Explanipedia

IKK/NF-κB Inactivation by Salidroside via Targeting TNF-α for the Treatment of LPS-Induced Colitis Open

Qi Ouyang, Hao Zhou, Ze Yu, Hong Jiang, C. S. Ji , et al. · 2025

Background: Tumor necrosis factor-alpha (TNF-α) serves as a central mediator of inflammation and represents key therapeutic target in inflammatory bowel disease (IBD). This study investigates the protective effects of salidroside (Sal) aga…

Region-weighted gradient and motion-aware camera exposure control for robust visual odometry Open

Qirui Sun, Qi Ouyang, Xiaolong Li, Zhe Cheng · 2025

Bioactivity Deep Learning for Complex Structure-Free Compound-Protein Interaction Prediction Open

Yaowen Gu, Song Xia, Qi Ouyang, Yingkai Zhang · 2025

Protein-ligand binding affinity assessment plays a pivotal role in virtual drug screening, yet conventional data-driven approaches rely heavily on limited protein-ligand crystal structures. Structure-free compound-protein interaction (CPI)…

MRI-based habitat radiomics for preoperatively predicting IDH status in gliomas Open

Wan-Yi Zheng, Ri-Hui Yang, Zhifang Wan, Hui Li, Chao Ma , et al. · 2025

OBJECTIVE The intratumoral heterogeneous vascular permeability and cell density of gliomas are associated with IDH mutation status. Therefore, the authors aimed to construct vascular-cellular habitats based on MRI to investigate their corr…

Modeling liquid-liquid phase separation and its impact on proteasomal substrate degradation Open

Di Wu, Qi Ouyang, Hongli Wang · 2025

The proteasome, central to ubiquitin-proteasome mediated degradation, undergoes liquid-liquid phase separation (LLPS) during substrate processing. However, the mechanisms governing proteasomal LLPS and its functional interplay with degrada…

Salidroside inhibits melanin synthesis and melanoma growth via mTOR and PI3K/Akt pathways Open

Qi Ouyang, Shumei Tian, Hengyu Zhou, Ying Mao, Xiang Li , et al. · 2025

Background Melanomas are caused by the malignant transformation of melanocytes. Numerous studies have demonstrated that the tyrosol components of salidroside inhibit tyrosinase activity. The PI3K/Akt/mTOR signaling pathway plays a crucial …

The study on the construction of injectable tissue-engineered bone based on the injectable PRF combined with osteoblastic bone marrow mesenchymal stem cell sheets Open

Lei Han, Xiaobo Wu, Qi Ouyang, Jie Hu, Shichao Sun , et al. · 2025

Case Report: ALK-rearranged mesenchymal neoplasms with S100 and CD34 co-expression: additional cases with distinct characteristics Open

Qi Ouyang, Xiaohong Guo, Rongjun Mao, Zhixing Cao · 2025

ALK rearrangements are rarely documented in superficial soft tissue neoplasms exhibiting an infantile fibrosarcoma-like spindle cell tumor (IFS) pattern or stromal, resembling Neurotrophic Tyrosine Kinase Receptor( NTRK )rearranged spindle…

Dynamic mechanisms of time-of-day-dependent adaptive immunity and vaccination responses Open

Xue Weng, Qi Ouyang, Hongli Wang · 2025

The timing of vaccine administration during the day significantly affects immunogenicity and efficacy, yet the mechanism governing the time-of-day dependent adaptive immunity and vaccine response remains elusive. Using mathematical modelin…

A kinetic model for USP14 regulated substrate degradation in 26S proteasome Open

Di Wu, Qi Ouyang, Hongli Wang, Youdong Mao · 2025

Despite high-resolution structural studies on the USP14-proteasome-substrate complexes, time-resolved cryo-electron microscopy (cryo-EM) results on USP14-regulated allostery of the 26S proteasome are still very limited and a quantitative u…

297O Imlunestrant (Imlu) with or without abemaciclib (Abema) in advanced breast cancer (ABC): A subgroup analysis in CDK4/6 inhibitor (CDK4/6i)-pretreated patients (pts) from EMBER-3 Open

C. Saura Manich, LA Carey, G. Curigliano, N. Harbeck, J. O’Shaughnessy , et al. · 2025

Discovery of diverse and high-quality mRNA capping enzymes through a language model–enabled platform Open

Tianze Wang, Bowen R. Qin, S J Li, Zimo Wang, Xuejian Li , et al. · 2025

Mining and expanding high-quality genetic parts for synthetic biology and bioengineering are urgent needs in the research and development of next-generation biotechnology. However, gene mining has relied on sequence homology or ample exper…

Impact of a Terahertz electromagnetic field on the ion permeation of potassium and sodium channels Open

Zigang Song, Lingfeng Xue, Qi Ouyang, Chen Song · 2025

Complex structure-free compound-protein interaction prediction for mitigating activity cliff-induced discrepancies and integrated bioactivity learning Open

Yaowen Gu, Xia Song, Qi Ouyang, Yingkai Zhang · 2025

Protein-ligand binding affinity assessment plays a pivotal role in virtual drug screening, yet conventional data-driven approaches rely heavily on limited protein-ligand crystal structures. Structure-free compound-protein interaction (CPI)…

Protocol for simulating the effect of THz electromagnetic field on ion channels Open

Lingfeng Xue, Zigang Song, Qi Ouyang, Chen Song · 2025

Terahertz (THz) electromagnetic fields are increasingly recognized for their crucial roles in various aspects of medical research and treatment. Recent computational studies have demonstrated that THz waves can modulate ion channel functio…

