Qiao Yi Chen
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View article: Transcriptome analysis reveals physiological responses in liver tissues of Epinephelus cyanopodus under acute hypoxic stress
Transcriptome analysis reveals physiological responses in liver tissues of Epinephelus cyanopodus under acute hypoxic stress Open
Dissolved oxygen (DO) in aquatic ecosystems plays a pivotal role in fish farming, serving as a critical determinant for the sustainable development of aquaculture practices. When fish suffer hypoxic stress, they undergo a cascade of physio…
View article: The economic ramifications of liver cancer on a global, regional, and national scale
The economic ramifications of liver cancer on a global, regional, and national scale Open
Background A comprehension of the macroeconomic losses on a worldwide, regional, and national scale attributable to liver cancer is crucial for the optimal distribution of medical and research materials. The authors conducted an investigat…
View article: Effects of dietary tryptophan supplementation on growth performance, intestinal health, and AhR/CYP1A1 signaling pathway in broiler chickens challenged with Clostridium perfringens
Effects of dietary tryptophan supplementation on growth performance, intestinal health, and AhR/CYP1A1 signaling pathway in broiler chickens challenged with Clostridium perfringens Open
This experiment investigated the effects of dietary tryptophan (Trp) supplementation on growth performance and intestinal health in broiler chickens challenged with Clostridium perfringens, and explored the underlying molecular mechanism. …
View article: Effects of chitosan oligosaccharide on the growth performance, antioxidant capacity, immune function, intestinal digestive capacity and morphological structure in growing female minks
Effects of chitosan oligosaccharide on the growth performance, antioxidant capacity, immune function, intestinal digestive capacity and morphological structure in growing female minks Open
This study aimed to investigate the effects of dietary chitosan oligosaccharide (COS) supplementation on growth performance, antioxidant capacity, immune function, duodenal digestive enzyme activity, and jejunal morphology in growing femal…
View article: Molecular characterization and expression analysis of hypoxia inducible factor-1α during hypoxic stress in speckled blue grouper (Epinephelus cyanopodus)
Molecular characterization and expression analysis of hypoxia inducible factor-1α during hypoxic stress in speckled blue grouper (Epinephelus cyanopodus) Open
The speckled blue grouper ( Epinephelus cyanopodus ) is a coral reef-dwelling grouper with high market and ecological value. During intensive aquaculture and the transportation of live fish, fish often expose acute hypoxic stress. In this …
View article: The Association Between Low Muscle Mass and the Risk of Depressive Symptoms: A Cross‐Sectional Study Based on the Chinese Longitudinal Health Longevity Survey (CLHLS)
The Association Between Low Muscle Mass and the Risk of Depressive Symptoms: A Cross‐Sectional Study Based on the Chinese Longitudinal Health Longevity Survey (CLHLS) Open
Background Many studies have shown a strong link between sarcopenia and depression, and low muscle mass (LMM) is an important component in the diagnosis of sarcopenia; however, there have been no studies on the relationship between LMM and…
View article: Effects of hypoxia and reoxygenation on energy metabolism, immune response, and apoptosis in orange-spotted grouper (Epinephelus coioides)
Effects of hypoxia and reoxygenation on energy metabolism, immune response, and apoptosis in orange-spotted grouper (Epinephelus coioides) Open
Hypoxia is an unfavorable environmental condition that produces diverse negative effects in fish. High-density cultures of Epinephelus coioides are more likely to experience hypoxic conditions than those in natural environments. To assess …
View article: The Relationship Between BRI and Depressive Symptoms in Chinese Older Adults: A CLHLS‐Based Study
The Relationship Between BRI and Depressive Symptoms in Chinese Older Adults: A CLHLS‐Based Study Open
Background There is a lack of research examining the association between obesity and depressive symptoms in relation to mental health. This study aimed to examine the correlation between Body Roundness Index (BRI) and depressive symptoms i…
View article: Colon Cancer-Derived Exosomal LncRNA-XIST Promotes M2-like Macrophage Polarization by Regulating PDGFRA
Colon Cancer-Derived Exosomal LncRNA-XIST Promotes M2-like Macrophage Polarization by Regulating PDGFRA Open
