Qiankun Yang
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View article: Multicenter evaluation of fast multiplex PCR for detection of pathogens in lower respiratory tract infections
Multicenter evaluation of fast multiplex PCR for detection of pathogens in lower respiratory tract infections Open
Background This study aimed to compare the diagnostic performance between bacterial culture and a rapid multiplex PCR assay (Respiratory Pathogens Multiplex Nucleic Acid Diagnostic Kit) for detecting six bacterial (Pseudomonas aeruginosa, …
View article: Study on the Effects of Cadmium Exposure on Zinc Metabolism and FOXO3a Expression in the Preeclampsia Maternal-Fetal System
Study on the Effects of Cadmium Exposure on Zinc Metabolism and FOXO3a Expression in the Preeclampsia Maternal-Fetal System Open
The exposure and accumulation of Cd in the maternal-fetal system can affect the transport and metabolism of Zn in placenta, leading to increased expression of FOXO3a under oxidative stress, causing the occurrence and development of PE.
View article: Cardiovascular Health Optimization Through Life’s Essential 8 Scores Reduces Gestational Diabetes Risk: Mediation by Platelet Activity and Inflammatory Pathways in a Nationwide Cohort
Cardiovascular Health Optimization Through Life’s Essential 8 Scores Reduces Gestational Diabetes Risk: Mediation by Platelet Activity and Inflammatory Pathways in a Nationwide Cohort Open
As the first study to integrate CVH metrics with platelet/inflammatory biomarkers in GDM pathogenesis, our findings demonstrate that optimizing LE8 scores, particularly through BMI, blood pressure, and lipid control, significantly mitigate…
View article: Study on the effect of sidebands of KSTAR-like traveling wave antenna power spectrum on helicon wave current drive in EXL-50U spherical torus plasma
Study on the effect of sidebands of KSTAR-like traveling wave antenna power spectrum on helicon wave current drive in EXL-50U spherical torus plasma Open
By integrating KSTAR-like traveling wave antenna (TWA) spectra with the GENRAY code, this study investigates the effects of asymmetrically distributed sidebands around the main peak on helicon current drive (HCD) in the EXL-50U spherical t…
View article: Safety Evaluation of the Influence of Mountain Blasting on Piles Under Construction
Safety Evaluation of the Influence of Mountain Blasting on Piles Under Construction Open
Blasting excavation can pose significant risks to adjacent structures, particularly during concrete pouring. Therefore, evaluating their safety is crucial. In addition, the influence of blasting vibration on the vibration of the foundation…
View article: Modulation in sintering characteristics and microwave dielectric properties of Ca3Co2SiV2O12 via Li+ inequivalent substitution
Modulation in sintering characteristics and microwave dielectric properties of Ca3Co2SiV2O12 via Li+ inequivalent substitution Open
View article: Dyslipidemia and aging: the non-linear association between atherogenic index of plasma (AIP) and aging acceleration
Dyslipidemia and aging: the non-linear association between atherogenic index of plasma (AIP) and aging acceleration Open
A total of 4,471 participants were included in this study, the median chronological age, PhenoAge and PhenoAgeAccel for the overall population were 49 (35-64) years, 42.85 (27.30-59.68) years, and - 6.92 (- 10.52 to -2.46) years, respectiv…
View article: Personality Traits and Teaching Commitment Among Pre-Service Teachers: Teaching Motivation as a Mediator
Personality Traits and Teaching Commitment Among Pre-Service Teachers: Teaching Motivation as a Mediator Open
With the HEXACO model of personality, this study examined the relationship between HEXACO traits (i.e., honesty–humility, emotionality, extraversion, agreeableness, conscientiousness, and openness to experience) and teaching commitment amo…
View article: Dietary riboflavin (vitamin B2) intake and osteoporosis in U.S. female adults: unveiling of association and exploration of potential molecular mechanisms
Dietary riboflavin (vitamin B2) intake and osteoporosis in U.S. female adults: unveiling of association and exploration of potential molecular mechanisms Open
View article: Development of a sense-antisense and dual-minor groove binder probe PCR assay in plasma for early detection of colorectal cancer
Development of a sense-antisense and dual-minor groove binder probe PCR assay in plasma for early detection of colorectal cancer Open