Subunit shuffling dynamics in KaiC’s central hub reveal the synchronization mechanism of the cyanobacterial circadian clock Open

Yang Tian, Zhou Zhen, Yuhai Tu, Qi Ouyang, Yuansheng Cao · 2025

Protein complexes are critical for cellular functions, and subunit exchange within these complexes is increasingly recognized as a key regulatory mechanism. In the cyanobacterial circadian clock, subunits shuffling of the core clock protei…

Effect of Early Curing Experiences on Mechanical Properties and Microstructure of ECO-UHPC Prepared by Gold Tailings Sand Open

Qi Ouyang, Xianxiang Zhou, Xian Liang, Biao Luo · 2025

Fine gold tailings particles generated from gold mining and refining have the potential to replace high-cost quartz sand in the preparation of economical ultra-high-performance concrete (ECO-UHPC) due to their large stockpiles, low cost, a…

An altruistic resource-sharing mechanism for synchronization: The energy-speed-accuracy tradeoff. Open

Dongliang Zhang, Yuansheng Cao, Qi Ouyang, Yuhai Tu · 2025

Synchronization among a group of active agents is ubiquitous in nature. Although synchronization based on direct interactions between agents described by the Kuramoto model is well understood, the other general mechanism based on indirect …

Downregulation of hnRNPA1 inhibits hepatocellular carcinoma cell progression by modulating alternative splicing of ZNF207 exon 9 Open

Qi Ouyang, Wenhui He, Yiping Guo, Lin Li, Ying Mao , et al. · 2025

Introduction Hepatocellular carcinoma (HCC) is the most prevalent liver cancer and a leading cause of cancer-related deaths worldwide. Heterogeneous nuclear ribonucleoprotein A1 (hnRNPA1) plays a critical role in RNA metabolism, including …

A kinetic model for USP14 regulated substrate degradation in 26S proteasome Open

Di Wu, Qi Ouyang, Hongli Wang, Youdong Mao · 2025

Despite high-resolution structural studies on the USP14-proteasome-substrate complexes, time-resolved cryo-electron microscopy (cryo-EM) results on USP14-regulated allostery of the 26S proteasome are still very limited and a quantitative u…

The Thermodynamic Model to Study the Slow Afterhyperpolarization in a Single Neuron at Different ATP Levels Open

Jianwei Li, S. Yu, M. J. Guo, X. Y. Shen, Qi Ouyang , et al. · 2024

The neuron consumes energy from ATP hydrolysis to maintain a far-from-equilibrium steady state inside the cell, thus all physiological functions inside the cell are modulated by thermodynamics. The neurons that manage information encoding,…

Transformation gap from research findings to large-scale commercialized products in microfluidic field Open

Yuqi Ma, Xiaoyi Sun, Ziwei Cai, Mengjing Tu, Yugang Wang , et al. · 2024

The field of microfluidics has experienced rapid growth in the last several decades, yet it isn't considered to be a large industry comparable to semiconductor and consumer electronics. In this review, we analyzed the entire process of the…

Parallel molecular data storage by printing epigenetic bits on DNA Open

Cheng Zhang, Ranfeng Wu, Fajia Sun, Yi‐Sheng Lin, Yuan Liang , et al. · 2024

Protocol for Simulating the Effect of THz Electromagnetic Field on Ion Channels Open

Lingfeng Xue, Zigang Song, Qi Ouyang, Chen Song · 2024

Terahertz (THz) electromagnetic fields are increasingly recognized for their crucial roles in various aspects of medical research and treatment. Recent computational studies have demon-strated that THz waves can modulate ion channel functi…

The Effect of THz Electromagnetic Field on the Conductance of Potassium and Sodium Channels Open

Zigang Song, Lingfeng Xue, Qi Ouyang, Chen Song · 2024

Ion channels are essential to various physiological processes and their defects are associated with many diseases. Previous research has revealed that Terahertz electromagnetic field can alter the channel conductance by affecting the motio…

Interplay between ATP and hydrolysis free energy in promoting and restraining biochemical switches Open

Dianjie Li, Siqi Liao, Qi Ouyang, Fangting Li · 2024

In living cells, the bistable switches involving phosphorylation-dephosphorylation (PdP) cycles, operate far from thermodynamic equilibrium and consume hydrolysis free energy to perform ultrasensitive response and exhibit strong robustness…

Characterizing Cellular Physiological States with Three-Dimensional Shape Descriptors for Cell Membranes Open

Guoye Guan, Yixuan Chen, Hongli Wang, Qi Ouyang, Chao Tang · 2024

The shape of a cell as defined by its membrane can be closely associated with its physiological state. For example, the irregular shapes of cancerous cells and elongated shapes of neuron cells often reflect specific functions, such as cell…

Temperature compensation through kinetic regulation in biochemical oscillators Open

Haochen Fu, Chenyi Fei, Qi Ouyang, Yuhai Tu · 2024

Nearly all circadian clocks maintain a period that is insensitive to temperature changes, a phenomenon known as temperature compensation (TC). Yet, it is unclear whether there is any common feature among different systems that exhibit TC. …

123P Goserelin 10.8 mg and 3.6 mg depots in breast cancer (BC): A large real-world noninferiority study Open

Yuzhuo Wang, Xiaodong Wang, Juan Wu, H. Liu, J. Zhao , et al. · 2024

BC pts in China (median age 48-50 y), with est. 60% being premenopausal, are younger than those in western countries. As an effective ovarian function suppression therapy that improves survival for premenopausal hormone receptor-positive (…

Mathematical modeling of viral infection and the immune response controlled by the circadian clock Open

Jiaxin Zhou, Hongli Wang, Qi Ouyang · 2024

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