Explanipedia

Improved Identification of Tumor-Specific TCRs from Circulating Lymphocytes Using Autologous Colorectal Tumor Organoids Open

Yun Bai, Lisha Ma, Xiya Wang, Qianjing Zhang, Zhaoya Gao , et al. · 2025

Identification and validation of tumor-specific T cell receptors from tumor infiltrating lymphocytes using tumor organoid co-cultures Open

Zhilang Li, Lisha Ma, Zhaoya Gao, Xiya Wang, Xuan Che , et al. · 2024

T cell receptor-engineered T cells (TCR-Ts) therapy is promising for cancer immunotherapy. Most studies have focused on identifying tumor-specific T cell receptors (TCRs) through predicted tumor neoantigens. However, current algorithms for…

Identification and validation of tumor-specific T cell receptors from tumor infiltrating lymphocytes using tumor organoid co-cultures Open

Zhilang Li, Lisha Ma, Zhaoya Gao, Xiya Wang, Xuan Che , et al. · 2024

T cell receptor-engineered T cells (TCR-Ts) therapy is promising for cancer immunotherapy. Most studies have focused on identifying tumor-specific T cell receptors (TCRs) through predicted tumor neoantigens. However, current prediction alg…

Ray Denoising: Depth-aware Hard Negative Sampling for Multi-view 3D Object Detection Open

Feng Liu, Tengteng Huang, Qianjing Zhang, Haotian Yao, Chi Zhang , et al. · 2024

Multi-view 3D object detection systems often struggle with generating precise predictions due to the challenges in estimating depth from images, increasing redundant and incorrect detections. Our paper presents Ray Denoising, an innovative…

Elastic Local Buckling and Width-to-Thickness Limits of I-Beams Incorporating Flange–Web Interactions Open

Lei Zhang, Qianjing Zhang, Gen-Shu Tong, Qunhong Zhu · 2024

The local buckling of I-section beams is investigated with the flange–web interactions taken into account. Using numerical results employing the finite element method and a semi-analytical method, the flange–web interactions of I-sections …

Enhancing T cell anti-tumor efficacy with a PD1-TIGIT chimeric immune-checkpoint switch receptor Open

Jingjing Zhao, Jiebin Dong, Changwen Deng, Qianjing Zhang, Shicheng Sun , et al. · 2023

Chimeric antigen receptor (CAR) T cell immunotherapy has demonstrated success in the treatment of hematological malignancies; however, its efficacy and applications in solid tumors remain limited. Immunosuppressive factors, particularly in…

Elastic Local Buckling of I-Sections under Axial Compression Incorporating Web–Flange Interaction Open

Qianjing Zhang, Lei Zhang, Yujia Zhang, Yufei Liu, Jia Zhou · 2023

The local buckling of I-section columns is investigated in this paper, where the interaction between the web and flanges is taken into account. An analytical method is first developed based on the classical theory of the elastic buckling o…

LNCGM1082-mediated NLRC4 activation drives resistance to bacterial infection Open

Yunhuan Gao, Yazheng Yang, Jianmei Wei, Jianmei Yue, Ya Wang , et al. · 2023

FABP4 in Paneth cells regulates antimicrobial protein expression to reprogram gut microbiota Open

Lei Su, Mengli Jin, Xu Chen, Yunhuan Gao, Yazheng Yang , et al. · 2022

Antimicrobial proteins possess a broad spectrum of bactericidal activity and play an important role in shaping the composition of gut microbiota, which is related to multiple diseases such as metabolic syndrome. However, it is incompletely…

LncRNA LNCGM1082-mediated NLRC4 activation resists against infection by intracellular bacteria Open

Rongcun Yang, Yunhuan Gao, Yazheng Yang, Jianmei Wei, Jianmei Yue , et al. · 2022

The activation of NLRC4 is a major host response against the infection by intracellular bacteria. However, there still remain challenges in understanding the activation upon sensing of diverse stimuli. We here found that lncRNA LNCGM1082 p…

Gut microbiota–derived metabolite 3-idoleacetic acid together with LPS induces IL-35+ B cell generation Open

Lei Su, Minying Zhang, Houbao Qi, Yunhuan Gao, Yazheng Yang , et al. · 2022

Background IL-35–producing Bregs and Treg cells critically regulate chronic illnesses worldwide via mechanisms related to disrupting the gut microbiota composition. However, whether the gut microbiota regulates these IL-35 + cells remains …

NLRC4 activation needs lncRNA LNCGM1082 Open

Yunhuan Gao, Yazheng Yang, Jianmei Wei, Jianmei Yue, Ya Wang , et al. · 2021

The activation of NLRC4 is a major host response against the infection by intracellular bacteria. However, there still remain challenges in understanding the activation upon sensing of diverse stimuli. We here found that lncRNA LNCGM1082 p…

Gut microbiota derived metabolites 3-idoleacetic acid with LPS induces generation of IL-35+B cells Open

Rongcun Yang, Lei Su, Houbao Qi, Minying Zhang, Yunhuan Gao , et al. · 2021

Background IL-35 producing B and Treg cells are critical regulators in worldwide chronic illnesses, which are related to disruptions of gut microbiota composition. Whether gut microbiota regulate these IL-35 + cells maintains elusive. Here…

Transforming growth factor β signaling pathway: A promising therapeutic target for cancer Open

Yuhong Chen, Cuixia Di, Xuetian Zhang, Jing Wang, Fang Wang , et al. · 2019

Transforming growth factor β (TGF‐β) is part of the transforming growth factor β superfamily which is involved in many physiological processes and closely related to the carcinogenesis. Here, we discuss the TGF‐β structure, function, and i…

Inhibition of SF3b1 by pladienolide B evokes cycle arrest, apoptosis induction and p73 splicing in human cervical carcinoma cells Open

Qianjing Zhang, Cuixia Di, Junfang Yan, Fang Wang, Tao Qu , et al. · 2019

Pladienolide B is a potent cancer cell growth inhibitor that targets the SF3b1 subunit of the spliceosome. There is considerable interest in the compound as a tool to study SF3b1 function in cancer. However, so far little information is av…

Function, clinical application, and strategies of Pre-mRNA splicing in cancer Open

Cuixia Di, Syafrizayanti Syafrizayanti, Qianjing Zhang, Yuhong Chen, Yupei Wang , et al. · 2018

Teratozoospermia with amorphous sperm head associate with abnormal chromatin condensation in a Chinese family Open

Ying Ma, Ning Xie, Yi Li, Ping Zhang, Dingxiong Xie , et al. · 2018

Male infertility affects approximately 7% of the male population. In about 40% of affected patients, the etiology remains unknown. Here, we report the cases of two infertile brothers who have a uniquely prevalent sperm phenotype with compl…

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