Liang Yu
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View article: Glucagon-like peptide-1 receptor agonist in large vessel occlusion treated by reperfusion therapy—a phase 2 randomized trial
Glucagon-like peptide-1 receptor agonist in large vessel occlusion treated by reperfusion therapy—a phase 2 randomized trial Open
We aimed to determine the effect of semaglutide on patients with acute large vessel occlusion (LVO) receiving endovascular therapy (EVT). In this phase 2, investigator-initiated, multicenter, prospective, randomized, open-label, blinded en…
View article: Targeting LRBA triggers CTLA4 degradation and antitumor immunity for cancer immunotherapy
Targeting LRBA triggers CTLA4 degradation and antitumor immunity for cancer immunotherapy Open
The lipopolysaccharide-responsive beige-like anchor protein (LRBA) deficiency causes severe autoimmune diseases and cytotoxic T-lymphocyte-associated protein 4 (CTLA4) loss in humans. However, the impact of LRBA on antitumor immunity remai…
View article: Two-Phase Orthodontic Treatment in an Adolescent With a 15 mm Severe Overjet
Two-Phase Orthodontic Treatment in an Adolescent With a 15 mm Severe Overjet Open
View article: FUSER: Feed-Forward MUltiview 3D Registration Transformer and SE(3)$^N$ Diffusion Refinement
FUSER: Feed-Forward MUltiview 3D Registration Transformer and SE(3)$^N$ Diffusion Refinement Open
Registration of multiview point clouds conventionally relies on extensive pairwise matching to build a pose graph for global synchronization, which is computationally expensive and inherently ill-posed without holistic geometric constraint…
View article: Generative Point Cloud Registration
Generative Point Cloud Registration Open
In this paper, we propose a novel 3D registration paradigm, Generative Point Cloud Registration, which bridges advanced 2D generative models with 3D matching tasks to enhance registration performance. Our key idea is to generate cross-view…
View article: Refractive outcome and visual quality of Ray-Tracing Guided LASIK: a prospective study
Refractive outcome and visual quality of Ray-Tracing Guided LASIK: a prospective study Open
Purpose This study aimed to evaluate the safety and effectiveness of Ray-Tracing Guided LASIK surgery and to compare the refractive outcomes and visual quality between patients with spherical equivalent (SEQ) differences of ≤ 0.75D and > 0…
View article: Leveraging Transfection Dose Streamlines the Establishment of a Chinese Hamster Ovary Cell Targeted Integration System
Leveraging Transfection Dose Streamlines the Establishment of a Chinese Hamster Ovary Cell Targeted Integration System Open
Targeted integration (TI) expression system has emerged as an alternative to random integration in cell line development (CLD) involved in biologics development and manufacturing. A key element of a robust TI CLD system is the construction…
View article: Trade-Offs and Synergies Among Habitat, Water, and Carbon Services Driven by Urbanization: A Spatiotemporal Analysis of the Chang-Zhu-Tan City Cluster
Trade-Offs and Synergies Among Habitat, Water, and Carbon Services Driven by Urbanization: A Spatiotemporal Analysis of the Chang-Zhu-Tan City Cluster Open
Understanding the evolution of ecosystem services (ESs) is crucial for sustainable development in rapidly urbanizing regions. This study quantifies the spatiotemporal evolution of habitat quality (HQ), water yield (WY), and carbon storage …
View article: HHFT: Hierarchical Heterogeneous Feature Transformer for Recommendation Systems
HHFT: Hierarchical Heterogeneous Feature Transformer for Recommendation Systems Open
We propose HHFT (Hierarchical Heterogeneous Feature Transformer), a Transformer-based architecture tailored for industrial CTR prediction. HHFT addresses the limitations of DNN through three key designs: (1) Semantic Feature Partitioning: …
View article: Potassium Sorbate Triggers Kidney Injury via Dysregulated Intercellular Communication: A Study Combining Network Toxicology, Machine Learning, Molecular Docking, and Single‐Cell RNA Sequencing
Potassium Sorbate Triggers Kidney Injury via Dysregulated Intercellular Communication: A Study Combining Network Toxicology, Machine Learning, Molecular Docking, and Single‐Cell RNA Sequencing Open
Acute kidney injury (AKI) is a clinically significant syndrome, characterized by high mortality rates and the potential for progression to chronic kidney disease. Potassium sorbate (PS), a widely‐used food preservative with a high safety p…
View article: Protective effects of Angelica sinensis polysaccharide on chemotherapy-injured rats with premature ovarian insufficiency and its impact on gut microbiota
Protective effects of Angelica sinensis polysaccharide on chemotherapy-injured rats with premature ovarian insufficiency and its impact on gut microbiota Open
Objective This study aimed to investigate the therapeutic effects and action mechanisms of Angelica sinensis polysaccharides (ASP) on a chemotherapy-induced premature ovarian insufficiency (POI) rat model along with screening for the optim…
View article: Prediction of the Ki-67 proliferation index in lung adenocarcinoma using an interpretable CT-based deep learning radiomics model: a two-center study
Prediction of the Ki-67 proliferation index in lung adenocarcinoma using an interpretable CT-based deep learning radiomics model: a two-center study Open
Purpose To develop an interpretable computed tomography (CT)-based deep learning radiomics (DLR) model that integrates deep learning (DL) and radiomics features to predict the preoperative Ki-67 proliferation index in lung adenocarcinoma. …
View article: Functional analysis of StMAPK19 gene in response to salt stress in potato (Solanum tuberosum L.)
