Qi Zheng
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View article: Bidirectional Mendelian randomization analysis of the causal associations between serum vitamin D levels and multiple kidney diseases
Bidirectional Mendelian randomization analysis of the causal associations between serum vitamin D levels and multiple kidney diseases Open
View article: Bidirectional Mendelian randomization analysis of the causal associations between serum vitamin D levels and multiple kidney diseases
Bidirectional Mendelian randomization analysis of the causal associations between serum vitamin D levels and multiple kidney diseases Open
Background The relationship between vitamin D levels and the risk of kidney diseases, such as IgA nephropathy (IgAN), membranous nephropathy (MN), and diabetic nephropathy (DN), is still debated in observational studies. This research aims…
View article: Clinicopathological characteristics and prognostic outcomes of resectable hepatoid adenocarcinoma of the stomach: insights from a multicenter case-control study
Clinicopathological characteristics and prognostic outcomes of resectable hepatoid adenocarcinoma of the stomach: insights from a multicenter case-control study Open
Hepatoid adenocarcinoma of the stomach (HAS) is a rare subtype of gastric cancer (GC). This multicenter case-control study aimed to elucidate the clinicopathological features and prognosis of patients with resectable HAS. This retrospectiv…
View article: Estimating Healthcare Expenditure Using Parametric Change Point Models
Estimating Healthcare Expenditure Using Parametric Change Point Models Open
Estimating healthcare expenditures is important for policymakers and clinicians. The expenditure of patients facing a life-threatening illness can often be segmented into four distinct phases: diagnosis, treatment, stable, and terminal pha…
View article: Research on Heterogeneous Information Network Link Prediction Based on Representation Learning
Research on Heterogeneous Information Network Link Prediction Based on Representation Learning Open
A heterogeneous information network, which is composed of various types of nodes and edges, has a complex structure and rich information content, and is widely used in social networks, academic networks, e-commerce, and other fields. Link …
View article: RDP: Ranked Differential Privacy for Facial Feature Protection in Multiscale Sparsified Subspace
RDP: Ranked Differential Privacy for Facial Feature Protection in Multiscale Sparsified Subspace Open
With the widespread sharing of personal face images in applications' public databases, face recognition systems faces real threat of being breached by potential adversaries who are able to access users' face images and use them to intrude …
View article: Lycorine (Lycoris radiata)- A unique natural medicine on breast cancer
Lycorine (Lycoris radiata)- A unique natural medicine on breast cancer Open
Background : Breast cancer (BC) is one of the most common types of cancer among women worldwide. Lycorine ( Lycoris radiata ), a small molecule derived from the traditional Chinese herb Amaryllidaceae plants, has appeared potential effect …
View article: HNF4G accelerates glioma progression by facilitating NRP1 transcription
HNF4G accelerates glioma progression by facilitating NRP1 transcription Open
Hepatocyte nuclear factor 4γ (HNF4G) is considered to be a transcription factor and functions as an oncogene in certain types of human cancer. However, the precise functions and the potential molecular mechanisms of HNF4G in glioma remain …
View article: Consumption of fish oil high-fat diet induces murine hair loss via epidermal fatty acid binding protein in skin macrophages
Consumption of fish oil high-fat diet induces murine hair loss via epidermal fatty acid binding protein in skin macrophages Open
View article: Conditional Kaplan–Meier Estimator with Functional Covariates for Time-to-Event Data
Conditional Kaplan–Meier Estimator with Functional Covariates for Time-to-Event Data Open
Due to the wide availability of functional data from multiple disciplines, the studies of functional data analysis have become popular in the recent literature. However, the related development in censored survival data has been relatively…
View article: Silencing of <scp>lncRNA MIR31HG</scp> promotes nasopharyngeal carcinoma cell proliferation and inhibits apoptosis through suppressing the <scp>PI3K</scp>/<scp>AKT</scp> signaling pathway
Silencing of <span>lncRNA MIR31HG</span> promotes nasopharyngeal carcinoma cell proliferation and inhibits apoptosis through suppressing the <span>PI3K</span>/<span>AKT</span> signaling pathway Open
Background MIR31HG has been affirmed to regulate the tumorigenesis of head–neck squamous cell carcinoma (HNSC). This study aims to reveal the function of MIR31HG in nasopharyngeal carcinoma (NPC), which falls into the category of HNSC. Met…
View article: Globally Adaptive Longitudinal Quantile Regression With High Dimensional Compositional Covariates
Globally Adaptive Longitudinal Quantile Regression With High Dimensional Compositional Covariates Open
In this work, we propose a longitudinal quantile regression framework that enables a robust characterization of heterogeneous covariate-response associations in the presence of high-dimensional compositional covariates and repeated measure…
View article: Inference for High Dimensional Censored Quantile Regression
Inference for High Dimensional Censored Quantile Regression Open
With the availability of high dimensional genetic biomarkers, it is of interest to identify heterogeneous effects of these predictors on patients' survival, along with proper statistical inference. Censored quantile regression has emerged …
View article: Inference for High-Dimensional Censored Quantile Regression
Inference for High-Dimensional Censored Quantile Regression Open
With the availability of high dimensional genetic biomarkers, it is of interest to identify heterogeneous effects of these predictors on patients' survival, along with proper statistical inference. Censored quantile regression has emerged …
View article: Inference for High-Dimensional Censored Quantile Regression
Inference for High-Dimensional Censored Quantile Regression Open
With the availability of high-dimensional genetic biomarkers, it is of interest to identify heterogeneous effects of these predictors on patients’ survival, along with proper statistical inference. Censored quantile regression has emerged …
View article: Inference for High Dimensional Censored Quantile Regression
