Qichen Long
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View article: Comparative diagnostic performance of metagenomic and two targeted sequencing methods in lower respiratory infection
Comparative diagnostic performance of metagenomic and two targeted sequencing methods in lower respiratory infection Open
Lower respiratory tract infections are characterized by high morbidity and mortality, the latter associated with the low sensitivity and long turnaround time (TAT) of traditional diagnostic methods. Advances in next-generation sequencing (…
View article: Comparative of metagenomic and targeted next-generation sequencing in lower respiratory tract fungal infections
Comparative of metagenomic and targeted next-generation sequencing in lower respiratory tract fungal infections Open
Objectives This study aims to compare the diagnostic efficiency and consistency of metagenomic next-generation sequencing (mNGS) and targeted next-generation sequencing (tNGS) in patients with lower respiratory tract fungal infections. Met…
View article: Diagnostic performance of metagenomic sequencing in patients with suspected infection: a large-scale retrospective study
Diagnostic performance of metagenomic sequencing in patients with suspected infection: a large-scale retrospective study Open
Background Metagenomic next-generation sequencing (mNGS) has been widely reported to identify pathogens in infectious diseases (IDs). In this work, we intended to investigate the diagnostic value and clinical acceptance of paired-samples m…
View article: Comparative performance of three next-generation sequencing techniques in real clinical lower respiratory tract infections
Comparative performance of three next-generation sequencing techniques in real clinical lower respiratory tract infections Open
Background Lower respiratory tract infections, notorious for high mortality, are inadequately addressed by traditional diagnostics, highlighting the need for more effective methods. The advent of next-generation sequencing (NGS) offers a p…
View article: The effects of sequencing strategies on Metagenomic pathogen detection using bronchoalveolar lavage fluid samples
The effects of sequencing strategies on Metagenomic pathogen detection using bronchoalveolar lavage fluid samples Open
Increasing dataset sizes and read lengths can enhance the performance of mNGS in pathogen detection but increase the economic and time costs of sequencing and data analysis. Currently, the 20 M reads in SE75 mode may be the best sequencing…
View article: Gut microbiota and metabolic biomarkers in metabolic dysfunction–associated steatotic liver disease
Gut microbiota and metabolic biomarkers in metabolic dysfunction–associated steatotic liver disease Open
Metabolic dysfunction–associated steatotic liver disease (MASLD), a replacement of the nomenclature employed for NAFLD, is the most prevalent chronic liver disease worldwide. Despite its high global prevalence, NAFLD is often under-recogni…
View article: Immunoinformatics Prediction and Protective Efficacy of Vaccine Candidate PiuA-PlyD4 Against Streptococcus Pneumoniae
Immunoinformatics Prediction and Protective Efficacy of Vaccine Candidate PiuA-PlyD4 Against Streptococcus Pneumoniae Open
The study indicates that PiuA-PlyD4, whether the results are predicted by immunoinformatics or experimentally validated in vivo and in vitro, has good immunogenicity and immunoreactivity and can provide effective protection against S. pneu…
View article: A candidate reference method and multiple commutable control materials for serum 25‐hydroxyvitamin D measurement
A candidate reference method and multiple commutable control materials for serum 25‐hydroxyvitamin D measurement Open
Objectives The aim of the current study was to establish a reliable candidate reference method for serum 25‐hydroxyvitamin D [25(OH)D] measurement and to assess the commutability of multiple control materials among liquid chromatography–ta…
View article: The consistency of aminotransferase analysis in China: a comparison of six mainstream aminotransferase routine methods and recalibration using human pooled serum preparations supplemented with human recombinant aminotransferases
The consistency of aminotransferase analysis in China: a comparison of six mainstream aminotransferase routine methods and recalibration using human pooled serum preparations supplemented with human recombinant aminotransferases Open
Background: To evaluate the consistency of six mainstream homogeneous systems for aminotransferase measurements and improve the consistency of measurements by applying uniform calibrators. Methods: 200 individual samples were grouped into …
View article: Commutability Assessment of Candidate External Quality Assessment Materials for Aminotransferase Activity Measurements Based on Different Approaches in China
Commutability Assessment of Candidate External Quality Assessment Materials for Aminotransferase Activity Measurements Based on Different Approaches in China Open
Mixed leftover samples showed desirable commutability characteristics as candidate EQA materials for routine aminotransferase activity measurements. Human serum bases supplemented with HOR were commutable for most routine ALT activity meas…