Qiaoqiao Xu
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View article: PFOS Disrupts Oocyte Maturation and Early Embryonic Development via Ovarian FOXK1 O‐GlcNAcylation in Mice
PFOS Disrupts Oocyte Maturation and Early Embryonic Development via Ovarian FOXK1 O‐GlcNAcylation in Mice Open
Perfluorooctane sulfonate (PFOS) is of great concern due to its accumulation in living organisms and reproductive toxicity. Although prior studies indicate that PFOS exposure causes female reproductive disorders, the underlying mechanism r…
View article: Cardiovascular disease risk associated with housing disadvantages among middle-aged and older populations in China: a cohort study
Cardiovascular disease risk associated with housing disadvantages among middle-aged and older populations in China: a cohort study Open
These findings suggested that housing disadvantages were associated with CVD risk in China and highlighted geographical inequality in cardiovascular diseases associated with housing disadvantages.
View article: Insights into the disinfection byproduct bromochloroacetamide-induced cardiotoxicity of zebrafish embryo–larvae: A multiomics approach and comparison of biomarker responsiveness
Insights into the disinfection byproduct bromochloroacetamide-induced cardiotoxicity of zebrafish embryo–larvae: A multiomics approach and comparison of biomarker responsiveness Open
View article: Association Between Preoperative Cognitive Performance and Postoperative Delirium in Older Patients: Results From a Multicenter, Prospective Cohort Study, and a Mendelian Randomization Study
Association Between Preoperative Cognitive Performance and Postoperative Delirium in Older Patients: Results From a Multicenter, Prospective Cohort Study, and a Mendelian Randomization Study Open
This study evaluated the association between preoperative cognitive performance and postoperative delirium (POD) using a multicenter prospective cohort, and explored potential causality using Mendelian randomization (MR) analysis. We analy…
View article: Advancing brain injury treatment and neuroprotection with ligustilide: Mechanisms and therapeutic potential
Advancing brain injury treatment and neuroprotection with ligustilide: Mechanisms and therapeutic potential Open
View article: Perfluorohexane Sulfonic Acid Disrupts the Immune Microenvironment for Spermatogenesis by Damaging the Structure of the Blood‐Testis Barrier in Mice
Perfluorohexane Sulfonic Acid Disrupts the Immune Microenvironment for Spermatogenesis by Damaging the Structure of the Blood‐Testis Barrier in Mice Open
Perfluorohexane sulfonic acid (PFHxS) is extensively used in waterproof coatings and fire‐fighting foams, and several studies have found it to be a potential health hazard, but there is still unknown about its effects on spermatogenesis. O…
View article: Transcranial direct current stimulation for patients with walking difficulties caused by cerebral small vessel disease: a randomized controlled study
Transcranial direct current stimulation for patients with walking difficulties caused by cerebral small vessel disease: a randomized controlled study Open
Introduction Cerebral small vessel disease (CSVD) is a chronic systemic degenerative disease affecting small blood vessels in the brain, leading to cognitive impairments. Transcranial direct current stimulation (tDCS), a non-invasive brain…
View article: Adverse reproductive outcomes and future risk of incident dementia: The modifying effect of genetic susceptibility
Adverse reproductive outcomes and future risk of incident dementia: The modifying effect of genetic susceptibility Open
Background: Adverse reproductive outcomes (AROs) in women can lead to the occurrence of a variety of diseases later in life. However, research on AROs and dementia risk in women has not been reported. Objective: This study explored the eff…
View article: Impact of Maternal BPA Exposure during Pregnancy on Obesity in Male Offspring: A Mechanistic Mouse Study of Adipose-Derived Exosomal miRNA
Impact of Maternal BPA Exposure during Pregnancy on Obesity in Male Offspring: A Mechanistic Mouse Study of Adipose-Derived Exosomal miRNA Open
The present study corroborates the regulatory function of adipose-derived exosomal miRNAs in obesity in male offspring mice resulting from BPA exposure during pregnancy. Exosomal miRNA may be a key and novel molecular biomarker in the adve…
View article: Potential tumor-specific antigens and immune landscapes identification for mRNA vaccine in thyroid cancer
Potential tumor-specific antigens and immune landscapes identification for mRNA vaccine in thyroid cancer Open
