Qiaoran Wang
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View article: MeloKids: Multisensory VR System to Enhance Speech and Motor Coordination in Children with Hearing Loss
MeloKids: Multisensory VR System to Enhance Speech and Motor Coordination in Children with Hearing Loss Open
Children with hearing impairments face ongoing challenges in language and motor development. This study explores how multi-sensory feedback technology based on virtual reality (VR), integrating auditory, visual, and tactile stimuli, can en…
View article: Immunogenicity of Minhai 13-valent pneumococcal polysaccharide conjugate vaccine in experimental mice
Immunogenicity of Minhai 13-valent pneumococcal polysaccharide conjugate vaccine in experimental mice Open
Diseases caused by pneumococci are a global public health problem. The widespread use of antibiotics has led to a sharp increase in the drug resistance of pneumococci, making research on pneumococcal vaccines highly relevant. Pfizer's 13-v…
View article: A single-cell transcriptomic atlas of the lungs of patients with pulmonary tuberculosis
A single-cell transcriptomic atlas of the lungs of patients with pulmonary tuberculosis Open
Patients with a history of mycobacterium tuberculosis infection commonly acquire irreversible and often progressive pulmonary defects. Here, we sought to understand, at a high resolution, the mechanisms underlying structural changes and fu…
View article: DNA methylation clocks for estimating biological age in Chinese cohorts
DNA methylation clocks for estimating biological age in Chinese cohorts Open
Epigenetic clocks are accurate predictors of human chronological age based on the analysis of DNA methylation (DNAm) at specific CpG sites. However, a systematic comparison between DNA methylation data and other omics datasets has not yet …
View article: HALL: a comprehensive database for human aging and longevity studies
HALL: a comprehensive database for human aging and longevity studies Open
Diverse individuals age at different rates and display variable susceptibilities to tissue aging, functional decline and aging-related diseases. Centenarians, exemplifying extreme longevity, serve as models for healthy aging. The field of …
View article: Single-cell transcriptomic Atlas of mouse cochlear aging
Single-cell transcriptomic Atlas of mouse cochlear aging Open
Progressive functional deterioration in the cochlea is associated with age-related hearing loss (ARHL). However, the cellular and molecular basis underlying cochlear aging remains largely unknown. Here, we established a dynamic single-cell…
View article: Multi-Functional Potassium Ion Assists Ammonium Vanadium Oxide Cathode for High-Performance Aqueous Zinc-Ion Batteries
Multi-Functional Potassium Ion Assists Ammonium Vanadium Oxide Cathode for High-Performance Aqueous Zinc-Ion Batteries Open
Ammonium vanadium oxide (NH4V4O10) is a promising layered cathode for aqueous zinc-ion batteries owing to its high specific capacity (>300 mA h g−1). However, the structural instability causes serious cycling degradation through irreversib…
View article: Cross-species metabolomic analysis identifies uridine as a potent regeneration promoting factor
Cross-species metabolomic analysis identifies uridine as a potent regeneration promoting factor Open
Regenerative capacity declines throughout evolution and with age. In this study, we asked whether metabolic programs underlying regenerative capability might be conserved across species, and if so, whether such metabolic drivers might be h…
View article: OUP accepted manuscript
OUP accepted manuscript Open
Aging in humans is intricately linked with alterations in circadian rhythms concomitant with physiological decline and stem cell exhaustion. However, whether the circadian machinery directly regulates stem cell aging, especially in primate…
View article: SIRT3 consolidates heterochromatin and counteracts senescence
SIRT3 consolidates heterochromatin and counteracts senescence Open
Sirtuin 3 (SIRT3) is an NAD+-dependent deacetylase linked to a broad range of physiological and pathological processes, including aging and aging-related diseases. However, the role of SIRT3 in regulating human stem cell homeostasis remain…
View article: Resurrection of endogenous retroviruses during aging reinforces senescence
Resurrection of endogenous retroviruses during aging reinforces senescence Open
SUMMARY Whether and how certain transposable elements with viral origins, such as endogenous retroviruses (ERVs) dormant in our genomes, can become awakened and contribute to the aging process are largely unknown. In human senescent cells,…
View article: Aging Atlas: a multi-omics database for aging biology
Aging Atlas: a multi-omics database for aging biology Open
Organismal aging is driven by interconnected molecular changes encompassing internal and extracellular factors. Combinational analysis of high-throughput ‘multi-omics’ datasets (gathering information from genomics, epigenomics, transcripto…
View article: Single-cell transcriptomic atlas of primate cardiopulmonary aging
Single-cell transcriptomic atlas of primate cardiopulmonary aging Open
Aging is a major risk factor for many diseases, especially in highly prevalent cardiopulmonary comorbidities and infectious diseases including Coronavirus Disease 2019 (COVID-19). Resolving cellular and molecular mechanisms associated with…
View article: Heating energy use in China: the current situation, challenges, and possibilities
Heating energy use in China: the current situation, challenges, and possibilities Open
Heating energy consumption in China is continually increasing because of the rapid urbanization and accompanied rising living standards. A panoptic description of China's current heating status is still in need of developing effective heat…