Inference for High Dimensional Censored Quantile Regression Open
With the availability of high dimensional genetic biomarkers, it is of interest to identify heterogeneous effects of these predictors on patients’ survival, along with proper statistical inference. Censored quantile regression has emerged …
View article: Consistent Estimation of Generalized Linear Models with High Dimensional Predictors via Stepwise Regression
Consistent Estimation of Generalized Linear Models with High Dimensional Predictors via Stepwise Regression Open
Predictive models play a central role in decision making. Penalized regression approaches, such as least absolute shrinkage and selection operator (LASSO), have been widely used to construct predictive models and explain the impacts of the…
View article: Estimation of change‐point for a class of count time series models
Estimation of change‐point for a class of count time series models Open
We apply a three‐step sequential procedure to estimate the change‐point of count time series. Under certain regularity conditions, the estimator of change‐point converges in distribution to the location of the maxima of a two‐sided random …
View article: Analysis of a stochastic IVGTT glucose-insulin model with time delay
Analysis of a stochastic IVGTT glucose-insulin model with time delay Open
Diabetes mellituse has been one of the major diseases in the world due to the high percentage of diabetics in the global population and the increasing growth rate of its onset. Identifying individual physiological characteristics, e.g., in…
View article: Combination of Broccoli Sprout Extract and Zinc Provides Better Protection against Intermittent Hypoxia-Induced Cardiomyopathy Than Monotherapy in Mice
Combination of Broccoli Sprout Extract and Zinc Provides Better Protection against Intermittent Hypoxia-Induced Cardiomyopathy Than Monotherapy in Mice Open
Nuclear factor-E2-related factor 2 (Nrf2) and metallothionein have each been reported to protect against chronic intermittent hypoxia- (IH-) induced cardiomyopathy. Sulforaphane-rich broccoli sprout extract (BSE) and zinc can effectively i…
View article: Building generalized linear models with ultrahigh dimensional features: A sequentially conditional approach
Building generalized linear models with ultrahigh dimensional features: A sequentially conditional approach Open
Conditional screening approaches have emerged as a powerful alternative to the commonly used marginal screening, as they can identify marginally weak but conditionally important variables. However, most existing conditional screening metho…
View article: Regression analysis and variable selection for two‐stage multiple‐infection group testing data
Regression analysis and variable selection for two‐stage multiple‐infection group testing data Open
Group testing, as a cost‐effective strategy, has been widely used to perform large‐scale screening for rare infections. Recently, the use of multiplex assays has transformed the goal of group testing from detecting a single disease to diag…
View article: Protection against diabetic cardiomyopathy is achieved using a combination of sulforaphane and zinc in type 1 diabetic OVE26 mice
Protection against diabetic cardiomyopathy is achieved using a combination of sulforaphane and zinc in type 1 diabetic OVE26 mice Open
Sulforaphane (SFN) can effectively induce nuclear factor E2–related factor 2 (Nrf2), and zinc (Zn) can effectively induce metallothionein (MT), both of which have been shown to protect against diabetic cardiomyopathy (DCM). However, it is …
View article: Forward regression for Cox models with high-dimensional covariates
Forward regression for Cox models with high-dimensional covariates Open
View article: Expression of Adipocyte/Macrophage Fatty Acid–Binding Protein in Tumor-Associated Macrophages Promotes Breast Cancer Progression
Expression of Adipocyte/Macrophage Fatty Acid–Binding Protein in Tumor-Associated Macrophages Promotes Breast Cancer Progression Open
Tumor-associated macrophages (TAM) play a critical role in cancer development and progression. However, the heterogeneity of TAM presents a major challenge to identify clinically relevant markers for protumor TAM. Here, we report that expr…
View article: High dimensional censored quantile regression
High dimensional censored quantile regression Open
Censored quantile regression (CQR) has emerged as a useful regression tool for survival analysis. Some commonly used CQR methods can be characterized by stochastic integral-based estimating equations in a sequential manner across quantile …
View article: Autophagy flux inhibition augments gastric cancer resistance to the anti-human epidermal growth factor receptor 2 antibody trastuzumab
Autophagy flux inhibition augments gastric cancer resistance to the anti-human epidermal growth factor receptor 2 antibody trastuzumab Open
The autophagy involved in the occurrence, development and prognosis of human epidermal growth factor receptor 2 (HER2) gene-amplified cancer also controls the resistance of this type of cancer to the monoclonal antibody, trastuzumab (Tzb).…
View article: Application and interpretation of functional data analysis techniques to differential scanning calorimetry data from lupus patients
Application and interpretation of functional data analysis techniques to differential scanning calorimetry data from lupus patients Open
Changes in thermograms observed in the disease state likely reflect covalent modifications of plasma proteins or changes in large protein-protein interacting networks resulting in the stabilization of plasma proteins towards thermal denatu…
View article: Study on apoptosis effect of human breast cancer cell MCF-7 induced by lycorine hydrochloride via death receptor pathway
Study on apoptosis effect of human breast cancer cell MCF-7 induced by lycorine hydrochloride via death receptor pathway Open
As research was conducted on the early apoptosis of human breast cancer cell MCF-7 caused by lycorine hydrochloride and the expression of the related apoptosis proteins. The early-period apoptosis rate of human breast cancer cell MCF-7 was…
View article: Consistent model identification of varying coefficient quantile regression with BIC tuning parameter selection
Consistent model identification of varying coefficient quantile regression with BIC tuning parameter selection Open
Quantile regression provides a flexible platform for evaluating covariate effects on different segments of the conditional distribution of response. As the effects of covariates may change with quantile level, contemporaneously examining a…