Explanipedia

Neuro-immune regulation of sepsis-associated delirium via the PBN-CeA-spleen axis Open

Mingqing Dong, Yu Zou, Zhiwen Ye, Wangyuan Zou, Lina Zhang , et al. · 2025

N20-P25 Amplitude can Predict Awakening from Coma Open

Li Huang, Zhihan Li, Meilin Ai, Qi Liu, Qianyi Peng , et al. · 2025

Background The objective of this study was to evaluate the relationship between the N20-P25 amplitude of short-latency somatosensory evoked potentials (SSEPs) and neurologic outcomes in patients in a coma state. Methods We retrospectively …

The association between Oxford Acute Severity of Illness Score and mortality in critical hemorrhagic stroke patients: a retrospective cohort study Open

Yuan Jiang, Shuying Qiu, Qianyi Peng, Li Huang, Lina Zhang · 2025

Hemorrhagic stroke is a kind of disastrous cerebrovascular disease, Oxford Acute Severity of Illness Score (OASIS) was only evaluated among mixed critically ill patients, its predictive value in hemorrhagic stroke patients remains undiscov…

N20 amplitude can predict awakening from coma Open

Li Huang, Zhong-chen LI, Meilin Ai, Qi Liu, Qianyi Peng , et al. · 2024

Introduction: To evaluate the relationship between the N20 amplitude of short-latency somatosensory evoked potentials (SSEPs) and neurologic outcomes in patients in a coma state. Methods We retrospectively enrolled neurocritical patients w…

Application of high-quality targeted temperature management guided by multimodal brain monitoring in brain protection of patients with cardiac arrest: A case series Open

Xia Wei-ping, Mei-Ling Ai, Xinhua Ma, Can Hu, Qianyi Peng , et al. · 2024

Rationale: Cardiac arrest (CA) is an acute emergency with high mortality and is closely associated with the risk of brain damage or systemic ischemia–reperfusion injury, post-traumatic stress symptoms. Patient concerns: Targeted temperatur…

Acute Pancreatitis and Leukemoid Reaction as the Presenting Manifestation of Hemorrhagic Fever with Renal Syndrome: A Case Report Open

Lanlan Zhong, H. Shi, Hang Li, Xiaoxia Lü, Qianyi Peng , et al. · 2024

This report emphasizes the importance of recognizing atypical presentations of HFRS and the benefits of a prompt and comprehensive treatment strategy. Early diagnosis and a tailored therapeutic approach are crucial for improving patient ou…

Cerebral autoregulation-directed optimal blood pressure management reduced the risk of delirium in patients with septic shock Open

Qianyi Peng, Xia Liu, Meilin Ai, Li Huang, Li Li , et al. · 2024

Erratum to “Relationship between PaO2/FiO2 and delirium in intensive care: A cross-sectional study” [Journal of Intensive Medicine volume 3 (2023) 73–78.] Open

Fang Gong, Yuhang Ai, Lina Zhang, Qianyi Peng, Quan Zhou , et al. · 2023

Effect of β-blockers on mortality in patients with sepsis: A propensity-score matched analysis Open

Chenglong Ge, Lina Zhang, Yuhang Ai, Wei Chen, Zhiwen Ye , et al. · 2023

Objectives We aimed to evaluate the association between β-blocker therapy and mortality in patients with sepsis. Methods Patients with sepsis were selected from the Medical Information Mart for Intensive Care (MIMIC)-III. Propensity score …

Effect of basal metabolic rate on osteoporosis: A Mendelian randomization study Open

Jingyu Zhou, Zhiwen Ye, Peng Wei, Yi Feng, Min Ouyang , et al. · 2023

Purpose Basal metabolic rate may play a key role in the pathogenesis and progression of osteoporosis. We performed Mendelian random analysis to evaluate the causal relationship between basal metabolic rate and osteoporosis. Methods Instrum…

Chemogenetic activation of the HPC-mPFC pathway improves cognitive dysfunction in lipopolysaccharide -induced brain injury Open

