Qing-Tao Shen
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View article: PT109B, a Multikinase Inhibitor, Converts Astrocytes into Dopaminergic Neurons and Alleviates Parkinson's Disease in Mice
PT109B, a Multikinase Inhibitor, Converts Astrocytes into Dopaminergic Neurons and Alleviates Parkinson's Disease in Mice Open
Background Parkinson’s disease (PD) is characterized by the progressive loss of dopaminergic neurons (DANs), leading to motor dysfunction, while current treatments fail to restore neuronal loss. Reprogramming astrocytes into induced DANs b…
View article: Investigation of Rare-Earth Ion-Photon Interaction and Strong Coupling in Optical Microcavities
Investigation of Rare-Earth Ion-Photon Interaction and Strong Coupling in Optical Microcavities Open
The strong coupling between an emitter and a cavity is significant for advancing quantum networks. Due to their long optical and spin coherence times, rare-earth ions (REIs) represent a compelling platform for quantum networks. However, th…
View article: Coherence Properties of Rare-Earth Spins in Micrometer-Thin Films
Coherence Properties of Rare-Earth Spins in Micrometer-Thin Films Open
Rare-earth ions in bulk crystals are excellent solid-state quantum systems in quantum information science, owing to the exceptional optical and spin coherence properties. However, the weak fluorescence of single rare-earth ions present a s…
View article: Three-dimensional architecture of ESCRT-III flat spirals on the membrane
Three-dimensional architecture of ESCRT-III flat spirals on the membrane Open
The endosomal sorting complexes required for transport (ESCRTs) are responsible for membrane remodeling in many cellular processes, such as multivesicular body biogenesis, viral budding, and cytokinetic abscission. ESCRT-III, the most abun…
View article: Dysregulated inter-mitochondrial crosstalk in glioblastoma cells revealed by in situ cryo-electron tomography
Dysregulated inter-mitochondrial crosstalk in glioblastoma cells revealed by in situ cryo-electron tomography Open
Glioblastomas (GBMs) are the most lethal primary brain tumors with limited survival, even under aggressive treatments. The current therapeutics for GBMs are flawed due to the failure to accurately discriminate between normal proliferating …
View article: Microsporidia dressing up: the spore polaroplast transport through the polar tube and transformation into the sporoplasm membrane
Microsporidia dressing up: the spore polaroplast transport through the polar tube and transformation into the sporoplasm membrane Open
Microsporidia, which are obligate intracellular pathogenic organisms, cause huge economic losses in agriculture and even threaten human health. The key to successful infection by the microsporidia is their unique invasion apparatus which i…
View article: Harvesting Inertial Energy and Powering Wearable Devices: A Review
Harvesting Inertial Energy and Powering Wearable Devices: A Review Open
Amidst the swift progression of microelectronics and Internet of Things technology, wearable devices are gradually gaining ground in the domains of human health monitoring. Recently, human bioenergy harvesting has emerged as a plausible al…
View article: Microsporidia dressing up: the spore polaroplast transport through the polar tube and transformation into the sporoplasm membrane
Microsporidia dressing up: the spore polaroplast transport through the polar tube and transformation into the sporoplasm membrane Open
Microsporidia are obligate intracellular parasites that infect a wide variety of hosts, including humans. Microsporidian spores possess a unique, highly specialized invasion apparatus involving the polar filament, polaroplast and posterior…
View article: Ring-stacked capsids of white spot syndrome virus and structural transitions with genome ejection
Ring-stacked capsids of white spot syndrome virus and structural transitions with genome ejection Open
White spot syndrome virus (WSSV) is one of the largest DNA viruses and the major pathogen responsible for white spot syndrome in crustaceans. The WSSV capsid is critical for genome encapsulation and ejection and exhibits the rod-shaped and…
View article: A prospective cohort study of cigarette smoking, alcohol drinking and liver cancer incidence in Chinese men
A prospective cohort study of cigarette smoking, alcohol drinking and liver cancer incidence in Chinese men Open
Objectives Population‐based prospective studies on the associations of cigarette smoking, alcohol drinking, and primary liver cancer remain limited in Mainland China. Our study was designed to evaluate such relationships in middle‐aged Chi…
View article: Annealing synchronizes the 70 <i>S</i> ribosome into a minimum-energy conformation
Annealing synchronizes the 70 <i>S</i> ribosome into a minimum-energy conformation Open
Significance In metallurgy, annealing heats a metal or alloy to a predetermined temperature, holds this temperature for a certain time, and then decreases the metal to room temperature to change the physical and sometimes also the chemical…
View article: Insights into Paramyxovirus Nucleocapsids from Diverse Assemblies
Insights into Paramyxovirus Nucleocapsids from Diverse Assemblies Open
All paramyxoviruses, which include the mumps virus, measles virus, Nipah virus, Newcastle disease virus, and Sendai virus, have non-segmented single-stranded negative-sense RNA genomes. These RNA genomes are enwrapped throughout the viral …
View article: Structural plasticity of mumps virus nucleocapsids with cryo-EM structures
Structural plasticity of mumps virus nucleocapsids with cryo-EM structures Open
Mumps virus (MuV) is a highly contagious human pathogen and frequently causes worldwide outbreaks despite available vaccines. Similar to other mononegaviruses such as Ebola and rabies, MuV uses a single-stranded negative-sense RNA as its g…
View article: Annealing synchronizes the 70<i>S</i> ribosome into a minimum-energy conformation
Annealing synchronizes the 70<i>S</i> ribosome into a minimum-energy conformation Open
Researchers commonly anneal metals, alloys, and semiconductors to repair defects and improve microstructures via recrystallization. Theoretical studies indicate simulated annealing on biological macromolecules helps predict the final struc…
View article: Characterization of a New M4 Metalloprotease With Collagen-Swelling Ability From Marine Vibrio pomeroyi Strain 12613
Characterization of a New M4 Metalloprotease With Collagen-Swelling Ability From Marine Vibrio pomeroyi Strain 12613 Open
The ocean harbors a variety of bacteria that contain huge protease resources and offer a great potential for industrial and biotechnological applications. Here, we isolated a protease-secreting bacterium Vibrio pomeroyi strain 12613 from A…
View article: Self-capping of nucleoprotein filaments protects the Newcastle disease virus genome
Self-capping of nucleoprotein filaments protects the Newcastle disease virus genome Open
Non-segmented negative-strand RNA viruses, such as measles, ebola and Newcastle disease viruses (NDV), encapsidate viral genomic RNAs into helical nucleocapsids, which serve as the template for viral replication and transcription. Here, th…