Mengqi Zhang
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View article: PCSK9 and High-Fat Diet Synergistically Induce Neurovascular Dysfunction and Neuroinflammation
PCSK9 and High-Fat Diet Synergistically Induce Neurovascular Dysfunction and Neuroinflammation Open
Cerebral small vessel disease (CSVD) is strongly linked to metabolic risk factors and represents a major cause of vascular cognitive impairment and dementia. The interactions of genetic and environmental risk factors driving cerebrovascula…
View article: Regime shift in extreme wildfires within northern Eurasia and their impacts
Regime shift in extreme wildfires within northern Eurasia and their impacts Open
Wildfires heighten the risks of ecosystem degradation and increase carbon emissions, significantly impacting ecological stability and climate change. However, changes in extreme wildfire regimes and their consequential impact on carbon emi…
View article: A thermostable Cas9-based genome editing system for thermophilic acetogenic bacterium <i>Thermoanaerobacter kivui</i>
A thermostable Cas9-based genome editing system for thermophilic acetogenic bacterium <i>Thermoanaerobacter kivui</i> Open
Thermoanaerobacter kivui is a thermophilic acetogenic bacterium capable of thriving at elevated temperatures up to 66°C. It metabolizes carbohydrates such as glucose, mannose, and fructose and can also grow lithotrophically utilizing hydro…
View article: Decoding monocyte signatures in ischemic stroke: A multi-scale transcriptomic approach
Decoding monocyte signatures in ischemic stroke: A multi-scale transcriptomic approach Open
Monocytes play a crucial role in post-stroke immune infiltration, yet the intricate immune regulatory networks they orchestrate in ischemic stroke remain poorly understood. This knowledge gap has hindered the development of targeted monocy…
View article: Wastewater-based Surveillance Reveals Incomplete Gut Microbiome Recovery Following Easing of COVID-19 Restrictions in Wuhan, China
Wastewater-based Surveillance Reveals Incomplete Gut Microbiome Recovery Following Easing of COVID-19 Restrictions in Wuhan, China Open
While SARS-CoV-2 infection is known to disrupt the gut microbiome, its population-level impact and long-term recovery trajectory remain poorly understood. Here, we applied longitudinal wastewater metagenomics in Wuhan, China, to track the …
View article: Safety Profile and Predictors of Adverse Events of Incadronate Disodium in Treating Breast Cancer Patients with Bone Metastases: A Retrospective Study
Safety Profile and Predictors of Adverse Events of Incadronate Disodium in Treating Breast Cancer Patients with Bone Metastases: A Retrospective Study Open
Incadronate disodium demonstrates a favorable safety profile for treating bone metastases in breast cancer patients. Identified risk factors, such as prolonged treatment duration and lower hemoglobin levels, highlight the need for intensif…
View article: Historical data analysis and future prediction of lung cancer in Zhejiang province, China
Historical data analysis and future prediction of lung cancer in Zhejiang province, China Open
Environmental factors have known to cause lung cancer. However, the relationship between lung cancer and the environmental factors are not well explored or quantified. Using Zhejiang Province of China as a case study, the spatiotemporal di…
View article: Astrocyte Lipid Droplet Dynamics Orchestrate Neurological Disorders and Therapeutic Horizons
Astrocyte Lipid Droplet Dynamics Orchestrate Neurological Disorders and Therapeutic Horizons Open
Astrocytes, the predominant glial cells in the central nervous system (CNS), play a pivotal role in maintaining neuronal homeostasis and function. Accumulating evidence suggests that astrocytic dysfunction is closely associated with the pa…
View article: PATJ regulates cell stress responses and vascular remodeling post-stroke
PATJ regulates cell stress responses and vascular remodeling post-stroke Open
PALS1-associated tight junction (PATJ) protein is linked to metabolic disease and stroke in human genetic studies. Despite the recognized role of PATJ in cell polarization, its specific functions in metabolic disease and ischemic stroke re…
View article: Giant switchable ferroelectric photovoltage in double-perovskite epitaxial films through chemical negative strain
Giant switchable ferroelectric photovoltage in double-perovskite epitaxial films through chemical negative strain Open
Double-perovskite films have been extensively studied in multifunctional fields due to their modifiability. Here, a controlled process strategy to induce chemical strain and anomalous Poisson deformation is proposed for perovskite-based fi…
View article: An empirical study on the alleviation of policewomen’ anxiety by mindfulness-based aerobic dance through affecting emotion regulation
An empirical study on the alleviation of policewomen’ anxiety by mindfulness-based aerobic dance through affecting emotion regulation Open
Anxiety impacts both physical and mental health, yet it can be alleviated through exercise. This study aimed to investigate the effects of mindfulness-based aerobic dance on policewomen's anxiety and compare them with those of traditional …
View article: A Qualitative Study on the Supportive Care Needs Preferences of Older Colorectal Cancer Patients: Insights from Patient Experiences
A Qualitative Study on the Supportive Care Needs Preferences of Older Colorectal Cancer Patients: Insights from Patient Experiences Open
It is essential to prioritize the care needs of OPCRC by enhancing symptomatic management and providing comprehensive information support. Additionally, addressing their emotional well-being is crucial, and effective social assistance shou…