View article: Trichomonas vaginalis inhibits autophagy in VK2/E6E7 cells via the AMPK-ULK1 pathway
Trichomonas vaginalis inhibits autophagy in VK2/E6E7 cells via the AMPK-ULK1 pathway Open
View article: Giardiavirus infection alleviates growth restriction and intestinal damage caused by the intestinal parasite Giardia duodenalis
Giardiavirus infection alleviates growth restriction and intestinal damage caused by the intestinal parasite Giardia duodenalis Open
View article: Associations of prognostic nutritional index with cardiovascular all-cause mortality among CVD patients with diabetes or prediabetes: evidence from the NHANES 2005–2018
Associations of prognostic nutritional index with cardiovascular all-cause mortality among CVD patients with diabetes or prediabetes: evidence from the NHANES 2005–2018 Open
Background Immunonutritional status is linked to the prognosis of cardiovascular disease (CVD) and diabetes, but the relationship between immunonutritional disorders and clinical outcomes in CVD patients with diabetes is unclear. This stud…
View article: The associations of physical activity patterns and the triglyceride-glucose index in US adults: a secondary data analysis of NHANES (2007–2018)
The associations of physical activity patterns and the triglyceride-glucose index in US adults: a secondary data analysis of NHANES (2007–2018) Open
View article: Analytical and Diagnostic Performance of a Dual‐Target Blood Detection Test for Hepatocellular Carcinoma
Analytical and Diagnostic Performance of a Dual‐Target Blood Detection Test for Hepatocellular Carcinoma Open
Background Surveillance approaches with high sensitivity and specificity for hepatocellular carcinoma (HCC) are still urgently needed. Previous studies have shown that methylation of GNB4 and Riplet can effectively diagnose HCC. Aims This …
View article: Association between physical activity and visceral adiposity index (VAI) in U.S. population with overweight or obesity: a cross-sectional study
Association between physical activity and visceral adiposity index (VAI) in U.S. population with overweight or obesity: a cross-sectional study Open
View article: DNA methylation and gene expression profiling reveal potential association of retinol metabolism related genes with hepatocellular carcinoma development
DNA methylation and gene expression profiling reveal potential association of retinol metabolism related genes with hepatocellular carcinoma development Open
Background Aberrant DNA methylation patterns play a critical role in the development of hepatocellular carcinoma (HCC). However, the molecular mechanisms associated with these aberrantly methylated genes remain unclear. This study aimed to…
View article: Discovering methylation markers and development of a sense-antisense and dual-MGB probe PCR assay in plasma for colorectal cancer early detection
Discovering methylation markers and development of a sense-antisense and dual-MGB probe PCR assay in plasma for colorectal cancer early detection Open
Background: Screening for colorectal cancer (CRC) using plasma cell-free DNA (cfDNA) methylation is more challenging than stool testing due to the low abundance of cfDNA. Therefore, the development of signal amplification assays based on a…
View article: Discovering methylation markers and development of a sense-antisense and dual-MGB probe PCR assay in plasma for colorectal cancer early detection
Discovering methylation markers and development of a sense-antisense and dual-MGB probe PCR assay in plasma for colorectal cancer early detection Open
Screening for colorectal cancer (CRC) using plasma methylation is challenging due to the low abundance of cell-free DNA (cfDNA). Therefore, the development of signal amplification assays based on appropriate markers is essential to increas…
View article: IKZF1 and UBR4 gene variants drive autoimmunity and Th2 polarization in IgG4-related disease
IKZF1 and UBR4 gene variants drive autoimmunity and Th2 polarization in IgG4-related disease Open
IgG4-related disease (IgG4-RD) is a systemic immune-mediated fibroinflammatory disease whose pathomechanisms remain poorly understood. Here, we identified gene variants in familial IgG4-RD and determined their functional consequences. All …
View article: Whether weekend warriors (WWs) achieve equivalent benefits in lipid accumulation products (LAP) reduction as other leisure-time physical activity patterns? -Results from a population-based analysis of NHANES 2007–2018
