Qianling Xin
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View article: Exploring CAR-macrophages in non-tumor diseases: Therapeutic potential beyond cancer
Exploring CAR-macrophages in non-tumor diseases: Therapeutic potential beyond cancer Open
This review provides a comprehensive understanding of CAR-M for the treatment of non-tumor diseases, analyzes the advantages and characteristics of CAR-M therapy, and highlights the important impact of CAR intracellular domain design on th…
View article: Trogocytosis in CAR immune cell therapy: a key mechanism of tumor immune escape
Trogocytosis in CAR immune cell therapy: a key mechanism of tumor immune escape Open
Immune cell therapy based on chimeric antigen receptor (CAR) technology platform has been greatly developed. The types of CAR immune cell therapy have expanded from T cells to innate immune cells such as NK cells and macrophages, and the d…
View article: IgD/FcδR is involved in T-cell acute lymphoblastic leukemia and regulated by IgD-Fc-Ig fusion protein
IgD/FcδR is involved in T-cell acute lymphoblastic leukemia and regulated by IgD-Fc-Ig fusion protein Open
T-cell acute lymphoblastic leukemia (T-ALL) has a poor prognosis as a result of severe immunosuppression and rapid tumor progression with resistance to conventional chemotherapy. Excessive IgD may play a role in T cell activation via IgD F…
View article: IgD enhances the release of neutrophil extracellular traps (NETs) via FcδR in rheumatoid arthritis patients
IgD enhances the release of neutrophil extracellular traps (NETs) via FcδR in rheumatoid arthritis patients Open
Background and Purpose Neutrophils and the release of neutrophil extracellular traps (NETs) play important roles in the pathogenesis of RA. However, IgD, which was abnormally higher in RA, has not been studied for its pathological role in …