Explanipedia

Human organoids reveal PTEN-driven mesendoderm specification via retinoic acid signaling suppression Open

Wuming Wang, Qiqi He, Hong Zhang, See-Wing Chan, Zhiqiang Xiong , et al. · 2025

During early embryogenesis, epiblast cells ingress through the primitive streak (PS) and commit to a mesendoderm (MES) fate, giving rise to both mesodermal and endodermal lineages. Despite advancements in human organoid technology for mode…

Operating a non-Hermitian atomic magnetometer with programmable digital electronics Open

Hui Jing, Tianyu Qian, Jipeng Xu, Ran Huang, Keyu Xia , et al. · 2025

Non-Hermitian systems with exceptional points (EPs) have attracted much attention for their potential to increase measurement sensitivity. However, EPs are difficult to generate and control accurately in most physical systems, as these sys…

Generation of a human induced pluripotent stem cell line (LZUSHi003-A) from peripheral mononuclear cells of a patient carrying the c.3682delG mutation in the dystrophin gene Open

Jie Shi, Yang Jiao, Huijun Gao, Lan Yang, Y. Zhang , et al. · 2025

Duchenne muscular dystrophy (DMD) is characterized by progressive muscle degeneration and is caused by mutations in the dystrophin gene. Here, we used Sendai virus to generate a human induced pluripotent stem cell line, LZUSHi003-A, from t…

Mechanistic insights into high-sugar stress promoted erythritol biosynthesis in Yarrowia lipolytica revealed using multi-omics analysis Open

Yupeng Nie, Xuebing Ren, Jiayuan Liang, Zhiqiang Xiong, Lianzhong Ai , et al. · 2025

Computational Fluid Dynamics Analysis of Draft Tube Flow Characteristics in a Kaplan Turbine Open

Qinwen Yan, Zhiqiang Xiong, Yuan Zheng, Cheng Feng, Zhenlin Li , et al. · 2025

This study presents a numerical investigation of the internal flow characteristics within the draft tube of a Kaplan turbine using computational fluid dynamics (CFD). The distribution and evolution of vortical structures, particularly the …

Al-induced trace B2 phase enhances strength-ductility synergy in Ti2Zr0.75NbVAlx high-entropy alloys through dislocation bundling Open

Lei Zhang, Xinlong Zhang, Zhiqiang Xiong, Zhiyu Feng, Chunyu Zhao · 2025

Proteomic Analysis of Bifidobacterium animalis AR668 and AR668-R1 Under Aerobic Culture Open

Yaping Liu, Xiaoxiao Zhao, Yang Miao, Xin Song, Guangqiang Wang , et al. · 2025

Bifidobacterium animalis is a widely used probiotic with significant health benefits, but its application is limited by oxygen sensitivity. Our laboratory previously developed an oxygen-tolerant B. animalis AR668-R1 using adaptive laborato…

On the sensitivity of different ensemble filters to the type of assimilated observation networks Open

Zhiqiang Xiong, Siming Liang, Feng Bao, Guannan Zhang, Hristo G. Chipilski · 2025

Recent advances in data assimilation (DA) have focused on developing more flexible approaches that can better accommodate nonlinearities in models and observations. However, it remains unclear how the performance of these advanced methods …

Costs and benefits of temporal expectations on somatosensory perception and decision-making Open

Zhiqiang Xiong, Xavier Job, Konstantina Kilteni · 2025

Our perception is shaped by prior expectations, including those about the timing of our sensations. These temporal expectations can be formed by recognizing patterns in the onset of sensory inputs. However, in the somatosensory domain, it …

STModule: identifying tissue modules to uncover spatial components and characteristics of transcriptomic landscapes Open

Ran Wang, Qian Yan, Xiaojing Guo, Fangda Song, Zhiqiang Xiong , et al. · 2025

Here we present STModule, a Bayesian method developed to identify tissue modules from spatially resolved transcriptomics that reveal spatial components and essential characteristics of tissues. STModule uncovers diverse expression signals …

Engineering UDP‐sugar synthesis pathways for exopolysaccharide biosynthesis in Streptococcus thermophilusAR333 Open

Yizhou Fan, Jin‐Song Shi, Xin Song, Guangqiang Wang, Yongjun Xia , et al. · 2025

BACKGROUND Exopolysaccharide (EPS) produced by Streptococcus thermophilus can significantly improve the viscosity, texture and taste of dairy products, which have broad application potential in the food industry. However, EPS production is…

Research Progress on Biosynthesis and Regulation of Conjugated Linoleic Acid in Lactic Acid Bacteria Open

Xinxin Liu, Selar Izzat, Guangqiang Wang, Zhiqiang Xiong, Lianzhong Ai · 2025

Conjugated linoleic acid (CLA) has gained considerable attention and has been extensively studied owing to its physiological functions, including weight loss, immune regulation, and anti‐carcinogenesis. However, the CLA content is very low…

The bsh1 gene of Lactobacillus plantarum AR113 ameliorates liver injury in colitis mice Open

Junlin Shao, Yongjun Xia, Guangqiang Wang, Zhiqiang Xiong, Yijin Yang , et al. · 2025

Mechanistic evaluation of enhanced graphene toxicity to Bacillus induced by humic acid adsorption Open

Xuejiao Zhang, Jin Zeng, Jason C. White, Fangbai Li, Zhiqiang Xiong , et al. · 2025

