 400 million people annually. The infection and pathogenesis remain incompletely understood, and no antiviral drug is currently approved for DENV treatmen…
View article: Impact of Helicobacter pylori infection on iron deficiency anemia in children: a systematic review and meta-analysis with early intervention implications
Impact of Helicobacter pylori infection on iron deficiency anemia in children: a systematic review and meta-analysis with early intervention implications Open
Background This study investigates the association between Helicobacter pylori ( H. pylori ) infection and iron deficiency (ID) as well as its potential link to iron deficiency anemia (IDA) in children. Methods As of August 2024, we conduc…
View article: Variations in Intestinal Microbiota Among Three Species in the Cervidae Family Under the Same Feeding Conditions
Variations in Intestinal Microbiota Among Three Species in the Cervidae Family Under the Same Feeding Conditions Open
The breeding of large animals in the family Cervidae in China contributes to achieving two tasks: restoring the provenance of wild populations and providing raw materials for traditional Chinese medicine. Currently, red deer (Cervus elaphu…
View article: Surface-Dependent Meteorological Responses to a Taklimakan Dust Event During Summer near the Northern Slope of the Tibetan Plateau
Surface-Dependent Meteorological Responses to a Taklimakan Dust Event During Summer near the Northern Slope of the Tibetan Plateau Open
The northern slope of the Tibetan Plateau (TP) is the crucial affected area for dust originating from the Taklimakan Desert (TD). However, few studies have focused on the meteorological element responses to TD dust over different surface t…
View article: Functional Characterization of MaSPL8 Reveals Its Different Roles in Biotic and Abiotic Stress Responses in Mulberry
Functional Characterization of MaSPL8 Reveals Its Different Roles in Biotic and Abiotic Stress Responses in Mulberry Open
The Squamosa promoter-binding protein-like (SPL) family proteins plays pivotal roles in plant development and stress adaptation. In this study, we functionally characterized MaSPL8 in mulberry (Morus alba) and investigated its regulatory r…
View article: AMPK acts to remove immune barriers to CD8<sup>+</sup>T cell-mediated immunity against hepatocellular carcinoma
AMPK acts to remove immune barriers to CD8<sup>+</sup>T cell-mediated immunity against hepatocellular carcinoma Open
Dysregulated metabolism in tumor tissues, and para-tumor tissues alike, can lead to immunosuppression, which may underlie cancer development. However, metabolic intervention as a therapeutic strategy has been of no avail. In this study, we…
View article: Machine learning–based predictive model for post-stroke dementia
Machine learning–based predictive model for post-stroke dementia Open
Our findings suggest that ML models, especially extreme gradient boosting, can best predict the risk of PSD.
View article: Metabolic stress induces a double-positive feedback loop between AMPK and SQSTM1/p62 conferring dual activation of AMPK and NFE2L2/NRF2 to synergize antioxidant defense
Metabolic stress induces a double-positive feedback loop between AMPK and SQSTM1/p62 conferring dual activation of AMPK and NFE2L2/NRF2 to synergize antioxidant defense Open
Co-occurring mutations in KEAP1 in STK11/LKB1-mutant NSCLC activate NFE2L2/NRF2 to compensate for the loss of STK11-AMPK activity during metabolic adaptation. Characterizing the regulatory crosstalk between the STK11-AMPK and KEAP1-NFE2L2 …
View article: AMPK targets PDZD8 to trigger carbon source shift from glucose to glutamine
AMPK targets PDZD8 to trigger carbon source shift from glucose to glutamine Open
The shift of carbon utilization from primarily glucose to other nutrients is a fundamental metabolic adaptation to cope with decreased blood glucose levels and the consequent decline in glucose oxidation. AMP-activated protein kinase (AMPK…