Meng Zhang
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View article: Indoor Recirculating Aquaculture Versus Traditional Ponds: Effects on Muscle Nutrient Profiles, Texture, and Flavour Compounds in Largemouth Bass (Micropterus salmoides)
Indoor Recirculating Aquaculture Versus Traditional Ponds: Effects on Muscle Nutrient Profiles, Texture, and Flavour Compounds in Largemouth Bass (Micropterus salmoides) Open
This study compared the muscle quality of largemouth bass (Micropterus salmoides) reared in a simplified indoor factory-scale recirculating aquaculture system (F-RAS) with those reared in a traditional pond (TP). Juveniles from the same co…
View article: Network Perturbation Analysis Identifies Three Molecular Subtypes With Distinct Clinical Outcomes and Therapeutic Vulnerabilities in Endometrial Cancer
Network Perturbation Analysis Identifies Three Molecular Subtypes With Distinct Clinical Outcomes and Therapeutic Vulnerabilities in Endometrial Cancer Open
View article: Balanced Expression of the Diiron Oxygenase BioE Is Essential for Biotin Homeostasis in <i>Elizabethkingia meningoseptica</i>
Balanced Expression of the Diiron Oxygenase BioE Is Essential for Biotin Homeostasis in <i>Elizabethkingia meningoseptica</i> Open
Biotin is an essential cofactor for central metabolic pathways in all organisms. The newly identified BioE‐BioL module constitutes a new biotin biosynthesis pathway, yet its mechanisms remain incompletely characterized. Phylogenetic analys…
View article: Proton pump inhibitor increases intestinal epithelial paracellular permeability via the p38-MAPK/NF-κB signaling pathway
Proton pump inhibitor increases intestinal epithelial paracellular permeability via the p38-MAPK/NF-κB signaling pathway Open
Although the absence of macroscopic intestinal lesions, PPI directly enhances intestinal epithelial paracellular permeability by decreasing the expression of the tight junction protein occludin, mediated by the p38-MAPK/NF-κB signaling pat…
View article: Network Pharmacology, Molecular Docking, and Molecular Dynamics Simulations to Elucidate the Potential Mechanism of Ermiao San in Osteoarthritis
Network Pharmacology, Molecular Docking, and Molecular Dynamics Simulations to Elucidate the Potential Mechanism of Ermiao San in Osteoarthritis Open
This study aims to identify the active components and molecular mechanisms of Ermiao San (EMS) in the treatment of osteoarthritis (OA) through network pharmacology, molecular docking, and molecular dynamics simulations. EMS compounds and t…
View article: Overexpression of the heavy metal-associated Isoprenylated plant protein (HIPP) gene <i>IbHIPP7</i> reduces cadmium accumulation and alleviates cadmium toxicity in sweetpotato
Overexpression of the heavy metal-associated Isoprenylated plant protein (HIPP) gene <i>IbHIPP7</i> reduces cadmium accumulation and alleviates cadmium toxicity in sweetpotato Open
Cadmium (Cd) contamination in farmland soils poses a potential threat to crop safety and human health. Heavy metal-associated isoprenylated plant proteins (HIPPs), a unique group of proteins in vascular plants, play a crucial role in abiot…
View article: Bidirectional Regulatory Roles in the Immune Modulation, Organ Dysfunction, and Therapy of Sepsis
Bidirectional Regulatory Roles in the Immune Modulation, Organ Dysfunction, and Therapy of Sepsis Open
Exosomes have emerged as central mediators in sepsis pathogenesis and therapy. Exosomes play an important role in cell communication by transferring functional proteins, metabolites, and nucleic acids to recipient cells. Recently, Low-immu…
View article: Design of a porous biodegradable internal fixation for the treatment of pauwels type III femoral neck fractures
Design of a porous biodegradable internal fixation for the treatment of pauwels type III femoral neck fractures Open
Prolonged internal fixation in the femur can cause issues like osteosclerosis and stress masking, which hinder fracture recovery. AZ31b magnesium alloy has already been widely investigated and shown to be biocompatible and biodegradable. T…
View article: TNF-α in traumatic brain injury: a bidirectional effect in regulating neuroimmune and inflammatory responses
TNF-α in traumatic brain injury: a bidirectional effect in regulating neuroimmune and inflammatory responses Open
View article: S100A10 knockdown exacerbates phenylephrine-induced cardiomyocyte hypertrophy via modulating mitochondrial oxidative phosphorylation
S100A10 knockdown exacerbates phenylephrine-induced cardiomyocyte hypertrophy via modulating mitochondrial oxidative phosphorylation Open