Whether weekend warriors (WWs) achieve equivalent benefits in lipid accumulation products (LAP) reduction as other leisure-time physical activity patterns? -Results from a population-based analysis of NHANES 2007–2018 Open
Background Obesity is characterized by excessive fat accumulation in the body. Physical activity (PA) is an effective intervention to combat obesity, but the effectiveness of different PA patterns on controlling obesity is unclear. Lipid a…
View article: The association between different physical activity (PA) patterns and cardiometabolic index (CMI) in US adult population from NHANES (2007–2016)
The association between different physical activity (PA) patterns and cardiometabolic index (CMI) in US adult population from NHANES (2007–2016) Open
Being regularly active is associated with significant CMI reduction, while being weekend warriors and insufficiently active do not achieve equivalent benefits. For non-inactive individuals, engaging in PA for more than 330 min weekly helps…
View article: Plasma methylated GNB4 and Riplet as a novel dual-marker panel for the detection of hepatocellular carcinoma
Plasma methylated GNB4 and Riplet as a novel dual-marker panel for the detection of hepatocellular carcinoma Open
Early detection of hepatocellular carcinoma (HCC) can greatly improve the survival rate of patients. We aimed to develop a novel marker panel based on cell-free DNA (cfDNA) methylation for the detection of HCC. The differentially methylate…
View article: Long-term application of silver nanoparticles in dental restoration materials: potential toxic injury to the CNS
Long-term application of silver nanoparticles in dental restoration materials: potential toxic injury to the CNS Open
View article: DNA methylation and gene expression profiling highlight retinol metabolism's vital role in Hepatocellular carcinoma development
DNA methylation and gene expression profiling highlight retinol metabolism's vital role in Hepatocellular carcinoma development Open
Purpose Abnormal DNA methylation patterns play a critical role in the development of hepatocellular carcinoma (HCC). However, the molecular mechanisms associated with these aberrantly methylated genes remain unclear. In this study, we aime…
View article: Scutellarin prevents acute alcohol-induced liver injury via inhibiting oxidative stress by regulating the Nrf2/HO-1 pathway and inhibiting inflammation by regulating the AKT, p38 MAPK/NF-κB pathways
Scutellarin prevents acute alcohol-induced liver injury via inhibiting oxidative stress by regulating the Nrf2/HO-1 pathway and inhibiting inflammation by regulating the AKT, p38 MAPK/NF-κB pathways Open
Alcoholic liver disease (ALD) is the most frequent liver disease worldwide, resulting in severe harm to personal health and posing a serious burden to public health. Based on the reported antioxidant and anti-inflammatory capacities of scu…
View article: Malvidin alleviates mitochondrial dysfunction and ROS accumulation through activating AMPK-α/UCP2 axis, thereby resisting inflammation and apoptosis in SAE mice
Malvidin alleviates mitochondrial dysfunction and ROS accumulation through activating AMPK-α/UCP2 axis, thereby resisting inflammation and apoptosis in SAE mice Open
This study aimed to explore the protective roles of malvidin in life-threatened sepsis-associated encephalopathy (SAE) and illustrate the underlying mechanism. SAE mice models were developed and treated with malvidin for subsequently prote…
View article: A novel stemness-hypoxia-related signature for prognostic stratification and immunotherapy response in hepatocellular carcinoma
A novel stemness-hypoxia-related signature for prognostic stratification and immunotherapy response in hepatocellular carcinoma Open
View article: <i>A. caviae</i> infection triggers IL-1β secretion through activating NLRP3 inflammasome mediated by NF-κB signaling pathway partly in a TLR2 dependent manner
<i>A. caviae</i> infection triggers IL-1β secretion through activating NLRP3 inflammasome mediated by NF-κB signaling pathway partly in a TLR2 dependent manner Open
Aeromonas caviae, an important food-borne pathogen, induces serious invasive infections and inflammation. The pro-inflammatory IL-1β functions against pathogenic infections and is elevated in various Aeromonas infection cases…
View article: Identification of HM13 as a prognostic indicator and a predictive biomarker for immunotherapy in hepatocellular carcinoma
Identification of HM13 as a prognostic indicator and a predictive biomarker for immunotherapy in hepatocellular carcinoma Open