Functional analysis of StMAPK19 gene in response to salt stress in potato (Solanum tuberosum L.) Open
View article: SAFENLIDB: A Privacy-Preserving Safety Alignment Framework for LLM-based Natural Language Database Interfaces
SAFENLIDB: A Privacy-Preserving Safety Alignment Framework for LLM-based Natural Language Database Interfaces Open
The rapid advancement of Large Language Models (LLMs) has driven significant progress in Natural Language Interface to Database (NLIDB). However, the widespread adoption of LLMs has raised critical privacy and security concerns. During int…
View article: Precise Measurement of Cosmic Ray Light and Helium Spectra above 0.1 Peta-electron-Volt
Precise Measurement of Cosmic Ray Light and Helium Spectra above 0.1 Peta-electron-Volt Open
We report a measurement of the cosmic ray helium energy spectrum in the energy interval 0.16 -- 13 PeV, derived by subtracting the proton spectrum from the light component (proton and helium) spectrum obtained with observations made by the…
View article: Efficient n‐Doping of Organic Semiconductors via a Broadly Applicable Nucleophilic‐Attack Mechanism
Efficient n‐Doping of Organic Semiconductors via a Broadly Applicable Nucleophilic‐Attack Mechanism Open
The development of efficient and broadly applicable n‐doping strategies for organic semiconductors (OSCs) is crucial for advancing the performance of various organic electronic devices. Here, a novel nucleophilic‐attack n‐doping mechanism …
View article: Innovative strategies for high-throughput discovery and engineering of plant immune receptors
Innovative strategies for high-throughput discovery and engineering of plant immune receptors Open
View article: Competitive dynamics of ST764 and ST5 MRSA in a new tertiary ICU: enhanced hospital adaptation via agrC mutations post-COVID-19
Competitive dynamics of ST764 and ST5 MRSA in a new tertiary ICU: enhanced hospital adaptation via agrC mutations post-COVID-19 Open
Environmental contamination is the primary source of MRSA transmission in ICUs. The agrC-T43I mutation drives ST5 dominance post-pandemic by enhancing biofilm-dependent persistence, underscoring the need for genomic surveillance to guide i…
View article: Unraveling the mechanism of tetracycline-induced renal injury: an evaluation of drug safety based on network toxicology and molecular dynamics simulations
Unraveling the mechanism of tetracycline-induced renal injury: an evaluation of drug safety based on network toxicology and molecular dynamics simulations Open
Background Tetracyline, a widely used antibiotic, is associated with nephrotoxicity, though its underlying mechanisms require further investigation. Methods We investigated the toxicological process of tetracycline-induced renal injury usi…
View article: Haematological toxicities with targeted drugs in tumors: A systematic review and network meta-analysis of randomized controlled trials
Haematological toxicities with targeted drugs in tumors: A systematic review and network meta-analysis of randomized controlled trials Open
Objective: Tumor-targeted drug monotherapy or chemotherapy is becoming increasingly important in cancer treatment, yet the concomitant issue of hematological toxicities is gradually gaining attention. Existing studies lack a comprehensive …
View article: Exploring the anti-AML mechanisms of compound zhebei granule via integrated network pharmacology, transcriptomic sequencing, and experimental validation
Exploring the anti-AML mechanisms of compound zhebei granule via integrated network pharmacology, transcriptomic sequencing, and experimental validation Open
Background: Acute myeloid leukemia (AML) is a hematologic malignancy with a poor prognosis. In recent years, the clinical application of the Bcl-2 inhibitor Venetoclax (VEN) has significantly improved remission rates and short-term surviva…
View article: Analysis of Fall Incidence and Influencing Factors Among Home-Dwelling Elderly in China
Analysis of Fall Incidence and Influencing Factors Among Home-Dwelling Elderly in China Open