Background Mitochondrial dysfunction is a well-established hallmark of pathological cardiac hypertrophy, though its underlying mechanisms are not fully understood. S100A10, a calcium-binding protein, participates in diverse cellular proces…
View article: Assessment of skin in patients with systemic sclerosis using high‐frequency ultrasound and shear wave elastography: A comparative study with histology, molecular and clinical parameters
Assessment of skin in patients with systemic sclerosis using high‐frequency ultrasound and shear wave elastography: A comparative study with histology, molecular and clinical parameters Open
Objective Ultrasound (US) has been proposed as a potential tool for assessing skin fibrosis in systemic sclerosis (SSc). However, a large‐scale comparison of US‐based assessment with histological markers of skin fibrosis has not been repor…
View article: A radiomics model based on diffusion-weighted imaging developed using machine learning enables prediction of microsatellite instability in endometrial cancer
A radiomics model based on diffusion-weighted imaging developed using machine learning enables prediction of microsatellite instability in endometrial cancer Open
Background The objective of this research was to develop and validate a machine learning-based prediction model integrating clinical data, apparent diffusion coefficient (ADC) value, and diffusion- weighted imaging (DWI)-based radiomic fea…
View article: The value of cough sound monitoring via an audio-enabled smartwatch for OSA screening in COPD patients: a cross-sectional exploratory study
The value of cough sound monitoring via an audio-enabled smartwatch for OSA screening in COPD patients: a cross-sectional exploratory study Open
Objective The purpose of this study is to explore the value of cough sounds and forced exhalation sounds monitored by smartwatches with audio collection capabilities for screening obstructive sleep apnea (OSA) in patients with chronic obst…
View article: Nanodelivery Strategies for STING Agonists: Toward Efficient Cancer Immunotherapy
Nanodelivery Strategies for STING Agonists: Toward Efficient Cancer Immunotherapy Open
cGAS-STING (cyclic GMP-AMP synthetase-interferon gene stimulator) signaling pathway has great potential in tumor treatment, and its superior performance in tumor treatment makes it a new method for tumor treatment. However, the delivery of…
View article: Outcomes of patients treated with venetoclax plus azacitidine versus azacitidine alone stratified by advanced age and acute myeloid leukemia composite model
Outcomes of patients treated with venetoclax plus azacitidine versus azacitidine alone stratified by advanced age and acute myeloid leukemia composite model Open
Venetoclax plus azacitidine is recognized as standard of care for patients with acute myeloid leukemia (AML) ineligible for intensive chemotherapy (IC). However, some patients may still not be treated with venetoclax combinations due to fr…
View article: Non-Averaged Single-Molecule 3D Structures Capture RNA Maturation Intermediates by Individual-Particle Cryo-Electron Tomography
Non-Averaged Single-Molecule 3D Structures Capture RNA Maturation Intermediates by Individual-Particle Cryo-Electron Tomography Open
Understanding the structural dynamics of biomolecules at the single-particle level is essential for elucidating molecular functions, folding mechanisms, and conformational transitions that underlie biological processes. RNA molecules, in p…
View article: Clinical characteristics and endoscopic outcomes of upper GI foreign bodies in children: sedated versus unsedated approaches
Clinical characteristics and endoscopic outcomes of upper GI foreign bodies in children: sedated versus unsedated approaches Open
Objective To investigate the clinical characteristics of upper gastrointestinal foreign bodies in children and compare the clinical efficacy and safety of painless gastroscopy versus conventional gastroscopy for foreign body extraction. Me…
View article: Single-Cell RNA Sequencing Reveals Cellular Heterogeneity and Microenvironmental Remodeling in Human Ureteral Scar Stricture Tissue
Single-Cell RNA Sequencing Reveals Cellular Heterogeneity and Microenvironmental Remodeling in Human Ureteral Scar Stricture Tissue Open
This study presents the first high-resolution single-cell atlas of ureteral scar stricture tissue, revealing profound cellular heterogeneity and remodeling of the immune-stromal-epithelial landscape. The findings also highlight intensified…
View article: SNTA1-deficient human cardiomyocytes show shorter field potential duration and slower conduction velocity