Background Tumor mRNA vaccines have been identified as a promising technology for cancer therapy in multiple cancer types, while their efficacy in thyroid cancer (THCA) is unclear. Immunotyping is strongly associated with the immune microe…
View article: Baicalin Inhibits VSMC Phenotypic Transition and Ameliorates Atherosclerosis via GSK3β-TCF21 Signaling Pathway
Baicalin Inhibits VSMC Phenotypic Transition and Ameliorates Atherosclerosis via GSK3β-TCF21 Signaling Pathway Open
Background Atherosclerosis (AS) is the pathological basis of acute myocardial infarction, acute stroke, and other acute critical illnesses. Vascular smooth muscle cell (VSMC) phenotypic transformation plays a remarkable role in the occurre…
View article: Development of machine learning-based prediction models of inadequate postoperative analgesia after noncardiac surgery: a retrospective cohort study
Development of machine learning-based prediction models of inadequate postoperative analgesia after noncardiac surgery: a retrospective cohort study Open
Background Early identification of high-risk patients with inadequate postoperative analgesia is crucial in noncardiac surgery. This study aimed to develop prediction models for inadequate postoperative analgesia in noncardiac surgery usin…
View article: Development of interpretable machine learning models for prediction of acute kidney injury after noncardiac surgery: a retrospective cohort study
Development of interpretable machine learning models for prediction of acute kidney injury after noncardiac surgery: a retrospective cohort study Open
Background: Early identification of patients at high-risk of postoperative acute kidney injury (AKI) can facilitate the development of preventive approaches. This study aimed to develop prediction models for postoperative AKI in noncardiac…
View article: Alterations in sperm DNA methylation may as a mediator of paternal air pollution exposure and offspring birth outcomes: Insight from a birth cohort study
Alterations in sperm DNA methylation may as a mediator of paternal air pollution exposure and offspring birth outcomes: Insight from a birth cohort study Open
Paternal exposure to environmental risk factors influences the offspring health. This study aimed to evaluate the association between paternal air pollution exposure mediated by sperm DNA methylation and adverse birth outcomes in offspring…
View article: Changes in Multiparametric Magnetic Resonance Imaging and Plasma Amyloid-Beta Protein in Subjective Cognitive Decline
Changes in Multiparametric Magnetic Resonance Imaging and Plasma Amyloid-Beta Protein in Subjective Cognitive Decline Open
The association between plasma amyloid-beta protein (Aβ) and subjective cognitive decline (SCD) remains controversial. We aimed to explore the correlation between neuroimaging findings, plasma Aβ, and neuropsychological scales using data f…
View article: Prognostic significance of preoperative nutritional status for postoperative acute kidney injury in older patients undergoing major abdominal surgery: a retrospective cohort study
Prognostic significance of preoperative nutritional status for postoperative acute kidney injury in older patients undergoing major abdominal surgery: a retrospective cohort study Open
Background: The association between malnutrition and postoperative acute kidney injury (AKI) has not been well studied. In this study, the authors examined the association between preoperative nutritional status and postoperative AKI in ol…
View article: Association of maternal metals exposure, metabolites and birth outcomes in newborns: A prospective cohort study
Association of maternal metals exposure, metabolites and birth outcomes in newborns: A prospective cohort study Open
This study provides new epidemiological evidence indicating the associations of metals exposure and neonatal birth outcomes, and emphasizes the potential role of metabolite biomarkers and their importance in monitoring adverse birth outcom…
View article: Caloric restriction remodels the hepatic chromatin landscape and bile acid metabolism by modulating the gut microbiota
Caloric restriction remodels the hepatic chromatin landscape and bile acid metabolism by modulating the gut microbiota Open
View article: Maternal BPAF exposure impaired synaptic development and caused behavior abnormality in offspring
Maternal BPAF exposure impaired synaptic development and caused behavior abnormality in offspring Open
Bisphenol A (BPA) has been widely restricted, leading to a significant increase in the production of bisphenol AF (BPAF), one of the most common bisphenol analogs use as a substitute for BPA. However, there is limit evidence on the neuroto…
