Qiangge Zhang
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View article: A cross-species spatial transcriptomic atlas of the human and non-human primate basal ganglia
A cross-species spatial transcriptomic atlas of the human and non-human primate basal ganglia Open
The basal ganglia are interconnected subcortical nuclei with complex topographical organization that orchestrate goal-directed behaviors and are implicated in neurodegenerative movement disorders. We generated a cellular-resolution, spatia…
View article: A partially automated method for DNA extraction from marmoset hair follicles to avoid blood chimerism
A partially automated method for DNA extraction from marmoset hair follicles to avoid blood chimerism Open
Marmosets are valuable non-human primate models, however their unique reproduction results in high levels of blood chimerism, making blood unreliable for DNA sequencing. Hair follicles have lower levels of chimerism however DNA extraction …
View article: Astrocyte regional specialization is shaped by postnatal development
Astrocyte regional specialization is shaped by postnatal development Open
Astrocytes are an abundant class of glial cells with critical roles in neural circuit assembly and function. Though many studies have uncovered significant molecular distinctions between astrocytes from different brain regions, how this re…
View article: Integrated platform for multiscale molecular imaging and phenotyping of the human brain
Integrated platform for multiscale molecular imaging and phenotyping of the human brain Open
Understanding cellular architectures and their connectivity is essential for interrogating system function and dysfunction. However, we lack technologies for mapping the multiscale details of individual cells and their connectivity in the …
View article: Evolutionary and developmental specialization of foveal cell types in the marmoset
Evolutionary and developmental specialization of foveal cell types in the marmoset Open
In primates, high-acuity vision is mediated by the fovea, a small specialized central region of the retina. The fovea, unique to the anthropoid lineage among mammals, undergoes notable neuronal morphological changes during postnatal matura…
View article: Sibling chimerism among microglia in marmosets
Sibling chimerism among microglia in marmosets Open
Chimerism happens rarely among most mammals but is common in marmosets and tamarins, a result of fraternal twin or triplet birth patterns in which in utero connected circulatory systems (through which stem cells transit) lead to persistent…
View article: Sibling chimerism among microglia in marmosets
Sibling chimerism among microglia in marmosets Open
Chimerism happens rarely among most mammals but is common in marmosets and tamarins, a result of fraternal twin or triplet birth patterns in which in utero connected circulatory systems (through which stem cells transit) lead to persistent…
View article: Author Correction: Conserved and divergent gene regulatory programs of the mammalian neocortex
Author Correction: Conserved and divergent gene regulatory programs of the mammalian neocortex Open
In the version of the article initially published, in Figs.2c andd and5e, numbers in labels had been rounded.These have been corrected to exact numbers.In Fig. 2c andd, the labels now read "Mammal level 3 (16,068)", "Human biased ↑ (10,743…
View article: Astrocyte Regional Specialization is Shaped by Postnatal Development
Astrocyte Regional Specialization is Shaped by Postnatal Development Open
View article: Conserved and divergent gene regulatory programs of the mammalian neocortex
Conserved and divergent gene regulatory programs of the mammalian neocortex Open
View article: Evolutionary and Developmental Specialization of Foveal Cell Types in the Marmoset
Evolutionary and Developmental Specialization of Foveal Cell Types in the Marmoset Open
In primates, high-acuity vision is mediated by the fovea, a small specialized central region of the retina. The fovea, unique to the anthropoid lineage among mammals, undergoes notable neuronal morphological changes during postnatal matura…
View article: Pathway-specific alterations in striatal excitability and cholinergic modulation in a SAPAP3 mouse model of compulsive motor behavior
Pathway-specific alterations in striatal excitability and cholinergic modulation in a SAPAP3 mouse model of compulsive motor behavior Open
Deletion of the obsessive-compulsive disorder (OCD)-associated gene SAP90/PSD-95-associated protein 3 (Sapap3), which encodes a postsynaptic anchoring protein at corticostriatal synapses, causes OCD-like motor behaviors in mice. While cort…
View article: Sibling chimerism among microglia in marmosets
Sibling chimerism among microglia in marmosets Open
Chimerism happens rarely among most mammals but is common in marmosets and tamarins, a result of fraternal twin or triplet birth patterns in which in utero connected circulatory systems (through which stem cells transit) lead to persistent…
View article: A marmoset brain cell census reveals regional specialization of cellular identities
A marmoset brain cell census reveals regional specialization of cellular identities Open
The mammalian brain is composed of many brain structures, each with its own ontogenetic and developmental history. We used single-nucleus RNA sequencing to sample over 2.4 million brain cells across 18 locations in the common marmoset, a N…
