Qifang Wu
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View article: Astragaloside IV Alleviates Fructose-Induced Intestinal Metabolic Senescence by Targeting Ketohexokinase Asn261/Ala226 to Preserve Intestinal Stem Cell Homeostasis
Astragaloside IV Alleviates Fructose-Induced Intestinal Metabolic Senescence by Targeting Ketohexokinase Asn261/Ala226 to Preserve Intestinal Stem Cell Homeostasis Open
Excessive fructose intake drives intestinal aging and impairs intestinal stem cell (ISC) function, yet effective therapeutic interventions remain elusive. Astragaloside IV (AS-IV), a natural saponin from Astragalus membranaceus, has…
View article: Intestinal inflammation mediates PFOA-induced sleep fragmentation and growth impairment in Drosophila
Intestinal inflammation mediates PFOA-induced sleep fragmentation and growth impairment in Drosophila Open
View article: JUN mediates glucocorticoid resistance by stabilizing HIF1a in T cell acute lymphoblastic leukemia
JUN mediates glucocorticoid resistance by stabilizing HIF1a in T cell acute lymphoblastic leukemia Open
[This corrects the article DOI: 10.1016/j.isci.2023.108242.].
View article: Perfluorooctane sulfonate mediates GSH degradation leading to oral keratinocytes ferroptosis and mucositis through activation of the ER stress-ATF4-CHAC1 axis
Perfluorooctane sulfonate mediates GSH degradation leading to oral keratinocytes ferroptosis and mucositis through activation of the ER stress-ATF4-CHAC1 axis Open
Perfluorooctane sulfonate (PFOS) is a persistent organic pollutant that induces inflammatory response and oxidative stress in oral mucosa. Ferroptosis, a form of cell death characterized by iron-dependent lipid peroxidation (the oxidative …
View article: Angiotensin IV does not exert prothrombotic effects in vivo
Angiotensin IV does not exert prothrombotic effects in vivo Open
Thrombosis and thromboembolism are serious clinical complications of cardiovascular diseases and are among the leading causes of mortality worldwide. Dysregulation of the renin-angiotensin system is associated with an increased incidence o…
View article: Mechanistic Insights into cardiac regeneration and protection through MEIS Inhibition
Mechanistic Insights into cardiac regeneration and protection through MEIS Inhibition Open
MEIS1, a member of the TALE-type homeobox gene family, has emerged as a pivotal regulator of cardiomyocyte cell cycle arrest and represents a promising therapeutic target. Our study reveals that inhibition of MEIS1 using two novel small mo…
View article: Fucoidan alleviates high sucrose-induced metabolic disorders and enhances intestinal homeostasis through modulation of Notch signaling
Fucoidan alleviates high sucrose-induced metabolic disorders and enhances intestinal homeostasis through modulation of Notch signaling Open
Our findings demonstrate the multifaceted therapeutic effects of FUC in mitigating metabolic disorders and maintaining intestinal health. FUC holds promise as a therapeutic agent, with its effects attributed partly to the sulfate group and…
View article: Fucoidan Alleviates High Sucrose-Induced Metabolic Disorders and Enhances Intestinal Homeostasis Through Modulation of Notch Signaling
Fucoidan Alleviates High Sucrose-Induced Metabolic Disorders and Enhances Intestinal Homeostasis Through Modulation of Notch Signaling Open
View article: Direct inhibition of dioxygenases TET1 by the rheumatoid arthritis drug auranofin selectively induces cancer cell death in T-ALL
Direct inhibition of dioxygenases TET1 by the rheumatoid arthritis drug auranofin selectively induces cancer cell death in T-ALL Open
View article: JUN mediates glucocorticoid resistance by stabilizing HIF1a in T cell acute lymphoblastic leukemia
JUN mediates glucocorticoid resistance by stabilizing HIF1a in T cell acute lymphoblastic leukemia Open
Dexamethasone (Dex) plays a critical role in T-ALL treatment, but the mechanisms of Dex resistance are poorly understood. Here, we demonstrated that the expression of JUN was regulated in Dex-resistant T-ALL cell lines and patient samples.…
View article: ATF4 renders human T-cell acute lymphoblastic leukemia cell resistance to FGFR1 inhibitors through amino acid metabolic reprogramming
ATF4 renders human T-cell acute lymphoblastic leukemia cell resistance to FGFR1 inhibitors through amino acid metabolic reprogramming Open
View article: lncRNA IGF2‐AS regulates miR‐500a‐3p/PPP4R1/p‐VEGFR2 signalling pathway to promote thyroid carcinoma progression and tubulogenesis
lncRNA IGF2‐AS regulates miR‐500a‐3p/PPP4R1/p‐VEGFR2 signalling pathway to promote thyroid carcinoma progression and tubulogenesis Open
To the Editor Thyroid carcinoma (THCA) continues to rise globally, with an estimated 52 890 new cases and 2180 deaths in the United States in 2020.1 It is reported that an increasing number of long noncoding RNAs (lncRNAs) have been involv…
View article: ATF4 drives the resistance of T-ALL against FGFR1 inhibitors through amino acid metabolic reprogramming
ATF4 drives the resistance of T-ALL against FGFR1 inhibitors through amino acid metabolic reprogramming Open
Background Abnormalities of FGFR1 have been reported in multiple malignancies, which proposes FGFR1 as a potential target for precision treatment, whereas drug resistance remains a formidable obstacle simultaneously. Methods RNA-seq analys…
View article: Additional file 1 of Direct inhibition of dioxygenases TET1 by the rheumatoid arthritis drug auranofin selectively induces cancer cell death in T-ALL
Additional file 1 of Direct inhibition of dioxygenases TET1 by the rheumatoid arthritis drug auranofin selectively induces cancer cell death in T-ALL Open
Additional file 1. Supplementary tables.
