Qingsong Ye
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View article: Focal Mechanism of 2020–2025 Mw > 5.0 Earthquake Sequence in Bárðarbunga Volcanic Zone, Iceland, and Its Implications for Magma Inflow Activity
Focal Mechanism of 2020–2025 Mw > 5.0 Earthquake Sequence in Bárðarbunga Volcanic Zone, Iceland, and Its Implications for Magma Inflow Activity Open
Iceland is an emergent segment of the Mid-Atlantic Ridge, and the Bárðarbunga volcano lies in central Iceland beneath the Vatnajökull glacier, the largest glacier in Europe. Geodetic and seismic observations indicate persistent post-erupti…
View article: Dental Pulp Stem Cell-Derived Intracellular Vesicles Promote Cartilage Regeneration and Alleviate Pain in Temporomandibular Joint Osteoarthritis
Dental Pulp Stem Cell-Derived Intracellular Vesicles Promote Cartilage Regeneration and Alleviate Pain in Temporomandibular Joint Osteoarthritis Open
DPSC-IVs, with higher yield and simpler extraction, deliver therapeutic efficacy comparable to DPSC-EVs, offering a more clinically feasible strategy for TMJ-OA treatment.
View article: Proteomic analysis identifies novel molecular signatures and immune-metabolic pathways in rheumatoid arthritis-associated interstitial lung disease
Proteomic analysis identifies novel molecular signatures and immune-metabolic pathways in rheumatoid arthritis-associated interstitial lung disease Open
Rheumatoid arthritis (RA)-associated interstitial lung disease (RA-ILD) is a severe extra-articular manifestation of RA characterized by complex pathogenesis and limited therapeutic options. The present study aimed to identify circulating …
View article: SUN-730 TYRA-300 Promotes Bone Growth In Two Mouse Models Of FGFR3-related Skeletal Dysplasia
SUN-730 TYRA-300 Promotes Bone Growth In Two Mouse Models Of FGFR3-related Skeletal Dysplasia Open
Disclosure: J.H. Starrett: None. C. Lemoine: None. M. Guillo: None. C. Fayad: None. N. Kaci: None. M. Neal: None. E. Pettitt: None. M. Pache: None. Q. Ye: None. M.S. Stalvey: None. R. Charlton: None. R.V. Swanson: None. L. Legeai-Mallet: N…
View article: PTEN loss and ERBB2/ERBB3-mediated AKT reactivation drive resistance to MET inhibition in MET-amplified hepatocellular carcinoma
PTEN loss and ERBB2/ERBB3-mediated AKT reactivation drive resistance to MET inhibition in MET-amplified hepatocellular carcinoma Open
Our study identifies PTEN deficiency and ERBB2/ERBB3-mediated reactivation as key resistance mechanisms to MET inhibition in MET-amplified HCC. The findings support biomarker-informed combination strategies and underscore the importance of…
View article: Author Correction: A noninvasive model for chronic kidney disease screening and common pathological type identification from retinal images
Author Correction: A noninvasive model for chronic kidney disease screening and common pathological type identification from retinal images Open
View article: <b>Application of Dental Pulp Stem Cell-Derived Intracellular Vesicles for Diabetic Wound Healing</b>
<b>Application of Dental Pulp Stem Cell-Derived Intracellular Vesicles for Diabetic Wound Healing</b> Open
Diabetic wounds represent a significant clinical and economic burden, affecting both patients and healthcare systems. While current therapeutic approaches such as negative pressure wound therapy offer benefits, their limitations necessitat…
View article: <b>Application of Dental Pulp Stem Cell-Derived Intracellular Vesicles for Diabetic Wound Healing</b>
<b>Application of Dental Pulp Stem Cell-Derived Intracellular Vesicles for Diabetic Wound Healing</b> Open
Diabetic wounds represent a significant clinical and economic burden, affecting both patients and healthcare systems. While current therapeutic approaches such as negative pressure wound therapy offer benefits, their limitations necessitat…
View article: Biological age acceleration predicts osteoporosis and reduced longevity in a large prospective cohort
Biological age acceleration predicts osteoporosis and reduced longevity in a large prospective cohort Open
Accelerated biological aging is an independent predictor of osteoporosis and premature mortality. Integration of BAA into clinical assessment could enhance early identification of at-risk individuals and support aging-targeted intervention…
View article: Effect of aerobic exercise on the susceptibility of atrial fibrillation among aged mice
Effect of aerobic exercise on the susceptibility of atrial fibrillation among aged mice Open
