Qidi Zhang
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View article: Dexmedetomidine pretreatment improves postsurgical delay in neurocognitive recovery in aged mice by inhibiting hippocampal microglial activation via activation of cholinergic anti-inflammatory pathways
Dexmedetomidine pretreatment improves postsurgical delay in neurocognitive recovery in aged mice by inhibiting hippocampal microglial activation via activation of cholinergic anti-inflammatory pathways Open
View article: YBX1/CD36 positive feedback loop-mediated lipid accumulation drives metabolic dysfunction-associated steatotic liver disease
YBX1/CD36 positive feedback loop-mediated lipid accumulation drives metabolic dysfunction-associated steatotic liver disease Open
Metabolic dysfunction-associated steatotic liver disease (MASLD) is a common chronic liver disorder mainly caused by an imbalance in lipid homeostasis. Y-box binding protein 1 (YBX1) participates in multiple pathophysiological processes, i…
View article: Experimental Study on the Seismic Performance of Confined High Walls of Autoclaved Aerated Concrete Panels Used in Subway Stations
Experimental Study on the Seismic Performance of Confined High Walls of Autoclaved Aerated Concrete Panels Used in Subway Stations Open
This study addresses the unique challenge of the partition walls in subway stations, featuring high height, fire prevention, and located outside the main frames, by introducing a confined autoclaved aerated concrete (AAC) panel wall system…
View article: [Molecular allergen IgE tests show neosensitizaions occurring during house dust mite specific immunotherapy].
[Molecular allergen IgE tests show neosensitizaions occurring during house dust mite specific immunotherapy]. Open
Objective:Neosensitizations may be occur during the allergen specific immunotherapy（AIT） due to the differences between allergen vaccine's content and a patient's molecular sensitization profile. This study investigates whether AIT …
View article: 4-Oxo-2-Nonenal- and Agitation-Induced Aggregates of α-Synuclein and Phosphorylated α-Synuclein with Distinct Biophysical Properties and Biomedical Applications
4-Oxo-2-Nonenal- and Agitation-Induced Aggregates of α-Synuclein and Phosphorylated α-Synuclein with Distinct Biophysical Properties and Biomedical Applications Open
α-Synuclein (α-syn) can form oligomers, protofibrils, and fibrils, which are associated with the pathogenesis of Parkinson’s disease and other synucleinopathies. Both the lipid peroxidation product 4-oxo-2-nonenal (ONE) and agitation can i…
View article: Alteration and Predictive Ability of Cervical Length for Preterm Delivery in Each Gestational Trimester
Alteration and Predictive Ability of Cervical Length for Preterm Delivery in Each Gestational Trimester Open
Background To investigate the variations in cervical length (CL) across the first, second and third trimesters and the association with preterm delivery (PTD). Methods In total, 16,352 women (32,543 measurements) who delivered singleton li…
View article: Inhibition of adult hippocampal neurogenesis induced by postoperative CD8 + T-cell infiltration is associated with cognitive decline later following surgery in adult mice
Inhibition of adult hippocampal neurogenesis induced by postoperative CD8 + T-cell infiltration is associated with cognitive decline later following surgery in adult mice Open
View article: Overexpression of IGF2 affects mouse weight and glycolipid metabolism and IGF2 is positively related to macrosomia
Overexpression of IGF2 affects mouse weight and glycolipid metabolism and IGF2 is positively related to macrosomia Open
Objective To investigate the effects of insulin-like growth factor 2 (IGF2) on growth and glycolipid metabolism, as well as the underlying mechanism. Methods A mouse model of IGF2 overexpression was constructed to measure weight gain befor…
View article: Irisin participates in the beneficial effects of exercise in preventing gestational diabetes mellitus in overweight and obese pregnant women and a mouse model
