Explanipedia

scMFF: a machine learning framework with multiple feature fusion strategies for cell type identification Open

Nan Sun, Yu Wang, Rongling Wu · 2025

Research progress on complications of rheumatoid arthritis Open

Haiqing Zeng, Ziwei Yuan, Rongling Wu, Zhisheng Huang · 2025

Rheumatoid arthritis (RA) is an autoimmune disease characterized by synovial inflammation, joint injury, and deformity in the limbs. This disease is widely distributed, with a large number of patients, and there is a possibility of further…

Screening and Whole-Genome Analysis of Sheep-Derived Lactic Acid Bacteria Open

Leo Yao, Yao Huang, Linchong Zhang, Yusheng Wang, Jun Jia , et al. · 2025

Probiotics (lactic acid bacteria) are widely used as microbial feed additives in livestock production and play an important role in preventing and treating animal diarrhea as well as regulating host immune function. In this study, lactic a…

Analysis of acupoint selection rules of acupuncture and moxibustion in ancient medical books for the treatment of somnolence: A review Open

Haiqing Zeng, Z. Y. Yuan, Rongling Wu, A-ling Tang, Zhi-sheng Huang · 2025

This study aimed to explore the rule of acupoint selection in the treatment of somnolence by ancient acupuncture and moxibustion. Using “Duomei” and other words as search terms in the Encyclopaedia of Traditional Chinese Medicine, a table …

A SERIAL MEDIATION MODEL OF PSYCHOLOGICAL RESILIENCE RELATED TO DEPRESSION SEVERITY AMONG PATIENTS WITH MAJOR DEPRESSIVE DISORDERS Open

Rongling Wu, Chao Huang, Yun Chang, Shulan Hsieh, Hsien Yuan Lane , et al. · 2025

Background Patients diagnosed with major depressive disorders (MDD) often grapple with impaired emotion regulation and frequently experience high levels of distress. Existing literature has further indicated that the cumulative burden of d…

Hypernetwork modeling and topology of high-order interactions for complex systems Open

Feng Li, Huiying Gong, Shen Zhang, Xiang Liu, Yu Wang , et al. · 2024

Interactions among the underlying agents of a complex system are not only limited to dyads but can also occur in larger groups. Currently, no generic model has been developed to capture high-order interactions (HOI), which, along with pair…

Association of SNP-SNP interactions of surfactant protein genes with severity of respiratory syncytial virus infection in children Open

Chintan K. Gandhi, Lynnlee C. Depicolzuane, Chixiang Chen, Catherine M. Roberts, Natalie Sicher , et al. · 2024

Although surfactant protein (SP) genetic variants are associated with respiratory syncytial virus (RSV) severity, the impact of single-nucleotide polymorphism (SNP)-SNP interactions of SP genes remained unexplored. Using advanced statistic…

Mapping the Influence of Light Intensity on the Transgenerational Genetic Architecture of Arabidopsis thaliana Open

Jie Mei, Jincan Che, Yunzhu Shi, Yudian Fang, Rongling Wu , et al. · 2024

Light is a crucial environmental factor that influences the phenotypic development of plants. Despite extensive studies on the physiological, biochemical, and molecular mechanisms of the impact of light on phenotypes, genetic investigation…

Mapping the Influence of Light Intensity on the Transgenerational Genetic Architecture of <em>Arabidopsis thaliana</em> Open

Jie Mei, Jincan Che, Yunzhu Shi, Yudian Fang, Rongling Wu , et al. · 2024

Light is a crucial environmental factor that influences the phenotypic development of plants. Despite extensive studies on the physiological, biochemical, and molecular mechanisms of the impact of light on phenotypes, genetic investigation…

Prolonged lymphopenia and prognoses among inpatients with different respiratory virus infections: A retrospective cohort study Open

Guohui Fan, Wuyue Yang, Dingyi Wang, Feiya Xu, Yeming Wang , et al. · 2024

Inaugural editorial: <i>Statistics Innovation</i> Open

Rongling Wu · 2024

The metabolomic physics of complex diseases Open

Shuang Wu, Xiang Liu, Ang Dong, Claudia Gragnoli, Christopher Griffin , et al. · 2023

