Victor Wei Zhang
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View article: Prognostic value of brown adipocyte-related genes in colorectal cancer: a multi-omics and Mendelian randomization study
Prognostic value of brown adipocyte-related genes in colorectal cancer: a multi-omics and Mendelian randomization study Open
ADD2, PDE1B, LZTS1, and PCSK5 were identified as prognostic genes. A prognostic model related to BARGs in CRC was established, offering fresh perspectives on the prognostic treatment of CRC.
View article: Compensatory Efficacy and Bilateral Symmetry of Ocular Residual Astigmatism in Myopic Astigmatism Adults
Compensatory Efficacy and Bilateral Symmetry of Ocular Residual Astigmatism in Myopic Astigmatism Adults Open
This study established a hierarchical relationship between ORA and myopia severity. ORA's compensatory effect on ACA attenuated significantly with higher myopia. High myopia patients exhibited lower ORA magnitude and reduced interocular OR…
View article: Endovascular treatment of pediatric vertebral artery dissection: Case report and literature review
Endovascular treatment of pediatric vertebral artery dissection: Case report and literature review Open
View article: Evidence-Based Optimization of Urban Block Morphology for Enhanced Photovoltaic Potential
Evidence-Based Optimization of Urban Block Morphology for Enhanced Photovoltaic Potential Open
Urban morphology is a critical determinant of photovoltaic (PV) potential in cities, yet current design practices rarely incorporate this relationship systematically. Existing studies often struggle to balance analytical precision with com…
View article: Trimethylamine- <i>N</i> -Oxide Affects Cell Type–Specific Pathways and Networks in Mouse Aorta to Promote Atherosclerotic Plaque Vulnerability
Trimethylamine- <i>N</i> -Oxide Affects Cell Type–Specific Pathways and Networks in Mouse Aorta to Promote Atherosclerotic Plaque Vulnerability Open
BACKGROUND: Trimethylamine- N -oxide (TMAO) has been significantly linked to atherosclerosis via several mechanisms, but its direct effect on the atherosclerosis-prone vasculature remains unclear. The objective of this study was to charact…
View article: Adsorption Behavior of Tetracycline by Polyethylene Microplastics in Groundwater Environment
Adsorption Behavior of Tetracycline by Polyethylene Microplastics in Groundwater Environment Open
Previous studies have mostly focused on the adsorption behavior of microplastics for antibiotics in soil or aqueous environments. This study explores the adsorption characteristics of microplastics for antibiotics under groundwater environ…
View article: National and subnational burden of brain and central nervous system cancers in China and global from 1990 to 2021: results from the global burden of disease study 2021
National and subnational burden of brain and central nervous system cancers in China and global from 1990 to 2021: results from the global burden of disease study 2021 Open
From 1990 to 2021, China experienced sustained increases in both ASIR and ASPR of CNS cancers, indicating a growing disease burden.The disease burden exhibited significant age and sex disparities: males showed higher ASIR, ASMR, and ASDR, …
View article: Correction: A non-invasive method for screening mitochondrial diabetes
Correction: A non-invasive method for screening mitochondrial diabetes Open
[This corrects the article DOI: 10.3389/fgene.2025.1536331.].