Irisin participates in the beneficial effects of exercise in preventing gestational diabetes mellitus in overweight and obese pregnant women and a mouse model Open
Objective We aimed to explore whether irisin participates in the beneficial effects of exercise in preventing gestational diabetes mellitus (GDM) in overweight and obese pregnant women. Study design Sixty overweight and obese pregnant wome…
View article: Recent advances in supported acid/base ionic liquids as catalysts for biodiesel production
Recent advances in supported acid/base ionic liquids as catalysts for biodiesel production Open
Biodiesel is considered a potential substitute for fossil diesel because of its unique environmentally friendly and renewable advantages. The efficient and durable heterogeneous catalysts are vital to greenly and efficiently drive the biod…
View article: Characterization of a Novel Monoclonal Antibody for Serine-129 Phosphorylated α-Synuclein: A Potential Application for Clinical and Basic Research
Characterization of a Novel Monoclonal Antibody for Serine-129 Phosphorylated α-Synuclein: A Potential Application for Clinical and Basic Research Open
The Lewy bodies (LBs) are the pathological hallmark of Parkinson's disease (PD). More than 90% of α-synuclein (α-syn) within LBs is phosphorylated at the serine-129 residue [pSer129 α-syn (p-α-syn)]. Although various studies have revealed …
View article: Dextran Sulfate Sodium Salt-Induced Colitis Aggravates Gut Microbiota Dysbiosis and Liver Injury in Mice With Non-alcoholic Steatohepatitis
Dextran Sulfate Sodium Salt-Induced Colitis Aggravates Gut Microbiota Dysbiosis and Liver Injury in Mice With Non-alcoholic Steatohepatitis Open
Objective: Inflammatory bowel disease (IBD) is characterized by gut microbiota dysbiosis, which is also frequently observed in patients with non-alcoholic fatty liver disease. Whether gut microbiota dysbiosis in IBD patients promotes the d…
View article: Piperine promotes autophagy flux by P2RX4 activation in <i>SNCA</i> /α-synuclein-induced Parkinson disease model
Piperine promotes autophagy flux by P2RX4 activation in <i>SNCA</i> /α-synuclein-induced Parkinson disease model Open
Olfactory dysfunction, one of the earliest non-motor symptoms of Parkinson disease (PD), is accompanied by abnormal deposition of SNCA/α-synuclein in the olfactory bulb (OB). The macroautophagy/autophagy-lysosome pathway (ALP) plays an imp…
View article: [A preliminary study on the biomarkers of local inflammation in allergic rhinitis].
[A preliminary study on the biomarkers of local inflammation in allergic rhinitis]. Open
Objective:This study aimed to explore the biomarkers in nasal secretion that can assist in the diagnosis of allergic rhinitis（AR） and can be used to evaluate the therapeutic effect of AR. Methods:Thirty-three patients with AR…
View article: Diagnostic Performance of FibroTouch Ultrasound Attenuation Parameter and Liver Stiffness Measurement in Assessing Hepatic Steatosis and Fibrosis in Patients With Nonalcoholic Fatty Liver Disease
Diagnostic Performance of FibroTouch Ultrasound Attenuation Parameter and Liver Stiffness Measurement in Assessing Hepatic Steatosis and Fibrosis in Patients With Nonalcoholic Fatty Liver Disease Open
INTRODUCTION: To evaluate the diagnostic performance of ultrasound attenuation parameter (UAP) and liver stiffness measurement (LSM) by FibroTouch for diagnosis of hepatic steatosis and fibrosis in patients with nonalcoholic fatty liver di…
View article: Piperine promotes autophagy flux by P2RX4 activation in <i>SNCA</i>/α-synuclein-induced Parkinson disease model
Piperine promotes autophagy flux by P2RX4 activation in <i>SNCA</i>/α-synuclein-induced Parkinson disease model Open
Olfactory dysfunction, one of the earliest non-motor symptoms of Parkinson disease (PD), is accompanied by abnormal deposition of SNCA/α-synuclein in the olfactory bulb (OB). The macroautophagy/autophagy-lysosome pathway (ALP) plays an imp…
View article: The Diagnosis Value of a Novel Model with 5 Circulating miRNAs for Liver Fibrosis in Patients with Chronic Hepatitis B