View article: Sulforaphane alleviates high fat diet-induced insulin resistance via AMPK/Nrf2/GPx4 axis
Sulforaphane alleviates high fat diet-induced insulin resistance via AMPK/Nrf2/GPx4 axis Open
View article: <i>Pyropia yezoensis</i> porphyran alleviates metabolic disorders via modulating gut microbiota in high‐sucrose‐fed <i>Drosophila melanogaster</i>
<i>Pyropia yezoensis</i> porphyran alleviates metabolic disorders via modulating gut microbiota in high‐sucrose‐fed <i>Drosophila melanogaster</i> Open
BACKGROUND Prebiotics, such as algal polysaccharides, can be used to manage metabolic diseases by modulating gut microbiota. However, the effect of Pyropia yezoensis porphyran (PYP), a red algal polysaccharide, on gut microbiota has not be…
View article: Chlordane exposure causes developmental delay and metabolic disorders in Drosophila melanogaster
Chlordane exposure causes developmental delay and metabolic disorders in Drosophila melanogaster Open
The incidence of metabolic diseases is increasing every year, and several studies have highlighted the activity of persistent organic pollutants (POPs) in causing hyperlipidemia and diabetes, and these compounds are considered to be endocr…
View article: Regulation of follistatin-like 3 expression by miR-486-5p modulates gastric cancer cell proliferation, migration and tumor progression
Regulation of follistatin-like 3 expression by miR-486-5p modulates gastric cancer cell proliferation, migration and tumor progression Open
Cancer development and progression can be regulated by the levels of endogenous factors. Gastric cancer is an aggressive disease state with poor patient prognosis, needing the development of new diagnostics and therapeutic strategies. We i…
View article: The Role of TRPC6 in Renal Ischemia/Reperfusion and Cellular Hypoxia/Reoxygenation Injuries
The Role of TRPC6 in Renal Ischemia/Reperfusion and Cellular Hypoxia/Reoxygenation Injuries Open
Renal ischemia/reperfusion (I/R), a major cause of acute kidney injury (AKI), is a serious clinical event in patients during post-renal transplantation. I/R is associated with renal dysfunction and tubular apoptosis, and calcium (Ca 2+ ) o…
View article: Optimization of Porphyran Extraction from Pyropia yezoensis by Response Surface Methodology and Its Lipid-Lowering Effects
Optimization of Porphyran Extraction from Pyropia yezoensis by Response Surface Methodology and Its Lipid-Lowering Effects Open
Macroalgae polysaccharides are phytochemicals that are beneficial to human health. In this study, response surface methodology was applied to optimize the extraction procedure of Pyropia yezoensis porphyran (PYP). The optimum extraction pa…
View article: Transient Receptor Potential Channel 6 Knockout Ameliorates Kidney Fibrosis by Inhibition of Epithelial–Mesenchymal Transition
Transient Receptor Potential Channel 6 Knockout Ameliorates Kidney Fibrosis by Inhibition of Epithelial–Mesenchymal Transition Open
Kidney fibrosis is generally confirmed to have a significant role in chronic kidney disease, resulting in end-stage kidney failure. Epithelial–mesenchymal transition (EMT) is an important molecular mechanism contributing to fibrosis. Tubul…
View article: Pharmaceutical and Nutraceutical Potential Applications of <i>Sargassum fulvellum</i>
Pharmaceutical and Nutraceutical Potential Applications of <i>Sargassum fulvellum</i> Open
Sargassum fulvellum is a brown seaweed of the Sargassaceae family which has been demonstrated to exhibit antipyretic, analgesic, antiedema, antimicrobial, antioxidant, antitumor, neuroprotective, anticoagulative, anti‐inflammatory, and hep…