Qiaofei Liu
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View article: Deep learning-based recurrent laryngeal nerve detection during endoscopic thyroidectomy
Deep learning-based recurrent laryngeal nerve detection during endoscopic thyroidectomy Open
View article: Pancreatic cancer cells escape T/NK cell immune surveillance through the expressional separation of CD58
Pancreatic cancer cells escape T/NK cell immune surveillance through the expressional separation of CD58 Open
Background Membrane (m) CD58 is a co-stimulatory ligand that binds to CD2, and the CD2-(m) CD58 axis participates in lymphocyte activation. In addition to mCD58, a soluble form of CD58 (sCD58) has been reported in human serum, urine, and i…
View article: Neoantigens in the application of adoptive cell therapy for solid tumors
Neoantigens in the application of adoptive cell therapy for solid tumors Open
Neoantigens, also known as tumor-specific antigens (TSAs), represent a current research hotspot in the field of tumor immunology, offering immense potential for cancer treatment. Adoptive cell therapy (ACT), an emerging and rapidly evolvin…
View article: Proactive emergency laparoscopic cholecystectomy for complex acute cholecystitis: a prospective cohort at a national emergency center in China
Proactive emergency laparoscopic cholecystectomy for complex acute cholecystitis: a prospective cohort at a national emergency center in China Open
Background: While emergency laparoscopic cholecystectomy (ELC) is the standard treatment for acute cholecystitis (AC), optimal management of complex cases, particularly those with symptom duration ≥7 days or severe inflammation, remains co…
View article: Fucosterol exerts an anti-atherosclerotic action via NF-κB and p38/Erk MAPK signaling pathways
Fucosterol exerts an anti-atherosclerotic action via NF-κB and p38/Erk MAPK signaling pathways Open
The current investigation revealed that fucosterol attenuates atherosclerotic plaques in apoE-/- mice through the inhibition of hyperlipidemia, inflammation, and oxidative stress.
View article: Intraoperative indocyanine green cholangiography (ICGC) could be helpful for young surgeons to perform emergent laparoscopic cholecystectomy for acute cholecystitis patients: A prospective single-arm study of 97 consecutive cases
Intraoperative indocyanine green cholangiography (ICGC) could be helpful for young surgeons to perform emergent laparoscopic cholecystectomy for acute cholecystitis patients: A prospective single-arm study of 97 consecutive cases Open
View article: NFE2-driven neutrophil polarization promotes pancreatic cancer liver metastasis progression
NFE2-driven neutrophil polarization promotes pancreatic cancer liver metastasis progression Open
Pancreatic cancer liver metastasis is an important factor leading to dismal prognoses. The details of adaptive immune remodeling in liver metastasis, especially the role of neutrophils, remain elusive. Here, combined single-cell sequencing…
View article: Molecular Profiling Reveals the Malignant Potential in Solid Pseudopapillary Neoplasms of the Pancreas
Molecular Profiling Reveals the Malignant Potential in Solid Pseudopapillary Neoplasms of the Pancreas Open
View article: Chimeric antigen receptor macrophages targeting c-MET(CAR-M-c-MET) inhibit pancreatic cancer progression and improve cytotoxic chemotherapeutic efficacy
Chimeric antigen receptor macrophages targeting c-MET(CAR-M-c-MET) inhibit pancreatic cancer progression and improve cytotoxic chemotherapeutic efficacy Open
This study provides compelling evidence for the safety and efficacy of CAR-M therapy in treating pancreatic cancer. The results demonstrate that CAR-M-c-MET significantly suppresses pancreatic cancer progression and enhances the effectiven…
View article: Identification of crucial genes through WGCNA in the progression of clear cell renal cell carcinoma
Identification of crucial genes through WGCNA in the progression of clear cell renal cell carcinoma Open
Background Due to the limited clinical treatment options for clear cell renal cell carcinoma (ccRCC), this study aimed to explore the molecular mechanisms underlying ccRCC and identify potential therapeutic targets. Methods A series of bio…
View article: Solid pseudopapillary neoplasm (SPN) of the pancreas: a peculiar tumor that needs special care and attention
Solid pseudopapillary neoplasm (SPN) of the pancreas: a peculiar tumor that needs special care and attention Open
View article: 21O Coformulated vibostolimab/pembrolizumab in advanced cervical cancer: KEYVIBE-005