View article: Intraoperative enhancement of effective connectivity in the default mode network predicts postoperative delirium following cardiovascular surgery
Intraoperative enhancement of effective connectivity in the default mode network predicts postoperative delirium following cardiovascular surgery Open
Postoperative delirium is a common and preventable complication after cardiovascular surgery and is associated with increased risk of morbidity and mortality. However, strategies for identifying at-risk patients are limited. In this prospe…
View article: Successful diagnosis of intravascular large B-cell lymphoma from a neuromyelitis optica presentation in a patient with primary Sjögren’s syndrome: a case report
Successful diagnosis of intravascular large B-cell lymphoma from a neuromyelitis optica presentation in a patient with primary Sjögren’s syndrome: a case report Open
Background Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune neurological disorder characterized by the presence of serum anti-aquaporin-4 autoantibodies (AQP4 IgG). There have been previous reports of NMOSD associated with p…
View article: Additional file 7 of Caloric restriction remodels the hepatic chromatin landscape and bile acid metabolism by modulating the gut microbiota
Additional file 7 of Caloric restriction remodels the hepatic chromatin landscape and bile acid metabolism by modulating the gut microbiota Open
Additional file 7. Differentially identified BAs in livers (HFD vs HFDR).
View article: Additional file 3 of Caloric restriction remodels the hepatic chromatin landscape and bile acid metabolism by modulating the gut microbiota
Additional file 3 of Caloric restriction remodels the hepatic chromatin landscape and bile acid metabolism by modulating the gut microbiota Open
Additional file 3. Top20 GO enrichment analysis of hepatic DEGs.
View article: Additional file 4 of Caloric restriction remodels the hepatic chromatin landscape and bile acid metabolism by modulating the gut microbiota
Additional file 4 of Caloric restriction remodels the hepatic chromatin landscape and bile acid metabolism by modulating the gut microbiota Open
Additional file 4. Top20 KEGG pathway analysis of hepatic DEGs.
View article: Additional file 5 of Caloric restriction remodels the hepatic chromatin landscape and bile acid metabolism by modulating the gut microbiota
Additional file 5 of Caloric restriction remodels the hepatic chromatin landscape and bile acid metabolism by modulating the gut microbiota Open
Additional file 5. Differentially expressed metabolites in livers.
View article: Additional file 6 of Caloric restriction remodels the hepatic chromatin landscape and bile acid metabolism by modulating the gut microbiota
Additional file 6 of Caloric restriction remodels the hepatic chromatin landscape and bile acid metabolism by modulating the gut microbiota Open
Additional file 6. Differentially identified BAs in livers (AL vs CR).
View article: Additional file 2 of Caloric restriction remodels the hepatic chromatin landscape and bile acid metabolism by modulating the gut microbiota
Additional file 2 of Caloric restriction remodels the hepatic chromatin landscape and bile acid metabolism by modulating the gut microbiota Open
Additional file 2. Differential expressed genes in livers (AL vs CR).
View article: Association between Blood Manganese Levels and Visceral Adipose Tissue in the United States: A Population-Based Study
Association between Blood Manganese Levels and Visceral Adipose Tissue in the United States: A Population-Based Study Open
Background: Manganese (Mn) is an essential trace element with a narrow toxic margin for human health. The association between Mn exposure and adverse visceral adipose tissue (VAT) accumulation is unclear. Objective: This study aimed to est…
View article: Analysis on the Sustainability of People to People Assistance and High quality Elderly Care
Analysis on the Sustainability of People to People Assistance and High quality Elderly Care Open
The rapidly developing population aging is deeply and inevitably affecting the economic and social development of China. At present, the rural elderly care is the biggest weakness in the elderly care service system, so solving the aging di…
View article: CHIP Decline Is Associated With Isoflurane-Induced Neurodegeneration in Aged Mice
CHIP Decline Is Associated With Isoflurane-Induced Neurodegeneration in Aged Mice Open
Perioperative neurocognitive disorders (PND) commonly occur in elderly patients, and isoflurane could be a risk factor. During the pathogenesis of neurodegeneration, the ubiquitin–proteasome system (UPS) participates in the process of agin…