Qianting Yang
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View article: Revised therapeutic window for vancomycin in pediatric patients: evidence from a retrospective therapeutic drug monitoring study
Revised therapeutic window for vancomycin in pediatric patients: evidence from a retrospective therapeutic drug monitoring study Open
View article: Integrated Metabolomics and Transcriptomics Reveals Metabolic Pathway Changes in Common Carp Muscle Under Oxidative Stress
Integrated Metabolomics and Transcriptomics Reveals Metabolic Pathway Changes in Common Carp Muscle Under Oxidative Stress Open
Hydrogen peroxide (H2O2), a ubiquitous reactive oxygen species in aquatic ecosystems, has been shown to induce toxicological effects in aquatic animals. However, the molecular mechanisms underlying H2O2-mediated alterations in muscle quali…
View article: Therapeutic Drug Monitoring of Vancomycin in Pediatric Patients: A Retrospective Study
Therapeutic Drug Monitoring of Vancomycin in Pediatric Patients: A Retrospective Study Open
Objective Methicillin-resistant Staphylococcus aureus (MRSA) infections among children are escalating annually. Vancomycin stands as the frontline therapeutic agent against MRSA infections. However, determining the therapeutic window for v…
View article: Oxidative Stress Disrupts Gill Function in Eriocheir sinensis: Consequences for Ion Transport, Apoptosis, and Autophagy
Oxidative Stress Disrupts Gill Function in Eriocheir sinensis: Consequences for Ion Transport, Apoptosis, and Autophagy Open
Oxidative stress is a key mediator of physiological dysfunction in aquatic organisms under environmental challenges, yet its comprehensive impacts on gill physiology require further clarification. This study investigated the molecular and …
View article: Elevated PD-1 and PDL-1 autoantibodies and association with tuberculosis
Elevated PD-1 and PDL-1 autoantibodies and association with tuberculosis Open
View article: Granzyme A as biomarker for diagnosis in tuberculous pleural effusion
Granzyme A as biomarker for diagnosis in tuberculous pleural effusion Open
BACKGROUNDCurrent diagnostic tools for tuberculous pleural effusion (TPE) are often inadequate, making accurate diagnosis challenging. Effective identification of TPE is critical for ensuring proper treatment and preventing tuberculosis re…
View article: Therapeutic Drug Monitoring of Vancomycin in Pediatric Patients: Defining a Therapeutic Drug Window
Therapeutic Drug Monitoring of Vancomycin in Pediatric Patients: Defining a Therapeutic Drug Window Open
Background Methicillin-resistant Staphylococcus aureus (MRSA) infections among children are escalating annually. Vancomycin stands as the frontline therapeutic agent against MRSA infections. However, determining the therapeutic window for …
View article: Exploring TSPAN4 promoter methylation as a diagnostic biomarker for tuberculosis
Exploring TSPAN4 promoter methylation as a diagnostic biomarker for tuberculosis Open
Background: Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), is a persistent infectious disease threatening human health. The existing diagnostic methods still have significant shortcomings, including a low positivity rate in…
View article: Evaluation of Sulfasalazine as an Adjunctive Therapy in Treating Pulmonary Pre-XDR-TB: Efficacy, Safety, and Treatment Implication
Evaluation of Sulfasalazine as an Adjunctive Therapy in Treating Pulmonary Pre-XDR-TB: Efficacy, Safety, and Treatment Implication Open
Both 9-month short-course, all-oral regimens manifested commendable primary efficacy in treating pre-XDR-TB patients. The SASP-regimen emerged as effective, safe, well-tolerated, and cost-effective.
