Qiaoping Wu
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View article: Inflammatory markers from routine blood tests predict survival in multiple myeloma: a Systematic Review and meta-analysis
Inflammatory markers from routine blood tests predict survival in multiple myeloma: a Systematic Review and meta-analysis Open
Background Multiple myeloma (MM) is an incurable hematologic malignancy marked by abnormal plasma cell proliferation. Inflammatory indices derived from routine blood tests—such as neutrophil-to-lymphocyte ratio (NLR), lymphocyte-to-monocyt…
View article: The expression regulation of recA gene and bacterial class 2 integron-associated genes induced by antibiotics
The expression regulation of recA gene and bacterial class 2 integron-associated genes induced by antibiotics Open
Objective To investigate the effects and mechanisms of common antibiotics induction on the expression of class 2 integron integrase and variable region resistance genes in bacteria, as well as potential structural mutations. Methods Clinic…
View article: Molecular characterization of carbapenem resistance mechanisms and phenotypic correlations in clinical Klebsiella pneumoniae isolates from Ningbo, China
Molecular characterization of carbapenem resistance mechanisms and phenotypic correlations in clinical Klebsiella pneumoniae isolates from Ningbo, China Open
Objective The purpose of this study is to understand the antimicrobial susceptibility and molecular distribution characteristics of carbapenem-resistant Klebsiella pneumoniae (CRKP) in the region, and to evaluate their correlation. Additio…
View article: Study on the invitro synergistic susceptibility and biofilm inhibition mechanism of ceftazidime-avibactam combined with aztreonam against carbapenem-resistant Klebsiella pneumoniae
Study on the invitro synergistic susceptibility and biofilm inhibition mechanism of ceftazidime-avibactam combined with aztreonam against carbapenem-resistant Klebsiella pneumoniae Open
Objective This study aims to investigate the synergistic effects and biofilm inhibition mechanisms of ceftazidime-avibactam (CZA) combined with aztreonam (ATM) against carbapenem-resistant Klebsiella pneumoni a (CRKP) commonly found in the…
View article: New Option for Antibiotic Susceptibility Testing in Clinical Practice: Performance Evaluation of AutoMic-i600 Automatic System Based on Broth Microdilution Method
New Option for Antibiotic Susceptibility Testing in Clinical Practice: Performance Evaluation of AutoMic-i600 Automatic System Based on Broth Microdilution Method Open
Based on these findings, we recommend that the AutoMic-i600 system could be a new option for routine AST testing in a clinical setting. Particularly for drug-resistant bacteria and novel antibiotics, detection with AutoMic-i600 may be more…
View article: Distribution characteristics of integrons and correlation analysis of antibiotic resistance in urine isolated Enterobacter cloacae
Distribution characteristics of integrons and correlation analysis of antibiotic resistance in urine isolated Enterobacter cloacae Open
Objective This study aims to understand the distribution of integrons among Enterobacter cloacae isolated from clinical urine specimens in our hospital, as well as the molecular characteristics of the variable region resistance gene casset…
View article: Molecular Characteristics of Virulence Genes in Carbapenem-Resistant and Carbapenem-Sensitive Klebsiella Pneumoniae in Relation to Different Capsule Serotypes in Ningbo, China
Molecular Characteristics of Virulence Genes in Carbapenem-Resistant and Carbapenem-Sensitive Klebsiella Pneumoniae in Relation to Different Capsule Serotypes in Ningbo, China Open
CSKP isolates were detected more frequently than CRKP isolates for capsular serotype detection. K1 isolates had the most virulence gene and strongest virulence, K5 isolates carried the fewest virulence genes, and K54 isolates had the weake…
View article: Molecular Prevalence and Geographical Variations of Carbapenem-Resistant Klebsiella pneumoniae ST15 Isolates in a Tertiary Hospital in Ningbo, China
Molecular Prevalence and Geographical Variations of Carbapenem-Resistant Klebsiella pneumoniae ST15 Isolates in a Tertiary Hospital in Ningbo, China Open
BACKGROUND In China, the most prevalent type of CRKP is ST11, but the high-risk clone ST15 has grown in popularity in recent years, posing a serious public health risk. Therefore, we investigated the molecular prevalence characteristics of…
View article: Detecting early‐warning biomarkers associated with heart‐exosome genetic‐signature for acute myocardial infarction: A source‐tracking study of exosome
Detecting early‐warning biomarkers associated with heart‐exosome genetic‐signature for acute myocardial infarction: A source‐tracking study of exosome Open
The genetic information of plasma total‐exosomes originating from tissues have already proven useful to assess the severity of coronary artery diseases (CAD). However, plasma total‐exosomes include multiple sub‐populations secreted by vari…
View article: Differences in molecular characteristics and expression of virulence genes in carbapenem-resistant and sensitive Klebsiella pneumoniae isolates in Ningbo, China
Differences in molecular characteristics and expression of virulence genes in carbapenem-resistant and sensitive Klebsiella pneumoniae isolates in Ningbo, China Open
Background In recent years, Klebsiella pneumoniae has attracted attention because of its increasing drug resistance. At the same time, the migration and pathogenicity caused by its virulence genes also bring many difficulties to the diagno…
View article: Neglected Vitamin K Deficiency Causing Coagulation Dysfunction in an Older Patient with Pneumonia: A Case Report
Neglected Vitamin K Deficiency Causing Coagulation Dysfunction in an Older Patient with Pneumonia: A Case Report Open
Background: The development of coagulation disorders can be dangerous and fatal in the older people, especially those with multiple medical conditions. Vitamin K-dependent coagulation disorders are easily overlooked when anticoagulant drug…
View article: Distribution and Molecular Characterization of Functional Class 2 Integrons in Clinical Proteus mirabilis Isolates
Distribution and Molecular Characterization of Functional Class 2 Integrons in Clinical Proteus mirabilis Isolates Open
Wenjun Lu,1,* Quedan Qiu,2,* Keda Chen,2 Rongqing Zhao,2 Qingcao Li,2 Qiaoping Wu2 1Intensive Care Units of Ningbo Medical Centre Lihuili Hospital, Ningbo University, Ningbo, Zhejiang Province, Peopleâs Republic of China;…
View article: CDKAL1, KCNQ1, and IGF2BP2 are Identified as Type 2 Diabetes Susceptibility Genes in a Regional Chinese Population
CDKAL1, KCNQ1, and IGF2BP2 are Identified as Type 2 Diabetes Susceptibility Genes in a Regional Chinese Population Open
Aims: Diabetes has become a major public health problem in China.Recent advances in genetic studies have identified numerous susceptibility loci for type 2 diabetes (T2D).Current models to detect risk of T2D are largely based on studies fr…