View article: Singlet Fission c-Si Solar Cells: Beyond Tetracene
Singlet Fission c-Si Solar Cells: Beyond Tetracene Open
Singlet fission photovoltaics enable the extraction of two electron-hole pairs from each higher-energy photon while leveraging a mature technology such as crystalline silicon (c-Si) as the underlying cell. Significant steps have been made …
View article: Skin Biopsy as a Diagnostic Tool for <scp>ATTRv</scp> Amyloid Neuropathy in the <scp>UK</scp>
Skin Biopsy as a Diagnostic Tool for <span>ATTRv</span> Amyloid Neuropathy in the <span>UK</span> Open
Objective Gene silencing therapy for ATTRv has revolutionised treatment. In minimally symptomatic, early neuropathic disease, skin biopsy can aid in the diagnosis of ATTRv‐PN, assessing both amyloid deposition and IENFD. Our aim was to stu…
View article: Exploring the association between circadian rhythms and osteoporosis: new diagnostic and therapeutic targets identified via machine learning
Exploring the association between circadian rhythms and osteoporosis: new diagnostic and therapeutic targets identified via machine learning Open
Background Osteoporosis (OP) is a systemic metabolic bone disease that may increase the risk of disability or death. Increasing evidence suggests that circadian rhythms play an important role in OP, yet the specific mechanisms remain uncle…
View article: A Comparative Study of Medium-Coverage Genome Sequencing and SNP Array Technology in Identifying Chromosomal Abnormalities to Advance Prenatal and Postnatal Diagnosis
A Comparative Study of Medium-Coverage Genome Sequencing and SNP Array Technology in Identifying Chromosomal Abnormalities to Advance Prenatal and Postnatal Diagnosis Open
This study compared the performance of 5-fold genome sequencing (GS) with single nucleotide polymorphism (SNP) array technology in detecting chromosomal abnormalities, particularly in the context of prenatal and postnatal diagnostics. A to…
View article: A non-invasive method for screening mitochondrial diabetes
A non-invasive method for screening mitochondrial diabetes Open
Background Mitochondrial diabetes mellitus (MDM) is a special type of diabetes resulting from functional defects in mitochondria. Its incidence rate is low, and it can often be misdiagnosed as either type 1 or type 2 diabetes in clinical s…
View article: Using System Dynamics to Analyze Influencing Factors and Emission Reduction Potential of Geothermal Resources Development and Utilization in Tianjin
Using System Dynamics to Analyze Influencing Factors and Emission Reduction Potential of Geothermal Resources Development and Utilization in Tianjin Open
Geothermal resources are abundant in China and are distributed mainly in the eastern region where energy demand is high, especially in Tianjin. However, a significant disparity remains between the actual heating area and the potential heat…
View article: Association between third ventricular width assessed by transcranial sonography and plasma homocysteine in Parkinson’s disease with cognitive impairment and their potential to predict conversion to dementia
Association between third ventricular width assessed by transcranial sonography and plasma homocysteine in Parkinson’s disease with cognitive impairment and their potential to predict conversion to dementia Open
Plasma Hcy level and V3 width are associated with cognition function severity in PD patients, a V3 width is an independent predictor of MCI-dementia conversion in PD.
View article: Trimethylamine-N-oxide affects cell type-specific pathways and networks in mouse aorta to promote atherosclerotic plaque vulnerability
Trimethylamine-N-oxide affects cell type-specific pathways and networks in mouse aorta to promote atherosclerotic plaque vulnerability Open
Background Trimethylamine-N-oxide (TMAO) has been significantly linked to atherosclerosis via several mechanisms, but its direct effect on the atherosclerosis-prone vasculature remains unclear. The objective of this study was to characteri…
View article: MBNL overexpression rescues cardiac phenotypes in a myotonic dystrophy type 1 heart mouse model
MBNL overexpression rescues cardiac phenotypes in a myotonic dystrophy type 1 heart mouse model Open
Myotonic dystrophy type 1 (DM1) is an autosomal dominant disease caused by a CTG repeat expansion in the dystrophia myotonica protein kinase (DMPK) gene. The expanded CUG repeat RNA (CUGexp RNA) transcribed from the mutant allele sequester…
View article: Molecular Determinants Underlying Enhanced Ceftazidime Resistance Mediated by β-Lactamase CTX-M-55 Compared to CTX-M-14
Molecular Determinants Underlying Enhanced Ceftazidime Resistance Mediated by β-Lactamase CTX-M-55 Compared to CTX-M-14 Open