View article: How Reference Dependence and NetworkEmbeddedness Shape Residents’ FoodWaste Behavior? Evidence from China
How Reference Dependence and NetworkEmbeddedness Shape Residents’ FoodWaste Behavior? Evidence from China Open
Reducing food waste is an important initiative to ensure food security and mitigate climate change.Previous studies have largely ignored the influence of reference points on food waste behavior and the role of human-to-human relational int…
View article: Study protocol for safety and efficacy of all-oral shortened regimens for multidrug-resistant tuberculosis: a multicenter randomized withdrawal trial and a single-arm trial [SEAL-MDR]
Study protocol for safety and efficacy of all-oral shortened regimens for multidrug-resistant tuberculosis: a multicenter randomized withdrawal trial and a single-arm trial [SEAL-MDR] Open
Introduction The urgent need for new treatments for multidrug-resistant tuberculosis (MDR-TB) and pre-extensively drug-resistant tuberculosis (pre-XDR-TB) is evident. However, the classic randomized controlled trial (RCT) approach faces et…
View article: Potentially hazardous drug–drug interactions in cancer patients treated with tyrosine kinase inhibitors: A multicenter retrospective study
Potentially hazardous drug–drug interactions in cancer patients treated with tyrosine kinase inhibitors: A multicenter retrospective study Open
Aims: Tyrosine kinase inhibitors (TKIs) improve patient outcomes, but the prevalence of clinically significant TKI-associated drug–drug interaction (DDI) is unknown. We aim to assess the risk prevalence between TKIs and other drugs in canc…
View article: Selecting an appropriate all-oral short-course regimen for patients with multidrug-resistant or pre-extensive drug-resistant tuberculosis in China: A multicenter prospective cohort study
Selecting an appropriate all-oral short-course regimen for patients with multidrug-resistant or pre-extensive drug-resistant tuberculosis in China: A multicenter prospective cohort study Open
The primary outcome of the three tailored, 9-month, all-oral, 5-drug regimens was satisfactory in the vast majority of MDR-TB and pre-XDR-TB patients, with manageable and reversible AEs.
View article: The interaction of macrophages and CD8 T cells in bronchoalveolar lavage fluid is associated with latent tuberculosis infection
The interaction of macrophages and CD8 T cells in bronchoalveolar lavage fluid is associated with latent tuberculosis infection Open
Mycobacterium tuberculosis (Mtb) infection, including active tuberculosis (TB) and latent Mtb infection (LTBI), leads to diverse outcomes owing to different host immune responses. However, the immune mechanisms that govern the progression …
View article: Devising novel near-infrared aggregation-induced-emission luminogen labeling for point-of-care diagnosis of <i>Mycobacterium tuberculosis </i>
Devising novel near-infrared aggregation-induced-emission luminogen labeling for point-of-care diagnosis of <i>Mycobacterium tuberculosis </i> Open
Detecting and appropriately diagnosing a Mycobacterium tuberculosis infection remains technologically difficult because the pathogen commonly hides in macrophages in a dormant state. Described here is novel near-infrared aggregation-induce…
View article: Hematopoietic dysregulation caused by neutrophils underlies impaired T-cell response and enhanced susceptibility to tuberculosis.
Hematopoietic dysregulation caused by neutrophils underlies impaired T-cell response and enhanced susceptibility to tuberculosis. Open
Control of Mycobacterium tuberculosis (Mtb) infection requires the generation of T cells that migrate to granulomas, specialized immune structures surrounding sites of bacterial replication. Here we report that persistent influx of neutrop…
View article: Construction of a risk model and deep learning network based on patients with active pulmonary tuberculosis and pulmonary inflammation
Construction of a risk model and deep learning network based on patients with active pulmonary tuberculosis and pulmonary inflammation Open
Most patients with active pulmonary tuberculosis (TB) are difficult to be differentiated from pneumonia (PN), especially those with acid-fast bacillus smear-negative (AFB-) and interferon-γ release assay-positive (IGRA+
View article: A cross-sectional study: a breathomics based pulmonary tuberculosis detection method
A cross-sectional study: a breathomics based pulmonary tuberculosis detection method Open
Background Diagnostics for pulmonary tuberculosis (PTB) are usually inaccurate, expensive, or complicated. The breathomics-based method may be an attractive option for fast and noninvasive PTB detection. Method Exhaled breath samples were …
View article: A cytoderm metabolic labeling AIEgen for rapid detection and intracellular ablation of Mycobacterium tuberculosis
A cytoderm metabolic labeling AIEgen for rapid detection and intracellular ablation of Mycobacterium tuberculosis Open
Latent Mycobacterium tuberculosis (Mtb) shielded in macrophages is hard to detect and eradicate, causing lethal respiratory failure and systemic inflammation. Here, we synthesize an aggregation-induced emission luminogen (AIEgen) with meta…
View article: The interaction of macrophages and CD8 T cells in bronchoalveolar lavage fluid is associated with latent tuberculosis infection
The interaction of macrophages and CD8 T cells in bronchoalveolar lavage fluid is associated with latent tuberculosis infection Open