Colon cancer ranks second in overall cancer-related deaths and poses a serious risk to human life and health. In recent years, exosomes are believed to play an important and significant role in cancer, especially tumor-derived exosomes (TD…
View article: Association between kidney function and Parkinson’s disease risk: a prospective study from the UK Biobank
Association between kidney function and Parkinson’s disease risk: a prospective study from the UK Biobank Open
View article: FBXO32-mediated degradation of PTEN promotes lung adenocarcinoma progression
FBXO32-mediated degradation of PTEN promotes lung adenocarcinoma progression Open
FBXO32, a member of the F-box protein family, is known to play both oncogenic and tumor-suppressive roles in different cancers. However, the functions and the molecular mechanisms regulated by FBXO32 in lung adenocarcinoma (LUAD) remain un…
View article: LAMC2 mitigates ER stress by enhancing ER-mitochondria interaction via binding to MYH9 and MYH10
LAMC2 mitigates ER stress by enhancing ER-mitochondria interaction via binding to MYH9 and MYH10 Open
Highly proliferative and metastatic tumors are constantly exposed to both intrinsic and extrinsic factors that induce adaptation to stressful conditions. Chronic adaptation to endoplasmic reticulum (ER) ER stress is common to many differen…
View article: LAMC2 promotes EGFR cell membrane localization and acts as a novel biomarker for tyrosine kinase inhibitors (TKIs) sensitivity in lung cancer
LAMC2 promotes EGFR cell membrane localization and acts as a novel biomarker for tyrosine kinase inhibitors (TKIs) sensitivity in lung cancer Open
View article: Association of cerebral spinal fluid copper imbalance in amyotrophic lateral sclerosis
Association of cerebral spinal fluid copper imbalance in amyotrophic lateral sclerosis Open
A plethora of environmental risk factors has been persistently implicated in the pathogenesis of amyotrophic lateral sclerosis (ALS), including metal/metalloids. This study aimed to examine potential associations between cerebral spinal fl…
View article: Quantifying the parallel mediation influence of body mass index and depression on physical activity and cognitive function among 3,611 Chinese older adults
Quantifying the parallel mediation influence of body mass index and depression on physical activity and cognitive function among 3,611 Chinese older adults Open
Background Engagement in physically active lifestyles brings multidimensional health benefits including better cognitive function. While prior studies examined the link between physical activity and cognitive function, a remaining unanswer…
View article: Dynamic Activity of Histone H3-Specific Chaperone Complexes in Oncogenesis
Dynamic Activity of Histone H3-Specific Chaperone Complexes in Oncogenesis Open
Canonical histone H3.1 and variant H3.3 deposit at different sites of the chromatin via distinct histone chaperones. Histone H3.1 relies on chaperone CAF-1 to mediate replication-dependent nucleosome assembly during S-phase, while H3.3 var…
View article: Comparative assessment of blood Metal/metalloid levels, clinical heterogeneity, and disease severity in amyotrophic lateral sclerosis patients
Comparative assessment of blood Metal/metalloid levels, clinical heterogeneity, and disease severity in amyotrophic lateral sclerosis patients Open
Amyotrophic lateral sclerosis is an unremitting neurodegenerative (ND) disease characterized by progressive and fatal loss of motor neuron function. While underlying mechanisms for ALS susceptibility are complex, current understanding sugg…
View article: The Association Between Social Influencing Factors and Bipolar Disorder
The Association Between Social Influencing Factors and Bipolar Disorder Open
Many studies have shown that psychosocial factors play a role in bipolar disorder, but most of them mainly focused on the impact of a single factor on bipolar disorder, and the literature review on the social influencing factors of bipolar…
View article: FAM3A Ameliorates Brain Impairment Induced by Hypoxia–Ischemia in Neonatal Rat
FAM3A Ameliorates Brain Impairment Induced by Hypoxia–Ischemia in Neonatal Rat Open
Hypoxia–ischemia (HI) during crucial periods of brain formation can lead to changes in brain morphology, propagation of neuronal stimuli, and permanent neurodevelopmental impairment, which can have profound effects on cognitive function la…
View article: Characteristics of serum metabolites in sporadic amyotrophic lateral sclerosis patients based on gas chromatography-mass spectrometry
Characteristics of serum metabolites in sporadic amyotrophic lateral sclerosis patients based on gas chromatography-mass spectrometry Open
To identify differential metabolites and metabolic pathways and provide guidance for the novel biomarkers for diagnosis and prognosis of amyotrophic lateral sclerosis (ALS). ALS patients and people without nervous diseases were recruited. …
