Qidong Hu
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View article: SRPK1 acetylation modulates alternative splicing to regulate cisplatin resistance in breast cancer cells
SRPK1 acetylation modulates alternative splicing to regulate cisplatin resistance in breast cancer cells Open
Cisplatin and other platinum-based compounds are frequently used to treat breast cancer, but their utility is severely compromised by drug resistance. Many genes dictating drug responsiveness are subject to pre-mRNA alternative splicing wh…
View article: Role of PIWI-like 4 in modulating neuronal differentiation from human embryonal carcinoma cells
Role of PIWI-like 4 in modulating neuronal differentiation from human embryonal carcinoma cells Open
PIWI homologs constitute a subclass of the Argonaute family. Traditionally, they have been shown to associate with a specific class of small RNAs, piRNAs, to suppress transposable elements and protect genomic integrity in germ cells. Recen…
View article: Yin Yang 1 Suppresses Dilated Cardiomyopathy and Cardiac Fibrosis Through Regulation of <i>Bmp7</i> and <i>Ctgf</i>
Yin Yang 1 Suppresses Dilated Cardiomyopathy and Cardiac Fibrosis Through Regulation of <i>Bmp7</i> and <i>Ctgf</i> Open
Rationale: Pathogenic variations in the lamin gene ( LMNA ) cause familial dilated cardiomyopathy (DCM). LMNA insufficiency caused by LMNA pathogenic variants is believed to be the basic mechanism underpinning LMNA -related DCM. Objective:…
View article: Y-box binding protein-1 and STAT3 independently regulate ATP-binding cassette transporters in the chemoresistance of gastric cancer cells
Y-box binding protein-1 and STAT3 independently regulate ATP-binding cassette transporters in the chemoresistance of gastric cancer cells Open
Y-box binding protein-1 (YB-1) facilitates cancer chemoresistance through the upregulation of ATP-binding cassette (ABC) transporters associated with multidrug resistance, which is one of the primary obstacles in cancer treatment. Since ab…
View article: The Akt-SRPK-SR Axis Constitutes a Major Pathway in Transducing EGF Signaling to Regulate Alternative Splicing in the Nucleus
The Akt-SRPK-SR Axis Constitutes a Major Pathway in Transducing EGF Signaling to Regulate Alternative Splicing in the Nucleus Open
View article: The role of 17β‑estradiol‑induced upregulation of Piwi‑like�4 in modulating gene expression and motility in breast cancer cells
The role of 17β‑estradiol‑induced upregulation of Piwi‑like�4 in modulating gene expression and motility in breast cancer cells Open
A majority of breast cancer cases are positive for the estrogen receptor (ER), which means that they can respond to the estrogen hormone to achieve growth. Hence, the ER signaling pathway has been extensively targeted in pharmaceutical res…
View article: Oxidative stress promotes exit from the stem cell state and spontaneous neuronal differentiation
Oxidative stress promotes exit from the stem cell state and spontaneous neuronal differentiation Open
Reactive oxygen species (ROS) play important roles in fundamental cellular processes such as proliferation and survival. Here we investigated the effect of oxidative stress on stem cell maintenance and neuronal differentiation in a human e…