Mycobacterium tuberculosis (Mtb) infection, including active tuberculosis (TB) and latent Mtb infection (LTBI), leads to diverse outcomes owing to different host immune responses. However, the immune mechanisms that govern the progression …
View article: Detecting latent tuberculosis infection with a breath test using mass spectrometer: A pilot cross-sectional study
Detecting latent tuberculosis infection with a breath test using mass spectrometer: A pilot cross-sectional study Open
Mycobacterium tuberculosis (M.tb) infects a quarter of the world's population and may progress to active tuberculosis (ATB). There is no gold standard for diagnosing latent tuberculosis infection (LTBI). Some immunodiagnostic tests are rec…
View article: The recommended dosage regimen for caspofungin in patients with higher body weight or hypoalbuminaemia will result in low exposure: Five years of data based on a population pharmacokinetic model and Monte-Carlo simulations
The recommended dosage regimen for caspofungin in patients with higher body weight or hypoalbuminaemia will result in low exposure: Five years of data based on a population pharmacokinetic model and Monte-Carlo simulations Open
Background: To develop a population pharmacokinetic (PPK) model for caspofungin, identify parameters influencing caspofungin pharmacokinetics, and assess the required probability of target attainment (PTA) and cumulative fraction of respon…
View article: Efficacy and Safety of Combination Antifungals as Empirical, Preemptive, and Targeted Therapies for Invasive Fungal Infections in Intensive-Care Units
Efficacy and Safety of Combination Antifungals as Empirical, Preemptive, and Targeted Therapies for Invasive Fungal Infections in Intensive-Care Units Open
Patients who received CAS monotherapy as an empirical or preemptive therapy could achieve good outcomes. Patients who received CAS+VOR or CAS+L-AmB achieved almost the same outcomes when compared with those who received CAS, VOR, and L-AmB…
View article: Whole transcriptome sequencing reveals neutrophils’ transcriptional landscape associated with active tuberculosis
Whole transcriptome sequencing reveals neutrophils’ transcriptional landscape associated with active tuberculosis Open
Neutrophils have been recognized to play an important role in the pathogenesis of tuberculosis in recent years. Interferon-induced blood transcriptional signatures in ATB are predominantly driven by neutrophils. In this study, we performed…
View article: In vitro synergistic antifungal activities of caspofungin in combination with fluconazole or voriconazole against Candida species determined by the Etest method
In vitro synergistic antifungal activities of caspofungin in combination with fluconazole or voriconazole against Candida species determined by the Etest method Open
View article: Neutrophils reprograms the bone marrow to impair T-cell immunity during tuberculosis
Neutrophils reprograms the bone marrow to impair T-cell immunity during tuberculosis Open
Mycobacterium tuberculosis (Mtb) infection induces persistent influx of neutrophils that associates with poor bacterial control and clinical outcome from tuberculosis (TB). Although implicated in TB pathology, the mechanism by which these …
View article: Pharmacokinetic/Pharmacodynamic Target Attainment of Different Antifungal Agents in De-escalation Treatment in Critically Ill Patients: a Step toward Dose Optimization Using Monte Carlo Simulation
Pharmacokinetic/Pharmacodynamic Target Attainment of Different Antifungal Agents in De-escalation Treatment in Critically Ill Patients: a Step toward Dose Optimization Using Monte Carlo Simulation Open
Differences in pharmacokinetics/pharmacodynamics (PK/PD) target attainment are rarely considered when antifungals are switched in critically ill patients. This study intends to explore whether the antifungal de-escalation treatment strateg…
View article: Corrigendum to ‘single-cell transcriptomics of blood reveals a natural killer cell subset depletion in tuberculosis’ [EBioMedicine 53 (2020) 102686]
Corrigendum to ‘single-cell transcriptomics of blood reveals a natural killer cell subset depletion in tuberculosis’ [EBioMedicine 53 (2020) 102686] Open
The authors regret that there was an error in Figure 5 of this article. Specifically, for Figure 5g, the X axis label of "After" and "Before" were reversed. The level of CD3-CD7+GZMB+ increased after initiation of treatment in TB patients.…
View article: Potentially Hazardous Drug-Drug Interactions Associated With Oral Antineoplastic Agents Prescribed in Chinese Tertiary Care Teaching Hospital Settings: A Multicenter Cross-Sectional Study
Potentially Hazardous Drug-Drug Interactions Associated With Oral Antineoplastic Agents Prescribed in Chinese Tertiary Care Teaching Hospital Settings: A Multicenter Cross-Sectional Study Open
Background: Oral administration increases the risk of interactions, because most oral antineoplastic agents (OAAs) are taken on a daily basis. Interactions can increase exposure to antitumoral agents or cause treatment failure. Potential d…
View article: Single-cell immune profiling reveals functional diversity of T cells in tuberculous pleural effusion
Single-cell immune profiling reveals functional diversity of T cells in tuberculous pleural effusion Open
Orchestration of an effective T lymphocyte response at infection sites is critical for protection against Mycobacterium tuberculosis (Mtb) infection. However, the local T cell immunity landscape in human tuberculosis is poorly defined. Tub…