21O Coformulated vibostolimab/pembrolizumab in advanced cervical cancer: KEYVIBE-005 Open
Vibostolimab (vibo) (anti-TIGIT) + pembrolizumab (pembro) has shown promising efficacy in cervical cancer. KEYVIBE-005 (NCT05007106) evaluated coformulated vibo/pembro in previously treated cervical cancer (cohort A). This open-label phase…
View article: Nano-trapping CXCL13 reduces regulatory B cells in tumor microenvironment and inhibits tumor growth
Nano-trapping CXCL13 reduces regulatory B cells in tumor microenvironment and inhibits tumor growth Open
View article: Inhibiting PI3 kinase-γ in both myeloid and plasma cells remodels the suppressive tumor microenvironment in desmoplastic tumors
Inhibiting PI3 kinase-γ in both myeloid and plasma cells remodels the suppressive tumor microenvironment in desmoplastic tumors Open
View article: Celastrol nanoemulsion induces immunogenicity and downregulates PD-L1 to boost abscopal effect in melanoma therapy
Celastrol nanoemulsion induces immunogenicity and downregulates PD-L1 to boost abscopal effect in melanoma therapy Open
View article: Gastrointestinal: Severe gastritis and colitis leading to gastrointestinal hemorrhage in a patient with drug reaction with eosinophilia and systemic symptoms syndrome
Gastrointestinal: Severe gastritis and colitis leading to gastrointestinal hemorrhage in a patient with drug reaction with eosinophilia and systemic symptoms syndrome Open
A 15-year-old adolescent male presented with a headache and recurrent fever for 5 months. A magnetic resonance imaging (MRI) of the brain suggested purulent meningitis, and the patient received vancomycin. However, within a month, the pati…
View article: Perceptions of pancreatic surgeons and the current status of palliative care for pancreatic cancer in China: a multi-center online questionnaire survey
Perceptions of pancreatic surgeons and the current status of palliative care for pancreatic cancer in China: a multi-center online questionnaire survey Open
Objective: To investigate the perceptions of pancreatic surgeons regarding palliative care for pancreatic cancer and the current status of palliative care for pancreatic cancer patients in China. Methods: An online questionnaire consisting…
View article: Long-term sustained clinical remission of peritoneal metastatic pancreatic ductal adenocarcinoma after sequential chemoradiation therapy: a case report
Long-term sustained clinical remission of peritoneal metastatic pancreatic ductal adenocarcinoma after sequential chemoradiation therapy: a case report Open
Patients with peritoneal metastatic pancreatic ductal adenocarcinoma (pmPDAC) with high-level serum carbohydrate antigens (CAs) always suffer extremely dismal prognosis, with a median survival of several months. Herein, we reported a case …
View article: Modulating ferroptosis sensitivity: environmental and cellular targets within the tumor microenvironment
Modulating ferroptosis sensitivity: environmental and cellular targets within the tumor microenvironment Open
Ferroptosis, a novel form of cell death triggered by iron-dependent phospholipid peroxidation, presents significant therapeutic potential across diverse cancer types. Central to cellular metabolism, the metabolic pathways associated with f…
View article: Heparin-induced thrombocytopenia thrombosis after pancreaticoduodenectomy without definitive prophylactic or therapeutic use of heparin: a case report
Heparin-induced thrombocytopenia thrombosis after pancreaticoduodenectomy without definitive prophylactic or therapeutic use of heparin: a case report Open
Heparin-induced thrombocytopenia thrombosis (HITT) is a rare and potentially life-threatening complication after abdominal surgery, and it always occurs after the prophylactic or therapeutic use of heparin. HITT after pancreaticoduodenecto…
View article: Local resection for solid pseudopapillary neoplasms of the pancreas shows improved postoperative gastrointestinal function and reduced mental stress: a multiquestionnaire survey from a large cohort
Local resection for solid pseudopapillary neoplasms of the pancreas shows improved postoperative gastrointestinal function and reduced mental stress: a multiquestionnaire survey from a large cohort Open
Background: Solid pseudopapillary neoplasm (SPN) of the pancreas is a rare, low-grade malignant pancreatic tumor with a highly favorable prognosis. Most SPN patients are young and middle-aged women. The main controversial topic for SPN is …
View article: Preventive Effect of 6-shogaol on D-galactosamine Induced Hepatotoxicity Through NF-κB/MAPK Signaling Pathway in Rats