View article: New insight into the role of altered brain cholesterol metabolism in the pathogenesis of AD: A unifying cholesterol hypothesis and new therapeutic approach for AD
New insight into the role of altered brain cholesterol metabolism in the pathogenesis of AD: A unifying cholesterol hypothesis and new therapeutic approach for AD Open
The dysregulation of cholesterol metabolism homeostasis has been universally suggested in the aeotiology of Alzheimer's disease (AD). Initially, studies indicate that alteration of serum cholesterol level might contribute to AD. However, b…
View article: Evaluation of the Health Status and Eldercare Needs of Urban Elderly People in Ili Kazak Autonomous Prefecture, Xinjiang Uygur Autonomous Region
Evaluation of the Health Status and Eldercare Needs of Urban Elderly People in Ili Kazak Autonomous Prefecture, Xinjiang Uygur Autonomous Region Open
Objective This study aimed to evaluate the health status and eldercare needs of elderly people in urban Ili Kazak Autonomous Prefecture of Xinjiang Uygur Autonomous Region. Methods Using an online questionnaire, 2057 elderly people aged >6…
View article: Identification of novel components of the Ced and Ups systems in <i>Saccharolobus islandicus</i> REY15A
Identification of novel components of the Ced and Ups systems in <i>Saccharolobus islandicus</i> REY15A Open
In Sulfolobales cells, transcription of the Ups (UV‐inducible pili of Sulfolobus ) and Ced (Crenarchaeal system for exchange of DNA) genes is highly induced by DNA damage, and the two systems play key roles in pili‐mediated cell aggregatio…
View article: Suppressing APOE4-induced neural pathologies by targeting the VHL–HIF axis
Suppressing APOE4-induced neural pathologies by targeting the VHL–HIF axis Open
The ε4 variant of human apolipoprotein E ( APOE4 ) is a key genetic risk factor for neurodegeneration in Alzheimer’s disease and elevated all-cause mortality in humans. Understanding the factors and mechanisms that can mitigate the harmful…
View article: Preparation of D-Phenyllactic Acid-Chitosan Biodegradable Composite Coating and Its Preservation Effect on Shine-Muscat Grape
Preparation of D-Phenyllactic Acid-Chitosan Biodegradable Composite Coating and Its Preservation Effect on Shine-Muscat Grape Open
Considering the pollution of plastic packaging and the harm of traditional food containing sulphur to the environment and human health, the development of green and edible coating materials with biodegradable power has become the focus of …
View article: Pyrotinib combined with metronomic etoposide in heavily pretreated HER2-positive metastatic breast cancer: a single-arm, phase II study
Pyrotinib combined with metronomic etoposide in heavily pretreated HER2-positive metastatic breast cancer: a single-arm, phase II study Open
Registry number: NCT03923179. Registered April 18, 2019.
View article: An improved wavelet threshold function denoising method based on IGA optimization
An improved wavelet threshold function denoising method based on IGA optimization Open
In single crystal diamond tool grinding, cutting-edge quality is affected by various parameters, with tool vibration playing a crucial role. Due to environmental factors and the complexity of the process, vibration signals are often noisy …
View article: Clinical benefit and safety profile of cross-line therapy with CDK4/6 inhibitors: a retrospective study of HR+/HER2– advanced breast cancer
Clinical benefit and safety profile of cross-line therapy with CDK4/6 inhibitors: a retrospective study of HR+/HER2– advanced breast cancer Open
Objective: CDK4/6 inhibitors (CDK4/6is) in combination with endocrine therapy have secured a central role in the treatment of hormone receptor (HR)-positive advanced breast cancer (ABC) and have transformed the therapeutic landscape. Cross…
View article: HIGD1B, as a novel prognostic biomarker, is involved in regulating the tumor microenvironment and immune cell infiltration; its overexpression leads to poor prognosis in gastric cancer patients
HIGD1B, as a novel prognostic biomarker, is involved in regulating the tumor microenvironment and immune cell infiltration; its overexpression leads to poor prognosis in gastric cancer patients Open
Background HIGD1B (HIG1 Hypoxia Inducible Domain Family Member 1B) is a protein-coding gene linked to the occurrence and progression of various illnesses. However, its precise function in gastric cancer (GC) remains unclear. Methods The ex…
View article: Neoadjuvant inetetamab and pertuzumab with taxanes and carboplatin (TCbIP) In locally advanced HER2-positive breast cancer: a prospective cohort study with propensity-matched analysis
Neoadjuvant inetetamab and pertuzumab with taxanes and carboplatin (TCbIP) In locally advanced HER2-positive breast cancer: a prospective cohort study with propensity-matched analysis Open
Background Inetetamab is the first domestically developed innovative anti-HER2 monoclonal antibody in China, proven effective and safe in HER2-positive advanced breast cancer. However, its efficacy and safety in neoadjuvant treatment of HE…
View article: Personalized PLGA/BCL Scaffold with Hierarchical Porous Structure Resembling Periosteum‐Bone Complex Enables Efficient Repair of Bone Defect
Personalized PLGA/BCL Scaffold with Hierarchical Porous Structure Resembling Periosteum‐Bone Complex Enables Efficient Repair of Bone Defect Open
Using bone regeneration scaffolds to repair craniomaxillofacial bone defects is a promising strategy. However, most bone regeneration scaffolds still exist some issues such as a lack of barrier structure, inability to precisely match bone …