Explanipedia

Molecular and microbial remolding in response to stressed vestibular system at sea Open

Panpan Wang, Hang Zhong, Feixiang He, Zhiyan Zhang, Ting Zhang , et al. · 2025

Implementation of an Australian helpline for low back pain: protocol of a type 2 hybrid effectiveness-implementation trial Open

Katharine E. Roberts, Christopher G. Maher, Melissa Baysari, J. Thompson, Rosemary Calder , et al. · 2025

Introduction Low back pain (LBP) is the leading contributor to disability globally. It has a substantial impact on the lives of those who experience it, and places considerable economic burden on healthcare systems. Despite these impacts, …

Prenatal greenness exposure and the decreased risk of low birthweight and small for gestational age: modification and mediation effects of air pollution Open

Da Zhan, Boning Deng, Qiang Li, Fatemeh Mayvaneh, Yunquan Zhang · 2025

Analysis and Algorithm for Multi IRS Collaborative Localization via Hybrid Time Angle Estimation Open

Ziheng Zhang, Wen Chen, Qingqing Wu, Haoran Qin, Qiang Li , et al. · 2025

This paper proposes a novel multiple intelligent reflecting surfaces (IRSs) collaborative hybrid localization system, which involves deploying multiple IRSs near the target area and achieving target localization through joint time delay an…

Mycoplasma Pneumoniae bronchiolitis and hypoxemia: A retrospective cohort study on risk and prognosis Open

Yu Chen, Chenxi Lin, Rui Huang, Qi Chen, M. Zhang , et al. · 2025

Objective Mycoplasma pneumoniae (MP) bronchiolitis can potentially lead to severe respiratory symptoms and long-term complications. This study aimed to determine the risk factors for the development of hypoxemia in MP bronchiolitis and rep…

Balanced Electrolyte solution versus Saline Trial for Diabetic KetoAcidosis-Statistical Analysis Plan Open

Anthony Devaux, Qiang Li, Laurent Billot, Balasubramanian Venkatesh, Mahesh Ramanan · 2025

Introduction Fluid therapy is a cornerstone of acute management of diabetic ketoacidosis (DKA), yet the optimal fluid type is unknown. The Balanced Electrolyte Solution versus Saline Trial for Diabetic Ketoacidosis (BEST-DKA) trial has bee…

Pathophysiological Mechanisms of Chronic Subdural Hematoma: Insights from Histopathological, Immunological, and Imaging Analyses Pathophysiological Mechanisms of CSDH Open

Renkun Zhang, Qiuyu Lu, Yuhao Tan, Yu Zhou, Zifu Li , et al. · 2025

Objective To further explore the pathophysiological mechanisms of the chronic subdural hematoma (CSDH) through the simultaneous histopathological, immunological, embolic-agent-detecting, and imaging analyses of the dura and the outer membr…

Mycorrhizal Type and Soil Nitrogen Content Coregulate Foliar Nutrient Responses to Neighborhood Functional Dissimilarity in Subtropical Forests Open

Xue Zhao, Zhihong Xu, Fulin Chen, Tao Wang, Qiang Li , et al. · 2025

Foliar nitrogen (N) and phosphorus (P) concentrations are of critical importance to plant productivity. Despite global declines in plant diversity, their effects on tree foliar N and P dynamics remain uncertain, especially under different …

Changes in frailty, intensive blood pressure treatment, and risks of adverse clinical outcomes: a post hoc analysis of the SPRINT trial Open

Xiaoyun Zhang, Meng Xi, Siyu Wang, Qiang Li, Yueyue Wang , et al. · 2025

Preliminary Study on Phonation Reconstruction Using Free Anterolateral Thigh and Sternohyoid Myocutaneous Flaps After Total Laryngectomy Open

Hongming Wei, Jian Li, Huilei Dong, Xinjian Yang, Xiaofei Li , et al. · 2025

Objective In this study, we evaluated and compared the outcomes of phonation reconstruction using free anterolateral thigh (ALT) and sternohyoid myocutaneous flaps in patients undergoing total laryngectomy for locally advanced laryngeal an…

Enhancing emergency medical service diversion decision-making through integrating large language models Open

Z. Shen, Yu Tian, Qiang Li, Dubai Li, Yinghao Zhao , et al. · 2025

Phenotyping obesity through a two-dimensional tree structure reveals cardiometabolic heterogeneity Open

Xiaojing Jia, Hong Lin, Yilan Ding, Chunyan Hu, Shuangyuan Wang , et al. · 2025

Obesity, a major public health challenge, is characterized by substantial phenotypic heterogeneity. Here, we employ the discriminative dimensionality reduction tree (DDRTree) method to routine clinical data from 18,733 Chinese individuals …

The diagnostic value of 18 F-FAPI-04 PET/CT in unresectable hepatocellular carcinoma: a head-to-head comparison with 18 F-FDG PET/CT Open

Huanyu Gong, Yong Cheng, Qiang Li, Yong He, Qijun Cai , et al. · 2025

Exploring the Influence of Loneliness on Cognitive Decline: Differential Effects in Black and White Older Adults Open

Qiang Li, Mahsa Dadar, Michael Oliver, Lisa L. Barnes, Cassandra Morrison · 2025

Objectives Loneliness is prevalent among older adults, who may experience age-related or pathological cognitive changes. However, there’s a limited understanding of how loneliness affects cognitive decline and if the relationship differs b…

Outcome prediction model for patients with unresectable hepatocellular carcinoma treated with targeted therapy Open