Chenglong Ge, Wei Chen, Lina Zhang, Yuhang Ai, Yu Zou , et al. · 2023

Rationale: Although sepsis-associated encephalopathy (SAE) is a common psychiatric complication in septic patients, the underlying mechanisms remain unclear. Here, we explored the role of the hippocampus (HPC) - medial prefrontal co…

Hippocampus‐prefrontal cortex inputs modulate spatial learning and memory in a mouse model of sepsis induced by cecal ligation puncture Open

Chenglong Ge, Wei Chen, Lina Zhang, Yuhang Ai, Yu Zou , et al. · 2022

Aims Sepsis‐associated encephalopathy (SAE) often leads to cognitive impairments. However, the pathophysiology of SAE is complex and unclear. Here, we investigated the role of hippocampus (HPC)‐prefrontal cortex (PFC) in cognitive dysfunct…

Association between albumin infusion and septic patients with coronary heart disease: A retrospective study based on medical information mart for intensive care III database Open

Zhiwen Ye, Ming Gao, Chenglong Ge, Wenrui Lin, Lina Zhang , et al. · 2022

Coronary heart disease (CHD) is a common comorbidity in intensive care unit (ICU) patients, particularly in the elderly. This particular population may have worse conditions during sepsis, and it presents an overwhelming challenge for clin…

Machine learning for early prediction of sepsis-associated acute brain injury Open

Chenglong Ge, Fuxing Deng, Wei Chen, Zhiwen Ye, Lina Zhang , et al. · 2022

Background Sepsis-associated encephalopathy (SAE) is defined as diffuse brain dysfunction associated with sepsis and leads to a high mortality rate. We aimed to develop and validate an optimal machine-learning model based on clinical featu…

Relationship between PaO2/FiO2 and delirium in intensive care: A cross-sectional study Open

Fang Gong, Yuhang Ai, Lina Zhang, Qianyi Peng, Quan Zhou , et al. · 2022

Association between albumin infusion and outcomes in patients with acute kidney injury and septic shock Open

Chenglong Ge, Qianyi Peng, Wei Chen, Wenchao Li, Lina Zhang , et al. · 2021

Clinical values of cerebral oxygen saturation monitoring in patients with septic shock. Open

Qianyi Peng, Lina Zhang, Meilin Ai, Li Huang, Yuhang Ai · 2021

Cerebral anoxia and hyperoxia, as well as the large fluctuation of cerebral oxygen saturation are important factors that affect the outcomes and the incidence of delirium in septic shock patients, which should be paid attention to in clini…

Relationship Between Cerebral Hemodynamics, Tissue Oxygen Saturation, and Delirium in Patients With Septic Shock: A Pilot Observational Cohort Study Open

Qing Feng, Meilin Ai, Li Huang, Qianyi Peng, Yuhang Ai , et al. · 2021

Background: Septic shock patients have tendencies toward impairment in cerebral autoregulation and imbalanced cerebral oxygen metabolism. Tissue Oxygen Saturation (StO 2 ) and Transcranial Doppler (TCD) monitoring were undertaken to observ…

NU9056, a KAT 5 Inhibitor, Treatment Alleviates Brain Dysfunction by Inhibiting NLRP3 Inflammasome Activation, Affecting Gut Microbiota, and Derived Metabolites in LPS-Treated Mice Open

Lu Chen, Wenxiang Qing, Zexiong Yi, Guoxin Lin, Qianyi Peng , et al. · 2021

Background: The pathogenesis of sepsis-associated encephalopathy (SAE) is complicated, while the efficacy of current treatment technologies is poor. Therefore, the discovery of related targets and the development of new drugs are essential…

Differences in clinical characteristics between younger and older patients with COVID-19 and their relationship with the length of hospital stay Open

Qianyi Peng, Xinhua Ma, Zhiyong Liu, Chunguang Zhao, Lei Zhang , et al. · 2021

Effect of focused cardiopulmonary ultrasonography on clinical outcome of septic shock: a randomized study Open