SNTA1-deficient human cardiomyocytes show shorter field potential duration and slower conduction velocity Open
View article: The Non-Traditional Cardiovascular Culprits in Chronic Kidney Disease: Mineral Imbalance and Uremic Toxin Accumulation
The Non-Traditional Cardiovascular Culprits in Chronic Kidney Disease: Mineral Imbalance and Uremic Toxin Accumulation Open
Chronic kidney disease (CKD) is associated with a significantly elevated mortality rate, primarily due to cardiovascular disease (CVD), highlighting a complex bidirectional relationship between the two conditions. Life-threatening cardiova…
View article: NSGA-II-TLBO algorithm for optimizing campus environment art design scheme
NSGA-II-TLBO algorithm for optimizing campus environment art design scheme Open
The study proposes an improved algorithm based on non-dominated sorting genetic algorithm II (NSGA-II) and teaching learning-based optimization algorithm for optimizing campus layout configurations. By introducing teaching learning-based o…
View article: Public Health Policy Approaches to Enhancing Children’s Visual Acuity: Evaluating the Role of Physical Intervention Programs
Public Health Policy Approaches to Enhancing Children’s Visual Acuity: Evaluating the Role of Physical Intervention Programs Open
Purpose: To investigate the effect of wearing eyeglasses in physical education classes on uncorrected distance visual acuity (UDVA), kinetic visual acuity (KVA), and accommodative facility. Method: Participants were 54 fifth graders (10–11…
View article: Illuminating Mitochondrial Dynamics: Ultrahigh Labeling Stability Probe for Long-Term SIM Super-Resolution Imaging of Mitochondria
Illuminating Mitochondrial Dynamics: Ultrahigh Labeling Stability Probe for Long-Term SIM Super-Resolution Imaging of Mitochondria Open
Delineating intricate mitochondrial dynamic changes over extended time scales through combined fluorescent probes and super-resolution microscopy is pivotal for deciphering the pathogenesis of mitochondrial-related diseases. However, a maj…
View article: Identification and evaluation of metabolic mRNAs and key miRNAs in colorectal cancer liver metastasis
Identification and evaluation of metabolic mRNAs and key miRNAs in colorectal cancer liver metastasis Open
View article: Differential expression of cytokines and vitamin D in benign and malignant thyroid diseases
Differential expression of cytokines and vitamin D in benign and malignant thyroid diseases Open
View article: Comparative analgesic efficacy of erector spinae plane block versus quadratus lumborum block in laparoscopic renal cancer surgery: a double-blind randomized trial
Comparative analgesic efficacy of erector spinae plane block versus quadratus lumborum block in laparoscopic renal cancer surgery: a double-blind randomized trial Open
Chinese Clinical Trial Registry, ChiCTR2300074743.
View article: 157P Nivolumab (NIVO) plus ipilimumab (IPI) vs lenvatinib (LEN) or sorafenib (SOR) as first-line (1L) treatment in Chinese patients with unresectable/advanced hepatocellular carcinoma (HCC): CheckMate 9DW expanded analyses
157P Nivolumab (NIVO) plus ipilimumab (IPI) vs lenvatinib (LEN) or sorafenib (SOR) as first-line (1L) treatment in Chinese patients with unresectable/advanced hepatocellular carcinoma (HCC): CheckMate 9DW expanded analyses Open
View article: Characteristic parameter analysis of magnetic resonance diffusion tensor imaging in children with autism spectrum disorder: a retrospective study
Characteristic parameter analysis of magnetic resonance diffusion tensor imaging in children with autism spectrum disorder: a retrospective study Open
View article: Advances in pharmacological research on myocardial remodeling agents: A decade in review
Advances in pharmacological research on myocardial remodeling agents: A decade in review Open
Myocardial remodeling, a complex adaptive response to pathological stimuli, plays a pivotal role in the progression of various cardiovascular diseases, including arrhythmias and heart failure. Significant progress has been made in understa…
View article: Role of radiotherapy in advanced oncogenic-driven oligometastatic non-small cell lung cancer patients: a narrative review
Role of radiotherapy in advanced oncogenic-driven oligometastatic non-small cell lung cancer patients: a narrative review Open
The combination of TKIs with RT presents promising survival benefits for oligometastatic EGFR-mutant NSCLC patients, yet timing remains critical to optimizing therapeutic outcomes. This review highlights the need for future research to ref…