Qiang Ruan, Xiaohui Wang, Qiang Li, Tao Yu, Xun Yang , et al. · 2025

There is no well-established model to predict the outcomes of patients with unresectable hepatocellular carcinoma (u-HCC) receiving targeted therapy. The goal of this study was to develop and validate a prediction model that accurately pre…

Disrupted Alternative Splicing of <span>RAB11FIP3</span> Contributes to Diabetic Foot Ulcer Dysfunction Open

Dong Zhu, Feifei Chen, X. Li, Qianqian Ning, Jian Wang , et al. · 2025

Dysregulation of alternative splicing (AS) has been associated with various complications of diabetes, yet its role in the pathogenesis of diabetic foot ulcers (DFUs) and its involvement in metabolic memory (MM) remain unclear. In this stu…

De novo designed protein guiding targeted protein degradation Open

Qiang Li, Gan Qiao, Xianghe Wang, Ming Wang, Jinyu Cheng , et al. · 2025

Sex-specific hemoglobin thresholds and longitudinal trajectories in intracerebral hemorrhage outcomes: a multicenter cohort study Open

Yujia Jin, Guoying Karen Yu, Lili Tang, Jiawen Li, Qiang Li , et al. · 2025

Clinical trials NCT06548737 (retrospectively registered).

Construction and Optimization of shRNA/siRNA Lentivral Vectors for microRNA-486-5p Using miR-30/451 and miRNA Sponges Open

Wenlun Wang, Feng Zhang, Min Lu, Xiaomin Wu, Ze Yu , et al. · 2025

Elucidating the heterogeneity of prediabetes through subphenotyping with a two-dimensional tree structure Open

Hong Lin, Yilan Ding, Xiaojing Jia, Xuejiang Gu, Shuangyuan Wang , et al. · 2025

Research on optimizing the networking mode of low-voltage distribution network in Internet of Things system based on improved ACO Open

Long Xu, Xiao Liu, Jie Han, Qiang Li, Y. Celia Huang , et al. · 2025

Optimizing the stability and transmission efficiency of low-voltage distribution networks remains a critical challenge in smart grid systems. This study proposes an AI-enhanced optimization framework that integrates an improved Ant Colony …

Retraction notice to "Effect of Pleurotus eryngii mycelial fermentation on the composition and antioxidant properties of tartary buckwheat" [Heliyon 10 (2024) e25980] Open

Lijiao Li, Xiaonian Cao, Jingwei Huang, Ting Zhang, Qian Wu , et al. · 2025

Comparative interpretation of elbow and hip dislocation mechanisms using the “Hand-as-Foot” teaching method Open

Yaxing Zhang, Qiang Li, Yafei Xu, Rui Liu · 2025

The role of disulfidptosis-related genes in the clinical prognosis and immune status of hepatocellular carcinoma Open

Qiang Li, Yang Li, Jiaqian Mo, Xin Xie, Mo‐Xian Chen , et al. · 2025

Drug resistance and poor prognosis in hepatocellular carcinoma (HCC) underscore the urgent need for novel treatments. Disulfidptosis, a recently identified form of metabolism-related regulated cell death, plays a complex role in anti-tumor…

Endothelial SIRT3 deficiency predisposes brown adipose tissue to whitening in diet-induced obesity Open

Qing Zhou, Zongshi Lu, Bowen Wang, Mengling Liu, Li Li , et al. · 2025

Endothelial dysfunction and vascular rarefaction are supposed to be secondary to metabolic diseases, while recent evidence has revealed the primary roles of endothelium in initiating and accelerating metabolic disorders. Here, the effects …

Donafenib and sintilimab combined with hepatic arterial infusion chemotherapy for unresectable hepatocellular carcinoma: a prospective, single-arm phase II trial (DoHAICs study) Open

Wei Gao, Zhao-Long Pan, Zhao Xiao-hui, Lu Yang, Junbo Cao , et al. · 2025

Tianjin Key Medical Discipline (Specialty) Construction Project (TJYXZDXK-009A) and Precision Treatment Project of Surgical Oncology of Tianjin Medical University Cancer Institute and Hospital (No. ZLWKJZZL14).

Efficacy and safety of TACE combined with TKIs and PD-1 inhibitors in HCC patients with prior TIPS Open

Kai Xiong, Kuiyuan Huang, Yulong Liu, Huajin Pang, Gengwei Huo , et al. · 2025

Purpose To compare the efficacy and safety of TACE combined with TKIs and PD-1 inhibitors between HCC patients with and without prior TIPS Methods This retrospective propensity score matching (PSM) study included advanced HCC patients trea…

Outcome prediction model for patients with unresectable hepatocellular carcinoma treated with targeted therapy Open

Qiang Ruan, Xiaohui Wang, Qiang Li, Tao Yu, Xun Yang , et al. · 2025

There is no well-established model to predict the outcomes of patients with unresectable hepatocellular carcinoma (u-HCC) receiving targeted therapy. The goal of this study was to develop and validate a prediction model that accurately pre…

Malakoplakia of the testis and epididymis: A case report and literature review Open

Ran Zheng, Qiang Li, Dan Yang, Fang Nie · 2025

Association between hyperlipidemia and postoperative delirium risk: a systematic review and meta-analysis Open

Li-quan Qiu, Jian-li Song, Licai Zhang, Bin Fan, Qiang Li , et al. · 2025

Introduction The association between hyperlipidemia and its potential role as a risk factor for postoperative delirium (POD) remains unclear. Methods We systematically searched PubMed, Embase, Web of Science, Cochrane Library, and Clinical…

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