Younan Xia
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View article: Silica Nanobottles Filled with Photo-cross-linked GelMA for the Sustained Release of Hydrophilic Biomacromolecules
Silica Nanobottles Filled with Photo-cross-linked GelMA for the Sustained Release of Hydrophilic Biomacromolecules Open
Nanobottles have garnered attention as a class of advanced carriers for drug delivery, because of their advantages, such as convenient loading, high capacity, and a well-defined wall for surface modification. However, strategies to achieve…
View article: Continuous and Scalable Production of Uniform Au Nanocrystals Capped by Citrate Species in Flow Reactors for Lateral Flow Tests
Continuous and Scalable Production of Uniform Au Nanocrystals Capped by Citrate Species in Flow Reactors for Lateral Flow Tests Open
Gold (Au) nanocrystals with uniform sizes and shapes are critical for enhancing the sensitivity and reliability of lateral flow tests (LFTs). Herein, a modular platform based on flow reactors for continuous and scalable production of unifo…
View article: Spatiotemporally controlled delivery of biological effectors from nanofiber scaffolds accelerates skin wound healing in porcine models
Spatiotemporally controlled delivery of biological effectors from nanofiber scaffolds accelerates skin wound healing in porcine models Open
Skin wound healing is a dynamic process, yet scaffolds enabling stage-specific modulation remain limited. We fabricated a nanofiber scaffold from FDA-approved materials, consisting of two outer layers of radially aligned and random poly(ε-…
View article: A-394 Scalable and continuous production of monodispersed gold nanospheres capped by citrate species for advanced lateral flow immunoassays
A-394 Scalable and continuous production of monodispersed gold nanospheres capped by citrate species for advanced lateral flow immunoassays Open
Background Lateral flow immunoassays (LFI) based on gold nanoparticles have emerged as a reliable tool for point-of-care applications. The conventional particles prepared using the Turkevich method are poorly defined in shape and size, mak…
View article: 33 Unresolved Questions in Nanoscience and Nanotechnology
33 Unresolved Questions in Nanoscience and Nanotechnology Open
Significant advances in science and engineering often emerge at the intersections of disciplines. Nanoscience and nanotechnology are inherently interdisciplinary, uniting researchers from chemistry, physics, biology, medicine, materials sc…
View article: Cu–Fe<sub>3</sub>O<sub>4</sub> Nanoclusters-Loaded HAMA Hydrogel Patches for Multifunctional Synergistic Wound Healing
Cu–Fe<sub>3</sub>O<sub>4</sub> Nanoclusters-Loaded HAMA Hydrogel Patches for Multifunctional Synergistic Wound Healing Open
Background: Skin wound healing is a common clinical challenge, facing multiple obstacles including delayed healing, local hypoxia, and bacterial infection, which may lead to prolonged nonhealing or wound infection. Traditional thera…
View article: Light-Driven Soft Actuators: Materials, Designs, and Applications
Light-Driven Soft Actuators: Materials, Designs, and Applications Open
Light-driven soft actuators have attracted extensive attention owning to their unique merits, including wireless remote actuation, precise spatiotemporal control, noncontact localized manipulation, as well as easily tunable properties. Thi…
View article: Microfluidic Synthesis of Channel‐Rich Pd‐Cu Alloy Nanodendrites for Efficient Electrocatalytic CO<sub>2</sub> Reduction to Formate
Microfluidic Synthesis of Channel‐Rich Pd‐Cu Alloy Nanodendrites for Efficient Electrocatalytic CO<sub>2</sub> Reduction to Formate Open
Palladium is a viable material for electrocatalytic CO 2 reduction to formate due to its high Faraday efficiencies (FEs) at relatively low potentials, but its durability is plagued by unavoidable surface CO poisoning. Herein, alloying and …
View article: Seeing Is Believing: How Does the Surface of Silver Nanocubes from a Polyol Synthesis Change during Sample Collection, Washing, and Redispersion
Seeing Is Believing: How Does the Surface of Silver Nanocubes from a Polyol Synthesis Change during Sample Collection, Washing, and Redispersion Open
While the synthesis of Ag nanocubes has been extensively studied, sample preparation (including collection, washing, and redispersion) after the synthesis has received far less attention. Herein, we leverage the unique capability of surfac…
View article: Biomimetic Scaffolds with Dual Gradients of Biological Effectors for Tendon‐to‐Bone Repair
Biomimetic Scaffolds with Dual Gradients of Biological Effectors for Tendon‐to‐Bone Repair Open
Due to the complexspatial gradients in composition and structure at the native tendon‐to‐bone attachment, it remains a clinical challenge to repair rotator cuff tears. Herein, we describe a biomimetic scaffold with dual gradients in osteog…
View article: What Makes Au Nanospheres Superior to Octahedral and Cubic Counterparts for the Deposition of a Pt Monolayer Shell?