View article: Mitigating autocorrelation during spatially resolved transcriptomics data analysis
Mitigating autocorrelation during spatially resolved transcriptomics data analysis Open
Several computational methods have recently been developed for characterizing molecular tissue regions in spatially resolved transcriptomics (SRT) data. However, each method fundamentally relies on spatially smoothing transcriptomic featur…
View article: Mitigating autocorrelation during spatially resolved transcriptomics data analysis
Mitigating autocorrelation during spatially resolved transcriptomics data analysis Open
Here we include the marmoset brain and mouse gut STARmap data introduced in the corresponding manuscript, "Mitigating autocorrelation during spatially resolved transcriptomics data analysis". We also include the mouse brain STARmap PLUS da…
View article: Mitigating autocorrelation during spatially resolved transcriptomics data analysis
Mitigating autocorrelation during spatially resolved transcriptomics data analysis Open
Here we include the marmoset brain STARmap data introduced in the corresponding manuscript, "Mitigating autocorrelation during spatially resolved transcriptomics data analysis". We also include the mouse brain STARmap PLUS data that was us…
View article: Comparative single cell epigenomic analysis of gene regulatory programs in the rodent and primate neocortex
Comparative single cell epigenomic analysis of gene regulatory programs in the rodent and primate neocortex Open
Sequence divergence of cis- regulatory elements drives species-specific traits, but how this manifests in the evolution of the neocortex at the molecular and cellular level remains to be elucidated. We investigated the gene regulatory prog…
View article: A marmoset brain cell census reveals influence of developmental origin and functional class on neuronal identity
A marmoset brain cell census reveals influence of developmental origin and functional class on neuronal identity Open
The mammalian brain is composed of many brain structures, each with its own ontogenetic and developmental history. Transcriptionally-based cell type taxonomies reveal cell type composition and similarity relationships within and across bra…
View article: 341 Repeats Is Not Enough for Methylation in a New Fragile X Mouse Model
341 Repeats Is Not Enough for Methylation in a New Fragile X Mouse Model Open
Fragile X syndrome (FXS) is a leading monogenic cause of intellectual disability and autism spectrum disorders, spurring decades of intense research and a multitude of mouse models. So far, these models do not recapitulate the genetic unde…
View article: Publisher Correction: Viral manipulation of functionally distinct interneurons in mice, non-human primates and humans
Publisher Correction: Viral manipulation of functionally distinct interneurons in mice, non-human primates and humans Open
View article: Brain-specific deletion of GIT1 impairs cognition and alters phosphorylation of synaptic protein networks implicated in schizophrenia susceptibility
Brain-specific deletion of GIT1 impairs cognition and alters phosphorylation of synaptic protein networks implicated in schizophrenia susceptibility Open
View article: Integrated platform for multi-scale molecular imaging and phenotyping of the human brain
Integrated platform for multi-scale molecular imaging and phenotyping of the human brain Open
Understanding cellular architectures and their connectivity is essential for interrogating system function and dysfunction. However, we lack technologies for mapping the multi-scale details of individual cells in the human organ-scale syst…
View article: Non-synaptic alterations in striatal excitability and cholinergic modulation in a SAPAP3 mouse model of compulsive motor behavior
Non-synaptic alterations in striatal excitability and cholinergic modulation in a SAPAP3 mouse model of compulsive motor behavior Open
Summary Deletion of the OCD-associated gene SAP90/PSD-95-associated protein 3 ( Sapap3 ), which encodes a postsynaptic anchoring protein at corticostriatal synapses, causes OCD-like motor behaviors in mice. While corticostriatal synaptic d…
View article: AAV capsid variants with brain-wide transgene expression and decreased liver targeting after intravenous delivery in mouse and marmoset
AAV capsid variants with brain-wide transgene expression and decreased liver targeting after intravenous delivery in mouse and marmoset Open
View article: Epitope-preserving magnified analysis of proteome (eMAP)
Epitope-preserving magnified analysis of proteome (eMAP) Open
eMAP preserves epitopes by purely physical tissue-hydrogel hybridization in swellable tissue-gel networks.
View article: Efficient embryonic homozygous gene conversion via RAD51-enhanced interhomolog repair
Efficient embryonic homozygous gene conversion via RAD51-enhanced interhomolog repair Open
View article: Author Correction: Innovations present in the primate interneuron repertoire
Author Correction: Innovations present in the primate interneuron repertoire Open
View article: Innovations present in the primate interneuron repertoire
Innovations present in the primate interneuron repertoire Open
View article: Viral manipulation of functionally distinct interneurons in mice, non-human primates and humans
Viral manipulation of functionally distinct interneurons in mice, non-human primates and humans Open