View article: Understanding risks of refractive error among Chinese children amidst pandemic disruptions: results from a rapid survey
Understanding risks of refractive error among Chinese children amidst pandemic disruptions: results from a rapid survey Open
Background Despite effectiveness in delaying the spread of the pandemic, frequent and extended disruption to children’s livelihoods have fomented new norms in which learning routines encounter immense change. In particular, increased seden…
View article: Exosomal Proteins and miRNAs as Mediators of Amyotrophic Lateral Sclerosis
Exosomal Proteins and miRNAs as Mediators of Amyotrophic Lateral Sclerosis Open
Recent advances in the neurobiology and neurogenerative diseases have attracted growing interest in exosomes and their ability to carry and propagate active biomolecules as a means to reprogram recipient cells. Alterations in exosomal prot…
View article: Examining risk factors related to digital learning and social isolation: Youth visual acuity in COVID-19 pandemic
Examining risk factors related to digital learning and social isolation: Youth visual acuity in COVID-19 pandemic Open
The COVID-19 pandemic led to favorable conditions for myopigenic behavioral changes characterized by extended sedentary engagement with digital devices, which are significantly associated with higher risks of myopia incidence. Relatedly, p…
View article: Association of Exosomal miR-210 with Signaling Pathways Implicated in Lung Cancer
Association of Exosomal miR-210 with Signaling Pathways Implicated in Lung Cancer Open
MicroRNA is a class of non-coding RNA involved in post-transcriptional gene regulation. Aberrant expression of miRNAs is well-documented in molecular cancer biology. Extensive research has shown that miR-210 is implicated in the progressio…
View article: RUNX2/miR‑31/SATB2 pathway in nickel‑induced BEAS‑2B cell transformation
RUNX2/miR‑31/SATB2 pathway in nickel‑induced BEAS‑2B cell transformation Open
Nickel (Ni) compounds are classified as Group 1 carcinogens by the International Agency for Research on Cancer (IARC) and are known to be carcinogenic to the lungs. In our previous study, special AT‑rich sequence‑binding protein 2 (SATB2) …
View article: Adolescent Vision Health During the Outbreak of COVID-19: Association Between Digital Screen Use and Myopia Progression
Adolescent Vision Health During the Outbreak of COVID-19: Association Between Digital Screen Use and Myopia Progression Open
The coronavirus (COVID-19) pandemic has impacted education systems globally, making digital devices common arrangements for adolescent learning. However, vision consequences of such behavioral changes are not well-understood. This study in…
View article: Student Health Implications of School Closures during the COVID-19 Pandemic: New Evidence on the Association of e-Learning, Outdoor Exercise, and Myopia
Student Health Implications of School Closures during the COVID-19 Pandemic: New Evidence on the Association of e-Learning, Outdoor Exercise, and Myopia Open
The coronavirus disease 2019 (COVID-19) pandemic forced many education systems to consider alternative remote e-learning modalities, which have consequential behavioral and health implications for youth. In particular, increased e-learning…
View article: Arsenic: A Global Environmental Challenge
Arsenic: A Global Environmental Challenge Open
Arsenic is a naturally occurring metalloid and one of the few metals that can be metabolized inside the human body. The pervasive presence of arsenic in nature and anthropogenic sources from agricultural and medical use have perpetuated hu…
View article: Polyadenylation of Histone H3.1 mRNA Promotes Cell Transformation by Displacing H3.3 from Gene Regulatory Elements
Polyadenylation of Histone H3.1 mRNA Promotes Cell Transformation by Displacing H3.3 from Gene Regulatory Elements Open
Replication-dependent canonical histone messenger RNAs (mRNAs) do not terminate with a poly(A) tail at the 3' end. We previously demonstrated that exposure to arsenic, an environmental carcinogen, induces polyadenylation of canonical histo…
View article: Dominant Heterogeneity of Upper and Lower Motor Neuron Degeneration to Motor Manifestation of Involved Region in Amyotrophic Lateral Sclerosis
Dominant Heterogeneity of Upper and Lower Motor Neuron Degeneration to Motor Manifestation of Involved Region in Amyotrophic Lateral Sclerosis Open
The aim of this study was to localize the anatomic distribution of upper motor neuron (UMN) loss through examining cortical thickness at the clinical onset of amyotrophic lateral sclerosis (ALS) and explore motor manifestation in functiona…