Qianjin Liao
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View article: Breaking the shields of resistance: multidimensional therapeutic strategies in the breast cancer drug resistance conundrum
Breaking the shields of resistance: multidimensional therapeutic strategies in the breast cancer drug resistance conundrum Open
Breast cancer remains a leading threat to women’s health worldwide, and optimizing its treatment urgently requires the deep integration of multidimensional strategies. Current therapeutic regimens are founded on chemotherapeutic agents but…
View article: Causal association between oral microbiota and oral cancer: a mendelian randomization study
Causal association between oral microbiota and oral cancer: a mendelian randomization study Open
Many studies have reported an association between oral microbiota and oral cancer (OC). Yet, the causal relationship between oral microbiota and OC remains undetermined. This Mendelian randomization (MR) study utilized the most recent geno…
View article: Mechanism and application of lactylation in cancers
Mechanism and application of lactylation in cancers Open
View article: Correction: The cGAS‒STING pathway in cancer immunity: mechanisms, challenges, and therapeutic implications
Correction: The cGAS‒STING pathway in cancer immunity: mechanisms, challenges, and therapeutic implications Open
View article: The cGAS‒STING pathway in cancer immunity: mechanisms, challenges, and therapeutic implications
The cGAS‒STING pathway in cancer immunity: mechanisms, challenges, and therapeutic implications Open
Innate immunity represents the body's first line of defense, effectively countering the invasion of external pathogens. Recent studies have highlighted the crucial role of innate immunity in antitumor defense, beyond its established functi…
View article: The regulatory role and mechanism of energy metabolism and immune response in head and neck cancer
The regulatory role and mechanism of energy metabolism and immune response in head and neck cancer Open
View article: SRSF9 mediates oncogenic RNA splicing of SLC37A4 via liquid–liquid phase separation to promote oral cancer progression
SRSF9 mediates oncogenic RNA splicing of SLC37A4 via liquid–liquid phase separation to promote oral cancer progression Open
This study elucidates the mechanism by which SRSF9 phase separation mediates splicing in oral cancer, thereby establishing a basis for considering SRSF9 and its associated SLC37A4-S isoforms as potential therapeutic targets for oral cancer…
View article: Noncoding RNA-encoded peptides in cancer: biological functions, posttranslational modifications and therapeutic potential
Noncoding RNA-encoded peptides in cancer: biological functions, posttranslational modifications and therapeutic potential Open
In the present era, noncoding RNAs (ncRNAs) have become a subject of considerable scientific interest, with peptides encoded by ncRNAs representing a particularly promising avenue of investigation. The identification of ncRNA-encoded pepti…
View article: Long non‑coding RNA ABHD11‑AS1 inhibits colorectal cancer progression through interacting with EGFR to suppress the EGFR/ERK signaling pathway
Long non‑coding RNA ABHD11‑AS1 inhibits colorectal cancer progression through interacting with EGFR to suppress the EGFR/ERK signaling pathway Open
Long non‑coding (lnc)RNAs participate in colorectal cancer (CRC) occurrence and progression. The present study aimed to investigate whether lncRNA ABHD11‑AS1 regulates malignant biological behavior of CRC cells. Bioinformatic analysis, rev…
View article: CircRNF13 enhances IGF2BP1 phase separation-mediated ITGB1 mRNA stabilization in an m6A-dependent manner to promote oral cancer cisplatin chemoresistance
CircRNF13 enhances IGF2BP1 phase separation-mediated ITGB1 mRNA stabilization in an m6A-dependent manner to promote oral cancer cisplatin chemoresistance Open
Oral cancer ranks among the most common malignancies within the head and neck region; however, its etiology remains inadequately understood despite substantial research advances in recent years. Many studies highlight the regulatory role o…
View article: Fusion genes in cancers: Biogenesis, functions, and therapeutic implications
Fusion genes in cancers: Biogenesis, functions, and therapeutic implications Open
View article: Complete genome sequence of Bacillus pumilus NWMCC0302, a strain for degrading bovine blood
Complete genome sequence of Bacillus pumilus NWMCC0302, a strain for degrading bovine blood Open
Background Directly discharging livestock and poultry slaughter blood without proper treatment can cause severe ecological damage. Exploring the use of microorganisms to break down waste blood into smaller molecules such as peptides and am…
View article: Autophagy: a critical mechanism of N6-methyladenosine modification involved in tumor progression and therapy resistance
Autophagy: a critical mechanism of N6-methyladenosine modification involved in tumor progression and therapy resistance Open
View article: Correction: TRPM7 promotes the epithelial– mesenchymal transition in ovarian cancer through the calcium-related PI3K / AKT oncogenic signaling
Correction: TRPM7 promotes the epithelial– mesenchymal transition in ovarian cancer through the calcium-related PI3K / AKT oncogenic signaling Open
View article: Human papillomavirus-encoded circular RNA circE7 promotes immune evasion in head and neck squamous cell carcinoma
Human papillomavirus-encoded circular RNA circE7 promotes immune evasion in head and neck squamous cell carcinoma Open
Immune evasion represents a crucial milestone in the progression of cancer and serves as the theoretical foundation for tumor immunotherapy. In this study, we reveal a negative association between Human Papillomavirus (HPV)-encoded circula…
View article: Altered glycosylation in cancer: molecular functions and therapeutic potential
Altered glycosylation in cancer: molecular functions and therapeutic potential Open