Both moderate- and vigorous-intensity aerobic exercise significantly reduced the susceptibility of the aged mice to develop AF while concurrently enhancing mitochondrial morphology and structural integrity, ultimately leading to improved m…
View article: A noninvasive model for chronic kidney disease screening and common pathological type identification from retinal images
A noninvasive model for chronic kidney disease screening and common pathological type identification from retinal images Open
View article: Application of dental pulp stem cell-conditioned medium combined with deep cryopreservation of autologous cranial flaps
Application of dental pulp stem cell-conditioned medium combined with deep cryopreservation of autologous cranial flaps Open
Considering the superiority of osteogenesis and vascularization in vivo and in vitro, as well as the modulating of the local inflammatory microenvironment, DPSC-CM synergistic combination deep cryopreservation emerges as a novel strategy o…
View article: Tailored Extracellular Vesicles from Dental Stem Cells: Advances in Specific Modifications for Enhanced Therapeutic Applications
Tailored Extracellular Vesicles from Dental Stem Cells: Advances in Specific Modifications for Enhanced Therapeutic Applications Open
Extracellular vesicles(EVs) derived from dental stem cells have emerged as a key focus in regenerative medicine, owing to their remarkable ability to promote tissue repair and regeneration. Recent advancements revealed that targeted modifi…
View article: Recent progress in the identification and in vitro culture of skin organoids
Recent progress in the identification and in vitro culture of skin organoids Open
View article: Tryptophan Metabolic Enzyme <scp>IL4I1</scp> Inhibits Ferroptosis by Decreasing Ubiquitination of Nrf2 via <scp>I3P</scp> in Glioblastoma
Tryptophan Metabolic Enzyme <span>IL4I1</span> Inhibits Ferroptosis by Decreasing Ubiquitination of Nrf2 via <span>I3P</span> in Glioblastoma Open
Glioblastoma multiforme (GBM) is the deadliest brain tumour with an extremely poor prognosis. Tryptophan catabolism could enhance an array of protumour‐genic signals and promoted tumour progression in GBM. However, the mechanisms of oncoge…
View article: Crafting the future of bone regeneration: the promise of supramolecular peptide nanofiber hydrogels
Crafting the future of bone regeneration: the promise of supramolecular peptide nanofiber hydrogels Open
Bone tissue engineering has rapidly emerged as an ideal strategy to replace autologous bone grafts, establishing a comprehensive system centered on biomaterial scaffolds, seeding cells, bioactive factors, and biophysical stimulation, thus …
View article: Trends in noninvasive ocular nanoparticle drug delivery: A bibliometric analysis (2004–2023)
Trends in noninvasive ocular nanoparticle drug delivery: A bibliometric analysis (2004–2023) Open
This study presents a bibliometric analysis of research on noninvasive nanoparticle drug delivery systems for the transocular surface from 2004 to 2023. Relevant publications were retrieved from the Web of Science Core Collection. VOSviewe…
View article: Characteristics, sources, and health risks of PM2.5-bound trace elements at a national park site in southern China
Characteristics, sources, and health risks of PM2.5-bound trace elements at a national park site in southern China Open
The health effects of trace elements in PM2.5 have been the subject of widespread public concern. In this study, the 18 trace elements in PM2.5 samples collected at a national park were measured to analyze their conce…
View article: Injective hydrogel encapsulating dental pulp stem cells for the treatment of traumatic optic nerve injury
Injective hydrogel encapsulating dental pulp stem cells for the treatment of traumatic optic nerve injury Open
Objectives The study aimed to evaluate the effect of GeLMA/bFGF hydrogel loaded with dental pulp stem cells (DPSCs) on the repair and regeneration of traumatic optic nerve injury. Materials and methods GeLMA/bFGF hydrogel was photo-cross-l…
View article: Apoptotic mesenchymal stem cells and their secreted apoptotic extracellular vesicles: therapeutic applications and mechanisms
Apoptotic mesenchymal stem cells and their secreted apoptotic extracellular vesicles: therapeutic applications and mechanisms Open