The Diagnosis Value of a Novel Model with 5 Circulating miRNAs for Liver Fibrosis in Patients with Chronic Hepatitis B Open
Background and Aim . miRNAs play an important role in the development of human fibrosis. However, miRNA expression profiles during different stages of chronic hepatitis B (CHB) are not well defined. In this study, we aimed to further valid…
View article: Elucidation of the Initial Growth Process and the Infection Mechanism of Penicillium digitatum on Postharvest Citrus (Citrus reticulata Blanco)
Elucidation of the Initial Growth Process and the Infection Mechanism of Penicillium digitatum on Postharvest Citrus (Citrus reticulata Blanco) Open
Green mold disease, a common citrus post-harvest disease caused by Penicillium digitatum, has an unresolved initial infection mechanism. Understanding the infection mechanism leads to the development of potential controls and preventive me…
View article: Autophagy promotes hepatic differentiation of hepatic progenitor cells by regulating the Wnt/β-catenin signaling pathway
Autophagy promotes hepatic differentiation of hepatic progenitor cells by regulating the Wnt/β-catenin signaling pathway Open
View article: <scp>CXCL</scp>6‐<scp>EGFR</scp>‐induced Kupffer cells secrete <scp>TGF</scp>‐β1 promoting hepatic stellate cell activation via the <scp>SMAD</scp>2/<scp>BRD</scp>4/C‐<scp>MYC</scp>/<scp>EZH</scp>2 pathway in liver fibrosis
<span>CXCL</span>6‐<span>EGFR</span>‐induced Kupffer cells secrete <span>TGF</span>‐β1 promoting hepatic stellate cell activation via the <span>SMAD</span>2/<span>BRD</span>4/C‐<span>MYC</span>/<span>EZH</span>2 pathway in liver fibrosis Open
Liver fibrosis is the excessive accumulation of extracellular matrix proteins in response to the inflammatory response that accompanies tissue injury, which at an advanced stage can lead to cirrhosis and even liver failure. This study inve…
View article: Exosomes derived from miR‐181‐5p‐modified adipose‐derived mesenchymal stem cells prevent liver fibrosis <i>via</i> autophagy activation
Exosomes derived from miR‐181‐5p‐modified adipose‐derived mesenchymal stem cells prevent liver fibrosis <i>via</i> autophagy activation Open
Proliferating hepatic stellate cells ( HSC s) respond to liver damage by secreting collagens that form fibrous scar tissue, which can lead to cirrhosis if in appropriately regulated. Advancement of micro RNA (mi RNA ) hepatic therapies has…
View article: Y-box Protein-1 Regulates the Expression of Collagen I in Hepatic Progenitor Cells via PDGFR-<i>β</i>/ERK/p90RSK Signalling
Y-box Protein-1 Regulates the Expression of Collagen I in Hepatic Progenitor Cells via PDGFR-<i>β</i>/ERK/p90RSK Signalling Open
Y-box protein-1 (YB-1) is a highly conserved transcription factor that is involved in multiple biological processes via transcriptional regulation of several genes, including p53 , cyclin D1 , and EGFR . YB-1 has been reported to be overex…
View article: CXCL6 promotes human hepatocyte proliferation through the CXCR1–NFκB pathway and inhibits collagen I secretion by hepatic stellate cells
CXCL6 promotes human hepatocyte proliferation through the CXCR1–NFκB pathway and inhibits collagen I secretion by hepatic stellate cells Open
Hepatocyte proliferation and collagen I (COLI) secretion are important processes during liver regeneration. This study aimed to investigate the role of CXCL6 in hepatocyte proliferation and COLI secretion. Serum CXCL6 levels in patients wi…
View article: Analysis of the differential expression of circulating microRNAs during the progression of hepatic fibrosis in patients with chronic hepatitis B virus infection
Analysis of the differential expression of circulating microRNAs during the progression of hepatic fibrosis in patients with chronic hepatitis B virus infection Open
Considering the limitations of liver biopsy, reliable non‑invasive serum biomarkers of liver fibrosis are required for early diagnosis. The present study analyzed the expression profile of circulating micro (mi)RNAs during the development …