Preventive Effect of 6-shogaol on D-galactosamine Induced Hepatotoxicity Through NF-κB/MAPK Signaling Pathway in Rats Open
This analysis aims to see whether 6-shogaol could protect rats against D-galactosamine (D-GalN)-induced Hepatotoxicity. The Wistar rats were divided into four groups (n=6). Group 1 received a standard diet, Group 2 received an oral adminis…
View article: Supplementary Figures 1-7 from Antigen Presentation by Dendritic Cells in Tumors Is Disrupted by Altered Metabolism that Involves Pyruvate Kinase M2 and Its Interaction with SOCS3
Supplementary Figures 1-7 from Antigen Presentation by Dendritic Cells in Tumors Is Disrupted by Altered Metabolism that Involves Pyruvate Kinase M2 and Its Interaction with SOCS3 Open
Supplementary Figures 1-7 from Antigen Presentation by Dendritic Cells in Tumors Is Disrupted by Altered Metabolism that Involves Pyruvate Kinase M2 and Its Interaction with SOCS3
View article: Supplementary Figures 1-7 from Antigen Presentation by Dendritic Cells in Tumors Is Disrupted by Altered Metabolism that Involves Pyruvate Kinase M2 and Its Interaction with SOCS3
Supplementary Figures 1-7 from Antigen Presentation by Dendritic Cells in Tumors Is Disrupted by Altered Metabolism that Involves Pyruvate Kinase M2 and Its Interaction with SOCS3 Open
Supplementary Figures 1-7 from Antigen Presentation by Dendritic Cells in Tumors Is Disrupted by Altered Metabolism that Involves Pyruvate Kinase M2 and Its Interaction with SOCS3
View article: Data from Antigen Presentation by Dendritic Cells in Tumors Is Disrupted by Altered Metabolism that Involves Pyruvate Kinase M2 and Its Interaction with SOCS3
Data from Antigen Presentation by Dendritic Cells in Tumors Is Disrupted by Altered Metabolism that Involves Pyruvate Kinase M2 and Its Interaction with SOCS3 Open
Dendritic cell (DC) function is negatively affected by tumors and tumor-derived factors, but little is known about the underlying mechanisms. Here, we show that intracellular SOCS3 in DCs binds to pyruvate kinase type M2 (M2-PK), which pla…
View article: Data from Antigen Presentation by Dendritic Cells in Tumors Is Disrupted by Altered Metabolism that Involves Pyruvate Kinase M2 and Its Interaction with SOCS3
Data from Antigen Presentation by Dendritic Cells in Tumors Is Disrupted by Altered Metabolism that Involves Pyruvate Kinase M2 and Its Interaction with SOCS3 Open
Dendritic cell (DC) function is negatively affected by tumors and tumor-derived factors, but little is known about the underlying mechanisms. Here, we show that intracellular SOCS3 in DCs binds to pyruvate kinase type M2 (M2-PK), which pla…
View article: Adoptive cellular immunotherapy for solid neoplasms beyond CAR-T
Adoptive cellular immunotherapy for solid neoplasms beyond CAR-T Open
In recent decades, immune checkpoint blockade and chimeric antigen receptor T cell (CAR-T) therapy are two milestone achievements in clinical immunotherapy. However, both show limited efficacies in most solid neoplasms, which necessitates …
View article: Comprehensive analysis of mixed neuroendocrine non-neuroendocrine neoplasms (MiNENs): A SEER database analysis of 767 cases
Comprehensive analysis of mixed neuroendocrine non-neuroendocrine neoplasms (MiNENs): A SEER database analysis of 767 cases Open
Background Mixed neuroendocrine non-neuroendocrine neoplasm (MiNEN) is an extremely rare entity, consisting of neuroendocrine and non-neuroendocrine components. It can occur in various organs throughout the body, with a rising incidence. I…
View article: Digestive tract reconstruction in pancreaticoduodenectomy in University Hospitals of China: a national questionnaire survey
Digestive tract reconstruction in pancreaticoduodenectomy in University Hospitals of China: a national questionnaire survey Open
Background: Pancreaticoduodenectomy (PD) has been widely applied in general hospitals in China; however, there is still a lack of unified standards for each surgical technique and procedure. This survey is intended to investigate the curre…
View article: The effect of minimally invasive or open radical antegrade modular pancreatosplenectomy on pancreatic cancer: A multicenter randomized clinical trial protocol
The effect of minimally invasive or open radical antegrade modular pancreatosplenectomy on pancreatic cancer: A multicenter randomized clinical trial protocol Open
Background Radical antegrade modular pancreatosplenectomy (RAMPS) has been proven to improve R0 resection and lymph harvest in treating patients with distal pancreatic cancer. The development of minimally invasive surgery has advantages in…