Mesenchymal stem cells (MSCs), an accessible and less ethically controversial class of adult stem cells, have demonstrated significant efficacy in treating a wide range of diseases in both the preclinical and clinical phases. However, we d…
View article: Pathogenesis and therapeutic applications of microglia receptors in Alzheimer’s disease
Pathogenesis and therapeutic applications of microglia receptors in Alzheimer’s disease Open
Microglia, the resident immune cells of the central nervous system, continuously monitor the brain’s microenvironment through their array of specific receptors. Once brain function is altered, microglia are recruited to specific sites to p…
View article: Dental pulp stem cells alleviate Schwann cell pyroptosis via mitochondrial transfer to enhance facial nerve regeneration
Dental pulp stem cells alleviate Schwann cell pyroptosis via mitochondrial transfer to enhance facial nerve regeneration Open
View article: Dental pulp stem cell-derived intracellular vesicles prevent orthodontic relapse by inhibiting PI3K/Akt/NF-κB-mediated osteoclast activity
Dental pulp stem cell-derived intracellular vesicles prevent orthodontic relapse by inhibiting PI3K/Akt/NF-κB-mediated osteoclast activity Open
View article: Nyctinastic herbs decoction for the treatment of sleep-wake rhythm disorders associated with Parkinson's disease: A randomized, double-blind, placebo-controlled study
Nyctinastic herbs decoction for the treatment of sleep-wake rhythm disorders associated with Parkinson's disease: A randomized, double-blind, placebo-controlled study Open
View article: Testicular Sertoli Cell Membrane-Modified Schisandrin A-Loaded Catalase Nanoparticles Ameliorate Cytoxan-Induced Testicular Injury
Testicular Sertoli Cell Membrane-Modified Schisandrin A-Loaded Catalase Nanoparticles Ameliorate Cytoxan-Induced Testicular Injury Open
Cytoxan (CTX), an alkylating chemotherapeutic agent, produces severe testicular toxicity in male patients by generating mitochondrial dysfunction and redox imbalance, resulting in an excess buildup of reactive oxygen species (ROS) that com…
View article: Vitamin K‐dependent gamma‐carboxyglutamic acid protein 1 promotes pancreatic ductal adenocarcinoma progression through stabilizing oncoprotein KRAS and tyrosine kinase receptor EGFR
Vitamin K‐dependent gamma‐carboxyglutamic acid protein 1 promotes pancreatic ductal adenocarcinoma progression through stabilizing oncoprotein KRAS and tyrosine kinase receptor EGFR Open
Background Vitamin K‐dependent γ‐glutamic acid carboxylation (Gla) proteins are calcium‐binding and membrane‐associated, participating in coagulation, bone turnover, and cancer biology. The molecular function of transmembrane proline‐rich …
View article: Regulatory Design of Bifunctional Double-Chain Quasi-Macrocyclic Polymers with Rich Reaction Site Skeleton Support for Efficient Capture of Uranium (Vi)
Regulatory Design of Bifunctional Double-Chain Quasi-Macrocyclic Polymers with Rich Reaction Site Skeleton Support for Efficient Capture of Uranium (Vi) Open
View article: Unraveling Synergistic Pathways for Se(Iv) Immobilization: Ferrous Hydroxide Complex-Pyrite Interactions Mediated by Dual-Functional Coordination and Redox Chemistry
Unraveling Synergistic Pathways for Se(Iv) Immobilization: Ferrous Hydroxide Complex-Pyrite Interactions Mediated by Dual-Functional Coordination and Redox Chemistry Open
View article: Clinical-grade human dental pulp stem cells improve adult hippocampal neural regeneration and cognitive deficits in Alzheimer's disease
Clinical-grade human dental pulp stem cells improve adult hippocampal neural regeneration and cognitive deficits in Alzheimer's disease Open
Background: Disrupted hippocampal functions and progressive neuronal loss represent significant challenges in the treatment of Alzheimer's disease (AD). How to achieve the improvement of pathological progression and effective neural…
View article: Ultrasonic-Controlled Drug Release Prevents Protumorigenic Transition and Improves Sequential Targeting Effect to Enhance Treatment of Residual Hepatocellular Carcinoma
Ultrasonic-Controlled Drug Release Prevents Protumorigenic Transition and Improves Sequential Targeting Effect to Enhance Treatment of Residual Hepatocellular Carcinoma Open
Insufficient radio-frequency ablation (IRFA) of hepatocellular carcinoma accelerates the recurrence of residual tumor, leading to a poor prognosis. Neutrophils (NEs), as the initial leukocytes to infiltrate the IRFA-associated inflammatory…