Objective: To explore the current situation of falls among elderly people at home in Hechi City, Guangxi, China, and its influencing factors, so as to provide a basis for the formulation of targeted fall prevention intervention strategies.…
View article: Independent and joint associations of sleep quality and physical activity with glycaemic control in patients with type 2 diabetes mellitus
Independent and joint associations of sleep quality and physical activity with glycaemic control in patients with type 2 diabetes mellitus Open
Background Although determinants of glycaemic control in type 2 diabetes mellitus (T2DM) have been extensively investigated, the joint influence of sleep quality and physical activity (PA) remains insufficiently studied. We aimed to examin…
View article: 1331 HCB101, a next-generation Fc-engineered anti-CD47 SIRPα fusion protein, demonstrates favorable safety and early antitumor activity in advanced cancers
1331 HCB101, a next-generation Fc-engineered anti-CD47 SIRPα fusion protein, demonstrates favorable safety and early antitumor activity in advanced cancers Open
View article: Engineered nano-bacteria hybrids for precision cancer immunotherapy
Engineered nano-bacteria hybrids for precision cancer immunotherapy Open
Bacterial therapy has emerged as a promising modality in precision cancer immunotherapy, leveraging bacteria's innate tumor-homing ability, immunostimulatory properties, and engineering flexibility to overcome limitations in conventional t…
View article: Paraneoplastic Pemphigus Unveiling Occult Lung Adenocarcinoma: A Rituximab‐Responsive Case With Diagnostic and Therapeutic Implications
Paraneoplastic Pemphigus Unveiling Occult Lung Adenocarcinoma: A Rituximab‐Responsive Case With Diagnostic and Therapeutic Implications Open
Paraneoplastic pemphigus (PNP) is a rare autoimmune disorder typically associated with hematologic or squamous cell malignancies. Its association with lung adenocarcinoma (LUAD) is exceptionally uncommon, with only sporadic cases reported.…
View article: Synergistic Catalysis: Sodium Perborate-Mediated Advanced Oxidation Processes Coupled with MIL-88B(Fe) for Photocatalytic Degradation of Methylene Blue
Synergistic Catalysis: Sodium Perborate-Mediated Advanced Oxidation Processes Coupled with MIL-88B(Fe) for Photocatalytic Degradation of Methylene Blue Open
Addressing the growing concerns of water pollution, requires the development of efficient advanced oxidation processes (AOPs). This study investigates a novel AOPs system that integrates the metal-organic framework MIL-88B(Fe) with sodium …
View article: Study on Motion Performance and Mooring Tension Response of 16 MW Tension Leg Platform Floating Wind Turbine Under Extreme Environmental Conditions
Study on Motion Performance and Mooring Tension Response of 16 MW Tension Leg Platform Floating Wind Turbine Under Extreme Environmental Conditions Open
This paper presents a 16 MW typhoon-resistant Tension Leg Platform floating offshore wind turbine (TLP FOWT) designed for the South China Sea. The survivability of the TLP FOWT under extreme environmental conditions is investigated through…
View article: Fluoride‐Engineered Electrolyte for Highly Stable and Efficient Alkaline Seawater Electrolysis at 2 A cm <sup>−2</sup>
Fluoride‐Engineered Electrolyte for Highly Stable and Efficient Alkaline Seawater Electrolysis at 2 A cm <sup>−2</sup> Open
Seawater electrolysis offers an energy‐efficient route for hydrogen production while alleviating freshwater scarcity. However, the presence of Cl − in seawater compromises anode activity and induces severe corrosion, requiring constructing…
View article: The prognostic value of POD24 for multiple myeloma: a comprehensive analysis based on traditional statistics and machine learning
The prognostic value of POD24 for multiple myeloma: a comprehensive analysis based on traditional statistics and machine learning Open
This study suggests that POD24 may be associated to the survival outcomes in multiple myeloma using both traditional statistical and machine learning approaches. Our findings highlight the potential value of POD24 in mortality risk predict…