What Makes Au Nanospheres Superior to Octahedral and Cubic Counterparts for the Deposition of a Pt Monolayer Shell? Open
This study demonstrates that Au nanospheres are advantageous over their octahedral and cubic counterparts as seeds in the synthesis of Au@Pt core-shell nanocrystals with a monolayer shell. In combination with experimental characterization,…
View article: Controllable fabrication of biocompatible microhelices based on the liquid rope coiling effect due to the phase viscosity difference
Controllable fabrication of biocompatible microhelices based on the liquid rope coiling effect due to the phase viscosity difference Open
View article: Steady-State Synthesis of Colloidal Metal Nanocrystals
Steady-State Synthesis of Colloidal Metal Nanocrystals Open
Despite remarkable progress, colloidal synthesis of metal nanocrystal is still far away from reaching the goal for robust, reproducible, and scalable production. Even with the adoption of seed-mediated growth, the synthesis can still be co…
View article: Understanding the Kinetic Aspects Responsible for the Formation of 3‐Aminophenol‐Formaldehyde Resin Beads with Different Morphologies
Understanding the Kinetic Aspects Responsible for the Formation of 3‐Aminophenol‐Formaldehyde Resin Beads with Different Morphologies Open
This work investigates the kinetics and mechanistic details involved in the synthesis of phenolic resin beads when formaldehyde is added in one‐shot or dropwise to react with an excess amount of 3‐aminophenol. In one‐shot synthesis, the sh…
View article: Seeing Is Believing: How Does the Surface of Silver Nanocubes Change during Their Growth in an Aqueous System
Seeing Is Believing: How Does the Surface of Silver Nanocubes Change during Their Growth in an Aqueous System Open
The seed-mediated growth involving cetyltrimethylammonium chloride (CTAC), silver trifluoroacetate (CF3COOAg), ascorbic acid (H2Asc), and Ag seeds covered by poly(vinylpyrrolidone) (PVP) in aqueous medium is a robust …
View article: Microenvironment-adaptive nanomedicine MXene promotes flap survival by inhibiting ROS cascade and endothelial pyroptosis
Microenvironment-adaptive nanomedicine MXene promotes flap survival by inhibiting ROS cascade and endothelial pyroptosis Open
In the field of large-area trauma flap transplantation, preventing avascular necrosis remains a critical challenge. Key mechanisms for improving flap viability include angiogenesis promotion, oxidative stress inhibition, and cell death pre…
View article: Multifunctional Janus Nanoparticles Capable of Anchoring to the Cell Membrane and Serving as “Cellular Backpacks” for Advanced Theranostics
Multifunctional Janus Nanoparticles Capable of Anchoring to the Cell Membrane and Serving as “Cellular Backpacks” for Advanced Theranostics Open
A cell-based theranostic system can be fabricated by attaching nanomedicines to the surface of carrier cells, but it remains a challenge to achieve the attachment without involving endocytosis. Herein, we address this challenge by developi…
View article: Rational Synthesis of Uniform Au Nanospheres under One-Shot Injection: From Mechanistic Understanding to Experimental Control
Rational Synthesis of Uniform Au Nanospheres under One-Shot Injection: From Mechanistic Understanding to Experimental Control Open
Gold nanospheres with uniform sizes greater than 30 nm are essential to quantitative lateral flow immunoassays for the rapid detection of pathogens such as viruses, bacteria, and fungi. However, scaling up their synthesis for commercial ap…
View article: Light‐Induced Welding of Electrospun Poly( <i>ε</i> ‐caprolactone) Nanofibers in a Nonwoven Mat by Leveraging the Photothermal Effect of Gold Nanocages
Light‐Induced Welding of Electrospun Poly( <i>ε</i> ‐caprolactone) Nanofibers in a Nonwoven Mat by Leveraging the Photothermal Effect of Gold Nanocages Open
Nonwoven mats of electrospun nanofibers are widely used in an array of applications, including those related to filtration, textiles, and tissue engineering. The performance of the mats is often plagued by their relatively weak mechanical …
View article: Synthesis of Ag@Pd Nanocubes and Pd‐based Nanoframes via One‐Shot Injection of a Halide‐Free Precursor for Continuous Production in a Flow Reactor
Synthesis of Ag@Pd Nanocubes and Pd‐based Nanoframes via One‐Shot Injection of a Halide‐Free Precursor for Continuous Production in a Flow Reactor Open
Noble‐metal open nanostructures have remarkable catalytic capabilities toward a wide range of reactions. In particular, Pd‐based open nanostructures have been synthesized and validated for superior catalytic performance toward formic acid …
View article: Noble-Metal Nanocrystals: From Synthesis to Biomedical Applications