Human diseases involve metabolic alterations. Metabolomic profiles have served as a vital biomarker for the early identification of high-risk individuals and disease prevention. However, current approaches can only characterize individual …

The genetic architecture of trait covariation in Populus euphratica, a desert tree Open

Kaiyan Lu, Xueshun Wang, Huiying Gong, Dengcheng Yang, Meixia Ye , et al. · 2023

Introduction The cooperative strategy of phenotypic traits during the growth of plants reflects how plants allocate photosynthesis products, which is the most favorable decision for them to optimize growth, survival, and reproduction respo…

Functional Mapping of Genes Modulating Plant Shade Avoidance Using Leaf Traits Open

Han Zhang, Yige Cao, Zijian Wang, Meixia Ye, Rongling Wu · 2023

Shade avoidance syndrome (SAS) refers to a set of plant responses that increases light capture in dense stands. This process is crucial for plants in natural and agricultural environments as they compete for resources and avoid suboptimal …

A Cartographic Tool to Predict Disease Risk-associated Pseudo-Dynamic Networks from Tissue-specific Gene Expression Open

Chixiang Chen, Biyi Shen, Lijun Zhang, Tonghui Yu, Ming Wang , et al. · 2023

Understanding how genes are differentially expressed across tissues is key to reveal the etiology of human diseases. Genes are never expressed in isolation, but rather co-expressed in a community; thus, they co-act through intricate but we…

Vaginal microbiota networks as a mechanistic predictor of aerobic vaginitis Open

Qian Wang, Ang Dong, Jinshuai Zhao, Chen Wang, Christipher Griffin , et al. · 2022

Aerobic vaginitis (AV) is a complex vaginal dysbiosis that is thought to be caused by the micro-ecological change of the vaginal microbiota. While most studies have focused on how changes in the abundance of individual microbes are associa…

The Genetic Architecture of Juvenile Growth Traits in the Conifer Torreya grandis as Revealed by Joint Linkage and Linkage Disequilibrium Mapping Open

Wenchong Chen, Weiwu Yu, Ang Dong, Yanru Zeng, Huwei Yuan , et al. · 2022

Despite its high economical and ornamental values, Torreya grandis , a dioecious non-timber coniferous species, has long been an underrepresented species. However, the advent and application of advanced genotyping technologies have stimula…

Genetic Architecture of Heterophylly: Single and Multi-Leaf Genome-Wide Association Mapping in Populus euphratica Open

Xuli Zhu, Fengshuo Sun, Mengmeng Sang, Meixia Ye, Wenhao Bo , et al. · 2022

Heterophylly is an adaptive strategy used by some plants in response to environmental changes. Due to the lack of representative plants with typical heteromorphic leaves, little is known about the genetic architecture of heterophylly in pl…

Single Nucleotide Polymorphisms (SNP) and SNP-SNP Interactions of the Surfactant Protein Genes Are Associated With Idiopathic Pulmonary Fibrosis in a Mexican Study Group; Comparison With Hypersensitivity Pneumonitis Open

Ata Abbasi, Chixiang Chen, Chintan K. Gandhi, Rongling Wu, Annie Pardo , et al. · 2022

Surfactant proteins (SPs) are important for normal lung function and innate immunity of the lungs and their genes have been identified with significant genetic variability. Changes in quantity or quality of SPs due to genetic mutations or …

SNP–SNP Interactions of Surfactant Protein Genes in Persistent Respiratory Morbidity Susceptibility in Previously Healthy Children Open

Chintan K. Gandhi, Neal J. Thomas, Meixia Ye, Debbie Spear, Chenqi Fu , et al. · 2022

We studied associations of persistent respiratory morbidity (PRM) at 6 and 12 months after acute respiratory failure (ARF) in previously healthy children with single-nucleotide polymorphisms (SNPs) of surfactant protein (SP) genes. Of the …