View article: Prediction of Oxidative Stability in Model Emulsions for Preterm Infant Formula: A Qsar-Based Approach to Ternary Regulation of Homogenization Parameters, Interfacial Properties, and Oxidation Characteristics
Prediction of Oxidative Stability in Model Emulsions for Preterm Infant Formula: A Qsar-Based Approach to Ternary Regulation of Homogenization Parameters, Interfacial Properties, and Oxidation Characteristics Open
View article: Test-time Adaptation for Cross-modal Retrieval with Query Shift
Test-time Adaptation for Cross-modal Retrieval with Query Shift Open
The success of most existing cross-modal retrieval methods heavily relies on the assumption that the given queries follow the same distribution of the source domain. However, such an assumption is easily violated in real-world scenarios du…
View article: Thyroid hormone T4 mitigates traumatic brain injury in mice by dynamically remodeling cell type specific genes, pathways, and networks in hippocampus and frontal cortex
Thyroid hormone T4 mitigates traumatic brain injury in mice by dynamically remodeling cell type specific genes, pathways, and networks in hippocampus and frontal cortex Open
The complex pathology of mild traumatic brain injury (mTBI) is a main contributor to the difficulties in achieving a successful therapeutic regimen. Thyroxine (T4) administration has been shown to prevent the cognitive impairments induced …
View article: Novel SPEF2 variants cause male infertility and likely primary ciliary dyskinesia
Novel SPEF2 variants cause male infertility and likely primary ciliary dyskinesia Open
View article: Identification of a novel KCNT2 variant in a family with developmental and epileptic encephalopathies: a case report and literature review
Identification of a novel KCNT2 variant in a family with developmental and epileptic encephalopathies: a case report and literature review Open
Background: Developmental and epileptic encephalopathies (DEEs) are a group of heterogeneous neurodevelopmental diseases characterized mainly by developmental delay/intellectual disability and early-onset epilepsy. Researchers have identif…
View article: Extended application of PGT-M strategies for small pathogenic CNVs
Extended application of PGT-M strategies for small pathogenic CNVs Open
View article: Maternal uniparental disomy for chromosome 6 in 2 prenatal cases with IUGR: case report and literature review
Maternal uniparental disomy for chromosome 6 in 2 prenatal cases with IUGR: case report and literature review Open
View article: 7'-Hydroxyl Substituted Xanthones from Gentianella Acuta Revert Hepatic Steatosis in Obese Diabetic Mice Through Preserving Mitochondrial Homeostasis
7'-Hydroxyl Substituted Xanthones from Gentianella Acuta Revert Hepatic Steatosis in Obese Diabetic Mice Through Preserving Mitochondrial Homeostasis Open
View article: Bi-allelic variants in <i>DNAH3</i> cause male infertility with asthenoteratozoospermia in humans and mice
Bi-allelic variants in <i>DNAH3</i> cause male infertility with asthenoteratozoospermia in humans and mice Open
STUDY QUESTION Are there other pathogenic genes for asthenoteratozoospermia (AT)? SUMMARY ANSWER DNAH3 is a novel candidate gene for AT in humans and mice. WHAT IS KNOWN ALREADY AT is a major cause of male infertility. Several genes underl…
View article: The clinical, myopathological, and genetic analysis of 155 Chinese mitochondrial ophthalmoplegia patients with mitochondrial <scp>DNA</scp> single large deletions
The clinical, myopathological, and genetic analysis of 155 Chinese mitochondrial ophthalmoplegia patients with mitochondrial <span>DNA</span> single large deletions Open
Background Progressive external ophthalmoplegia (PEO) is a common subtype of mitochondrial encephalomyopathy. Objective The study aimed to investigate the relationship between mitochondrial DNA (mtDNA) abnormalities, muscle pathology, and …
View article: Are Germline Mosaic TSC1/2 Variants Present in Controls? Implications for Diagnosis
Are Germline Mosaic TSC1/2 Variants Present in Controls? Implications for Diagnosis Open
•We found that 100 control individuals without tuberous sclerosis complex did not have pathogenic or likely pathogenic heterozygous or mosaic TSC1/TSC2 variants. Six individuals had variants of unknown significance or likely benign variant…
View article: Specific genetic aberrations of parathyroid in Chinese patients with tertiary hyperparathyroidism using whole-exome sequencing
Specific genetic aberrations of parathyroid in Chinese patients with tertiary hyperparathyroidism using whole-exome sequencing Open
Background Tertiary hyperparathyroidism (THPT) is a peculiar subtype of hyperparathyroidism that usually develops from chronic kidney disease (CKD) and persists even after kidney transplantation. Unlike its precursor, secondary hyperparath…