Noble-Metal Nanocrystals: From Synthesis to Biomedical Applications Open
Perspective Noble-Metal Nanocrystals: From Synthesis to Biomedical Applications Yidan Chen 1, Emily Yan 2, and Younan Xia 2,* 1 School of Materials Science and Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA 2 Wallace …
View article: <i>In Vivo</i> Ultrasound and Photoacoustic Imaging of Nanoparticle-Engineered T Cells and Post-Treatment Assessment to Guide Adoptive Cell Immunotherapy
<i>In Vivo</i> Ultrasound and Photoacoustic Imaging of Nanoparticle-Engineered T Cells and Post-Treatment Assessment to Guide Adoptive Cell Immunotherapy Open
Despite great promise, adoptive cell therapy (ACT) continues to fail at treating a majority of cancers, especially solid tumors. To inform development and expedite the translation of more potent cellular immunotherapies, advanced immunoima…
View article: Continuous-Flow and Scalable Synthesis of Pd@Pt<sub>nL</sub> Core–Shell Nanocrystals with Enhanced Activity toward Oxygen Reduction
Continuous-Flow and Scalable Synthesis of Pd@Pt<sub>nL</sub> Core–Shell Nanocrystals with Enhanced Activity toward Oxygen Reduction Open
We report a scalable method based on continuous-flow reactors for conformally coating the surfaces of facet-controlled Pd nanocrystals with uniform, ultrathin shells made of Pt. The key to the success of such an approach is the identificat…
View article: Nanocarriers Made of Natural Fatty Acids: Modulation of Their Release Profiles through Photo‐Crosslinking
Nanocarriers Made of Natural Fatty Acids: Modulation of Their Release Profiles through Photo‐Crosslinking Open
Natural fatty acids are attractive carrier materials for drug delivery, but their rapid dissolution and degradation in vivo calls for new strategies to enhance their stability. Here we report a simple and versatile method capable of photo‐…
View article: Nanocarriers Made of Natural Fatty Acids: Modulation of Their Release Profiles through Photo‐Crosslinking
Nanocarriers Made of Natural Fatty Acids: Modulation of Their Release Profiles through Photo‐Crosslinking Open
Natural fatty acids are attractive carrier materials for drug delivery, but their rapid dissolution and degradation in vivo calls for new strategies to enhance their stability. Here we report a simple and versatile method capable of photo‐…
View article: Facile Synthesis of Rhodium‐Based Nanocrystals in a Metastable Phase and Evaluation of Their Thermal and Catalytic Properties
Facile Synthesis of Rhodium‐Based Nanocrystals in a Metastable Phase and Evaluation of Their Thermal and Catalytic Properties Open
Controlling the polymorphism of metal nanocrystals is a promising strategy for enhancing properties and discovering new phenomena. However, previous studies on Rh nanocrystals have focused on their thermodynamically stable face‐centered‐cu…
View article: A Novel Bi-Directional and Bi-Temporal Delivery System for Enhancing Intrasynovial Tendon Repair
A Novel Bi-Directional and Bi-Temporal Delivery System for Enhancing Intrasynovial Tendon Repair Open
Article A Novel Bi-Directional and Bi-Temporal Delivery System for Enhancing Intrasynovial Tendon Repair Yidan Chen 1,, Seth Kinoshita 2,, Emily Yan 3, Min Hao 3,, Hua Shen 4,, Richard Gelberman 4,, Stavros Thomopoulos 5,, and Younan Xia 2…
View article: Strain-Controlled Galvanic Synthesis of Platinum Icosahedral Nanoframes and Their Enhanced Catalytic Activity toward Oxygen Reduction
Strain-Controlled Galvanic Synthesis of Platinum Icosahedral Nanoframes and Their Enhanced Catalytic Activity toward Oxygen Reduction Open
The unique strain distribution on the surface of a Pd icosahedral nanocrystal is leveraged to control the sites for oxidation and reduction involved in the galvanic replacement reaction. Specifically, Pd is oxidized and dissolved from the …
View article: Rational Fabrication of Functionally-Graded Surfaces for Biological and Biomedical Applications
Rational Fabrication of Functionally-Graded Surfaces for Biological and Biomedical Applications Open
As a ubiquitous feature of the biological world, gradation, in either composition or structure, is essential to many functions and processes. Taking protein gradation as an example, it plays a pivotal role in the development and evolution …
View article: Reliable Fabrication of Mineral‐Graded Scaffolds by Spin‐Coating and Laser Machining for Use in Tendon‐to‐Bone Insertion Repair
Reliable Fabrication of Mineral‐Graded Scaffolds by Spin‐Coating and Laser Machining for Use in Tendon‐to‐Bone Insertion Repair Open
A reliable method for fabricating biomimetic scaffolds with a controllable mineral gradient to facilitate the surgical repair of tendon‐to‐bone injuries and the regeneration of the enthesis is reported. The gradient in mineral content is c…