A Tracing Model for the Evolutionary Equilibrium of Octoploids Open

Jing Wang, Xuemin Lv, Feng Li, Ang Dong, Dan Liang , et al. · 2022

Testing Hardy-Weinberg equilibrium (HWE) is a fundamental approach for inferring population diversity and evolution, but its application to octoploids containing eight chromosome sets has not well been justified. We derive a mathematical m…

Asymptotic tests for Hardy–Weinberg equilibrium in hexaploids Open

Jing Wang, Feng Li, Shuaicheng Mu, Ang Dong, Jinwen Gan , et al. · 2022

Hexaploids, a group of organisms containing three complete sets of chromosomes in a single nucleus, are of utmost importance to evolutionary studies and breeding programs. Many studies have focused on hexaploid linkage analysis and QTL map…

An eco-evo-devo genetic network model of stress response Open

Li Feng, Tianyu Dong, Peng Jiang, Zhenyu Yang, Ang Dong , et al. · 2022

The capacity of plants to resist abiotic stresses is of great importance to agricultural, ecological and environmental sustainability, but little is known about its genetic underpinnings. Existing genetic tools can identify individual gene…

FunGraph: A statistical protocol to reconstruct omnigenic multilayer interactome networks for complex traits Open

Ang Dong, Li Feng, Dengcheng Yang, Shuang Wu, Jinshuai Zhao , et al. · 2021

A Holling Functional Response Model for Mapping QTLs Governing Interspecific Interactions Open

Xiaoyu Zhang, Huiying Gong, Qing Fang, Xuli Zhu, Libo Jiang , et al. · 2021

Genes play an important role in community ecology and evolution, but how to identify the genes that affect community dynamics at the whole genome level is very challenging. Here, we develop a Holling type II functional response model for m…

Single Nucleotide Polymorphisms Interactions of the Surfactant Protein Genes Associated With Respiratory Distress Syndrome Susceptibility in Preterm Infants Open

Shaili Amatya, Meixia Ye, Lili Yang, Chintan K. Gandhi, Rongling Wu , et al. · 2021

Background: Neonatal respiratory distress syndrome (RDS), due to surfactant deficiency in preterm infants, is the most common cause of respiratory morbidity. The surfactant proteins ( SFTP ) genetic variants have been well-studied in assoc…

Functional Mapping of Phenotypic Plasticity of Staphylococcus aureus Under Vancomycin Pressure Open

Dengcheng Yang, Xuyang Zheng, Libo Jiang, Meixia Ye, Xiaoqing He , et al. · 2021

Phenotypic plasticity is the exhibition of various phenotypic traits produced by a single genotype in response to environmental changes, enabling organisms to adapt to environmental changes by maintaining growth and reproduction. Despite i…

Modeling genome-wide by environment interactions through omnigenic interactome networks Open

Haojie Wang, Meixia Ye, Yaru Fu, Ang Dong, Miaomiao Zhang , et al. · 2021

How genes interact with the environment to shape phenotypic variation and evolution is a fundamental question intriguing to biologists from various fields. Existing linear models built on single genes are inadequate to reveal the complexit…

SNP and Haplotype Interaction Models Reveal Association of Surfactant Protein Gene Polymorphisms With Hypersensitivity Pneumonitis of Mexican Population Open

Chintan K. Gandhi, Chixiang Chen, Shaili Amatya, Lili Yang, Chenqi Fu , et al. · 2021

Background: Hypersensitivity pneumonitis (HP) is an interstitial lung disease caused by inhalation of common environmental organic particles. Surfactant proteins (SPs) play a role in innate immunity and surfactant function. We hypothesized…

Genetic dissection of growth trajectories in forest trees: From FunMap to FunGraph Open

Li Feng, Peng Jiang, Caifeng Li, Jinshuai Zhao, Ang Dong , et al. · 2021

Growth is the developmental process involving important genetic components. Functional mapping (FunMap) has been used as an approach to map quantitative trait loci (QTLs) governing growth trajectories by incorporating growth equations. Fun…

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