Glycosylation, a key mode of protein modification in living organisms, is critical in regulating various biological functions by influencing protein folding, transportation, and localization. Changes in glycosylation patterns are a signifi…
View article: Circular RNA hsa_circ_0000467 promotes colorectal cancer progression by promoting eIF4A3-mediated c-Myc translation
Circular RNA hsa_circ_0000467 promotes colorectal cancer progression by promoting eIF4A3-mediated c-Myc translation Open
Background Colorectal cancer (CRC) is the second most common malignant tumor worldwide, and its incidence rate increases annually. Early diagnosis and treatment are crucial for improving the prognosis of patients with colorectal cancer. Ci…
View article: Endoplasmic reticulum stress—a key guardian in cancer
Endoplasmic reticulum stress—a key guardian in cancer Open
Endoplasmic reticulum stress (ERS) is a cellular stress response characterized by excessive contraction of the endoplasmic reticulum (ER). It is a pathological hallmark of many diseases, such as diabetes, obesity, and neurodegenerative dis…
View article: METTL14 promotes lipid metabolism reprogramming and sustains nasopharyngeal carcinoma progression via enhancing m<sup>6</sup>A modification of ANKRD22 mRNA
METTL14 promotes lipid metabolism reprogramming and sustains nasopharyngeal carcinoma progression via enhancing m<sup>6</sup>A modification of ANKRD22 mRNA Open
Background N 6 ‐methyladenosine (m 6 A) modification is essential for modulating RNA processing as well as expression, particularly in the context of malignant tumour progression. However, the exploration of m 6 A modification in nasophary…
View article: KCNK1 promotes proliferation and metastasis of breast cancer cells by activating lactate dehydrogenase A (LDHA) and up-regulating H3K18 lactylation
KCNK1 promotes proliferation and metastasis of breast cancer cells by activating lactate dehydrogenase A (LDHA) and up-regulating H3K18 lactylation Open
Breast cancer is the most prevalent malignancy and the most significant contributor to mortality in female oncology patients. Potassium Two Pore Domain Channel Subfamily K Member 1 (KCNK1) is differentially expressed in a variety of tumors…
View article: Role of m6A modifications in immune evasion and immunotherapy
Role of m6A modifications in immune evasion and immunotherapy Open
RNA modification has garnered increasing attention in recent years due to its pivotal role in tumorigenesis and immune surveillance. N6-methyladenosine (m6A) modification is the most prevalent RNA modification, which …
View article: CircCDYL2 bolsters radiotherapy resistance in nasopharyngeal carcinoma by promoting RAD51 translation initiation for enhanced homologous recombination repair
CircCDYL2 bolsters radiotherapy resistance in nasopharyngeal carcinoma by promoting RAD51 translation initiation for enhanced homologous recombination repair Open
View article: RETRACTED: METTL14 Promotes Lipid Metabolism Reprogramming and Sustains Nasopharyngeal Carcinoma Progression via Enhancing m6A Modification of ANKRD22 mRNA
RETRACTED: METTL14 Promotes Lipid Metabolism Reprogramming and Sustains Nasopharyngeal Carcinoma Progression via Enhancing m6A Modification of ANKRD22 mRNA Open
The authors have requested that this preprint be removed from Research Square.
View article: The roles and molecular mechanisms of non-coding RNA in cancer metabolic reprogramming
The roles and molecular mechanisms of non-coding RNA in cancer metabolic reprogramming Open
View article: Spatial Transcriptomic and Metabolomic Landscapes of Oral Submucous Fibrosis‐Derived Oral Squamous Cell Carcinoma and its Tumor Microenvironment
Spatial Transcriptomic and Metabolomic Landscapes of Oral Submucous Fibrosis‐Derived Oral Squamous Cell Carcinoma and its Tumor Microenvironment Open
In South and Southeast Asia, the habit of chewing betel nuts is prevalent, which leads to oral submucous fibrosis (OSF). OSF is a well‐established precancerous lesion, and a portion of OSF cases eventually progress to oral squamous cell ca…
View article: Cellular metabolism: A key player in cancer ferroptosis
Cellular metabolism: A key player in cancer ferroptosis Open
Cellular metabolism is the fundamental process by which cells maintain growth and self‐renewal. It produces energy, furnishes raw materials, and intermediates for biomolecule synthesis, and modulates enzyme activity to sustain normal cellu…
View article: Diallyl disulfide induces DNA damage and growth inhibition in colorectal cancer cells by promoting POU2F1 ubiquitination
Diallyl disulfide induces DNA damage and growth inhibition in colorectal cancer cells by promoting POU2F1 ubiquitination Open
Previous studies have demonstrated that diallyl disulfide (DADS) exhibits potent anti-tumor activity. However, the pharmacological actions of DADS in inhibiting the growth of colorectal cancer (CRC) cells have not been clarified. Herein, w…
View article: Progesterone Enhances Niraparib Efficacy in Ovarian Cancer by Promoting Palmitoleic-Acid-Mediated Ferroptosis
Progesterone Enhances Niraparib Efficacy in Ovarian Cancer by Promoting Palmitoleic-Acid-Mediated Ferroptosis Open
Poly (adenosine 5′-diphosphate-ribose) polymerase inhibitors (PARPi) are increasingly important in the treatment of ovarian cancer. However, more than 40% of BRCA1/2- deficient patients do not respond to PARPi, and BRCA wild-type cases do …
View article: Ferritinophagy: research advance and clinical significance in cancers
Ferritinophagy: research advance and clinical significance in cancers Open
View article: Circular RNA circE7 Encoded by Human Papillomavirus Facilitates Immune Evasion in Head and Neck Squamous Cell Carcinoma through Epigenetically Downregulating Galectin-9
Circular RNA circE7 Encoded by Human Papillomavirus Facilitates Immune Evasion in Head and Neck Squamous Cell Carcinoma through Epigenetically Downregulating Galectin-9 Open
Immune evasion represents a crucial milestone in the progression of cancer and serves as the theoretical foundation for tumor immunotherapy. Currently, immune checkpoint inhibitors such as anti-PD-1/PD-L1 have shown promising therapeutic e…