Li Li, Yuhang Ai, Xiaoting Wang, Hongmin Zhang, Xinhua Ma , et al. · 2021

Objective To investigate the effect of focused ultrasonography on clinical outcomes of septic shock. Methods Patients with septic shock were randomized into an integrated cardiopulmonary ultrasonography (ICUS) group and conventional (CON) …

The Incidence and Prognosis of ICU Delirium: A Retrospective Study from a Single Center Open

Qing Feng, Yuhang Ai, Meilin Ai, Li Huang, Qianyi Peng , et al. · 2021

Purpose Delirium is a frequent occurrence amongst Intensive Care Unit (ICU) patients, but studies on its causes are sparse and its risk factors vary from disease to disease. Here, in this study, an attempt was made to investigate the facto…

Can bioimpedance cardiography assess hemodynamic response to passive leg raising in critically ill patients Open

Li Li, Yuhang Ai, Li Huang, Meilin Ai, Qianyi Peng , et al. · 2020

Passive leg raising (PLR) is a convenient and reliable test to predict fluid responsiveness. The ability of thoracic electrical bioimpedance cardiography (TEB) to monitor changes of cardiac output (CO) during PLR is unknown. In the present…

Impact of Colloid Infusion on Outcomes in Patients with Septic Shock Open

Chenglong Ge, Qianyi Peng, Yuan Jiang, Zhiyong Liu, Wenchao Li , et al. · 2020

Background: Although colloid solution has been widely used in practice, its impact on mortality in patients with septic shock remains unknown. We evaluated the association of colloid infusion with outcomes in septic shock patients.Methods:…

The Relationship Between PaO2/FiO2 and Delirium in Intensive Care: A Cross-Sectional Study Open

Fang Gong, Yuhang Ai, Lina Zhang, Qianyi Peng, Quan Zhou , et al. · 2020

Background: Studies investigating the association of delirium with ratio of partial pressure of arterial oxygen to fraction of inspired oxygen (PaO 2 /FiO 2 ) have been limited. The main purpose of the our study was to explore the relation…

The characteristics of echocardiography in ICU patients and its relationship with the outcomes Open

Qianyi Peng, Lixia Liu, Qian Zhang, Ying Zhu, Hongmin Zhang , et al. · 2020

Background Echocardiography is widely used for bedside monitoring in ICU. We aimed to describe the characteristics of echocardiography manifestations in different groups of ICU patients, and the association with the outcomes. Methods This …

Clinical characteristics of hospitalized patients with COVID-19 in Yueyang, Hunan, China Open

Chenglong Ge, Yuan Jiang, Qianyi Peng, Lei Wu, Kai Duan , et al. · 2020

The clinical characteristics of patients with novel coronavirus disease (COVID-19) in Hunan Province are less understood. We analyzed retrospectively the epidemiological, clinical characteristics, and risk factors associated with severity …

A Clinical Multi-center Study of Pregnant Women with COVID-19 in Hubei, China Open

Shujie Liao, Runji Wang, Dan Wu, Dan Fang, Daoyin Dong , et al. · 2020

Background: Coronavirus disease 2019 (COVID-19) has rapidly spread to more than 200 countries. Thus far, reports regarding multi-center data from throughout gestation in women with COVID-19 and newborn outcomes are scarce. Methods: We retr…

Using echocardiography to guide the treatment of novel coronavirus pneumonia Open

Qianyi Peng, Xiaoting Wang, Lina Zhang · 2020

Relationship between cerebral hemodynamics, tissue oxygen saturation, and delirium in patients with septic shock: a pilot observational trial Open

Qing Feng, Meilin Ai, Li Huang, Qianyi Peng, Yuhang Ai , et al. · 2020

Background Patients with septic shock are prone to have impaired cerebral autoregulation and to have an imbalance in cerebral oxygen metabolism. Transcranial doppler (TCD) and tissue oxygen saturation monitoring were performed to observe t…

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