The extensive application of graphene nanosheets (GNSs) has raised concerns over risks to sensitive species in the aquatic environment. The humic acid (HA) corona is traditionally considered to reduce GNSs toxicity. Here, we evaluate the e…

Development and Optimization of a High-Efficiency Conjugation System for CRISPR-Cas9 Genome Editing in Diverse Lactobacillus Species Open

Ziwei Li, Yongjun Xia, Fan Xie, Guangqiang Wang, Zhiqiang Xiong , et al. · 2025

Identification and Characterization of Oxygen- and Bile Salt-Inducible Promoters in Lactiplantibacillus Plantarum Ar113 for Probiotic Applications Open

Xin Feng, Guangqiang Wang, Yunhui Chen, Zhiqiang Xiong, Yongjun Xia , et al. · 2025

Effects of Lactiplantibacillus Plantarum Fermentation on Sensory and in Vitro Antioxidant Properties of Ginger Open

Hui Dou, Guangqiang Wang, Le Chu, Guangpeng Liu, Fatao He , et al. · 2025

Effects of Lactiplantibacillus plantarum fermentation on sensory and in vitro antioxidant properties of ginger Open

Lianzhong Ai, Hui Dou, Guangqiang Wang, Le Chu, Guangpeng Liu , et al. · 2025

Analysis of the New Era Internet Fengqiao Model Leading Public Opinion Management Pathways Open

Zhiqiang Xiong, Mingwei Li · 2025

New Insights on the Synergistic Regulation Mechanism of Strengthening and Corrosion Resistance in Al-Zn-Mg-Sc Alloys Aging Treatment Open

Jian-Ping Xie, Pei Liu, Yuhang Zhang, Zhiqiang Xiong, J Chen · 2025

Lactobacillus plantarum AR1074 alleviates rheumatoid arthritis by remodeling gut microbes and reducing inflammatory response Open

Junlin Shao, Xiao Jia, K. Chen, Guangqiang Wang, Zhiqiang Xiong , et al. · 2025

Potential Lactiplantibacillus Plantarum Ar342 Improves Hyperuricemia in Mice by Inhibiting Xanthine Oxidase Activity Open

Mingyue Xu, Yi Zhou, Zhuoming Tan, Guangqiang Wang, Xin Song , et al. · 2025

Chemical components, molecular characterization and rheological properties of exopolysaccharides produced by Streptococcus thermophilus strains Open

Caiqing Nie, Zhiqiang Xiong, Hui Zhang, Fan Xie, Xin Song , et al. · 2024

Oxygen tolerance mechanism of Bifidobacterium animalis AR668-R1 based on genomic and phenotypic analyses Open

Di Zhang, Yang Miao, Xin Song, Yongjun Xia, Lianzhong Ai , et al. · 2024

OmniEdit: Building Image Editing Generalist Models Through Specialist Supervision Open

Cong Wei, Zhiqiang Xiong, Weiming Ren, Xinrun Du, Ge ZHANG , et al. · 2024

Instruction-guided image editing methods have demonstrated significant potential by training diffusion models on automatically synthesized or manually annotated image editing pairs. However, these methods remain far from practical, real-li…

Unraveling the mechanism of Ligilactobacillus salivariusAR612 in response to glucose stress from the insights of genome and transcriptome analysis Open

Yong Yang, Xin Song, Guangqiang Wang, Yongjun Xia, Zhiqiang Xiong , et al. · 2024

Enhanced Electromagnetic Energy Conversion in an Entropy‐driven Dual‐magnetic System for Superior Electromagnetic Wave Absorption Open

Ruizhe Hu, Jianguo Luo, Hui‐Liang Wen, Chongbo Liu, Jinbin Peng , et al. · 2024

Thermochemical conversion is a highly effective method for upgrading organic solid wastes into high‐value materials, contributing to carbon neutrality and peak, carbon emission goals. It also serves as a pathway to develop energy‐efficient…

Evaluation of Functional Components of Lactobacillus plantarum AR495 on Ovariectomy-Induced Osteoporosis in Mice And RAW264.7 Cells Open

Zheng Chen, Junlin Shao, Yijin Yang, Guangqiang Wang, Zhiqiang Xiong , et al. · 2024

Osteoporosis is a disease characterized by abnormal bone metabolism, where bone resorption outpaces bone formation. In this study, we investigated the key functional components of Lactobacillus plantarum AR495 in mitigating ovariectomy (OV…

Black phosphorus nanosheets induce autophagy dysfunction by a size- and surface modification-related impairment of lysosomes in macrophages Open

Shuo Deng, Qing Zhao, Daxu Liu, Zhiqiang Xiong, Siyu Zhang , et al. · 2024

The widespread application of black phosphorus nanosheets (BPNSs) raises concerns about their potential impact on human health. Although that the autophagy-inducing properties of BPNSs in cancer cells are documented, their effects on macro…

Single Atom Engineered Antibiotics Overcome Bacterial Resistance Open

David Panáček, Jan Belza, Lucie Hochvaldová, Zdeňěk Baďura, Giorgio Zoppellaro , et al. · 2024

The outbreak of antibiotic‐resistant bacteria, or “superbugs”, poses a global public health hazard due to their resilience against the most effective last‐line antibiotics. Identifying potent antibacterial agents capable of evading bacteri…

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