Qian‐Fang Meng
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View article: Engineering Neutrophil Vesicles for Synergistic Protection against Ischemia/Reperfusion Injury after Lung Transplant
Engineering Neutrophil Vesicles for Synergistic Protection against Ischemia/Reperfusion Injury after Lung Transplant Open
Lung transplantation (LTx) is a life‐saving procedure for patients with end‐stage respiratory failure; however, primary graft dysfunction (PGD), primarily induced by ischemia/reperfusion injury (IRI), remains a major complication. Although…
View article: Antiviral covalent ACE2 vesicle spray
Antiviral covalent ACE2 vesicle spray Open
View article: Single-cell multiomics reveals endothelial mechanosensitive PIEZO1 coupling IL-33 regulates the development of pulmonary fibrosis
Single-cell multiomics reveals endothelial mechanosensitive PIEZO1 coupling IL-33 regulates the development of pulmonary fibrosis Open
Pulmonary fibrosis (PF) is a lethal lung disease characterized by aberrant lung scarring. Vascular endothelial cells (VECs), which activate fibroblasts through secreting pro-fibrotic molecules, are vital for the PF development. However, th…
View article: Tea polyphenol-engineered hybrid cellular nanovesicles for cancer immunotherapy and androgen deprivation therapy
Tea polyphenol-engineered hybrid cellular nanovesicles for cancer immunotherapy and androgen deprivation therapy Open
View article: Targeting BRD4 Ameliorates Experimental Emphysema by Disrupting Super-Enhancer in Polarized Alveolar Macrophage
Targeting BRD4 Ameliorates Experimental Emphysema by Disrupting Super-Enhancer in Polarized Alveolar Macrophage Open
Background Chronic obstructive pulmonary disease (COPD) is a progressive chronic lung disease characterized by chronic airway inflammation and emphysema. Macrophage polarization plays an important role in COPD pathogenesis by secreting inf…
View article: Inhalation delivery of dexamethasone with iSEND nanoparticles attenuates the COVID-19 cytokine storm in mice and nonhuman primates
Inhalation delivery of dexamethasone with iSEND nanoparticles attenuates the COVID-19 cytokine storm in mice and nonhuman primates Open
Dexamethasone (DEX) is the first drug to show life-saving efficacy in patients with severe coronavirus disease 2019 (COVID-19), while DEX is associated with serious adverse effects. Here, we report an inhaled, Self-immunoregulatory, Extrac…
View article: A decoy microrobot that removes SARS-CoV-2 and its variants in wastewater
A decoy microrobot that removes SARS-CoV-2 and its variants in wastewater Open
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which can persist in wastewater for several days, has a risk of waterborne-human transmission. The emergence of SARS-CoV-2 variants with increased infection capacity further…
View article: Biomimetic manganese-based theranostic nanoplatform for cancer multimodal imaging and twofold immunotherapy
Biomimetic manganese-based theranostic nanoplatform for cancer multimodal imaging and twofold immunotherapy Open
View article: Integration and Reanalysis of Four RNA-Seq Datasets Including BALF, Nasopharyngeal Swabs, Lung Biopsy, and Mouse Models Reveals Common Immune Features of COVID-19
Integration and Reanalysis of Four RNA-Seq Datasets Including BALF, Nasopharyngeal Swabs, Lung Biopsy, and Mouse Models Reveals Common Immune Features of COVID-19 Open
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2), has spread over the world causing a pandemic which is still ongoing since its emergence in late 2019. A great amount of effort has…
View article: Capturing Cytokines with Advanced Materials: A Potential Strategy to Tackle COVID‐19 Cytokine Storm
Capturing Cytokines with Advanced Materials: A Potential Strategy to Tackle COVID‐19 Cytokine Storm Open
The COVID‐19 pandemic, induced by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), has caused great impact on the global economy and people's daily life. In the clinic, most patients with COVID‐19 show none or mild symptoms, w…
View article: Activating Macrophage‐Mediated Cancer Immunotherapy by Genetically Edited Nanoparticles
Activating Macrophage‐Mediated Cancer Immunotherapy by Genetically Edited Nanoparticles Open
Immunomodulation of macrophages against cancer has emerged as an encouraging therapeutic strategy. However, there exist two major challenges in effectively activating macrophages for antitumor immunotherapy. First, ligation of signal regul…
View article: One-step synthesis of green emission carbon dots for selective and sensitive detection of nitrite ions and cellular imaging application
One-step synthesis of green emission carbon dots for selective and sensitive detection of nitrite ions and cellular imaging application Open
Schematic route of the carbon dots and their applications for the nitrite detection.
View article: Early Cancer Diagnosis: Platelet–Leukocyte Hybrid Membrane‐Coated Immunomagnetic Beads for Highly Efficient and Highly Specific Isolation of Circulating Tumor Cells (Adv. Funct. Mater. 34/2018)
Early Cancer Diagnosis: Platelet–Leukocyte Hybrid Membrane‐Coated Immunomagnetic Beads for Highly Efficient and Highly Specific Isolation of Circulating Tumor Cells (Adv. Funct. Mater. 34/2018) Open
In article number 1803531, Kan Liu, Yufeng Yuan, Wei Liu, and co-workers describe platelet–leukocyte hybrid membrane-coated immunomagnetic beads with enhanced cancer cell binding and reduced leukocyte interaction for highly efficient and h…
View article: Theranostics: Antitumor Platelet‐Mimicking Magnetic Nanoparticles (Adv. Funct. Mater. 9/2017)
Theranostics: Antitumor Platelet‐Mimicking Magnetic Nanoparticles (Adv. Funct. Mater. 9/2017) Open
An all-in-one nanoplatform based on platelet membrane-coated Fe3O4 magnetic nanoparticles (PLT-MNs) for enhanced tumor magnetic resonance imaging (MRI) and photothermal therapy (PTT) is presented by Wei Liu, Zhi-Jun Sun, and co-workers in …
View article: A Concentration-Controllable Microfluidic Droplet Mixer for Mercury Ion Detection
A Concentration-Controllable Microfluidic Droplet Mixer for Mercury Ion Detection Open
A microfluidic droplet mixer is developed for rapid detection of Hg(II) ions. Reagent concentration and droplets can be precisely controlled by adjusting the flow rates of different fluid phases. By selecting suitable flow rates of the oil…